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Organ Preservation

Organ Preservation Book
Author : D.R. Pegg
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401162670
Language : En, Es, Fr & De

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Book Description :

During the past 10 years, there have been many international meetings on the storage of organs prior to transplantation, and several have led to the publication of proceedings; there have also been a number of other books on this subject-. Most of these publications have concentrated on practical clinical aspects of organ preservation and on empirical animal experiments directed towards well-defined clinical objectives. Progress was rapid at first, but it is now generally agreed that there has been little improvement in techniques during the past 5 years, although understanding has certainly increased. In 1980 the Tissue Preservation and Banking Committee of the Transplantation Society decided that a fresh approach to the problem of improving preservation methods was needed: it was decided to hold a conference at which an opportunity would be provided to return to basic principles and to examine some of the advances that have occurred in recent yelns in areas of physiology that might be important for further improvements in preservation. The conference was held in Cambridge, UK, in April 1981 and this book is based upon the papers presented to that meeting and the work of a small discussion group that met after the main meeting. The book starts with six basic review chapters, followed by sections on the effects of ischaemia and anoxia, and on biochemical and pharmacological aspects of hypothermia. Chapters dealing with organ preservation by initial perfusion followed by hypothermia, and by continuous hypothermic perfusion, follow.

Organ Preservation for Transplantation

Organ Preservation for Transplantation Book
Author : Luis Horacio Toledo-Pereyra
Publisher : CRC Press
Release : 2010-01-18
ISBN : 1498713831
Language : En, Es, Fr & De

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Book Description :

The first edition of this book, Basic Concepts in Organ Procurement, Perfusion and Preservation for Transplantation, was published 27 years ago, in 1982 when organ procurement and preservation began to advance in the study of the best ways to preserve organs for transplantation. The second edition, Organ Procurement and Preservation for Transplanta

Organ Preservation and Transplant Surgery

Organ Preservation and Transplant Surgery Book
Author : Jean-Michel Dubernard,Marwan Dawahra,Paul McMaster
Publisher : Taylor & Francis
Release : 2003-03-27
ISBN : 9781841841281
Language : En, Es, Fr & De

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Book Description :

This new book, edited by internationally renowned specialists, also pools the experience of consultants from both Europe and the US. It is divided into three main sections: Organ Preservation, Organ Harvesting and Surgical Techniques. Many different organs are profiled, including the heart, kidneys, lungs, pancreas, intestine and bowel. The various aspects of preservation are discussed including cooling and preservation solutions, which are of special interest as researchers are actively exploring the composition of those solutions. Longer term preservation of the heart is still an unsolved problem and this is considered, as well as the pros and cons of organ donation from live or cadaveric donors. Fully referenced and illustrated with over 50 line drawings, Organ Preservation and Transplant Surgery will be of particular interest to those involved in the often complex surgery of organ harvesting or trainees in transplantation surgery. It gives clear accounts of techniques and a detailed update in the underlying science that determines and currently limits organ storage. It will also prove invaluable to the younger researcher who needs a clearer understanding of the scientific basis of organ preservation and the clinical need for better organ preservation.

Organ Preservation for Transplantation

Organ Preservation for Transplantation Book
Author : Armand M. Karow,David E. Pegg
Publisher : Marcel Dekker Incorporated
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Organ Preservation for Transplantation book written by Armand M. Karow,David E. Pegg, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Organ Procurement and Preservation

Organ Procurement and Preservation Book
Author : Goran B. Klintmalm
Publisher : CRC Press
Release : 1999-01-01
ISBN : 1498713262
Language : En, Es, Fr & De

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Book Description :

This handbook is a ready reference guide for organ procurement and preservation. Procurement coordinators, surgeons, residents and other health care professionals involved in organ retrieval will find most questions answered that will arise during their participation with these difficult and complex issues. This handbook will prove an invaluable re

The Multi Organ Donor A Guide to Selection Preservation and Procurement

The Multi Organ Donor  A Guide to Selection  Preservation and Procurement Book
Author : Robert S.D. Higgins,Juan A. Sanchez
Publisher : Bentham Science Publishers
Release : 2018-11-30
ISBN : 1681087561
Language : En, Es, Fr & De

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Book Description :

Advances in the science of immunology have improved the success rate of organ transplantations since the mid twentieth century. Organ transplantation is now a lifesaving medical procedure for thousands of patients around the world with end-organ diseases. The lifesaving potential of transplantation has been limited by the number and quality of appropriate organ donors. The evolution of brain death criteria by the Harvard Ad-Hoc Committee Report has opened the door to understanding the importance of medical, legal and ethical challenges of organ donation in support of the growth of the transplant science. The possibility of organ donation from living donors has enhanced organ availability for patients with kidney failure. Modern inotropes and immunosuppression regimens have been critical to the success of other organ transplant procedures. However, the cornerstone of successful transplantation continues to be the appropriate selection, evaluation, preservation of organ tissues and the successful surgical procurement process to mitigate the impact of tissue ischemia and reperfusion. In this textbook, the art and science of organ donation and tissue preservation is examined. Through this authoritative text by leaders in the field, the editors provide a state of the art review of modern preservation techniques, patient selection and screening criteria, as well as best practices for multi-organ procurement. Information presented in the book will familiarize readers with the initial steps of determining organ availability which ultimately enables health care professionals to realize the extraordinary potential of successful multi-organ transplant procedures. This guide is intended to be a fundamental resource for students, residents, faculty and staff for all disciplines allied to health care delivery and organ donation.

Advanced Therapy in Cardiac Surgery

Advanced Therapy in Cardiac Surgery Book
Author : Kenneth L. Franco,Edward D. Verrier
Publisher : PMPH-USA
Release : 2003
ISBN : 9781550090611
Language : En, Es, Fr & De

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Book Description :

Advanced Therapy in Cardiac Surgery - Second Edition This second edition of Advanced Therapy in Cardiac Surgery presents state-of-the-art techniques and an in-depth review of cardiac surgery from the leading authorities. Each of the 62 succinct chapters represents the personal treatment protocols of the experts. The Advanced ......

Immunobiology of Organ Transplantation

Immunobiology of Organ Transplantation Book
Author : David S. Wilkes,William J. Burlingham
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1441989994
Language : En, Es, Fr & De

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Book Description :

Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.

Transplantation Surgery

Transplantation Surgery Book
Author : Nadey Hakim,Gabriel Danovitch
Publisher : Springer Science & Business Media
Release : 2001-03-10
ISBN : 9781852332860
Language : En, Es, Fr & De

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Book Description :

It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.

Methods in Bioengineering

Methods in Bioengineering Book
Author : Korkut Uygun
Publisher : Artech House
Release : 2011
ISBN : 160807014X
Language : En, Es, Fr & De

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Book Description :

Written and edited by recognized experts in the field, the new Artech House Methods in Bioengineering book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. This first-of-its-kind volume addresses the important challenge of organ preservation and reengineering. The book presents cutting-edge techniques for damaged livers and hearts via normothermic perfusion, hypothermic machine perfusion for the liver, kidney and pancreas, and imaging techniques to assess the viability of injured kidneys. Professionals and researchers also find methods to decellularize whole organs to create scaffolds for tissue engineering. Moreover, the book presents an approach to enhancing hepatocyte recovery from marginal livers.

Organ Preservation for Clinical T2N0 Distal Rectal Cancer Using Neoadjuvant Chemoradiotherapy and Local Excision ACOSOG Z6041 Results of an Open label Single arm Multi institutional Phase 2 Trial

Organ Preservation for Clinical T2N0 Distal Rectal Cancer Using Neoadjuvant Chemoradiotherapy and Local Excision  ACOSOG Z6041   Results of an Open label  Single arm  Multi institutional  Phase 2 Trial Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Background: Local excision is an organ-preserving treatment alternative to transabdominal resection for patients with stage I rectal cancer. However, local excision alone is associated with a high risk of local recurrence and inferior survival compared with transabdominal rectal resection. We investigated the oncological and functional outcomes of neoadjuvant chemoradiotherapy and local excision for patients with stage T2N0 rectal cancer. Methods: We did a multi-institutional, single-arm, open-label, non-randomised, phase 2 trial of patients with clinically staged T2N0 distal rectal cancer treated with neoadjuvant chemoradiotherapy at 26 American College of Surgeons Oncology Group institutions. Patients with clinical T2N0 rectal adenocarcinoma staged by endorectal ultrasound or endorectal coil MRI, measuring less than 4 cm in greatest diameter, involving less than 40% of the circumference of the rectum, located within 8 cm of the anal verge, and with an Eastern Cooperative Oncology Group performance status of at least 2 were included in the study. Neoadjuvant chemoradiotherapy consisted of capecitabine (original dose 825 mg/m 2 twice daily on days 1–14 and 22–35), oxaliplatin (50 mg/m 2 on weeks 1, 2, 4, and 5), and radiation (5 days a week at 1·8 Gy per day for 5 weeks to a dose of 45 Gy, followed by a boost of 9 Gy, for a total dose of 54 Gy) followed by local excision. Because of adverse events during chemoradiotherapy, the dose of capecitabine was reduced to 725 mg/m 2 twice-daily, 5 days per week, for 5 weeks, and the boost of radiation was reduced to 5·4 Gy, for a total dose of 50·4 Gy. The primary endpoint was 3-year disease-free survival for all eligible patients (intention-to-treat population) and for patients who completed chemotherapy and radiation, and had ypT0, ypT1, or ypT2 tumours, and negative resection margins (per-protocol group). This study is registered withClinicalTrials.gov, numberNCT00114231 . Findings: Between May 25, 2006, and Oct 22, 2009, 79 eligible patients were recruited to the trial and started neoadjuvant chemoradiotherapy. Two patients had no surgery and one had a total mesorectal excision. Four additional patients completed protocol treatment, but one had a positive margin and three had ypT3 tumours. Thus, the per-protocol population consisted of 72 patients. Median follow-up was 56 months (IQR 46–63) for all patients. The estimated 3-year disease-free survival for the intention-to-treat group was 88·2% (95% CI 81·3–95·8), and for the per-protocol group was 86·9% (79·3–95·3). Of 79 eligible patients, 23 (29%) had grade 3 gastrointestinal adverse events, 12 (15%) had grade 3–4 pain, and 12 (15%) had grade 3–4 haematological adverse events during chemoradiation. Of the 77 patients who had surgery, six (8%) had grade 3 pain, three (4%) had grade 3–4 haemorrhage, and three (4%) had gastrointestinal adverse events. Interpretation: Although the observed 3-year disease free survival was not as high as anticipated, our data suggest that neoadjuvant chemoradiotherapy followed by local excision might be considered as an organ-preserving alternative in carefully selected patients with clinically staged T2N0 tumours who refuse, or are not candidates for, transabdominal resection. Funding: National Cancer Institute and Sanofi-Aventis.

Textbook of Organ Transplantation Set

Textbook of Organ Transplantation Set Book
Author : Allan D. Kirk,Stuart J. Knechtle,Christian P. Larsen,Joren C. Madsen,Thomas C. Pearson,Steven A. Webber
Publisher : John Wiley & Sons
Release : 2014-07-21
ISBN : 1118889622
Language : En, Es, Fr & De

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Book Description :

Brought to you by the world’s leading transplantclinicians, Textbook of Organ Transplantation provides acomplete and comprehensive overview of modern transplantation inall its complexity, from basic science to gold-standard surgicaltechniques to post-operative care, and from likely outcomes toconsiderations for transplant program administration, bioethics andhealth policy. Beautifully produced in full color throughout, and with over 600high-quality illustrations, it successfully: Provides a solid overview of what transplantclinicians/surgeons do, and with topics presented in an order thata clinician will encounter them. Presents a holistic look at transplantation, foregrounding theinterrelationships between transplant team members and non-surgicalclinicians in the subspecialties relevant to pre- andpost-operative patient care, such as gastroenterology, nephrology,and cardiology. Offers a focused look at pediatric transplantation, andidentifies the ways in which it significantly differs fromtransplantation in adults. Includes coverage of essential non-clinical topics such astransplant program management and administration; research designand data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leadingand definitive transplantation reference work, and essentialreading for all transplant surgeons, transplant clinicians, programadministrators, basic and clinical investigators and any othermembers of the transplantation team responsible for the clinicalmanagement or scientific study of transplant patients.

Organ Preservation

Organ Preservation Book
Author : David E. Pegg
Publisher : Unknown
Release : 1973
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Organ Preservation book written by David E. Pegg, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Organ Preservation Surgery for Laryngeal Cancer

Organ Preservation Surgery for Laryngeal Cancer Book
Author : Gregory S. Weinstein,Ollivier Laccourreye,Henri Laccourreye,Daniel Brasnu
Publisher : Singular
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Organ Preservation Surgery for Laryngeal Cancer is the first book/CD-ROM package to focus solely on the surgical techniques that preserve the functions of speech and swallowing without a permanent tracheostomy. Written by leading international authorities, this new groundbreaking work is

Current Status of Clinical Organ Transplantation

Current Status of Clinical Organ Transplantation Book
Author : G.M. Abouna
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9400956746
Language : En, Es, Fr & De

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Book Description :

MICHAEL F.A. WOODRUFF Emeritus Professor of Surgery, University of Edinburgh This book grew out of a very successful conference on Organ Transplantation held in Kuwait in December 1982. The material presented at the conference has been expanded and brought up to date, and the result is a well written and authoritative account of many aspects of organ transplantation by a distinguished team of contributors drawn from many countries. A unique feature of the book is the account it contains of the development of organ transplantation in the Middle East. Although, as yet, it has been virtually impossible in Islamic countries to take organs after death for use as transplants, it is beginning to look as if this situation may change. Meanwhile, using living volunteer donors and a small number of cadaveric organs sent from other countries, transplant teams in Kuwait and Turkey are obtaining results with kidney transplants which are as good, in terms of both transplant survival and patient survival, as those reported from acknowledged centres of excellence in the United States, Europe and other countries where organ transplantation has been established for many years.

Non Heart Beating Organ Transplantation

Non Heart Beating Organ Transplantation Book
Author : Institute of Medicine,Division of Health Care Services,Committee on Non-Heart-Beating Transplantation II: The Scientific and Ethical Basis for Practice and Protocols
Publisher : National Academies Press
Release : 2000-05-19
ISBN : 9780309066419
Language : En, Es, Fr & De

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Book Description :

In 1997, the Institute of Medicine published a report entitled Non-Heart- Beating Organ Transplantation: Medical and Ethical Issues in Procurement. The findings and recommendations of that study defined the ethical and scientific basis for non-heart-beating organ donation and transplantation, and provided specific recommendations for practices that affirm patient welfare, promote patient and family choice, and avoid conflicts of interest. Following the 1997 study, the Department of Health and Human Services requested a follow up study to promote such efforts. The central activity for this study was a workshop held in Washington, D.C., on May 24-25, 1999. The workshop provided the opportunity for extensive dialogue on non-heart-beating organ donation among hospitals and organ procurement organizations (OPOs) that are actively involved in non-heartbeating organ and tissue donation and those with concerns about whether and how to proceed. The findings and recommendations of this report are based in large measure on the discussions and insights from that workshop. Non-Heart-Beating Organ Transplantation includes seven recommendations for developing and implementing non-heart-beating-donor protocols. These recommendations were based on the findings and recommendations from the 1997 IOM report and consensus achieved among participants at the national workshop. The committee developed these recommendations as steps towards an approach to non-heart-beating-donor organ donation and procurement consistent with underlying scientific and ethical guidelines, patient and family options and choices, and public trust in organ donation.

Cryopreservation and low temperature biology in blood transfusion

Cryopreservation and low temperature biology in blood transfusion Book
Author : C.Th. Smit Sibinga,P.C. Das,H.T. Meryman
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461315158
Language : En, Es, Fr & De

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Book Description :

The theme of this 14th International Symposium on Blood Transfusion is closely related to the work and scientific contributions of the Dutch cryobiology pioneer Dr. Herman W. Krijnen of the Dutch Red Cross Central Laboratory. Dr. Krijnen was known and respected in the national and interna tional blood transfusion community as an extremely competent scientist and a beloved and admired colleague. Dr. Krijnen was intentionally honoured with the invitation to open this symposium on cryopreservation and low temperature biology in blood transfusion and be the guest of honour at this event. Unfortunately, Dr. Krijnen suddenly died on the first of June 1989. In honour and mem ory of Dr. Krijnen this symposium will therefore be dedicated to him. Since the lOth International Symposium on Blood Transfusion in 1985 highlighted the theme of "Future developments in blood banking", major changes have occurred in the blood banking world. Most of these changes were forced upon the Blood Banks by the fear of spreading AIDS through contaminated donations. This not only led to the wide spread testing of blood, but also to a more appropriate counselling of the community and the blood donors in specific. Additionally, virus inacti vation techniques were introduced for those components derived from multiple donations and intended for a regular transfusion in haemophi lia patients and others.

Organ Donation and Transplantation After Cardiac Death

Organ Donation and Transplantation After Cardiac Death Book
Author : David Talbot,Anthony D'Alessandro
Publisher : Oxford University Press
Release : 2009-03-12
ISBN : 0199217335
Language : En, Es, Fr & De

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Book Description :

With the success of organ transplantation and the declining number of heart beating cadaver donors, the number of patients awaiting a transplant continues to rise. This means that alternative sources of donors have been sought, including donors after cardiac death. Such donors sustain rapid damage to their organs due to ischaemia, and as a consequence some organs do not work initially and some none at all. Written by international experts,this book lays out the moral, legal and ethical restraints to using such donors for organ transplant together with the techniques that have been adopted to improve their outcome. The different approaches and results of renal transplant according to country are covered together with the procedures andoutcomes adopted to use other organs, notably liver and lung. The outcome of transplanting a vital organ which fails to function immediately is death of the recipient. The success of transplanting such 'damaged' organs shows how far progress has been made with utilising such donors and why the proportion of transplants has increased so dramatically in recent years (developments have allowed these programmes to flourish such that in the UK 25% of kidney transplants were from such donors in2006).

Head and Neck Cancer

Head and Neck Cancer Book
Author : K. Thomas Robbins,Thomas Murry
Publisher : Singular
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

(1E 1990) Overvi