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Oncogenomics

Oncogenomics Book
Author : Charles Brenner,David Duggan
Publisher : John Wiley & Sons
Release : 2004-11-19
ISBN : 0471476641
Language : En, Es, Fr & De

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Book Description :

This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.

The Oncogenomics Handbook

The Oncogenomics Handbook Book
Author : William J. LaRochelle,Richard A. Shimkets
Publisher : Springer Science & Business Media
Release : 2007-11-09
ISBN : 1592598935
Language : En, Es, Fr & De

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Book Description :

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Oncogenomics

Oncogenomics Book
Author : Franco Dammacco,Franco Silvestris
Publisher : Academic Press
Release : 2018-10-30
ISBN : 0128117869
Language : En, Es, Fr & De

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Book Description :

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

Oncogenomics

Oncogenomics Book
Author : Franco Dammacco,Franco Silvestris
Publisher : Academic Press
Release : 2018-11-15
ISBN : 9780128117859
Language : En, Es, Fr & De

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Book Description :

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to non-invasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers of pancreatic, gastrointestinal, breast, lung, hematological, osteotropic, genitourinary, and skin cancers among others Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics, and precision medicine

Oncogenomics and Cancer Proteomics

Oncogenomics and Cancer Proteomics Book
Author : Cesar Lopez-Camarillo,Elena Arechaga-Ocampo
Publisher : BoD – Books on Demand
Release : 2013-03-13
ISBN : 9535110411
Language : En, Es, Fr & De

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Book Description :

Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.

Systems and Integrative Approaches in Oncogenomics

Systems and Integrative Approaches in Oncogenomics Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Significant progress in technology has allowed systems level molecular profiling of cancer which has created a wealth of unprecedented genomics ('oncogenomics') data. Innovative and integrated approaches are needed to translate this rich information into knowledge. In this dissertation, I have explored 3 such case studies involving high throughput datasets such as RNAi screens, mutation profiling and microarrays. By generating and testing hypotheses from fusing different datasets, I have attempted to characterize genetic determinants of tumor biology and their relevance to drug discovery applications. Results include identifying novel cancer targets, shedding light on mechanism of recently discovered genetic aberrations and suggesting rational therapeutic applications for testing in the lab and clinic. These global approaches hold great promise and can be extended to enhance our understanding of the 'oncogenome' and to create opportunities for improvement of existing or future cancer treatment.

A Computational Approach for Comparative Oncogenomics Using Mouse Models

A Computational Approach for Comparative Oncogenomics Using Mouse Models Book
Author : Benjamin Thomas Brett,University of Iowa. Interdisciplinary Graduate Program in Genetics
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Combining this connectivity network with the set of cancer genes identified by the Integration Analysis System is a strategy for rapid and efficient interpretation of the genetic results.

Bioinformatics

Bioinformatics Book
Author : Mahmood A. Mahdavi
Publisher : IntechOpen
Release : 2011-11-02
ISBN : 9789533072821
Language : En, Es, Fr & De

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Book Description :

Bioinformatics - Trends and Methodologies is a collection of different views on most recent topics and basic concepts in bioinformatics. This book suits young researchers who seek basic fundamentals of bioinformatic skills such as data mining, data integration, sequence analysis and gene expression analysis as well as scientists who are interested in current research in computational biology and bioinformatics including next generation sequencing, transcriptional analysis and drug design. Because of the rapid development of new technologies in molecular biology, new bioinformatic techniques emerge accordingly to keep the pace of in silico development of life science. This book focuses partly on such new techniques and their applications in biomedical science. These techniques maybe useful in identification of some diseases and cellular disorders and narrow down the number of experiments required for medical diagnostic.

Systems and Integrative Approaches in Oncogenomics

Systems and Integrative Approaches in Oncogenomics Book
Author : Gopinath Ganji
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Systems and Integrative Approaches in Oncogenomics book written by Gopinath Ganji, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advances in Biology and Therapy of Multiple Myeloma

Advances in Biology and Therapy of Multiple Myeloma Book
Author : Nikhil C. Munshi,Kenneth C. Anderson
Publisher : Springer Science & Business Media
Release : 2012-11-15
ISBN : 146144666X
Language : En, Es, Fr & De

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Book Description :

Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

Applications of Biotechnology in Oncology

Applications of Biotechnology in Oncology Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2013-11-19
ISBN : 1461492459
Language : En, Es, Fr & De

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Book Description :

Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent literature on this topic and numerous tables and figures, Applications of Biotechnology in Oncology serves as an ideal reference for oncologists, scientists involved in research on cancer biology, and physicians in various specialties who deal with cancer.

Advances in Biology and Therapy of Multiple Myeloma

Advances in Biology and Therapy of Multiple Myeloma Book
Author : Nikhil C. Munshi,Kenneth C. Anderson
Publisher : Springer Science & Business Media
Release : 2012-12-09
ISBN : 1461452600
Language : En, Es, Fr & De

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Book Description :

Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

Critical Issues in Head and Neck Oncology

Critical Issues in Head and Neck Oncology Book
Author : Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O'Sullivan
Publisher : Springer
Release : 2018-11-12
ISBN : 3319988549
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /HNS), and radiation oncologists in chapters that discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the development of novel staging classifications, optimal larynx preservation approaches for laryngeal and hypopharyngeal cancer, surgical reconstruction, new surgical approaches in oropharynx cancer, potential for treatment de-escalation, systemic therapy in nasopharyngeal cancer and salivary gland tumors and treatment approaches for tumors of unknown primary site are discussed in detail. Finally, the role of immunotherapy in the field is highlighted. The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by many of the most internationally acclaimed authors in the field and are therefore an excellent source for all those interested or actively working in the field of head and neck cancer.

Cancer Genomics and Proteomics

Cancer Genomics and Proteomics Book
Author : Eden Dennis
Publisher : Unknown
Release : 2015-03-09
ISBN : 9781632420664
Language : En, Es, Fr & De

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Book Description :

The book focuses on the field of cancer genomics and proteomics. It has been compiled with elaborative reviews of the most general cancers, from bench to bedside applications by an internationally renowned team of veterans and it will certainly contribute to the medical and scientific community by illustrating updated discoveries of oncogenomics and their potential applications in cancer translational research. This comprehensive book aims to serve as a useful resource for clinicians, students, oncologists, scientists and health professionals engaged in cancer research.

Oncogenomics and Cancer Proteomics

Oncogenomics and Cancer Proteomics Book
Author : Cesar Lopez-Camarillo,Elena Arechaga-Ocampo
Publisher : IntechOpen
Release : 2013-03-13
ISBN : 9789535110415
Language : En, Es, Fr & De

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Book Description :

Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.

Molecular Polymorphism of Man

Molecular Polymorphism of Man Book
Author : Sergeĭ Dmitrievich Varfolomeev,Gennadiĭ Efremovich Zaikov
Publisher : Nova Science Pub Incorporated
Release : 2011-01-01
ISBN : 9781607418436
Language : En, Es, Fr & De

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Book Description :

Decoding of the human genome created a qualitatively new state in development of modern fields of science, technology and medicine. One of the basic results of this is formation of a basis for investigating genome of every individual with detection of differences at the gene and protein levels. The chemical-biological approach based on highly efficient physical methods provides an opportunity of detailed molecular genetic typing of the population, investigation of genetic polymorphism, individual features of enzymatic and molecular-receptor processes in every person. Achievements in human genomics and proteomics, chemical enzymology, bioinformatics and medical genetics form the basis of modern investigations and multiple practical uses. The accuracy and efficiency of modern analytical methods allows for assigning tasks of obtaining genetic and proteomic molecular portrait of every individual, detection of individual differences of personalities at the genetic and protein levels. In the nearest decade, post-genomic and proteomic investigations will lead to significant changes in many spheres of social life. At present, a new molecular medicine based on determination of the ultimate causes of many diseases is being established. Aptitudes and development of many diseases are genetically defined. Basing on post-genomic and proteomic studies, new branches, such as cardiogenomics, oncogenomics, neurogenomics, pharmacogenomics, based on objective appraisal and reduction of risks of cardiovascular diseases and cancer, forecast of neurodegenerative processes and ageing appear in medicine. Today it is referred to creation and development of individual medicine based on molecular-genetic and proteomic human portrait. Occupational guidance and study of personal dispositions in various spheres of action may be based on molecular-genetic analysis. Molecular genetic typing is the foundation for reasonable determination of potential professional abilities. The study of polymorphism of genes defining physical, psychological and intellectual human characteristics seems to be of crucial importance. In the modern post-genomic process, one of the main targets is creation of a unified platform for genetic analysis and the basis for genotyping of the population. Functional reserves of the human organism are significantly defined by the genotype of parents. At present in developed countries, and in the nearest future in Russia, a system for estimation of risks and abilities of children basing on genetic portrait of parents is being developed. It is expected that in full this system will start functioning in the nearest decade. Genetic forecasting of pathology risk and human abilities at the background of many social factors is the material basis for transition to genetically healthful population. Post-genomic projects suggest many special supplements; in particular, developed approaches provide full and unambiguous identification of an individual using superlow, trace quantities of biological materials. The molecular genetic approach becomes the foundation for many human sciences. Analysis of structural features of genomic DNA passed from generation to generation is fundamental for the modern approach to the study of origination and evolution of ethnoses. New fields of science, ethnogenomics and ethnogeography, appeared. Post-genomic development of the science touches upon many spheres of life of the modern society. Basing on molecular presentations created by modern physical, chemical and molecular biological methods and operating modern information technologies, which use an advanced mathematical apparatus, this field creates extremely socially meaningful products affecting development of the society in whole. This book is a review of modern scientific data and ideas of above-mentioned area.

Cancer Therapy

Cancer Therapy Book
Author : Georg F. Weber
Publisher : Taylor & Francis
Release : 2005
ISBN : 9781904933113
Language : En, Es, Fr & De

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Book Description :

Tumor-host interaction is critical for cancer proliferation and spread. Tumor mass, metastasis, invasion of host tissue, evasion of the host immune response, and tumor drug resistance are all affected by the interaction between the tumor cell and the host. Molecular strategies to interrupt the tumor-host interaction are among the most promising new leads to emerge in cancer pharmacogenomics and oncogenomics in recent years. This book critically reviews every aspect of this major topic in cancer research. In the opening chapter, Liang and colleagues describe the use of differential display to identify novel cancer-associated genes. This is followed by a chapter in which Aronow et al. describe possibilities for personalized cancer therapies including the potential new therapies identified by pharmacogenomics. Chapter 3 focuses on novel retinoid derived anti-cancer agents. The following chapters review in detail current advances in the targeting of specific events in cancinogenesis including: apoptosis (chapter 4), metastasis (chapters 6, 13), angiogenesis (chapters 7, 8, 10, 11), TGFb (chapter 5), the endothelin receptor (chapter 9), and drug resistance (chapter 15). This section is followed by two excellent chapters detailing strategies that enlist the assistance of the host immune system (chapters 12 and 14). The closing chapter provides a stimulating insight into current research with suicide gene therapy vectors.

Analysis of Human Genomics

Analysis of Human Genomics Book
Author : Bryan Evans
Publisher : Unknown
Release : 2019-06-13
ISBN : 9781632417985
Language : En, Es, Fr & De

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Book Description :

Genes are the determiners of human-inherited traits. The study of the human genome provides a way to understand diseases. Genetic tests can be performed to evaluate genetic conditions, such as Down syndrome, muscular dystrophy, Tay-Sachs disease, phenylketonuria, etc. The field of clinicogenomics is widely being used for personalized medicine such as oncogenomics and pharmacogenomics. It studies the entire human genome, thus allowing the detection of a wide number of mutations and structural anomalies. The future of human genomics holds immense potential as individuals may be sequenced at birth and also periodically throughout their lives to detect potential health risks. Thus, individuals will be able to change their lifestyles and behavior to minimize their predisposition to diseases. This book provides comprehensive insights into the field of human genomics. It elucidates new techniques and the applications of human genomics in a multidisciplinary manner. It aims to equip students and experts with the advanced topics and upcoming concepts in this area.

Disease Pathways

Disease Pathways Book
Author : Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Publisher : Elsevier
Release : 2019-10-18
ISBN : 0128170875
Language : En, Es, Fr & De

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Book Description :

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Scientist book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.