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Oncogenomics

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Oncogenomics

Oncogenomics Book
Author : Charles Brenner,David Duggan
Publisher : John Wiley & Sons
Release : 2004-11-19
ISBN : 0471476641
Language : En, Es, Fr & De

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Book Description :

This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.

Oncogenomics

Oncogenomics Book
Author : Franco Dammacco,Franco Silvestris
Publisher : Academic Press
Release : 2018-10-30
ISBN : 0128117869
Language : En, Es, Fr & De

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Book Description :

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

Biochemistry and Molecular Biology Compendium

Biochemistry and Molecular Biology Compendium Book
Author : Roger L. Lundblad
Publisher : CRC Press
Release : 2019-11-11
ISBN : 1351680536
Language : En, Es, Fr & De

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Book Description :

This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers

The Oncogenomics Handbook

The Oncogenomics Handbook Book
Author : William J. LaRochelle,Richard A. Shimkets
Publisher : Springer Science & Business Media
Release : 2005-04-15
ISBN : 1588294250
Language : En, Es, Fr & De

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Book Description :

"In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development." --Résumé de l'éditeur.

Molecular Genetics of Liver Neoplasia

Molecular Genetics of Liver Neoplasia Book
Author : Xin Wei Wang,Joe W. Grisham,Snorri S. Thorgeirsson
Publisher : Springer Science & Business Media
Release : 2010-11-08
ISBN : 1441960821
Language : En, Es, Fr & De

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Book Description :

Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.

The Cancer Clock

The Cancer Clock Book
Author : Sotiris Missailidis
Publisher : John Wiley & Sons
Release : 2007-10-15
ISBN : 0470061510
Language : En, Es, Fr & De

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Book Description :

Edited by the winner of the 2008 Mike Price Fellowship The Cancer Clock is a comprehensive overview of cancer as a single topic and provides an all-encompassing account of the key aspects related to the disease from its causes and initial diagnosis through to treatment and care and the different support mechanisms available. Carefully divided into three key parts, the first part of the book focuses on the genesis of the disease through environmental, lifestyle and socioeconomic factors. The second part moves on to consider early disease, disease development, diagnosis, monitoring and imaging of the disease. The book then discusses standard treatments such as surgery, chemotherapy, radiotherapy and immunotherapy along with current developments in the field such as targeted therapeutics, antibody therapies and novel chemotherapy agents. The book closes with a discussion of patient care, pain control, nursing in cancer patients and rehabilitation processes and a final chapter that looks at the psychological and psychosocial aspects of the disease, from coping with the knowledge of having cancer to coping with the side effects of the treatments, family support and dedicated support groups. Written in a clear, accessible manner this book is an ideal starting point for students of pharmacy, pharmacology, the biomedical sciences and other related disciplines where an understanding of cancer as a whole is required. takes an interdisciplinary approach covering the chemistry, epidemiology, basic biology and genetics, radiology, medical physics, medicine, nursing, health and social welfare all associated with cancer diagnosis, treatment and care explains the various causes of cancer and suggests actions for the prevention of the disease includes chapters on current diagnostic tests, drug development and the techniques used in drug design both chemical and biological considers current experimental therapeutic and diagnostic approaches and their potential for future therapeutic development examines aspects of cancer care, physiotherapy, rehabilitation and the psychological aspects of the disease includes self assessment questions/answers, summary sections and review questions and information boxes to enhance student understanding

Clinical Applications for Next Generation Sequencing

Clinical Applications for Next Generation Sequencing Book
Author : Urszula Demkow,Rafal Ploski
Publisher : Academic Press
Release : 2015-09-10
ISBN : 0128018410
Language : En, Es, Fr & De

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Book Description :

Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments. Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients. The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia. Fills the gap between state-of-the-art technology and evidence-based practice Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment Promotes a practical tool that clinicians can apply directly to patient care Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases Presents evidence regarding the important role of NGS in current diagnostic strategies

The Epigenetics Revolution

The Epigenetics Revolution Book
Author : Nessa Carey
Publisher : Columbia University Press
Release : 2012-03-06
ISBN : 0231530714
Language : En, Es, Fr & De

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Book Description :

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Man Machine Interactions 4

Man   Machine Interactions 4 Book
Author : Aleksandra Gruca,Agnieszka Brachman,Stanisław Kozielski,Tadeusz Czachórski
Publisher : Springer
Release : 2015-10-01
ISBN : 3319234374
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the current state of research on development and application of methods, algorithms, tools and systems associated with the studies on man-machine interaction. Modern machines and computer systems are designed not only to process information, but also to work in dynamic environment, supporting or even replacing human activities in areas such as business, industry, medicine or military. The interdisciplinary field of research on man-machine interactions focuses on broad range of aspects related to the ways in which human make or use computational artifacts, systems and infrastructure. This monograph is the fourth edition in the series and presents new concepts concerning analysis, design and evaluation of man-machine systems. The selection of high-quality, original papers covers a wide scope of research topics focused on the main problems and challenges encountered within rapidly evolving new forms of human-machine relationships. The presented material is structured into following sections: human-computer interfaces, robot, control, embedded and navigation systems, bio-data analysis and mining, biomedical signal processing, image and motion data processing, decision support and expert systems, pattern recognition, fuzzy systems, algorithms and optimisation, computer networks and mobile technologies, and data management systems.

Handbook of Oncogenomics

Handbook of Oncogenomics Book
Author : Zena Murray
Publisher : American Medical Publishers
Release : 2021-11-16
ISBN : 9781639272518
Language : En, Es, Fr & De

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Book Description :

The accumulation of DNA mutations and epigenetic variations that leads to uncontrolled cell proliferation and formation of neoplasm refers to cancer. It is a genetic disease. The sub branch of genomics that deals with the study of cancer related genes is known as oncogenomics. The primary goal of the discipline is to recognize new tumor suppressor genes and oncogenes that may lead to new insights in the diagnosis of cancer, help predict the clinical outcome of different cancers and identify new targets for cancer therapies. It uses the techniques of transciptomes, genome sequencing, bioinformatics, functional analysis of oncogenes, etc. The field is also concerned with personalizing cancer treatment by identifying and targeting mutations in an individual patient. The book elucidates the concepts and innovative models around the prospective developments with respect to oncogenomics. The various studies that are constantly contributing towards advancing technologies and evolution of this field are examined in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.

Applications of Biotechnology in Oncology

Applications of Biotechnology in Oncology Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2013-11-19
ISBN : 1461492459
Language : En, Es, Fr & De

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Book Description :

Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent literature on this topic and numerous tables and figures, Applications of Biotechnology in Oncology serves as an ideal reference for oncologists, scientists involved in research on cancer biology, and physicians in various specialties who deal with cancer.

                                                    Book
Author : 陈方,任爱军著
Publisher : 清華大學出版社
Release : 2011
ISBN : 7302256128
Language : En, Es, Fr & De

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Book Description :

本书是美国名校入学考试指导系列之一,旨在为计划到美国名校接受高等教育的高中同学提供帮助。 全书分为三个部分。前两部分对美国大学申请文进行了概述,并着重分析了如何创作一篇出色的申请文,为申请者整套的申请材料增光添彩。后一部分收集了67篇近年大学申请文实例供读者参考,以助其构思出一篇成功的文章。 它是一本美国大学申请文的写作指南,能够帮助同学们提高写作能力,创作出一篇个性十足且颇具说服力的申请文,从而在众多申请者中脱颖而出。

Bioinformatics

Bioinformatics Book
Author : Mahmood A. Mahdavi
Publisher : BoD – Books on Demand
Release : 2011-11-02
ISBN : 9533072822
Language : En, Es, Fr & De

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Book Description :

Bioinformatics - Trends and Methodologies is a collection of different views on most recent topics and basic concepts in bioinformatics. This book suits young researchers who seek basic fundamentals of bioinformatic skills such as data mining, data integration, sequence analysis and gene expression analysis as well as scientists who are interested in current research in computational biology and bioinformatics including next generation sequencing, transcriptional analysis and drug design. Because of the rapid development of new technologies in molecular biology, new bioinformatic techniques emerge accordingly to keep the pace of in silico development of life science. This book focuses partly on such new techniques and their applications in biomedical science. These techniques maybe useful in identification of some diseases and cellular disorders and narrow down the number of experiments required for medical diagnostic.

Toxicogenomics in Predictive Carcinogenicity

Toxicogenomics in Predictive Carcinogenicity Book
Author : Michael D. Waters,Russell S. Thomas
Publisher : Royal Society of Chemistry
Release : 2016
ISBN : 1782621628
Language : En, Es, Fr & De

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Book Description :

Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.

Keeping up with Genome Sequence and Expression

Keeping up with Genome Sequence and Expression Book
Author : Christian Neri
Publisher : Bentham Science Publishers
Release : 2014-08-05
ISBN : 1608058204
Language : En, Es, Fr & De

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Book Description :

Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research, allowing readers to capture the essence and diversity of genomics in contemporary science. The third volume of this ebook series features a variety of articles exploring oncogenomics, mouse genetics, feline genetics, genetic mechanism for pain, the genetics of weeds and much more.

Head and Neck Cancer

Head and Neck Cancer Book
Author : Jacques Bernier
Publisher : Springer Science & Business Media
Release : 2011-06-15
ISBN : 1441994645
Language : En, Es, Fr & De

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Book Description :

In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

Clinical Epigenetics

Clinical Epigenetics Book
Author : Luke B. Hesson,Antonia L. Pritchard
Publisher : Springer Nature
Release : 2019-08-31
ISBN : 9811389586
Language : En, Es, Fr & De

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Book Description :

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

Cancer Genomics

Cancer Genomics Book
Author : Shile Zhang,Jun S. Wei,Javed Khan
Publisher : Elsevier Inc. Chapters
Release : 2013-11-21
ISBN : 0128061014
Language : En, Es, Fr & De

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Book Description :

The complexity of the transcriptome has been appreciated in recent years in light of the Encyclopedia of DNA Elements (ENCODE) project. While less than 3% of the genome is annotated with protein-coding genes, 62% of the genome is long RNA molecules (>200 nucleotides). With an increasing sequencing throughput and a decreasing cost, RNA sequencing (RNA-seq) is becoming a frequently used technology in transcriptome research. This chapter summarizes the advantages of RNA-seq compared to hybridization-based microarrays, the RNA-seq experiment workflow and reviews current applications of RNA-seq in the field of cancer research. With advantages in expression analysis of non-coding genes, fusion genes, investigation of expressed allelic imbalance, pseudogenes, viral integrated genes, and post-transcriptional regulation analysis including splicing, polyadenylation as well as RNA editing, RNA-seq technology has a tremendous potential to elucidate the complexity of the transcriptome and its working mechanisms in the initiation and development of cancer. Along with expression and pathway analysis, RNA-seq data can clarify the functional consequences of any potential genomic (DNA) variances and thus help to distinguish “driver” from “passenger” genomic events. In summary, RNA-seq allows a genome-wide interrogation of complex transcriptomes and will help elucidate important biological mechanisms linked to cancer phenotypes. In addition, the non-protein-coding transcriptome has the potential to provide novel biomarkers for early detection, diagnostics, prognostics and targets for therapy.

Cardiothoracic Surgical Critical Care An Issue of Critical Care Nursing Clinics of North America

Cardiothoracic Surgical Critical Care  An Issue of Critical Care Nursing Clinics of North America Book
Author : Bryan Boling
Publisher : Elsevier Health Sciences
Release : 2019-07-27
ISBN : 0323708692
Language : En, Es, Fr & De

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Book Description :

In consultation with Consulting Editor, Dr. Jan Foster, Dr. Brian Boling has put together a state-of the-art issue of the Critical Care Nursing Clinics devoted to Cardiothoracic Surgical Critical Care. Clinical review articles are specifically devoted to the following: Fast Track Cardiac Surgery; Options for Minimally Invasive Valvular Surgery; Surgical Interventions for the Treatment of Advanced Heart Failure; Lung Transplantation; Surgical Treatment of Lung Cancer; Post-Operative Management of Tetralogy of Fallot; Advanced Hemodynamic Monitoring in Cardiothoracic Surgery; Vasoactive Infusions in Cardiothoracic Surgery; Common Post Cardiothoracic Surgery Arrhythmias; Pain Control in the Cardiothoracic Surgery Patient; Renal Complications of Cardiothoracic Surgery; The Role of ECMO in Post Cardiotomy Shock; Resuscitation of Patients Who Arrest After Cardiac Surgery; and End of Life Care in Cardiothoracic Surgery. Readers will come away with the latest information they need to improve improves of cardiothoracic surgical patients.

Microarray Data Analysis

Microarray Data Analysis Book
Author : Michael J. Korenberg
Publisher : Springer Science & Business Media
Release : 2008-02-03
ISBN : 1597453900
Language : En, Es, Fr & De

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Book Description :

In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-depth insights into presentations of genomic signal processing. Also detailed is the use of tiling arrays for large genomes analysis. The protocols follow the successful Methods in Molecular BiologyTM series format, offering step-by-step instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls.