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Ocular Transporters And Receptors

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Ocular Transporters and Receptors

Ocular Transporters and Receptors Book
Author : Ashim K Mitra
Publisher : Elsevier
Release : 2013-10-31
ISBN : 190881831X
Language : En, Es, Fr & De

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Book Description :

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery Book
Author : Joyce Tombran-Tink,Colin J. Barnstable
Publisher : Springer Science & Business Media
Release : 2008-04-09
ISBN : 9781597453752
Language : En, Es, Fr & De

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Book Description :

In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.

Prodrugs and Targeted Delivery

Prodrugs and Targeted Delivery Book
Author : Jarkko Rautio
Publisher : John Wiley & Sons
Release : 2011-01-11
ISBN : 3527633189
Language : En, Es, Fr & De

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Book Description :

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

The Biology of the Eye

The Biology of the Eye Book
Author : Jorge Fischbarg
Publisher : Elsevier
Release : 2005-12-09
ISBN : 9780080476094
Language : En, Es, Fr & De

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Book Description :

Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research. * Combines basic science and practical opthalmological subjects * Written with the simplicity of a textbook, while maintaining the comprehensive and rigorous approach of science papers * Includes contributions by well-known experts

Pharmacology of Ocular Therapeutics

Pharmacology of Ocular Therapeutics Book
Author : Thirumurthy Velpandian
Publisher : Springer
Release : 2016-02-29
ISBN : 3319254987
Language : En, Es, Fr & De

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Book Description :

This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.

Polysaccharide Carriers for Drug Delivery

Polysaccharide Carriers for Drug Delivery Book
Author : Sabyasachi Maiti,Sougata Jana
Publisher : Woodhead Publishing
Release : 2019-06-14
ISBN : 0081025548
Language : En, Es, Fr & De

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Book Description :

Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented is scattered, therefore becoming difficult for readers and researchers to digest in a concise manner. This gathering of information will help readers easily comprehend the subject matter. Focuses on biopolysaccharide-based, distinct approaches for drug delivery applications Illustrates new concepts and highlights future scope for clinical development Provides comprehensive, up-to-date information on different aspects of drug delivery technology

Chitin Chitosan

Chitin Chitosan Book
Author : Rajendra Dongre
Publisher : BoD – Books on Demand
Release : 2018-07-18
ISBN : 1789234069
Language : En, Es, Fr & De

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Book Description :

Chitin is the second most abundant biopolymer after cellulose and is a resourceful copious and cheap biomaterial discovered in 1859 owing to significant industrial and technological utility. Raw chitin-chitosan resembles keratin in its biological functions. Chitin chemistry vastly developed via innate unparalleled biological features and exceptional physicochemical characters. Chitosan endures assorted chemical/physical modifications easily at free proactive functionalities, yet intact bulk properties are achieved through processing, viz., film, membrane, composite, hybrid, nanofibre, nanoparticle, hydrogel and scaffolds. Rapidly lessen bioresources signify chitosan as an option due to renewable eco-friendliness and drive embryonic myriad applications in S

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book
Author : Pavan Muttil,Nitesh K. Kunda
Publisher : Springer Nature
Release : 2020-03-18
ISBN : 3030359107
Language : En, Es, Fr & De

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Book Description :

Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Biobanks

Biobanks Book
Author : Antonella De Robbio
Publisher : Elsevier
Release : 2012-11-26
ISBN : 1908818611
Language : En, Es, Fr & De

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Book Description :

Biobanks represent an invaluable research tool and, as a result of their intrinsic and extrinsic nature, may be looked upon as archives or repositories largely made up of libraries, or collections of content where the content is the biological material derived from different individuals or species, representing valuable tangible assets. Biobanks analyses aspects of the commons and common intellectual property relating to the concepts of private property, not only concerning data but biological materials as well, and the advantages and disadvantages of patents in scientific research. Several recent initiatives in biomedical research have attempted to make their data freely available to others, so as to foster innovation. Many of these initiatives have adopted the open source model, which has gained widespread recognition in the computer industry. This title is structured into eight chapters and begins with an introduction, which is followed by chapters that discuss how the term ‘biobank’ came about in scientific literature; legal matters relating to biobanks; and intellectual and physical property. Later chapters comprehensively analyse the intellectual property of biobanks within the sphere of copyright; biotechnological inventions and research patentability; open data sharing in biobanks; and biobanks as commons or vault. Considers biobanks as both repositories and as collections of tangible assets Argues that the data in biobanks represents a high value intangible asset Explores regulatory gaps exploited by the private sector

Design of Amino Acid Prodrugs of Acyclovir for Improved Bioavailability and Therapeutic Activity

Design of Amino Acid Prodrugs of Acyclovir for Improved Bioavailability and Therapeutic Activity Book
Author : Suresh Katragadda,Ashim K. Mitra
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Infection with herpes simplex virus is the single most frequent cause of corneal opacities in developed countries. Currently available therapy for HSV keratitis involves the use of trifluorothymidine, idoxuridine and vidarabine. However, one of major problems associated with these drugs is their poor ocular absorption and cytotoxicity restricting their use in long-term treatment. Acyclovir and L-Valyl ester prodrug of acyclovir (ACV), valacyclovir (VACV) have been indicated in the treatment of genital herpes, the incidence of which has increased significantly in the last 20 years. Acyclovir with its selective mechanism of action can cause less cytotoxicity but its poor permeability across cellular barrier limits its utility. Thus, the development of a safe, long-acting, effective, non-toxic, and stable tropical antiviral drops and oral formulations that requires less frequent dosing for fewer days of lower concentrations would represent a significant improvement over the currently available antivirals used against ocular, oral and genital HSV infections. Recently significant amount of work has been reported on substrate specificities of membrane transporters and receptors leading to successful design of prodrugs targeted to them for improved efficacy and absorption. VACV is such a prodrug that is recognized by the peptide transporter, PEPT1 and amino acid transporter, B0̇+ resulting in enhancement of oral bioavailability of acyclovir by three to five fold in humans. Utilizing transporters present on the corneal epithelium may enhance corneal permeability of polar compounds. Recently the presence of oligopeptide and amino acid transport system on the corneal epithelium has been established in our laboratory. A series of novel water soluble amino acid ester prodrugs of acyclovir were thus synthesized in order to target the transporters present on the cornea and intestine for improved ocular bioavailability of acyclovir. These prodrugs once transported across or influxed into the target cells undergo chemical as well as enzymatic hydrolysis to release the active parent drug, ACV. In conclusion more permeable, less cytotoxic SACV exhibited excellent chemical/enzymatic stability and antiviral activity against herpes simplex viruses. These prodrugs also demonstrated higher bioavailability upon topical as well as oral administration, thereby rendering these compounds promising drug candidates against ocular, oral and genital herpes infections.

Nanomedicine in Drug Delivery

Nanomedicine in Drug Delivery Book
Author : Arun Kumar,Heidi M. Mansour,Adam Friedman,Eric R. Blough
Publisher : CRC Press
Release : 2013-06-05
ISBN : 1466506164
Language : En, Es, Fr & De

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Book Description :

There is a clear need for innovative technologies to improve the delivery of therapeutic and diagnostic agents in the body. Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. Nanomedicine in Drug Delivery gives an overview of aspects of nanomedicine to help readers design and develop novel drug delivery systems and devices that build on nanoscale technologies. Featuring contributions by leading researchers from around the world, the book examines: The integration of nanoparticles with therapeutic agents The synthesis and characterization of nanoencapsulated drug particles Targeted pulmonary nanomedicine delivery using inhalation aerosols The use of biological systems—bacteria, cells, viruses, and virus-like particles—as carriers to deliver nanoparticles Nanodermatology and the role of nanotechnology in the diagnosis and treatment of skin disease Nanoparticles for the delivery of small molecules, such as for gene and vaccine delivery The use of nanotechnologies to modulate and modify wound healing Nanoparticles in bioimaging, including magnetic resonance, computed tomography, and molecular imaging Nanoparticles to enhance the efficiency of existing anticancer drugs The development of nanoparticle formulations Nanoparticles for ocular drug delivery Nanoparticle toxicity, including routes of exposure and mechanisms of toxicity The use of animal and cellular models in nanoparticles safety studies With its practical focus on the design, synthesis, and application of nanomedicine in drug delivery, this book is a valuable resource for clinical researchers and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner. It explores a wide range of promising approaches for the diagnosis and treatment of diseases using cutting-edge nanotechnologies.

Biomedical Index to PHS supported Research pt A Subject access A H

Biomedical Index to PHS supported Research  pt  A  Subject access A H Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research pt A Subject access A H book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Biotech Manager s Handbook

A Biotech Manager s Handbook Book
Author : M O'Neill,M M Hopkins
Publisher : Elsevier
Release : 2012-05-02
ISBN : 1908818158
Language : En, Es, Fr & De

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Book Description :

A biotech manager's handbook lays out - in a simple, straightforward manner - for the manager or would-be entrepreneur the basic principles of running a biotech company. Most managers in biotechnology companies are working in their first company or in their first managerial role. Their expertise and experience in the scientific part of the work can be taken as a given but there is a whole range of other skills to be learned and areas of expertise to come to terms with. Small companies do not have big budgets to hire people or time to become an expert in so many areas. The book starts by outlining the state of the biopharmaceutical industry and goes on to explain the importance of planning (no matter what the size of the company). Succeeding chapters deal with the basics of intellectual property, perspectives from a university technology transfer office and how to raise some initial funding from an investor and entrepreneur. No other 'how to' manual exists for this sector Written by a range of expert professionals in each area, all in one book Is the only 'bench to bedside' book covering the whole spectrum of development

NMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research Book
Author : Miroslava Čuperlović-Culf
Publisher : Elsevier
Release : 2012-12-17
ISBN : 1908818263
Language : En, Es, Fr & De

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Book Description :

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Orphan Drugs

Orphan Drugs Book
Author : Elizabeth Hernberg-Ståhl,Miroslav Reljanović
Publisher : Elsevier
Release : 2013-11-15
ISBN : 1908818395
Language : En, Es, Fr & De

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Book Description :

This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups. The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey. After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs. The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs. A comprehensive overview of strategy, key activities and considerations of how to bring an orphan drug from concept to the market and make it available to patients A source of updated information, news and trends for those who are already active in this fast-evolving field Covers the global definitions and the criteria for getting an orphan drug designation in, for example, the US and Europe

Marine Enzymes for Biocatalysis

Marine Enzymes for Biocatalysis Book
Author : Antonio Trincone
Publisher : Elsevier
Release : 2013-09-30
ISBN : 1908818352
Language : En, Es, Fr & De

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Book Description :

Marine bioprospecting is a highly topical subject - in both applied and basic research - but, as yet, the marine ecosystem is a relatively unexplored source of natural bioactive substances with potential therapeutic activity. This book addresses the use of marine enzymes in biocatalysis through a series of chapters from leading scientists within academic and industrial fields. Biocatalytic processes can take advantage of the habitat-related properties of marine enzymes, such as salt tolerance, hyperthermostability, barophilicity, cold adaptivity, and so on, whilst also taking into consideration substrate specificity and affinity. These evolved properties are linked to the metabolic functions of the enzymes and to the ecological aspects of the natural source. New properties can also be discovered at the molecular level of catalysis, particularly concerning the stereochemical characteristics of products. Marine enzymes for biocatalysis initially examines the nature and level of interest in marine biological diversity, and outlines the fundamentals of biocatalysis. It goes on to detail sources of marine enzymes, and to analyse examples from both chemical and stereochemical viewpoints of catalysis, including microbial enzymes and animal or plant sources. The book goes on to explore the future potential of marine bioprospecting in biocatalysis. Compiles studies from leading scientists in a direct and accessible format. Includes practical descriptions of results, adding further details not often covered in formal articles Takes a molecular view which fully explains the enzymatic aspects of reactions, particularly regarding biocatalytic characteristics and descriptions of bioprocesses Selects examples of chemical and stereochemical aspects of enzymatic action with respect to known terrestrial counterparts

Matlab in Bioscience and Biotechnology

Matlab   in Bioscience and Biotechnology Book
Author : Leonid Burstein
Publisher : Elsevier
Release : 2011-06-05
ISBN : 1908818034
Language : En, Es, Fr & De

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Book Description :

MATLAB® in bioscience and biotechnology presents an introductory Matlab course oriented towards various collaborative areas of biotechnology and bioscience. It concentrates on Matlab fundamentals and gives examples of its application to a wide range of current bioengineering problems in computational biology, molecular biology, bio-kinetics, biomedicine, bioinformatics, and biotechnology. In the last decade Matlab has been presented to students as the first computer program they learn. Consequently, many non-programmer students, engineers and scientists have come to regard it as user-friendly and highly convenient in solving their specific problems. Numerous books are available on programming in Matlab for engineers in general, irrespective of their specialization, or for those specializing in some specific area, but none have been designed especially for such a wide, interdisciplinary, and topical area as bioengineering. Thus, in this book, Matlab is presented with examples and applications to various school-level and advanced bioengineering problems - from growing populations of microorganisms and population dynamics, reaction kinetics and reagent concentrations, predator-prey models, mass-transfer and flow problems, to sequence analysis and sequence statistics. This is the first book intended as a manual introducing biologists and other biotechnology engineers to work with Matlab It is suitable for beginners and inexperienced users; however, applications of Matlab to advanced problems such as the Monte Carlo method, curve fitting, and reliable machine diagnostics make the book relevant to university teachers as well The book is different in that it assumes a modest mathematical background for the reader and introduces the mathematical or technical concepts with a somewhat traditional approach; Matlab is then used as a tool for subsequent computer solution

Nanoparticulate Drug Delivery

Nanoparticulate Drug Delivery Book
Author : Vandana Patravale,Prajakta Dandekar,Ratnesh Jain
Publisher : Elsevier
Release : 2012-10-31
ISBN : 1908818190
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-based therapeutics, operating at scales of billionths of a metre, have great potential for future expansion in altering the scale and methods of drug delivery. The availability of these novel formulations to once-inaccessible areas of the body has greatly expanded the therapeutic window of existing drug molecules. Nanoparticulate drug delivery highlights and examines the transition of nanoparticulate drug delivery systems from the laboratory into a commercially viable sector. The first chapters of the book provide an overview of the use and characterization of nanoparticulate systems as drug carriers, including the assessment of their morphology, sterility and potential toxicity. In the latter part of the book, chapters cover nanotoxicology, regulatory aspect and clinical trials, ending with an overview of several case studies and a look towards future developments. Discusses the issues surrounding nanoparticulate products, based on personal experience of their formulation Provides an overview of new application areas, including RNA interference Outlines the pros and cons of nanoparticulate products, and discusses how these may influence their route into the commercial sector

The Funding of Biopharmaceutical Research and Development

The Funding of Biopharmaceutical Research and Development Book
Author : David R Williams
Publisher : Elsevier
Release : 2013-10-31
ISBN : 1908818387
Language : En, Es, Fr & De

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Book Description :

The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public. Presents a comprehensive view of the funding issues of R&D in this market sector, adopting a theory-to-practice approach A comprehensive and analytical review of the biopharmaceutical R&D literature and practice An overview of the various and competing/complementary theories of the firm and valuation methods as they apply to biopharmaceutical R&D

Clinical Research in Asia

Clinical Research in Asia Book
Author : U Sahoo
Publisher : Elsevier
Release : 2012-05-25
ISBN : 1908818131
Language : En, Es, Fr & De

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Book Description :

Asia is increasingly taking on a leading role in the fields of Good Clinical Practice (GCP) and ethics, two areas that are central to clinical research practices worldwide. Clinical research in Asia examines the evolution of these key sectors in the Asian countries where the greatest developments are taking place, offering valuable perspectives on a wide range of issues affecting clinical research. Following an introduction that provides an overview of the topic and its strengths and weaknesses, each chapter of the book is devoted to clinical research in a specific country, focusing on issues including the history and evolution of clinical research, clinical trials and regulatory aspects. The chapters also offer a perspective on future trends in clinical research in each country. The book concludes with a discussion of the importance of political, economic, socio-cultural, technological, legal and environmental factors (PESTLE analysis). Analysis from a leading and highly respected professional in the sector An overview of country-specific regulatory environments Discussion of challenges and solutions for clinical research