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Nutritional Epigenomics

Nutritional Epigenomics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-07-20
ISBN : 0128173106
Language : En, Es, Fr & De

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Book Description :

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies

Impact of Nutritional Epigenomics on Disease Risk and Prevention

Impact of Nutritional Epigenomics on Disease Risk and Prevention Book
Author : T. P. Ong
Publisher : Unknown
Release : 2012
ISBN : 9783805599504
Language : En, Es, Fr & De

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Book Description :

Nutritional epigenomics is an emerging subject that has been implicated in disease risk and prevention. Epigenetics has been a concern in cancer research for the last 3 decades, but only in recent years has interest in its connection to other fields developed, including cardiovascular and neurodegenerative diseases, obesity, diabetes and nutrition. Epigenetics is generally used to refer to heritable changes in gene expression that are not accompanied by alterations in DNA sequence. Because epigenetic marks are potentially reversible and are implicated in the pathogenesis of diverse non-communicable diseases representing major public health problems in both developed and developing countries, the epigenome is an attractive target for nutritional intervention. Indeed, accumulating evidence shows that epigenetic processes can be influenced by nutritional components; Nutritional modulation of epigenetic processes thus adds a further layer of complexity to gene-nutrient interactions and should be considered for the definition of strategies for health promotion and disease prevention. This publication presents four review papers that address the impact of nutritional epigenomics on disease risk and prevention in various settings. It thus provides stimulating reading for anyone interested in the field.

Nutrition Diet and Cancer

Nutrition  Diet and Cancer Book
Author : Sharmila Shankar,Rakesh K. Srivastava
Publisher : Springer Science & Business Media
Release : 2012-03-13
ISBN : 9400729235
Language : En, Es, Fr & De

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Book Description :

Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.

Nutrition Therapy and Pathophysiology

Nutrition Therapy and Pathophysiology Book
Author : Marcia Nelms,Kathryn P. Sucher
Publisher : Cengage Learning
Release : 2015-01-01
ISBN : 1305446003
Language : En, Es, Fr & De

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Book Description :

NUTRITION THERAPY AND PATHOPHYSIOLOGY, 3E provides a comprehensive review of disease pathophysiology and treatment with a focus on current research into and application of evidence-based nutritional care for students, clinicians, and researchers. The third edition continues to provide an all-in-one resource for the study of nutrition therapy that closely integrates the nutrition care process through its chapter organization and pedagogy. NUTRITION THERAPY AND PATHOPHYSIOLOGY strives to prepare students for success in clinical practice and foster growth in expertise in their field. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Human Epigenomics

Human Epigenomics Book
Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer
Release : 2018-02-01
ISBN : 9811076146
Language : En, Es, Fr & De

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Book Description :

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.

Nutrition Diet and Cancer

Nutrition  Diet and Cancer Book
Author : Sharmila Shankar,Rakesh K. Srivastava
Publisher : Springer
Release : 2014-04-13
ISBN : 9789401782968
Language : En, Es, Fr & De

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Book Description :

Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.

Nutrition Therapy and Pathophysiology Book Only

Nutrition Therapy and Pathophysiology Book Only Book
Author : Marcia Nelms,Kathryn P. Sucher
Publisher : Cengage Learning
Release : 2019-02-13
ISBN : 0357390598
Language : En, Es, Fr & De

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Book Description :

A practical all-in-one resource for students, clinicians and researchers, NUTRITION THERAPY AND PATHOPHYSIOLOGY, 4th Edition, delivers a comprehensive review of disease pathophysiology and treatment that reflects the latest research, evidence-based practice guidelines, and scope and standards of dietetics practice. It clearly connects nutrition therapy practices and expected outcomes to underlying disease processes at every level--from cells to organ systems. Detailed illustrations enhance your understanding of disease progression, surgical procedures and treatment protocols, while end-of-chapter tables describing complementary and alternative therapies provide a quick-reference resource. In addition Practitioner Interviews provide insight for working with patients in real-world practice. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Functional Food and Human Health

Functional Food and Human Health Book
Author : Vibha Rani,Umesh C. S. Yadav
Publisher : Springer
Release : 2018-10-12
ISBN : 9811311234
Language : En, Es, Fr & De

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Book Description :

Global health and the increasing incidence of various diseases are a cause for concern, and doctors and scientists reason that the diet, food habits and lifestyle are contributing factors. Processed food has reduced the nutritional value of our diet, and although supplementing foods with various additives is considered an alternative, the long-term impact of this is not known. Many laboratories around the world are working to identify various nutritional components in our daily food and their effect on human health. These have been classified as Nutraceuticals or functional food, and they may have preventive and therapeutic effects in a number of pathologies associated with modern dietary habits and lifestyles. This book addresses various aspects of this issue, revitalizing the discussion and consolidating the latest research on nutritional and functional food and their effects in in-vitro, in-vivo and human clinical studies.

Systems Biology of Cancer

Systems Biology of Cancer Book
Author : Sam Thiagalingam
Publisher : Cambridge University Press
Release : 2015-04-09
ISBN : 1316239527
Language : En, Es, Fr & De

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Book Description :

With over two hundred types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate research goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Readers are provided with a realistic view of what is known and what is yet to be uncovered on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health.

Nutritional Health

Nutritional Health Book
Author : Norman J. Temple,Ted Wilson,David R. Jacobs, Jr.
Publisher : Springer Science & Business Media
Release : 2012-07-27
ISBN : 1617798940
Language : En, Es, Fr & De

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Book Description :

Now going into its third much-expanded edition, the highly praised Nutritional Health: Strategies for Disease Prevention has been brought fully up to date to include all the new thinking and discoveries that have the greatest capacity to improve human health and nutritional advancement. About half the new edition will be revised and updated from the second edition while the other half will consist of major revisions of previous chapters or new subjects. Like the two previous editions the book will consist of general reviews on various topics in nutrition, especially those of much current interest. The authors provide extensive, in-depth chapters covering the most important aspects of the complex interactions between diet, its nutrient components, and their impacts on disease states, and on those health conditions that increase the risk of chronic dieases. Up to date and comprehensive, Nutritional Health: Strategies for Disease Prevention, Third Edition offers physicians, dietitians, and nutritionists a practical, data-driven, integrated resource to help evaluate the critical role of nutrition.

Nutritional Genomics

Nutritional Genomics Book
Author : Wayne R. Bidlack,Raymond L. Rodriguez
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439844534
Language : En, Es, Fr & De

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Book Description :

The notion of matching diet with an individual's genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and g

Epi Informatics

Epi Informatics Book
Author : Jose Medina-Franco
Publisher : Academic Press
Release : 2016-02-24
ISBN : 0128028092
Language : En, Es, Fr & De

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Book Description :

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more

Nutrition in Lifestyle Medicine

Nutrition in Lifestyle Medicine Book
Author : James M. Rippe
Publisher : Humana Press
Release : 2016-12-29
ISBN : 3319430270
Language : En, Es, Fr & De

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Book Description :

This newest addition to the Nutrition and Health series focuses on nutrition’s key role in lifestyle interventions to prevent and manage diseases. The book pays particular attention to nutritional considerations related to obesity, diabetes, and cardiovascular disease. Edited by cardiologist, Dr. James Rippe, a well-known expert in the nascent specialty of Lifestyle Medicine, Nutrition in Lifestyle Medicine will also focus on a variety of specialized areas such as nutrition for athletes and physically active individuals, hydration, and nutrition throughout the life cycle (spanning from children to individuals over the age of 60). In addition, chapters will be included on controversies in nutrition, such as health effects of added sugars and saturated fatty acids in the diet. Finally, specialized chapters will be included in such areas as nutrition for women, nutrition for men, nutrition for latinos, the use of supplements, communication about nutrition, public policy issues, and the interface between nutrition and physical activity. Lifestyle Medicine, supported by the American Journal of Lifestyle Medicine, Dr. Rippe’s textbook Lifestyle Medicine (CRC Press, 2013) and American College of Lifestyle Medicine (ACLM), is a new national medicine specialty that stresses the use of lifestyle interventions in the treatment and management of disease. Its practitioners effectively manage medical treatments alongside the lifestyle interventions, for example lowering insulin treatment for patients with diabetes, reducing the dose of anti-hypertension medications for people with hypertension, and prescribing certain medical interventions that aid in smoking cessation.

Early Life Origins of Health and Disease

Early Life Origins of Health and Disease Book
Author : E. Marelyn Wintour-Coghlan,Julie Owens
Publisher : Springer Science & Business Media
Release : 2007-02-26
ISBN : 0387326324
Language : En, Es, Fr & De

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Book Description :

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.

Nutrition Diet and Cancer

Nutrition  Diet and Cancer Book
Author : Sharmila Shankar,Rakesh K. Srivastava
Publisher : Springer Science & Business Media
Release : 2012-03-16
ISBN : 9400729227
Language : En, Es, Fr & De

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Book Description :

Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.

Nutrition Research Methodologies

Nutrition Research Methodologies Book
Author : Julie A. Lovegrove,Leanne Hodson,Sangita Sharma,Susan A. Lanham-New
Publisher : John Wiley & Sons
Release : 2015-01-12
ISBN : 1118554590
Language : En, Es, Fr & De

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Book Description :

A new book in the acclaimed Nutrition Society Textbook Series, Nutrition Research Methodologies addresses the rapidly advancing field of nutrition research. It covers the diverse methodologies required for robust nutritional research to ensure thorough understanding of key concepts, both for students at undergraduate and postgraduate levels and for scientists working in nutrition research. Combining theory with practical application, Nutrition Research Methodologies addresses both traditional research methods and new technologies, and focuses on a range of complex topics, including energy compensation, nutrient-gene interactions and metabolic adaptation. It also considers statistical issues as well as application of data to policy development. Provides the reader with the required scientific basics of nutrition research in the context of a systems and health approach Written specifically to meet the needs of individuals involved in nutrition research Combines the viewpoints of world-leading nutrition experts from academia and research with practical applications Accompanied by a companion website with a range of self-assessment material (www.wiley.com/go/lovegrove/nutritionresearch)

Early Nutrition Programming and Health Outcomes in Later Life Obesity and beyond

Early Nutrition Programming and Health Outcomes in Later Life  Obesity and beyond Book
Author : Berthold Koletzko,Tamás Decsi,Denes Molnár,Anne Hunty
Publisher : Springer Science & Business Media
Release : 2009-01-31
ISBN : 1402091737
Language : En, Es, Fr & De

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Book Description :

Obesity has reached epidemic proportions globally and presents a major challenge to policy makers and clinicians alike. Recent research has suggested that obesity has its origins in early life and that early diet can programme a developing fetus’ and young infant’s future susceptibility to obesity. This volume contains recent findings presented at the International Conference on Early Nutrition Programming and Health Outcomes in Later Life: Obesity and Beyond - a satellite meeting of the 15th European Congress on Obesity, held in Budapest in April 2007. Basic scientific research, data from epidemiological studies and clinical trial results were all presented during the programme. This volume includes articles discussing the evidence for an effect of early nutrition programming on later obesity and cardiovascular risk; the growing evidence for an intergenerational cycle of obesity; the role of maternal leptin in programming appetite; possible cellular mechanisms for altered energy balance, including mitochondrial programming and the effects of regulators of metabolism; and how epigenetic changes might be the fundamental underlying mechanism explaining programming effects. Consumer understanding of the concept of early nutrition programming and the extent to which early nutrition programming is taken into account in infant feeding policies are also discussed.

Nutrition Epigenetics and Health

Nutrition  Epigenetics and Health Book
Author : Burdge Graham,Lillycrop Karen
Publisher : World Scientific
Release : 2016-10-07
ISBN : 9813143320
Language : En, Es, Fr & De

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Book Description :

Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.

Nutrition and Oral Medicine

Nutrition and Oral Medicine Book
Author : Riva Touger-Decker,Connie Mobley,Joel B. Epstein
Publisher : Springer Science & Business Media
Release : 2014-03-28
ISBN : 1607614901
Language : En, Es, Fr & De

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Book Description :

This second edition addresses the complex, multifaceted relationships between nutrition and oral health, explores proposed relationships between oral, systemic and nutritional well-being and provides insights into interprofessional, comprehensive care for individuals. Chapters focus on diet, nutrition and oral health promotion and disease prevention across the lifespan, oral and dental diseases and disorders, oral manifestations of systemic diseases, and discussions of the synergy between oral tissues and nutrients. Cutting edge research issues regarding the relationship of individual antioxidants, trace elements, polyphenols and other nutrient substrates and oral health/disease, nutrigenomics, screening for nutrition and oral risk and other areas are covered in detail. Editors and authors include experts in nutrition and oral health from around the world. This second edition is a invaluable resource for health professionals in the fields of nutrition and dentistry as well as other disciplines whose research, practice and education includes nutrition and oral medicine. It is an excellent resource for graduate level nutrition and dental students, dental and nutrition practitioners, educators and researchers as well as other health professionals.

Design of human nutrigenomics studies

Design of human nutrigenomics studies Book
Author : Siân Astley,Linda Penn
Publisher : Wageningen Academic Publishers
Release : 2009-07-28
ISBN : 908686094X
Language : En, Es, Fr & De

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Book Description :

The key to exploiting links between diet and health is to have a better understanding of how our bodies respond to what we eat. In the past, many food constituents were regarded as unimportant because they lacked a specific nutritional role. More recently nutritional research has been limited to a few dietary compounds, a handful of relevant biochemical pathways and a small number of genes pertinent to specific diseases. These studies have given rise to specific examples of benefits provided by individual/ groups of food compounds including non-nutrients, and demonstrated that whilst poor diet can accelerate age-related degeneration, a diet rich in fruits and vegetables, cereals and plant oils significantly reduces our risk of chronic disease. However, the benefits of dietary and lifestyle choices are not the same for everyone.Nutrigenomics offers a more holistic approach to nutritional research. It considers not only our genes and the effect they have on our response to diet but, also how diet affects our genes and proteins to alter our metabolism and our risk of disease as we age. However, the logistics associated with human study design and interpretation of the data generated, using these technologies, is complex. The European Network of Excellence NuGO was established in 2004 with the specific aim of developing and integrating omic technologies for European nutritional research. This has meant focusing on technical problems specific to nutrition as well as training existing and new researchers to use the technology alongside existing and new approaches. The workshop, Design of human nutrigenomic studies, reviewed examples of successful human nutrition studies using post-genomics technologies (transcriptomics, metabolomics, and proteomics) and the issues discussed are described in detail in this publication.