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Nucleic Acid Nanotheranostics

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Nucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics Book
Author : Marco Filice,Jesús Ruiz-Cabello
Publisher : Elsevier
Release : 2019-02-26
ISBN : 0128144718
Language : En, Es, Fr & De

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Book Description :

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge. Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging Presents the only book to include an analysis of nanoformulations approved for clinical use

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine Book
Author : Yusuf Tutar
Publisher : Bentham Science Publishers
Release : 2020-06-08
ISBN : 9811456895
Language : En, Es, Fr & De

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Book Description :

Nanotheranostics is a recent medical field which integrates diagnostic imaging protocols and therapeutic functions to monitor real time drug release in the body and distribution to the target site. The combined processes allow technicians to observe the effectiveness of a specifically designed drug candidate and predict its possible side effects. All these features help clinicians in optimizing treatment options for cancer and other diseases for the individual patient. Current research is tailored to individual therapy because each drug may display a variety of responses depending on variations in an individual’s genetics and subsequently, their clinical biochemistry. Many tumors are still challenging for therapists in terms of available treatment and nanotheranostic strategies may help them to combat cancer more efficiently. Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine presents information about current theranostic technologies in use at clinics and recent research on nanotheranostic applications, with a focus on cancer treatment. Information is presented in seven organized chapters that cover the basics of cancer nanotheranostics, tumor microenvironmental factors, gene therapy and gene delivery concepts, and the combined application of diagnostic imaging with cancer chemotherapy. A chapter focusing on the role of non-coding MRNAs in breast cancer carcinogenesis is also included, giving readers a glimpse of the complexities in the molecular biology of cancer which drive the need for new theranostic technologies. The book is of interest to medical professionals (including oncologists and specialists in internal medicine), diagnostic imaging technicians, and researchers in the fields of pharmacology, molecular biology and nuclear medicine.

SPIONs as Nano Theranostics Agents

SPIONs as Nano Theranostics Agents Book
Author : Atefeh Zarepour,Ali Zarrabi,Arezoo Khosravi
Publisher : Springer
Release : 2017-01-20
ISBN : 9811035636
Language : En, Es, Fr & De

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Book Description :

This Brief introduces SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), the different synthesis approaches, their applications in the field of diagnostics and treatment and finally as theranostic agents in cancer.

Nano Oncologicals

Nano Oncologicals Book
Author : Maria José Alonso,Marcos Garcia-Fuentes
Publisher : Springer
Release : 2014-10-15
ISBN : 3319080849
Language : En, Es, Fr & De

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Book Description :

This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines). Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Cancer Nanotheranostics What Have We Learned So Far

Cancer Nanotheranostics  What Have We Learned So Far  Book
Author : João Conde,Pedro Viana Baptista,Jesús M De La Fuente,Furong Tian
Publisher : Frontiers Media SA
Release : 2016-03-17
ISBN : 288919776X
Language : En, Es, Fr & De

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Book Description :

After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.

Therapeutic and Diagnostic Nanomaterials

Therapeutic and Diagnostic Nanomaterials Book
Author : Devasena T
Publisher : Springer
Release : 2016-07-19
ISBN : 9811009236
Language : En, Es, Fr & De

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Book Description :

This brief highlights nanoparticles used in the diagnosis and treatment of prominent diseases and toxic conditions. Ecofriendly methods which are ideal for the synthesis of medicinally valued nanoparticles are explained and the characteristic features of these particles projected. The role of these particles in the therapeutic field, and the induced biological changes in some diseases are discussed. The main focus is on inflammation, oxidative stress and cellular membrane integrity alterations. The effect of nanoparticles on these changes produced by various agents are highlighted using in vitro and in vivo models. The mechanism of nanoparticles in ameliorating the biological changes is supported by relevant images and data. Finally, the brief demonstrates recent developments on the use of nanoparticles in diagnosis or sensing of some biological materials and biologically hazardous environmental materials.

Cancer Nano Theranostics with High Contrast MRI

Cancer Nano Theranostics with High Contrast MRI Book
Author : Sayoni Ray
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

One of the holy grails in cancer therapy is to simultaneously image and deliver drugs to the tumor site. The first part of the thesis has developed new ideas in cancer theranostics and the second part is about the development of a novel contrast agent for risk-free imaging of the tumor. In the first project of the thesis, I have discussed the development of a liposome-based cargo delivery strategy that can simultaneously monitor alternating magnetic field-induced drug release by observing the change in MRI relaxation parameter R1, and the location and condition of liposomal site (such as tumor) from MRI parameter R2. However, the loading of a contrast agent in liposomes generally results in poor contrast and suffers from various artifacts in in vivo experiments, compared to the use of free contrast agent. Thus, the second project of my work in this part demonstrates the effective filtering of artifacts and contrast enhancement to obtain high quality sensitive imaging of the tumor site in a mouse model using paramagnetic liposomes, a novel pulsing sequence in active-feedback MRI, and robust data analysis. The second part of my work is about using a self-replicating viral-RNA molecule derived from Nodamura, an insect virus, to express and amplify ferritin, leading to increased iron content of the cells in the form of ferrihydrite that acts as a novel contrast agent. In summary, my thesis is about the development of cancer theranostics and a novel contrast agent. In the last part of the thesis, I have reviewed the current development of rapidly growing state of the art magnetic resonance cancer theranostics for commonly used polymer-based nanovehicles.

Handbook of Nanomaterials for Cancer Theranostics

Handbook of Nanomaterials for Cancer Theranostics Book
Author : Joao Conde
Publisher : Elsevier
Release : 2018-06-27
ISBN : 0128133406
Language : En, Es, Fr & De

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Book Description :

Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments

Tissue Engineering

Tissue Engineering Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Tissue Engineering book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanotechnology COVID 19 Interface

Nanotechnology COVID 19 Interface Book
Author : Devasena T.
Publisher : Springer Nature
Release : 2021-06-21
ISBN : 9813363002
Language : En, Es, Fr & De

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Book Description :

Download Nanotechnology COVID 19 Interface book written by Devasena T., available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Engineering Layer by layer Nanoparticles for the Targeted Delivery of Therapeutics to Ovarian Cancer

Engineering Layer by layer Nanoparticles for the Targeted Delivery of Therapeutics to Ovarian Cancer Book
Author : Santiago Correa Echavarria Correa
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Survival rates for ovarian cancer haven't meaningfully improved in thirty years. Ovarian cancer is particularly difficult to treat because it is usually discovered after it has metastasized and it quickly develops resistance to the few drugs that are initially effective at controlling it. Nanomedicine has the potential to change the paradigm for ovarian cancer treatment by delivering complex combinations of conventional drugs plus next-generation therapies like small interfering RNA (siRNA) and immunotherapy. However, nanoparticles must be tailored to the particular drug-delivery challenges and opportunities posed by ovarian cancer. In this thesis, we designed layer-by-layer (LbL) nanoparticles (NPs) to target ovarian cancer using library-based approaches. Using this approach, we identified promising formulations for developing an advanced nanotheranostic that both treats and detects ovarian cancer. In order to develop LbL NPs for treating ovarian cancer, we identified and overcame process engineering and fundamental materials challenges, thereby improving synthesis robustness, throughput and scale. Chapter 2 describes how modern tangential flow filtration significantly improves throughput and scalability in colloidal LbL assembly. Chapter 3 implements this improved synthetic approach to generate a small library of LbL NPs that screen for tumor-targeting properties on ovarian cancer cells, both in vitro and in vivo. Our results demonstrate that ovarian cancer cells have a high affinity to carboxylated LbL NPs, and we report several tumor-targeting formulations with distinct subcellular trafficking patterns. Chapter 4 explores the role of salt in LbL colloidal assembly, and we develop strategies for robustly synthesizing LbL-modified liposomes with high loading of siRNA. Chapter 5 advances a promising formulation identified by our surface chemistry screen, which we developed into an advanced nanotheranostic device that delivers siRNA and mediates urinary-based tumor detection. Future work that continues to improve the synthesis of LbL NPs will be essential to generate larger and more ambitious LbL NP libraries. In turn, these libraries will facilitate systematic studies that further tailor the LbL platform to specific diseases and biomedical applications.