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Non Canonical Autophagy

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Non Canonical Autophagy

Non Canonical Autophagy Book
Author : Giulia Petroni,Lorenzo Galluzzi
Publisher : Academic Press
Release : 2021-05-01
ISBN : 0128209119
Language : En, Es, Fr & De

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Book Description :

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

A Study on Non canonical Autophagy Signalling

A Study on Non canonical Autophagy Signalling Book
Author : Cansu Karabiyik
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Study on Non canonical Autophagy Signalling book written by Cansu Karabiyik, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

ATG8 Regulation and Function in Non canonical Autophagy

ATG8 Regulation and Function in Non canonical Autophagy Book
Author : Katherine Sloan
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download ATG8 Regulation and Function in Non canonical Autophagy book written by Katherine Sloan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Novel Mechanisms of Atg16L1 Recruitment in Non canonical Autophagy

Novel Mechanisms of Atg16L1 Recruitment in Non canonical Autophagy Book
Author : Katherine Anne Fletcher
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Novel Mechanisms of Atg16L1 Recruitment in Non canonical Autophagy book written by Katherine Anne Fletcher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regulation of B Cell Responses by Non canonical Autophagy

Regulation of B Cell Responses by Non canonical Autophagy Book
Author : Paula Maldonado Villavicencio
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Regulation of B Cell Responses by Non canonical Autophagy book written by Paula Maldonado Villavicencio, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Canonical and Non canonical Autophagy Modulation in Human Primary Macrophages and Its Effect on the Adaptive Immune System

Canonical and Non canonical Autophagy Modulation in Human Primary Macrophages and Its Effect on the Adaptive Immune System Book
Author : Rebecca Bohn
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Canonical and Non canonical Autophagy Modulation in Human Primary Macrophages and Its Effect on the Adaptive Immune System book written by Rebecca Bohn, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones

The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones Book
Author : Anonim
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The canonical autophagy pathway has primarily been described as a degradative mechanism, which clears the cell of old damaged organelles, protein aggregates and pathogens. Central to the pathway is the de novo formation of a vesicle structure called the autophagosome, which fuses with lysosomes to degrade its content. The Atg8a/MAP1-LC3 protein family is essential for the formation of the autophagosome, and Atg8a mutations result in a variety of defects related to decreased autophagic function. Recently, we have observed a phenotype in Atg8a mutant Drosophila that is consistent with secretory defects of the peptide hormone Bursicon, which is responsible for wing expansion and cuticle hardening upon eclosion. This observation is in accordance with other recent findings which show that components of the autophagy pathway are also involved in the secretion of bioactive molecules. However, the intersection of autophagy and secretory pathways is not yet fully understood. Here, we show that along with Bursicon two additional peptide hormones are differentially secreted and show impaired hemolymph profiles when autophagic function is lowered in the fly nervous system. This includes the release of the pigment dispersing factor (PDF, circadian cycle) and the mesencephalic astrocyte-derived neurotrophic factor (dMANF, stress response), which is highlighted by the aberrant sleep-circadian behaviors (PDF) and trauma-mediated sensitivity (MANF) associated with Atg8a1 mutant flies. Based on the Bursicon wing phenotype, we conducted a secretion-based screen using the GAL4/UAS-dsRNAi knockdown system and identified Atg8a and other autophagy components involved with organelle initiation and membrane expansion that show impaired Bursicon release upon knockdown. Furthermore, this did not include genes involved with selective autophagy (aggrephagy) or endosomal-lysosomal trafficking. Findings from this research will have broad implications toward understanding complex secretory defects and the intersection of autophagy with other vesicle trafficking pathways.

Examining the Role of Autophagy in Osteoclast Function

Examining the Role of Autophagy in Osteoclast Function Book
Author : Anh Nhi Tran
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Examining the Role of Autophagy in Osteoclast Function book written by Anh Nhi Tran, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Non canonical Functions on the Essential Autophagy Protein ATG5 in Antigen Processing and Presentation

Non canonical Functions on the Essential Autophagy Protein ATG5 in Antigen Processing and Presentation Book
Author : Christian Wolfgang Keller
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Non canonical Functions on the Essential Autophagy Protein ATG5 in Antigen Processing and Presentation book written by Christian Wolfgang Keller, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer

Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer Book
Author : Malini Sen,Dennis A. Carson,Antje Blumenthal,Elena Martin-Orozco,Jere W. McBride
Publisher : Frontiers Media SA
Release : 2020-07-14
ISBN : 2889638596
Language : En, Es, Fr & De

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Book Description :

Download Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer book written by Malini Sen,Dennis A. Carson,Antje Blumenthal,Elena Martin-Orozco,Jere W. McBride, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book
Author : M. A. Hayat
Publisher : Academic Press
Release : 2015-02-12
ISBN : 0128010525
Language : En, Es, Fr & De

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Book Description :

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 7 provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; and the role of autophagy in apoptosis. Attention is given to autophagy in the cardiovascular system, with particular insights into the role of autophagy in atherosclerosis and the distinctive behavior of autophagy in the sinoatrial node. Cutting-edge findings in the relationships between autophagy and lifestyle are explored with the regulation of macroautophagy in response to exercise, as well as the promotion of carcinogenesis via autophagy in response to cigarette smoking. Volume 7 highlights the importance of understanding the role of autophagy in context, as the complexity of autophagic function becomes increasingly clear. Autophagy may be differentially regulated, and may perform distinctive cell-specific functions even within a single tissue. The overall significance of autophagy thus cannot be oversimplified, and must be explored with granular detail of the specific role, function, and area of impact. This book is an asset to newcomers as a concise overview of the complex significance of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology Book
Author : Anonim
Publisher : Academic Press
Release : 2018-02-03
ISBN : 0128146524
Language : En, Es, Fr & De

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Book Description :

International Review of Cell and Molecular Biology. Volume 336 reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This updated volume includes specific chapters on Membrane trafficking in autophagy, Targeting the metabolism of leukemic cells, Autophagic flux in Alzheimer's disease, Transcriptional alterations associated with celiac disease, and the Regulation of antitumor immunity by IDO1, amongst other timely topics. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, drawn from international sources Offers a wide range of perspectives on specific subjects

Autophagy of the Nervous System

Autophagy of the Nervous System Book
Author : Zhenyu Yue,Charleen T. Chu
Publisher : World Scientific
Release : 2012
ISBN : 9814350443
Language : En, Es, Fr & De

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Book Description :

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.

Ubiquitin and Autophagy

Ubiquitin and Autophagy Book
Author : Taras Y. Nazarko
Publisher : MDPI
Release : 2021-08-18
ISBN : 3036513426
Language : En, Es, Fr & De

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Book Description :

This book is a collection of articles from the Cells Special Issue on “Ubiquitin and Autophagy”. It contains an Editorial and 13 articles at the intersection of ubiquitin- and autophagy-related processes. Ubiquitin is a small protein modifier that is widely used to tag proteins, organelles, and pathogens for their degradation by the ubiquitin–proteasome system and/or autophagy–lysosomal pathway. Interestingly, several ubiquitin-like proteins are at a core of the autophagy mechanism. This book dedicates a lot of attention to the crosstalk between the ubiquitin–proteasome system and autophagy and serves as a good starting point for the readers interested in the current state of the knowledge on ubiquitin and autophagy.

DJ 1 PARK7 Protein

DJ 1 PARK7 Protein Book
Author : Hiroyoshi Ariga,Sanae M. M. Iguchi-Ariga
Publisher : Springer
Release : 2017-11-16
ISBN : 9811065837
Language : En, Es, Fr & De

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Book Description :

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.

Monitoring Vesicular Trafficking in Cellular Responses to Stress

Monitoring Vesicular Trafficking in Cellular Responses to Stress Book
Author : Anonim
Publisher : Academic Press
Release : 2021-06-30
ISBN : 0128235454
Language : En, Es, Fr & De

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Book Description :

Monitoring Vesicular Trafficking in Cellular Responses to Stress, Volume 164 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the topic of Monitoring vesicular trafficking in cellular responses to stress

Autophagy in Health and Disease

Autophagy in Health and Disease Book
Author : Beverly Rothermel,Abhinav Diwan
Publisher : Elsevier
Release : 2021-10-01
ISBN : 012822004X
Language : En, Es, Fr & De

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Book Description :

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. The book covers the history, trajectory of the research field, mechanisms of autophagy, and its regulation, developmental aspects, including stem cells, embryogenesis, hematopoiesis and paligenosis and focus on several systems, including Metabolic control and Diabetes, Cardiovascular, Nervous, Immune, Gastrointestinal, and Skeletal. The final chapters provide additional disease considerations, covering cancer, longevity, disease mechanisms, and the therapeutic targeting of autophagy. This book is invaluable to anyone looking for a broader understanding of autophagy outside their specific field. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology Presents extended coverage of the mechanisms mediating autophagy Includes the role of autophagy in stem cells and iPSCs, as well as the regenerative process of “paligenosis Focuses on new topics in this edition, including Metabolic Control and Diabetes (liver, adipose, pancreas, and skeletal muscle), the nervous system, neurodegeneration, cancer and cancer therapeutics

Porphyrins Advances in Research and Application 2013 Edition

Porphyrins   Advances in Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481691635
Language : En, Es, Fr & De

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Book Description :

Porphyrins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Chlorophyll. The editors have built Porphyrins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chlorophyll in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Porphyrins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Nanotechnology in Regenerative Medicine and Drug Delivery Therapy

Nanotechnology in Regenerative Medicine and Drug Delivery Therapy Book
Author : Haiyan Xu,Ning Gu
Publisher : Springer Nature
Release : 2020-07-21
ISBN : 9811553866
Language : En, Es, Fr & De

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Book Description :

The book focuses on the application of nanotechnologies in scaffold-guided tissue regeneration and in drug delivery systems for use in immunotherapy and overcoming drug resistance in cancer treatment. It covers a variety of topics, including nanomaterials for immunomodulation and immnunotherapy; molecular studies on self-assembly for peptides and DNA and related applications in tumor diagnosis and therapeutics and against human pathogenic bacteria; magnetic and conductive scaffolds for guiding tissue regeneration; multiple functions of magnetic nanoparticles in drug delivery and regenerative medicine; and re-purposing of traditional medicine in nano-formulations. In addition, it discusses common effects of nanomaterials, including reactive oxygen species and protein corona. Providing valuable insights and the presenting the latest research advances, the book allows readers to gain a systematic understanding of the topic.

Heat Shock Proteins and Stress

Heat Shock Proteins and Stress Book
Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Release : 2018-10-24
ISBN : 3319907255
Language : En, Es, Fr & De

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Book Description :

The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.