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Non Canonical Autophagy

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Non Canonical Autophagy

Non Canonical Autophagy Book
Author : Giulia Petroni,Lorenzo Galluzzi
Publisher : Academic Press
Release : 2021-05-01
ISBN : 0128209119
Language : En, Es, Fr & De

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Book Description :

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Regulation of B Cell Responses by Non canonical Autophagy

Regulation of B Cell Responses by Non canonical Autophagy Book
Author : Paula Maldonado Villavicencio
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Regulation of B Cell Responses by Non canonical Autophagy book written by Paula Maldonado Villavicencio, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Study on Non canonical Autophagy Signalling

A Study on Non canonical Autophagy Signalling Book
Author : Cansu Karabiyik
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Study on Non canonical Autophagy Signalling book written by Cansu Karabiyik, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

ATG8 Regulation and Function in Non canonical Autophagy

ATG8 Regulation and Function in Non canonical Autophagy Book
Author : Katherine Sloan
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download ATG8 Regulation and Function in Non canonical Autophagy book written by Katherine Sloan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Novel Mechanisms of Atg16L1 Recruitment in Non canonical Autophagy

Novel Mechanisms of Atg16L1 Recruitment in Non canonical Autophagy Book
Author : Katherine Anne Fletcher
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Novel Mechanisms of Atg16L1 Recruitment in Non canonical Autophagy book written by Katherine Anne Fletcher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Canonical and Non canonical Autophagy Modulation in Human Primary Macrophages and Its Effect on the Adaptive Immune System

Canonical and Non canonical Autophagy Modulation in Human Primary Macrophages and Its Effect on the Adaptive Immune System Book
Author : Rebecca Bohn
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Canonical and Non canonical Autophagy Modulation in Human Primary Macrophages and Its Effect on the Adaptive Immune System book written by Rebecca Bohn, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Membrane Biogenesis

Membrane Biogenesis Book
Author : Jos A.F. Op den Kamp
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3642731848
Language : En, Es, Fr & De

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Book Description :

Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.

Non canonical Functions on the Essential Autophagy Protein ATG5 in Antigen Processing and Presentation

Non canonical Functions on the Essential Autophagy Protein ATG5 in Antigen Processing and Presentation Book
Author : Christian Wolfgang Keller
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Non canonical Functions on the Essential Autophagy Protein ATG5 in Antigen Processing and Presentation book written by Christian Wolfgang Keller, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Examining the Role of Autophagy in Osteoclast Function

Examining the Role of Autophagy in Osteoclast Function Book
Author : Anh Nhi Tran
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Examining the Role of Autophagy in Osteoclast Function book written by Anh Nhi Tran, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy in Health and Disease

Autophagy in Health and Disease Book
Author : Roberta A. Gottlieb
Publisher : Academic Press
Release : 2012-10-16
ISBN : 0123851017
Language : En, Es, Fr & De

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Book Description :

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy in Autoimmunity

Autophagy in Autoimmunity Book
Author : Xu-jie Zhou,Panayotis Verginis,Jennifer Martinez,Marko Radic
Publisher : Frontiers Media SA
Release : 2019-05-15
ISBN : 2889458121
Language : En, Es, Fr & De

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Book Description :

Download Autophagy in Autoimmunity book written by Xu-jie Zhou,Panayotis Verginis,Jennifer Martinez,Marko Radic, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones

The Non canonical Role of Autophagy Components in the Secretion of Neural Peptide Hormones Book
Author : Anonim
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The canonical autophagy pathway has primarily been described as a degradative mechanism, which clears the cell of old damaged organelles, protein aggregates and pathogens. Central to the pathway is the de novo formation of a vesicle structure called the autophagosome, which fuses with lysosomes to degrade its content. The Atg8a/MAP1-LC3 protein family is essential for the formation of the autophagosome, and Atg8a mutations result in a variety of defects related to decreased autophagic function. Recently, we have observed a phenotype in Atg8a mutant Drosophila that is consistent with secretory defects of the peptide hormone Bursicon, which is responsible for wing expansion and cuticle hardening upon eclosion. This observation is in accordance with other recent findings which show that components of the autophagy pathway are also involved in the secretion of bioactive molecules. However, the intersection of autophagy and secretory pathways is not yet fully understood. Here, we show that along with Bursicon two additional peptide hormones are differentially secreted and show impaired hemolymph profiles when autophagic function is lowered in the fly nervous system. This includes the release of the pigment dispersing factor (PDF, circadian cycle) and the mesencephalic astrocyte-derived neurotrophic factor (dMANF, stress response), which is highlighted by the aberrant sleep-circadian behaviors (PDF) and trauma-mediated sensitivity (MANF) associated with Atg8a1 mutant flies. Based on the Bursicon wing phenotype, we conducted a secretion-based screen using the GAL4/UAS-dsRNAi knockdown system and identified Atg8a and other autophagy components involved with organelle initiation and membrane expansion that show impaired Bursicon release upon knockdown. Furthermore, this did not include genes involved with selective autophagy (aggrephagy) or endosomal-lysosomal trafficking. Findings from this research will have broad implications toward understanding complex secretory defects and the intersection of autophagy with other vesicle trafficking pathways.

Autophagy of the Nervous System

Autophagy of the Nervous System Book
Author : Zhenyu Yue,Charleen T. Chu
Publisher : World Scientific
Release : 2012
ISBN : 9814350443
Language : En, Es, Fr & De

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Book Description :

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.

The Autophagy Pathway Bacterial Pathogen Immunity and Evasion

The Autophagy Pathway  Bacterial Pathogen Immunity and Evasion Book
Author : Chinnaswamy Jagannath,Jere W. McBride,Isabelle Vergne
Publisher : Frontiers Media SA
Release : 2021-11-25
ISBN : 2889716856
Language : En, Es, Fr & De

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Book Description :

Download The Autophagy Pathway Bacterial Pathogen Immunity and Evasion book written by Chinnaswamy Jagannath,Jere W. McBride,Isabelle Vergne, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of Immunometabolism in Autoimmune Mediated and Autoinflammatory Disorders

The Role of Immunometabolism in Autoimmune Mediated and Autoinflammatory Disorders Book
Author : Valentina Pucino,Monica Guma
Publisher : Frontiers Media SA
Release : 2021-10-14
ISBN : 2889714942
Language : En, Es, Fr & De

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Book Description :

Download The Role of Immunometabolism in Autoimmune Mediated and Autoinflammatory Disorders book written by Valentina Pucino,Monica Guma, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy in Current Trends in Cellular Physiology and Pathology

Autophagy in Current Trends in Cellular Physiology and Pathology Book
Author : Nikolai Gorbunov,E. Marion Schneider
Publisher : BoD – Books on Demand
Release : 2016-11-10
ISBN : 9535127268
Language : En, Es, Fr & De

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Book Description :

Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Programmed Cell Death 2 0 The Quality of Cell Death

Programmed Cell Death 2 0  The Quality of Cell Death Book
Author : Michael Thomas Lotze,Yinan Gong,Jennifer Martinez,Na Dong
Publisher : Frontiers Media SA
Release : 2022-02-14
ISBN : 288974390X
Language : En, Es, Fr & De

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Book Description :

Download Programmed Cell Death 2 0 The Quality of Cell Death book written by Michael Thomas Lotze,Yinan Gong,Jennifer Martinez,Na Dong, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Transport Proteins

Transport Proteins Book
Author : Anonim
Publisher : Academic Press
Release : 2021-01-21
ISBN : 0128220880
Language : En, Es, Fr & De

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Book Description :

Transport Proteins, Volume 123, provides the latest information on the two major groups of transport proteins, those that carry molecules to different locations within a cell or organism and those that carry molecules across otherwise impermeable membranes. Chapters in the updated release include Biology of Iron Transport: Ferroportin, Transport of transition metals across biological membranes, The effect of sport and physical activity on transport proteins: implications for cancer prevention and control, Structural rearrangement in polyketide synthase for improvement its bio-physicochemical properties, Autophagy Proteins and its Homeostasis in Cellular Environment, and much more. Integrates experimental and computational methods for studying the structure and function of transport proteins and their implication in drug design Contains timely chapters written by well-renowned authorities in their field Includes a high number of top quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students

Novel Cancer Treatments based on Autophagy Modulation

Novel Cancer Treatments based on Autophagy Modulation Book
Author : Marco Cordani,Álvaro Somoza,Marco Tafani,Ilaria Dando,Suresh Kumar
Publisher : Frontiers Media SA
Release : 2021-06-11
ISBN : 2889668738
Language : En, Es, Fr & De

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Book Description :

Download Novel Cancer Treatments based on Autophagy Modulation book written by Marco Cordani,Álvaro Somoza,Marco Tafani,Ilaria Dando,Suresh Kumar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book
Author : M. A. Hayat
Publisher : Academic Press
Release : 2017-09-07
ISBN : 0128121475
Language : En, Es, Fr & De

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Book Description :

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. Presents the most advanced information regarding the role of the autophagic system in life and death States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease Authored by global leaders in the field, bringing the broadest, most expert coverage available