Skip to main content

Nmr Spectroscopy In Pharmaceutical Analysis

In Order to Read Online or Download Nmr Spectroscopy In Pharmaceutical Analysis Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

NMR Spectroscopy in Pharmaceutical Analysis

NMR Spectroscopy in Pharmaceutical Analysis Book
Author : Iwona Wawer,Bernd Diehl
Publisher : Elsevier
Release : 2017-07-07
ISBN : 008095152X
Language : En, Es, Fr & De

GET BOOK

Book Description :

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience Considers international pharmacopoeias, addressing the concern for licensing Features the work of academics and researchers, appealing to a broad readership

Pharmaceutical Analysis

Pharmaceutical Analysis Book
Author : David C Lee,Michael L. Webb
Publisher : John Wiley & Sons
Release : 2009-02-12
ISBN : 1405172991
Language : En, Es, Fr & De

GET BOOK

Book Description :

The use of analytical sciences in the discovery, development andmanufacture of pharmaceuticals is wide-ranging. From the analysisof minute amounts of complex biological materials to the qualitycontrol of the final dosage form, the use of analytical technologycovers an immense range of techniques and disciplines. This book concentrates on the analytical aspects of drugdevelopment and manufacture, focusing on the analysis of the activeingredient or drug substance. It provides those joining theindustry or other areas of pharmaceutical research with a source ofreference to a broad range of techniques and their applications,allowing them to choose the most appropriate analytical techniquefor a particular purpose. The volume is directed at analytical chemists, industrialpharmacists, organic chemists, pharmaceutical chemists andbiochemists.

Coupling of Capillary Electrophoresis with Nuclear Magnetic Resonance Spectroscopy for the Analysis of Pharmaceutical and Environmental Relevant Compo

Coupling of Capillary Electrophoresis with Nuclear Magnetic Resonance Spectroscopy for the Analysis of Pharmaceutical and Environmental Relevant Compo Book
Author : Joana Diekmann
Publisher : GRIN Verlag
Release : 2011-04
ISBN : 3640873599
Language : En, Es, Fr & De

GET BOOK

Book Description :

Master's Thesis from the year 2009 in the subject Chemistry - Analytical Chemistry, grade: 1,0, University of Hannover (Anorganische Chemie), language: English, comment: This Master Thesis was awarded with the "E.ON Future Award 2010" and it was carried out at the Leibniz University Hannover, Faculty of Natural Sciences, Institute for Inorganic Chemistry, Department of Analytical Chemistry, in cooperation with the Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, Livermore, CA, USA., abstract: Separation and identification of mass-limited chemical samples is the key to understand the complex nature of pharmaceutical and environmental systems. High efficiency separation techniques, such as capillary electrophoresis (CE), coupled to a non-destructive, information-rich detection, such as nuclear magnetic resonance (NMR) spectroscopy, have revolutionized the ability to separate and identify components in small sample volumes. Using this hyphenated system, structure elucidation of analytes separated during an electrophoretic process can be performed using NMR as an on-line detector. Although sensitivity remains an issue for on-line NMR detection, capillary NMR spectroscopy using microcoils has emerged as a major breakthrough for increasing the mass-sensitivity of NMR spectroscopy, because the limit of detection is proportional to the coil diameter. A further development is the miniaturization of the magnet enabling the possibility of a truly portable NMR system. This portable, low-cost NMR sensor, coupled to the rapid CE separation system could enable high-throughput and on-site identification of nanoliter amounts of solution. Furthermore, CE can provide on-line pre-concentration via electrokinetic injection or other stacking techniques to increase the sample concentration. In this research, coupling CE to a laboratory-scale NMR and to a portable NMR system are investigated, with the emphasis on the development of the miniaturized system.

NMR in Pharmaceutical Science

NMR in Pharmaceutical Science Book
Author : Robin K. Harris
Publisher : John Wiley & Sons
Release : 2015-09-28
ISBN : 1118660250
Language : En, Es, Fr & De

GET BOOK

Book Description :

NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes

Spectroscopic Analyses

Spectroscopic Analyses Book
Author : Eram Sharmin,Fahmina Zafar
Publisher : BoD – Books on Demand
Release : 2017-12-06
ISBN : 9535136275
Language : En, Es, Fr & De

GET BOOK

Book Description :

The book presents developments and applications of these methods, such as NMR, mass, and others, including their applications in pharmaceutical and biomedical analyses. The book is divided into two sections. The first section covers spectroscopic methods, their applications, and their significance as characterization tools; the second section is dedicated to the applications of spectrophotometric methods in pharmaceutical and biomedical analyses. This book would be useful for students, scholars, and scientists engaged in synthesis, analyses, and applications of materials/polymers.

Process Analytical Technology

Process Analytical Technology Book
Author : Katherine A. Bakeev
Publisher : John Wiley & Sons
Release : 2010-04-01
ISBN : 0470689609
Language : En, Es, Fr & De

GET BOOK

Book Description :

Process Analytical Technology explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added. Coverage includes: Implementation of Process Analytical Technologies UV-Visible Spectroscopy for On-line Analysis Infrared Spectroscopy for Process Analytical Applications Process Raman Spectroscopy Process NMR Spectrscopy: Technology and On-line Applications Fluorescent Sensing and Process Analytical Applications Chemometrics in Process Analytical Technology (PAT) On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing NIR Chemical Imaging This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT. It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT. Review from the First Edition “The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology.”—Current Engineering Practice

Quantitative NMR Spectroscopy in Pharmaceuticals

Quantitative NMR Spectroscopy in Pharmaceuticals Book
Author : Kalpesh S. Parikh,Hemant H. Gadape
Publisher : LAP Lambert Academic Publishing
Release : 2012-03
ISBN : 9783845478845
Language : En, Es, Fr & De

GET BOOK

Book Description :

Over the past fifty years nuclear magnetic resonance spectroscopy, commonly referred to as NMR, has become the preeminent technique for structure determination of organic compounds. With developments in both methodology and instrumentation in the past two decades, NMR has become one of the most powerful and versatile spectroscopic techniques for characterization and quantification. An increasing concern with the well being of individuals and life in general has led to initiatives for improvements in medicine and the world environment, and in these areas analytical chemistry has particularly vital roles to play. Where new drugs or materials with potential commercial value are synthesized, a complete chemical characterization may be required involving considerable analytical work. More than any other analytical method the NMR spectroscopy provides information about the chemical structure and the dynamics of organic molecules. NMR spectroscopy is by definition a quantitative spectroscopic tool because the intensity of a resonance line is directly proportional to the number of resonant nuclei (spins). This fact enables accurate and precise determinations of the amount of substance.

Natural Products Analysis

Natural Products Analysis Book
Author : Vladimir Havlicek,Jaroslav Spizek
Publisher : John Wiley & Sons
Release : 2014-09-17
ISBN : 1118876024
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book highlights analytical chemistry instrumentation andpractices applied to the analysis of natural products and theircomplex mixtures, describing techniques for isolating andcharacterizing natural products. • Applies analytical techniques to natural productsresearch – an area of critical importance to drugdiscovery • Offers a one-stop shop for most analytical methods:x-ray diffraction, NMR analysis, mass spectrometry, and chemicalgenetics • Includes coverage of natural products basics andhighlights antibacterial research, particularly important asefforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail forboth current practitioners and beginning researchers

Handbook of Modern Pharmaceutical Analysis

Handbook of Modern Pharmaceutical Analysis Book
Author : Satinder Ahuja,Stephen Scypinski
Publisher : Academic Press
Release : 2010-11-11
ISBN : 9780123759818
Language : En, Es, Fr & De

GET BOOK

Book Description :

Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use. Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS

Structure activity Relationship Studies in Drug Development by NMR Spectroscopy

Structure activity Relationship Studies in Drug Development by NMR Spectroscopy Book
Author : Atta-ur- Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Release : 2011
ISBN : 1608051641
Language : En, Es, Fr & De

GET BOOK

Book Description :

"NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parame"

Annual Reports on NMR Spectroscopy

Annual Reports on NMR Spectroscopy Book
Author : Graham A. Webb
Publisher : Academic Press
Release : 2014-07-22
ISBN : 0128003278
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. This volume of Annual Reports on NMR Spectroscopy focuses on the analytical tools used by chemists and physicists, taken together with other volumes of this series, an excellent account of progress in NMR and its many applications is provided and anyone using NMR will find interest in this Serial

Annual Reports on NMR Spectroscopy

Annual Reports on NMR Spectroscopy Book
Author : Graham A. Webb
Publisher : Academic Press
Release : 2021-06-04
ISBN : 0323850987
Language : En, Es, Fr & De

GET BOOK

Book Description :

Annual Reports on NMR Spectroscopy, Volume 103, the latest release in a series that has established itself as a premier resource for both specialists and non-specialists interested in new techniques and applications pertaining to NMR spectroscopy includes a variety of updated chapters covering Recent Applications of 17O Solid State NMR in Biochemistry, NMR Studies of Ferromagnetic Materials, Very Fast MAS Solid State NMR Studies of Pharmaceuticals, Recent Advances in Benchtop NMR and Applications, Ultra-Fast Magic Angle Spinning Nuclear Magnetic Resonance. Serves as the premier resource for learning new techniques and applications in NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)

On line LC NMR and Related Techniques

On line LC NMR and Related Techniques Book
Author : Klaus Albert
Publisher : John Wiley & Sons
Release : 2003-02-14
ISBN : 0470854812
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book gives a comprehensive overview of the basis and the current applications of LC-NMR and related techniques. It deals with the practical aspects of the hardware and software set-up for a successful performance of on-line coupling experiments. It covers the solution of real-word problems from the fields of biomedical, pharmaceutical and environmental studies as well as the analysis of natural products and polymeric compounds. Thus guidelines for an efficient application of the powerful hyphenated technique LC-NMR in combination with LC-MS are presented. Besides LC-NMR, important techniques such as the on-line coupling of gel permeation chromatography and supercritical fluid chromatography, together with 1H NMR spectroscopy, are described in detail. Fascinating further aspects, such as the application of capillary separation techniques either in the single or parallel detection mode, together with the possibilities of direct 13C monitoring of chromatographic events, are also discussed. Key features include: * Up-to-date information on the theoretical and experimental methodology * Coverage of applications in biomedical, pharmaceutical and natural product analysis, as well as environmental polymer and related hyphenated techniques * Information appropriate for researchers in organic, pharmaceutical and medical chemistry Overall, this book is a requirement for all researchers and staff members dealing with structure elucidation problems in separation science.

Pharmaceutical Analysis A Textbook for Pharmacy Students and Pharmaceutical Chemists 3

Pharmaceutical Analysis A Textbook for Pharmacy Students and Pharmaceutical Chemists 3 Book
Author : David G. Watson
Publisher : Elsevier Health Sciences
Release : 2012
ISBN : 0702046213
Language : En, Es, Fr & De

GET BOOK

Book Description :

An introductory text, written with the needs of the student in mind, which explains all the most important techniques used in the analysis of pharmaceuticals - a key procedure in ensuring the quality of drugs. The text is enhanced throughout with keypoints and self-assessment boxes, to aid student learning.

Implementation of Solution and Solid Sate Nuclear Magnetic Resonance NMR Spectroscopic Techniques for Quantitative and Qualitative Analysis of Molecular Species

Implementation of Solution and Solid Sate Nuclear Magnetic Resonance  NMR  Spectroscopic Techniques for Quantitative and Qualitative Analysis of Molecular Species Book
Author : Abrar S. Alnafisah
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

In this dissertation, spectroscopy has been used to solve a variety of problems in different domains of science. Therefore, each chapter consists of different examples that have been addressed using different concepts of spectroscopy. The objective of part I (application of solution state NMR spectroscopy in pharmaceutical sciences) is to apply NMR techniques in different pharmaceutical projects. In chapter 3, a real-time quantification of in vitro Bortezomib (BTZ) release from alginate microparticles using a solution state quantitative boron nuclear magnetic resonance (11B qNMR) method is presented. The method was validated according to International Conference on Harmonization (ICH) guidelines. Therefore, several analytical performance parameters were discussed such as limit of detection (LOD), limit of quantification (LOQ), linearity, specificity, accuracy, precision and robustness. The 11B qNMR method was applied to the in vitro release study of a model drug, bortezomib (BTZ) from alginate microparticles and results were compared to a commonly used dialysis method. Throughout the release study, the dialysis method consistently underestimated the level of drug released, probably due to the separating membrane that can interfere with the real-time drug transport process. Overall, compared to the dialysis method, the direct 11B qNMR method was accurate and provided a direct and real-time quantification of BTZ for an effective study of drug release kinetics. Similarly, in chapter 4, a 19F qNMR method was developed and validated and then applied to study the real-time release of maraviroc from a microparticle formulation in a vaginal and seminal stimulated environment. Different possibilities were discussed to control the release profile such as the crosslinking process and a pH sensitive polymer. In chapter 5, the project is a collaborative effort between the department of Chemistry and School of Pharmacy. Our contributions in that project are to utilize 11B NMR spectroscopy technique as a characterization tool for the reaction progression. Moreover, to perform theoretical and experimental calculations and compare them to each other in order to trace the reaction mechanism. The overall motivation of the project is to test an assumption about phenylboronic acid (PBA) to prevent HIV transmission. It has been found that phenylboronic acid can form boronic acid in the presence of cis-diol, like the one found in HIV-gp120 glycoproteins. In order to exam the proposed hypothesis, a derivative of phenylboronic acid was synthesized. The synthetic scheme and the spectroscopic results are presented and discussed in detail. The objective of part II (applications of solid-state NMR spectroscopy) is to apply SSNMR spectroscopy experiments in two projects to gain significant information about specific materials. In chapter 6, some main concepts of SSNMR spectroscopy are discussed as well as some basic SSNMR experiments. In chapter 7, boron carbide thin films were grown using plasma enhanced chemical vapor deposition (PECVD) under different growth conditions. Different possible spectroscopic techniques were discussed in order to discover the local physical structure of boron carbide thin films. However, most of these techniques have shown a lack of an ability to demonstrate the internal structure of thin films. SSNMR spectroscopy was successfully employed to reveal information about the internal structure of boron carbide thin films. In chapter 8, the optical properties of titanium oxide TiO2 were modified by introducing a hydrazine molecule. SSNMR spectroscopy was implemented to monitor the reaction progression of TiO2 to improve its optical properties.

Proceedings of 4th World Congress on Mass Spectrometry 2017

Proceedings of 4th World Congress on Mass Spectrometry 2017 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2021-09-18
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

June 19-21, 2017 London, UK Key Topics : Applications of Mass Spectrometry, New Approaches in Mass Spectrometry, Recent Advances and Development in Mass Spectrometry, Mass spectrometry Imaging, Fundamentals of Mass Spectrometry, Ionization Techniques, Mass Spectrometry Configurations and Separation Techniques, Chromatography and High Performance Liquid Chromatography (HPLC), Maintenance, Troubleshooting, Data Analysis and Experimentation in Mass Spectrometry, Mass Spectrometry in Proteome Research, Proteomics and its applications, Mass Spectrometry in Metabolomics and Lipidomics, Hyphenated Techniques (LC-NMR-MS, HPLC-ESI-MS, MC-ICP-MS, HPLC-ICP-MS, UPLC-Q-TOF/MS), Mass spectrometry in environmental analysis, Spectroscopy, Clinical application of mass spectrometry, UV, IR and Ion Spectroscopy, Nuclear Magnetic Resonance(NMR) Spectroscopy, Mass Spectrometry in Toxicology, Mass spectrometry in Analytical Science, Mass Spectrometry in Pharmaceutical Analysis,

Pharmaceutical Excipients

Pharmaceutical Excipients Book
Author : David E. Bugay,W. Paul Findlay
Publisher : CRC Press
Release : 1999-02-23
ISBN : 9780824793739
Language : En, Es, Fr & De

GET BOOK

Book Description :

Meeting the need for a hands-on guide elucidating the role of molecular spectroscopy in the physical characterization of pharmaceutical solids, two experts from the industry gather theoretical discussions of infrared, Raman, and nuclear magnetic resonance spectroscopy. They provide recommendations on spectral data acquisition techniques and include 600 spectra for 300 of the most commonly used excipients. Complete with references, equations, tables, and a CAS registry number index, the book covers the drug development process, including chemical identification of substances, investigative studies, competitor analysis, problem solving activities, reproduction of spectral data, and more.

NMR Spectroscopy in Drug Development and Analysis

NMR Spectroscopy in Drug Development and Analysis Book
Author : Ulrike Holzgrabe,Iwona Wawer,Bernd Diehl
Publisher : John Wiley & Sons
Release : 2008-07-11
ISBN : 352761365X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging. In short, this book covers all aspects of drug analysis.

Nuclear Magnetic Resonance

Nuclear Magnetic Resonance Book
Author : G. A. Webb,Krystyna Kamienska-Trela
Publisher : Royal Society of Chemistry
Release : 2010-03-01
ISBN : 1847550606
Language : En, Es, Fr & De

GET BOOK

Book Description :

As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids and NMR of Carbohydrates, Lipids and Membranes. For those wanting to become rapidly aquainted with specific areas of NMR, Nuclear Magnetic Resonance provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications.

Handbook of Pharmaceutical Analysis by HPLC

Handbook of Pharmaceutical Analysis by HPLC Book
Author : Satinder Ahuja,Michael Dong
Publisher : Elsevier
Release : 2005-02-09
ISBN : 9780080455181
Language : En, Es, Fr & De

GET BOOK

Book Description :

High pressure liquid chromatography–frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening). A complete reference guide to HPLC Describes best practices in HPLC and offers 'tricks of the trade' in HPLC operation and method development Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, sample preparations, and data handling