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New Therapeutics For Traumatic Brain Injury

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New Therapeutics for Traumatic Brain Injury

New Therapeutics for Traumatic Brain Injury Book
Author : Kim Heidenreich
Publisher : Academic Press
Release : 2016-09-27
ISBN : 0128027010
Language : En, Es, Fr & De

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Book Description :

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

New Therapeutics for Traumatic Brain Injury

New Therapeutics for Traumatic Brain Injury Book
Author : Kim Heidenreich
Publisher : Academic Press
Release : 2016-09-27
ISBN : 0128027010
Language : En, Es, Fr & De

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Book Description :

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury Book
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Release : 2015-12-01
ISBN : 1498766579
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Traumatic Brain Injury

Traumatic Brain Injury Book
Author : Jack W. Tsao
Publisher : Springer Nature
Release : 2019-11-19
ISBN : 3030224368
Language : En, Es, Fr & De

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Book Description :

This thoroughly revised and updated work covers numerous advances in traumatic brain injury diagnosis, evaluation, treatment, and pathophysiology. Since publication of the first edition in 2012, there has been greatly increased public awareness of the clinical consequences of even the mildest of head injuries, and the result has been a concerted effort of countries around the world to increase research funding. This second edition continues to focus on mild traumatic brain injury--or concussion--and contains updates to all the original chapters as well as adding new chapters addressing clinical sequelae, including pediatric concussion, visual changes, chronic traumatic encephalopathy, and blast-associated TBI. Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation, Second Edition, is a comprehensive resource designed for neurologists, primary care clinicians, sports physicians, and other medical providers, including psychologists and neuropsychologists, as well as athletic trainers who may evaluate and care for individuals who have sustained a TBI. The book features summaries of the most pertinent areas of diagnosis and therapy, which can be readily accessed by the busy clinician/professional. In addition, the book's treatment algorithms provide a highly practical reference to cutting edge therapies, and an updated appendix of ICD codes is included. An outstanding contribution to the literature, Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation, Second Edition, again offers an invaluable resource for all providers who treat patients with TBI.

Brain Neurotrauma

Brain Neurotrauma Book
Author : Firas H. Kobeissy
Publisher : CRC Press
Release : 2015-02-25
ISBN : 1466565993
Language : En, Es, Fr & De

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Book Description :

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Traumatic Brain Injury New Insights for the Healthcare Professional 2013 Edition

Traumatic Brain Injury  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481656287
Language : En, Es, Fr & De

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Book Description :

Traumatic Brain Injury: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Traumatic Brain Injury: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Traumatic Brain Injury: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cognitive Rehabilitation Therapy for Traumatic Brain Injury

Cognitive Rehabilitation Therapy for Traumatic Brain Injury Book
Author : Institute of Medicine,Board on the Health of Select Populations
Publisher : National Academies Press
Release : 2013-04-25
ISBN : 0309267862
Language : En, Es, Fr & De

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Book Description :

In October 2011, the Institute of Medicine (IOM) released the report Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence, assessing the published evidence for the effectiveness of using cognitive rehabilitation therapy (CRT) to treat people with traumatic brain injury (TBI). TBI has gained increasing attention in the past 15 years because of its status as the signature wound of American military conflicts in Iraq and Afghanistan. Growing numbers of U.S. service members are suffering traumatic brain injuries and are surviving them, given that (a) the majority of traumatic brain injuries are mild and (b) lifesaving measures for more severe injuries have significantly improved. People with any level of injury can require ongoing health care in their recovery, helping them to regain (or compensate for) their losses of function and supporting their full integration into their social structure and an improved quality of life. One form of treatment for TBI is CRT, a systematic, goal-oriented approach to helping patients overcome cognitive impairments. The Department of Defense (DoD) asked the IOM to evaluate CRT for traumatic brain injury in order to guide the DoD's use and coverage in the Military Health System. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence was the IOM's resulting study of the evidence. The report's conclusions revolved around the fact that there is little continuity among research studies of the effectiveness of different types of CRT, and there exist only small amounts of evidence (or, in many cases, none) demonstrating the effectiveness of using CRT to treat TBI-although the evidence that does exist generally indicates that CRT interventions have some effectiveness. The workshop brought together experts in health services administration, research, and clinical practice from the civilian and military arenas in order to discuss the barriers for evaluating the effectiveness of CRT care and for identifying suggested taxonomy, terminology, timing, and ways forward for CRT researchers. The workshop consisted of individuals and was not intended to constitute a comprehensive group. Select decision makers in the Military Health System and Veterans Affairs (VA) and researchers were invited to participate. The workshop was designed to spur thinking about (1) the types of research necessary to move the field forward toward evidence-based clinical guidelines, (2) what the translational pipeline looks like and what its current deficiencies are, and (3) considerations that decision makers may choose to use as they decide what research they will support and decide how they will balance the urgency of the need with the level of evidence for CRT interventions. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Model Study Protocols and Frameworks to Advance the State of the Science summarizes the happenings of the workshop.

Traumatic Brain Injury

Traumatic Brain Injury Book
Author : Jack W. Tsao
Publisher : Springer Science & Business Media
Release : 2012-06-13
ISBN : 0387878874
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) is a major cause of disability worldwide. Each year 1.7 million new TBIs occur in the United States, and it is also considered a signature injury of the Iraq and Afghanistan conflicts. Despite the relatively high incidence-within both civilian and military populations-the diagnosis and treatment, particularly of mild TBI/concussion, remains an inexact science. Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation is a concise guide designed for neurologists, primary care, and sports physicians and other medical providers, psychologists and neuropsychologists, and athletic trainers who may evaluate and care for patients with TBI. The book features summaries of the most pertinent areas of diagnosis and therapy, which can be readily accessed by the busy clinician/professional. In addition, the book's treatment algorithms provide a highly practical reference to cutting edge therapies. A superb contribution to the literature, Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation offers a well-designed, well-written, useful resource for all providers who treat patients with TBI.

Music Therapy and Traumatic Brain Injury

Music Therapy and Traumatic Brain Injury Book
Author : Simon Gilbertson,David Aldridge
Publisher : Jessica Kingsley Publishers
Release : 2008-07-15
ISBN : 9781846428289
Language : En, Es, Fr & De

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Book Description :

Musical improvisation is an increasingly recognised rehabilitative therapy for people who have experienced traumatic brain injury initially thought to be `unreachable' or `non-responsive'. Music Therapy and Traumatic Brain Injury demonstrates how music therapy can be used to attend to the holistic, rather than purely functional, needs of people affected by severe head trauma. Divided into three parts, the first section provides an introduction to the effects brain injury has on a person's livelihood. The second is a comprehensive review of available literature on the use of music therapy in the neurorehabilitative setting. The final section examines three case studies designed according to `therapeutic narrative analysis', an adaptive research method that uses interviewing and video, which focuses on the unique relationship between the professional and the patient. This book will give clinicians key notes for practice and a vision of the integral role music therapy can have in the successful rehabilitation from brain injury.

Traumatic Brain Injury New Insights for the Healthcare Professional 2012 Edition

Traumatic Brain Injury  New Insights for the Healthcare Professional  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-10
ISBN : 1464975965
Language : En, Es, Fr & De

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Book Description :

Traumatic Brain Injury: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Traumatic Brain Injury in a concise format. The editors have built Traumatic Brain Injury: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Traumatic Brain Injury in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Traumatic Brain Injury: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Psychological Therapy for Paediatric Acquired Brain Injury

Psychological Therapy for Paediatric Acquired Brain Injury Book
Author : Jenny Jim,Esther Cole
Publisher : Routledge
Release : 2019-10-18
ISBN : 1000228002
Language : En, Es, Fr & De

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Book Description :

Children, young people and families living with an acquired brain injury (ABI), whether through accident, illness, injury or abuse, are rarely offered psychological therapy, and yet the benefits of such interventions can be profound. This important new book, providing a selection of practice examples and insights from frontline practitioners, will be essential reading for any paediatric therapist or clinician. Beginning with a "life story" of the brain where emphasis is placed on how brain development is fundamentally related to its environment, the book offers key background knowledge before showcasing the core topics of assessment, psychological formulation and intervention. It features a range of therapeutic models, includes direct and indirect work, group work and family therapy, with settings varying from inpatient neurorehabilitation to community work and the transition to education. The long-term needs of those in the criminal justice system are also addressed. The closing chapters focus on the debate around effective outcome measurement and outline a vision for better services. Elevating the voices of our children, young people and families living with ABI, this pioneering book will provide practitioners with the confidence to work collaboratively across a range of children and young people with disorders of consciousness or communication to those with behaviour that challenges others to manage. It offers new ways to understand both children’s pasts and their futures, and will be essential reading for anyone in the field.

Neurotrauma New Insights into Pathology and Treatment

Neurotrauma  New Insights into Pathology and Treatment Book
Author : John T. Weber,Andrew I.R. Maas
Publisher : Elsevier
Release : 2007-07-27
ISBN : 9780080548876
Language : En, Es, Fr & De

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Book Description :

Neurotrauma is the leading cause of death and disability in young adults, and the incidence in older patients is increasing. Neurotrauma is also a field in medicine with one of the highest unmet needs. Concentrated, focused and multidisciplinary efforts are required to combat this important disease. Exciting findings from basic research open opportunities for improving treatment results. This volume presents a unique and comprehensive overview of the latest findings and insights on translational research in neurotrauma. This book should be a must for any TBI or SCI researcher interested in translating their work to the clinic, as well as to clinicians interested in the latest research findings which could provide novel treatment strategies for their patients. • Integrates results from research on traumatic brain injury and spinal cord injury, bridging basic science and clinical research • Includes contributions from a worldwide panel of leading researchers and clinicians in the fields of TBI and SCI

Occupational Therapy Approaches to Traumatic Brain Injury

Occupational Therapy Approaches to Traumatic Brain Injury Book
Author : Laura H Krefting,Jerry A Johnson
Publisher : Routledge
Release : 2013-01-11
ISBN : 1136580271
Language : En, Es, Fr & De

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Book Description :

This sensitive book provides a much-needed compilation and description of OT programs for the care of individuals disabled by traumatic brain injury (TBI). Focusing on the disabled individual, the family, and the societal responses to the injured, this comprehensive book covers the spectrum of available services from intensive care to transitional and community living. Both theoretical approaches to the problems of brain injury as well as practical treatment techniques are explored in Occupational Therapy Approaches to Traumatic Brain Injury. The processes of assessment and intervention are vital to the recovery of brain-injured patients and this thorough book devotes two chapters specifically to assessment and several chapters on intervention and family involvement. This useful volume contains information about rehabilitation from ‘coma to community,’as well as numerous other approaches. The findings and treatment suggestions presented here are applicable to many helping professionals working with TBI patients. Health care practitioners working with brain injured persons and their families in both institutional and community contexts, physical therapists, physicians, nurses, and psychologists and social workers involved with assessment will find this an invaluable addition to their professional references.

Traumatic Brain Injury

Traumatic Brain Injury Book
Author : Nikolai Gorbunov,Joseph Long
Publisher : BoD – Books on Demand
Release : 2018-05-09
ISBN : 1789231167
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) syndrome has emerged as a serious health concern worldwide due to the severity of outcomes and growing socioeconomic impacts of the diseases, e.g., high cost of long-term medical care and loss of quality of life. This book focuses on the TBI pathobiology as well as on the recent developments in advanced diagnostics and acute management. The presented topics encompass personal experience and visions of the chapter contributors as well as an extensive analysis of the TBI literature. The book is addressed to a broad audience of readers from students to practicing clinicians.

Interpretation of Bloodstain Evidence at Crime Scenes Second Edition

Interpretation of Bloodstain Evidence at Crime Scenes  Second Edition Book
Author : William G. Eckert,Stuart H. James
Publisher : CRC Press
Release : 1998-07-14
ISBN : 9780849313622
Language : En, Es, Fr & De

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Book Description :

As witnessed in landmark criminal cases, the quality and integrity of bloodstain evidence can be a crucial factor in determining a verdict. Since the first edition of Interpretation of Bloodstain Evidence at Crime Scenes was published nearly a decade ago, bloodstain pattern interpretation has continued to grow as a branch of forensic science. Revised and updated to reflect new technology and developments in the field, the second edition is packed with new information and illustrations-including 421 photographs and diagrams of improved quality that will aid in interpretation of evidence. Expanding on a single chapter presented in the bestselling first edition, the second edition details, in four chapters, an introduction to bloodstain interpretation; low-velocity impact and angular considerations; medium and high-velocity impact; and the significance of partially dried, clotted, aged, and physically altered bloodstains in four new chapters. A full chapter on the detection of blood with luminol, featuring high-quality, full-color photographs of luminol reactions, has been added. This new edition also includes 12 new case studies in addition to 8 original case studies from the first edition that have been retained for their interpretative value. Everyone involved in crime scene evaluation and interpretation-law enforcement officers, criminologists, medical examiners, forensic pathologists, medicolegal personnel, and prosecutors and defense attorneys-will benefit from the improved and expanded second edition of this definitive reference.

Cognitive Rehabilitation Therapy for Traumatic Brain Injury

Cognitive Rehabilitation Therapy for Traumatic Brain Injury Book
Author : Jennifer A. Ostergren
Publisher : Plural Publishing
Release : 2017-11-17
ISBN : 1635500567
Language : En, Es, Fr & De

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Book Description :

Cognitive Rehabilitation Therapy for Traumatic Brain Injury: A Guide for Speech-Language Pathologists is designed for speech-language pathologists (SLPs) treating adults with cognitive-communicative impairments following traumatic brain injury (TBI). Cognitive impairments are one of the cardinal features of TBI, affecting communication and activities of daily living. This book integrates scientific information into a user friendly and practical application tool for practicing SLPs and students in training to become SLPs. Section I contains chapters that serve as background for understanding the treatment of TBI. Included are chapters addressing mechanisms of injury, neuropathology, recovery patterns, and applicable classification and outcome measures following TBI. An overview of cognitive-communicative impairments is also included, as are sections devoted to common compounding and concomitant conditions that impact individuals with TBI and their rehabilitation. Section I also contains chapters describing the rehabilitation process following TBI from the broader landscape of interdisciplinary and patient-centered rehabilitation and specific to cognitive rehabilitation treatment (CRT) for adults with TBI. Section II contains chapters devoted to describing CRT in the areas of attention and information processing speed impairments, memory, executive function and awareness, and social communication. Chapters in section II focus on treatment approaches that have an established base, described in a clinically useable format. Each chapter includes a summary of the research evidence, recommended candidates, and background on a specific treatment approach. They also include a section devoted to 'Treatment in Action,' designed to explain applicable steps, procedures, and needed materials for implementation of a specific approach. Charts, figures, tables, and appendices are also included to facilitate the use of a specific approach. Cognitive Rehabilitation Therapy for Traumatic Brain Injury can serve as a supplemental textbook for graduate courses on neurologic communication disorders. It is also a valuable resource for students during clinical practicum with adults with TBI. This book is also a professional resource that summarizes information in a way that is applicable to practicing SLPs who work with adults with TBI and their families.

Traumatic Brain Injury

Traumatic Brain Injury Book
Author : Mark J. Ashley
Publisher : CRC Press
Release : 2003-12-29
ISBN : 9781439858127
Language : En, Es, Fr & De

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Book Description :

Traumatic Brain Injury: Rehabilitative Treatment and Case Management, Second Edition provides therapists, case managers and physicians with information about the longer-term issues faced by this population. Originally titled Traumatic Brain Injury Rehabilitation, this new edition updates the clinical information and broadens the scope of the best-s

Rehabilitation After Traumatic Brain Injury

Rehabilitation After Traumatic Brain Injury Book
Author : Blessen C. Eapen,David X. Cifu
Publisher : Elsevier Health Sciences
Release : 2018-01-24
ISBN : 0323544576
Language : En, Es, Fr & De

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Book Description :

Covering the full spectrum of rehabilitation after traumatic brain injury, this practical reference by Drs. Blessen C. Eapen and David X. Cifu presents best practices and considerations for numerous patient populations and their unique needs. In an easy-to-read, concise format, it covers the key information you need to guide your treatment plans and help patients relearn critical life skills and regain their independence. Covers neuroimaging, neurosurgical and critical care management, management of associated complications after TBI, pharmacotherapy, pain management, sports concussion, assistive technologies, and preparing patients for community reintegration. Discusses special populations, including pediatric, geriatric, and military and veteran patients. Consolidates today’s available information and guidance in this challenging and diverse area into one convenient resource.

Textbook of Traumatic Brain Injury

Textbook of Traumatic Brain Injury Book
Author : Jonathan M. Silver,Thomas W. McAllister,David B. Arciniegas
Publisher : American Psychiatric Pub
Release : 2018-12-13
ISBN : 1615372474
Language : En, Es, Fr & De

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Book Description :

Despite the increased public awareness of traumatic brain injury (TBI), the complexities of the neuropsychiatric, neuropsychological, neurological, and other physical consequences of TBI of all severities across the lifespan remain incompletely understood by patients, their families, healthcare providers, and the media. Keeping pace with advances in the diagnosis, treatment, and science of TBI, the Textbook of Traumatic Brain Injury, Third Edition, comprehensively fills this gap in knowledge. Nearly all 50 chapters feature new authors, all of them experts in their field. Chapters new to this edition include biomechanical forces, biomarkers, neurodegenerative dementias, suicide, endocrine disorders, chronic disease management, and social cognition. An entirely new section is devoted to the evaluation and treatment of mild TBI, including injuries in athletes, military service members and veterans, and children and adolescents. These chapters join newly updated sections on the assessment and treatment of the cognitive, emotional, behavioral, and other physical sequelae of TBI. The Textbook of Traumatic Brain Injury is a must-read for all of those working in any of the multitude of disciplines that contribute to the care and rehabilitation of persons with brain injury. This new volume is also a potentially useful reference for policymakers in both the public and private sectors.

Reducing the Societal Costs of Traumatic Brain Injury

Reducing the Societal Costs of Traumatic Brain Injury Book
Author : Woo Hyeun Kang
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

We also developed tolerance criteria relating mechanical injury parameters to electrophysiological function, an important step in developing more accurate computational simulations of TBI. Equipping FE models with new information on the functional response of the living brain will enhance their biofidelity, potentially leading to improved safety systems while reducing development costs. Finally, we utilized a novel in vitro TBI research platform, the SMEA, to investigate the effects of TBI on long-lasting network synchronization in the hippocampus. Compared to more labor intensive in vivo approaches, the ability of the SMEA to efficiently test TBI hypotheses within a single organotypic slice culture over extended durations could increase the speed of drug discovery through high-content screening. This multi-pronged approach is necessary to address the growing public health concern of TBI.