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New Combination Approaches To Enhance Rituximab Based Lymphoma Therapies

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New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies

New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies Book
Author : Anonim
Publisher : Academic Press
Release : 2020-07-15
ISBN : 9780128164075
Language : En, Es, Fr & De

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Book Description :

New Combination Approaches to Enhance Rituximab-based Lymphoma Therapies provides general updated information on the resistance of various human lymphoma/leukemia subtypes to anti-CD20 therapeutic antibodies. It discusses also the description of various targeted sensitizing agents that can reverse innate or acquired resistance when used in combination with various FDA-approved anti-CD20 antibodies. There have been a lot of reports in which the treatment with anti-CD20 antibodies for various lymphomas/leukemias has resulted in significant clinical responses; however, there have been also subsets of cancer patients who did not respond initially and several of the responding patients developed resistance to subsequent treatments with the same or different regimens. Therefore, the use of various immunosensitizing agents targeting resistant factors to reverse resistance has been considered and this book discusses each of them in depth, such as Bortexomib, Immunomodulation Agents, Obinutuzumab, Tumor Suppressors, and HDAC Inhibitors. This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of biomedical field interested in fighting cancer resistance to anti-CD20 antibodies. Provides a general overview of various sensitizing agents that can work effectively when used in combination with anti-CD20 antibodies to reverse resistance Offers potential underlying mechanisms by which the cancer cells are either inherently resistant or become unresponsive to further antibody treatments Discusses how to develop new targeted agents to underlie resistance in order to expand research on this field

Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Living with Lymphoma

Living with Lymphoma Book
Author : Elizabeth M. Adler
Publisher : JHU Press
Release : 2005-09-30
ISBN : 0801881803
Language : En, Es, Fr & De

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Book Description :

When neurobiologist Elizabeth M. Adler was diagnosed with non-Hodgkin's lymphoma, she learned everything she could about the disease. In "Living with Lymphoma," she combines her knowledge of lymphoma--both scientific and personal--with the desire to help other patients come to grips with this complex, and often baffling, disease. Readers gain sufficient background to understand and evaluate medical literature, and to ask their physicians questions specific to their own needs.

Perry s The Chemotherapy Source Book

Perry s The Chemotherapy Source Book Book
Author : Michael C. Perry,Donald C. Doll,Carl E. Freter
Publisher : Lippincott Williams & Wilkins
Release : 2012-07-30
ISBN : 1469803437
Language : En, Es, Fr & De

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Book Description :

Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.

Yonsei Medical Journal

Yonsei Medical Journal Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Combinatorial Approaches to Enhance Anti Tumor Immunity Focus on Immune Checkpoint Blockade Therapy

Combinatorial Approaches to Enhance Anti Tumor Immunity  Focus on Immune Checkpoint Blockade Therapy Book
Author : Patrik Andersson,Christian Ostheimer
Publisher : Frontiers Media SA
Release : 2019-12-27
ISBN : 2889631613
Language : En, Es, Fr & De

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Book Description :

The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2009-12
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Immunogenic Cell Death in Cancer From Benchside Research to Bedside Reality

Immunogenic Cell Death in Cancer  From Benchside Research to Bedside Reality Book
Author : Abhishek D Garg,Patrizia Agostinis
Publisher : Frontiers Media SA
Release : 2016-04-29
ISBN : 2889198383
Language : En, Es, Fr & De

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Book Description :

Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated ‘danger signaling’ remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and ‘danger signaling’ has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of “immunogenic cell death” (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.

Reversal of Drug Resistance in Non Hodgkin s Lymphoma by Immunotherapy

Reversal of Drug Resistance in Non Hodgkin s Lymphoma by Immunotherapy Book
Author : Steve Anthony Alas
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Reversal of Drug Resistance in Non Hodgkin s Lymphoma by Immunotherapy book written by Steve Anthony Alas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Biotherapy

Cancer Biotherapy Book
Author : Annie Young,Lewis Rowett,David Kerr
Publisher : Oxford University Press
Release : 2006-05-04
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Recent advances in biology and immunology have opened up new horizons in both our understanding of cancer as a disease, and the potential for cancer therapy. These major developments mean that chemotherapy, radiotherapy and surgery are no longer the only options. Biotherapy, or biological therapy, is now regarded as the fourth treatment modality for patients with cancer. It utilises the great increase in our knowledge of molecular biology, cell biology and immunology to achieve tumour control. New biological agents are currently being used to treat cancer, such as monoclonal antibodies and vaccine therapies to stimulate the body's immune system to attack cancer cells. Biotherapy may be targeted to act specifically on cancer cells. Drugs such as monoclonal antibodies can be designed to recognize and find a particular type of cancer cell, attach itself to them, and destroy them. Naturally occuring biological molecules such as cytokines are also used, and the manipulation of normal biological mechanisms to control or inhibit tumour growth is another key feature of biotherapy. Edited by a team with perspectives in pharmacology, oncology and nursing, and with contributions from experts in the various areas of biotherapy, this book serves as an introduction to the subject. It includes the principles behind biological therapy, with discussion of the impact on the future of the fight against cancer. It has a strong clinical focus, describing the relevant biology and immunology while highlighting clinical relevance and treatment issues.

The Journal of Immunology

The Journal of Immunology Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Immunology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual Meeting Proceedings

Annual Meeting Proceedings Book
Author : American Society of Clinical Oncology. Meeting
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Meeting Proceedings book written by American Society of Clinical Oncology. Meeting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nursing Times Nursing Mirror

Nursing Times  Nursing Mirror Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Nursing Times Nursing Mirror book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual Report

Annual Report Book
Author : Ohio State University. Comprehensive Cancer Center. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annual Report book written by Ohio State University. Comprehensive Cancer Center. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Basic and Clinical Pharmacology 12 E

Basic and Clinical Pharmacology 12 E Book
Author : Bertram G. Katzung,Susan Masters,Anthony Trevor
Publisher : McGraw Hill Professional
Release : 2012-01-03
ISBN : 0071764011
Language : En, Es, Fr & De

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Book Description :

Looks at the essential conepts in the science of pharmacology and its application to clinical practice.

Investigative Ophthalmology Visual Science

Investigative Ophthalmology   Visual Science Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Investigative Ophthalmology Visual Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Basic and Clinical Pharmacology 11th Edition

Basic and Clinical Pharmacology  11th Edition Book
Author : Bertram G. Katzung,Susan B. Masters,Anthony J. Trevor
Publisher : McGraw Hill Professional
Release : 2009-08-12
ISBN : 0071604065
Language : En, Es, Fr & De

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Book Description :

The most trusted and up-to-date pharmacology text in medicine -- completely redesigned to make the learning process even more interesting and efficient 5 Star Doody's Review! "This is the most widely used textbook for teaching pharmacology to health professionals. This 11th edition is far superior to any previous editions....The authors' goals are to provide a complete, authoritative, current, and readable textbook of pharmacology for students in health sciences. Testimony to their success is the widespread use of this work as required textbook for pharmacology courses around the world. This book is used extensively by thousands of medical, pharmacy, podiatry, nursing, and other health professions students to study pharmacology. Likewise, it remains a valuable resource for residents and practicing physicians....I continue to use this book as a required resource for all courses that I teach to medical, nursing, and allied health students. It is authoritative, readable, and supported by numerous learning tools."--Doody's Review Service Organized to reflect the syllabi in Pharmacology courses, Basic & Clinical Pharmacology covers all the important concepts students need to know about the science of pharmacology and its application to clinical practice. It is acknowledged worldwide as the field’s most current, authoritative, and comprehensive textbook. To be as clinically relevant as possible, the book features a strong focus on the choice and use of drugs in patients and the monitoring of their effects. Coverage that spans every important aspect of medical pharmacology: Basic Principles Autonomic Drugs Cardiovascular-Renal Drugs Drugs with Important Actions on Smooth Muscle Drugs that Act in the Central Nervous System Drugs Used to Treat Diseases of the Blood, Inflammation, and Gout Endocrine Drugs Chemotherapeutic Drugs Toxicology NEW to this edition: Full-color presentation, including 300+ illustrations Case studies introduce clinical problems in many chapters Drug summary tables for key information in comparative context Descriptions of important newly released drugs, including new immunopharmacologic agents Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters

Current Medical Diagnosis and Treatment 2000

Current Medical Diagnosis and Treatment 2000 Book
Author : Lawrence M. Tierney,Tierney,Papadakis,Stephen J McPhee, M D
Publisher : McGraw-Hill Companies
Release : 1999-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Exciting new print and electronic products. A new vision. And through-the-roof sales potential. That's what McGraw-Hill's acquisition of Appleton & Lange is all about. Since 1852, Appleton & Lange has been a major force in medical publishing. From the Lange Series of basic medical texts to the solutions-based Current Series, its popular medical references are more in demand than ever. And now, this long and vital tradition will become part of McGraw-Hill's own publishing legacy. For you, it all adds up to a winning -- and profitable -- combination. -- The leading annually updated general medical text -- the most comprehensive, reliable, and timely reference available -- Answers common questions in everyday clinical practice -- Covers all aspects of outpatient and inpatient care, including gynecology, obstetrics, urology, dermatology, psychiatry, neurology, otolaryngology, ophthalmology, and nutrition