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New Combination Approaches To Enhance Rituximab Based Lymphoma Therapies

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New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies

New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies Book
Author : N.A
Publisher : Academic Press
Release : 2020-11-01
ISBN : 0128167378
Language : En, Es, Fr & De

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Book Description :

New Combination Approaches to Enhance Rituximab-Based Lymphoma Therapies provides general updated information on the resistance of various human lymphoma/leukemia subtypes to anti-CD20 therapeutic antibodies. It discusses also the description of various targeted sensitizing agents that can reverse innate or acquired resistance when used in combination with various FDA-approved anti-CD20 antibodies. There have been a lot of reports in which the treatment with anti-CD20 antibodies for various lymphomas/leukemias has resulted in significant clinical responses; however, there have been also subsets of cancer patients who did not respond initially and several of the responding patients developed resistance to subsequent treatments with the same or different regimens. Therefore, the use of various immunosensitizing agents targeting resistant factors to reverse resistance has been considered and this book discusses each of them in depth, such as Bortexomib, Immunomodulation Agents, Obinutuzumab, Tumor Suppressors, and HDAC Inhibitors. This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of biomedical field interested in fighting cancer resistance to anti-CD20 antibodies. Provides a general overview of various sensitizing agents that can work effectively when used in combination with anti-CD20 antibodies to reverse resistance Offers potential underlying mechanisms by which the cancer cells are either inherently resistant or become unresponsive to further antibody treatments Discusses how to develop new targeted agents to underlie resistance in order to expand research on this field

Resistance to Targeted Therapies in Lymphomas

Resistance to Targeted Therapies in Lymphomas Book
Author : Ana C. Xavier,Mitchell S. Cairo
Publisher : Springer Nature
Release : 2019-09-13
ISBN : 3030244245
Language : En, Es, Fr & De

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Book Description :

Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.

Perry s The Chemotherapy Source Book

Perry s The Chemotherapy Source Book Book
Author : Michael C. Perry,Donald C. Doll,Carl E. Freter
Publisher : Lippincott Williams & Wilkins
Release : 2012-07-30
ISBN : 1469803437
Language : En, Es, Fr & De

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Book Description :

Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.

Non Hodgkin Lymphoma

Non Hodgkin Lymphoma Book
Author : Andrew M. Evens,Kristie A. Blum
Publisher : Springer
Release : 2015-02-06
ISBN : 3319131508
Language : En, Es, Fr & De

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Book Description :

This book provides clinical practitioners and the research community with detailed information on the diagnosis, prognosis, and treatment of non-Hodgkin lymphoma, taking into account the significant growth in knowledge including multiple therapeutic advances that have been achieved over the past 5-10 years. The work is subdivided into epidemiology, pathogenesis, pathology, imaging, and therapy of the non-Hodgkin lymphomas. The full range of therapeutic options are examined according to the major subtypes of non-Hodgkin lymphoma and the most up-to-date information is provided on current standard treatment options, including stem cell transplantation as well as new cutting-edge therapeutics.

Immunogenic Cell Death in Cancer From Benchside Research to Bedside Reality

Immunogenic Cell Death in Cancer  From Benchside Research to Bedside Reality Book
Author : Abhishek D Garg,Patrizia Agostinis
Publisher : Frontiers Media SA
Release : 2016-04-29
ISBN : 2889198383
Language : En, Es, Fr & De

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Book Description :

Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated ‘danger signaling’ remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and ‘danger signaling’ has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of “immunogenic cell death” (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.

Lymphoma Pathology Diagnosis and Treatment

Lymphoma  Pathology  Diagnosis and Treatment Book
Author : Robert Marcus,John W. Sweetenham,Michael E. Williams
Publisher : Cambridge University Press
Release : 2007-06-21
ISBN : 9780521865449
Language : En, Es, Fr & De

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Book Description :

Places the major advances which have occurred in the area of lymphoma into the context of daily clinical practice.

Clinical Radiation Oncology E Book

Clinical Radiation Oncology E Book Book
Author : Leonard L. Gunderson,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release : 2011-09-16
ISBN : 1455726036
Language : En, Es, Fr & De

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Book Description :

With thorough updates throughout, Clinical Radiation Oncology provides the most comprehensive, authoritative, and up-to-date information available for treating patients with cancer. From a multidisciplinary perspective, this new edition, edited by Drs. Leonard L. Gunderson and Joel E. Tepper, examines the therapeutic management of specific disease sites based on both single-modality and combined-modality approaches - providing you with the well-rounded, cutting-edge guidance you need to offer the most effective treatments. A consistent chapter format, full-color design, and access to the full text at www.expertconsult.com make reference fast and easy. It is an ideal resource for mastering the latest, most effective techniques and modalities! Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors –many of whom are new to this edition – affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at www.expertconsult.com, along with references, additional images and tables, video clips and more! Stay current with comprehensive updates throughout that include a new chapter on survivorship issues, and additional video clips on treatments such as prostate and penile cancer brachytherapy. Improve outcomes by providing the most effective treatment for each patient with expanded coverage of new modalities and treatment regimens. Understand and comply with the latest staging guidelines.

Clinical Radiation Oncology

Clinical Radiation Oncology Book
Author : Leonard L. Gunderson,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release : 2007
ISBN : 0443068402
Language : En, Es, Fr & De

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Book Description :

First Prize winner, Oncology Book Category, British Medical Association 2012 Medical Book Competition Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors -many of whom are new to this edition - affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at www.expertconsult.com, along with references, additional images and tables, video clips and more! Stay current with comprehensive updates throughout that include a new chapter on survivorship issues, and additional video clips on treatments such as prostate and penile cancer brachytherapy. Improve outcomes by providing the most effective treatment for each patient with expanded coverage of new modalities and treatment regimens. Understand and comply with the latest staging guidelines. Drs. Gunderson and Tepper give you quick access to all the clinical tools you need to master the newest techniques and modalities in radiation oncology.

Pediatric Lymphomas

Pediatric Lymphomas Book
Author : Howard J. Weinstein,Melissa M. Hudson,Michael P. Link
Publisher : Springer Science & Business Media
Release : 2007-01-20
ISBN : 354068753X
Language : En, Es, Fr & De

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Book Description :

This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology.

Rheumatoid Arthritis E Book

Rheumatoid Arthritis E Book Book
Author : Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman
Publisher : Elsevier Health Sciences
Release : 2008-11-07
ISBN : 0323071023
Language : En, Es, Fr & De

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Book Description :

First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state-of-the-art reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It’s the guidance you need to offer optimal care to your patients with rheumatoid arthritis. Presents the work of leading international experts in rheumatoid arthritis for guidance you can trust. Provides the very latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures—disease activity, joint assessment, imaging, and more—for expert diagnosis and monitoring of disease progression. Examines evidence-based treatment options—including traditional and biologic DMARDs and combination therapies—as well as promising therapies on the horizon, placing up-to-date guidance on disease modifying or disease controlling agents at your fingertips.

Cancer Research

Cancer Research Book
Author : N.A
Publisher :
Release : 2009-12
ISBN :
Language : En, Es, Fr & De

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Book Description :

Oncologic Imaging A Multidisciplinary Approach E Book

Oncologic Imaging  A Multidisciplinary Approach E Book Book
Author : Paul Silverman
Publisher : Elsevier Health Sciences
Release : 2012-04-27
ISBN : 1455733334
Language : En, Es, Fr & De

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Book Description :

Here’s the multidisciplinary guidance you need for optimal imaging of malignancies. Radiologists, surgeons, medical oncologists, and radiation oncologists offer state-of-the-art guidelines for diagnosis, staging, and surveillance, equipping all members of the cancer team to make the best possible use of today’s noninvasive diagnostic tools. Consult with the best. Dr. Paul M. Silverman and more than 100 other experts from MD Anderson Cancer Center provide you with today's most dependable answers on every aspect of the diagnosis, treatment, and management of the cancer patient. Recognize the characteristic presentation of each cancer via current imaging modalities and understand the clinical implications of your findings. Effectively use traditional imaging modalities such as Multidetector CT (MDCT), PET/CT, and MR in conjunction with the latest advances in molecular oncology and targeted therapies. Find information quickly and easily thanks to a consistent, highly templated format complete with "Key Point" summaries, algorithms, drawings, and full-color staging diagrams. Make confident decisions with guidance from comprehensive algorithms for better staging and imaging evaluation. Access the fully searchable text online, along with high-quality downloadable images for use in teaching and lecturing and online-only algorithms, at expertconsult.com.

Basic and Clinical Pharmacology 12 E

Basic and Clinical Pharmacology 12 E Book
Author : Bertram G. Katzung,Susan Masters,Anthony Trevor
Publisher : McGraw Hill Professional
Release : 2012-01-03
ISBN : 0071764011
Language : En, Es, Fr & De

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Book Description :

Looks at the essential conepts in the science of pharmacology and its application to clinical practice.

Basic and Clinical Pharmacology 11th Edition

Basic and Clinical Pharmacology  11th Edition Book
Author : Bertram G. Katzung,Susan B. Masters,Anthony J. Trevor
Publisher : McGraw Hill Professional
Release : 2009-08-12
ISBN : 0071604065
Language : En, Es, Fr & De

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Book Description :

The most trusted and up-to-date pharmacology text in medicine -- completely redesigned to make the learning process even more interesting and efficient 5 Star Doody's Review! "This is the most widely used textbook for teaching pharmacology to health professionals. This 11th edition is far superior to any previous editions....The authors' goals are to provide a complete, authoritative, current, and readable textbook of pharmacology for students in health sciences. Testimony to their success is the widespread use of this work as required textbook for pharmacology courses around the world. This book is used extensively by thousands of medical, pharmacy, podiatry, nursing, and other health professions students to study pharmacology. Likewise, it remains a valuable resource for residents and practicing physicians....I continue to use this book as a required resource for all courses that I teach to medical, nursing, and allied health students. It is authoritative, readable, and supported by numerous learning tools."--Doody's Review Service Organized to reflect the syllabi in Pharmacology courses, Basic & Clinical Pharmacology covers all the important concepts students need to know about the science of pharmacology and its application to clinical practice. It is acknowledged worldwide as the field’s most current, authoritative, and comprehensive textbook. To be as clinically relevant as possible, the book features a strong focus on the choice and use of drugs in patients and the monitoring of their effects. Coverage that spans every important aspect of medical pharmacology: Basic Principles Autonomic Drugs Cardiovascular-Renal Drugs Drugs with Important Actions on Smooth Muscle Drugs that Act in the Central Nervous System Drugs Used to Treat Diseases of the Blood, Inflammation, and Gout Endocrine Drugs Chemotherapeutic Drugs Toxicology NEW to this edition: Full-color presentation, including 300+ illustrations Case studies introduce clinical problems in many chapters Drug summary tables for key information in comparative context Descriptions of important newly released drugs, including new immunopharmacologic agents Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters

Pharmacology for Rehabilitation Professionals E Book

Pharmacology for Rehabilitation Professionals   E Book Book
Author : Barbara Gladson
Publisher : Elsevier Health Sciences
Release : 2010-09-15
ISBN : 1437707564
Language : En, Es, Fr & De

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Book Description :

Now fully revised and updated, Dr. Barbara Gladson's Pharmacology for Rehabilitation Professionals, 2nd Edition, remains your best resource for understanding how various drugs affect patients during therapeutic exercise and rehabilitation. Using case studies and engaging activities, it helps you apply essential pharmacology information directly to rehabilitation practice. New chapters, a new reader-friendly design, new artwork, and more enhance the text and bring you up to date with both basic pharmacologic principles as well as the mechanism of action and side effects of drugs commonly seen in rehabilitation practice. Helps you develop effective exercise programs by providing drug/exercise interactions from a pharmacokinetics perspective. You willl clearly see the implications for exercise for each specific condition and medication. Presents case studies in every chapter that demonstrate the effects of various drugs on the diagnosis, prognosis, and interventions in physical therapy, so you can more easily monitor patients for adverse drug effects. Features engaging activities in every chapter, ranging from patient interviews to challenging, real-life questions, helping you retain and apply what you've learned. Encourages you to use the latest research in your clinical decision making with evidence-based content incorporated throughout. Simplifies the complex topic of pharmacokinetics so that you will fully understand how it affects your individual patients and your care plans. Guides you in using the Internet for online drug information with references to specific sites, and when and how to use them to their fullest potential. Discusses lifespan considerations such as age, physical differences, and obesity, as well as the latest information on diabetes and glucose testing. A new chapter on Complementary and Alternative Medicine in Pharmacology covers popular herbal and alternative products used to promote health, as well as herbal remedies used during menopause and in the treatment of cancer, helping you recognize the impact of herbals on your patients' symptoms and response to therapy. A new chapter on Drugs Affecting the Integumentary System discusses skin disorders and their pharmacological treatment, prophylactic and debriding agents, antiseptics, and more. A new chapter on Nutrition and Pharmacology provides current information on vitamins and minerals, enteral and parenteral nutrition, and food and drug interactions -- important topics that affect rehabilitation outcomes. Updated drug information and new drugs are added throughout the text, keeping you up to date with current pharmacological information as it pertains to rehabilitation.