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New Approaches to Drug Discovery

New Approaches to Drug Discovery Book
Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
Publisher : Springer
Release : 2018-04-25
ISBN : 9783319804552
Language : En, Es, Fr & De

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Book Description :

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery Book
Author : Bhushan Patwardhan,Rathnam Chaguturu
Publisher : Academic Press
Release : 2016-10-03
ISBN : 0128018224
Language : En, Es, Fr & De

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Book Description :

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

New Approaches to Drug Discovery and Design

New Approaches to Drug Discovery and Design Book
Author : Edward J. Glamkowski
Publisher : Unknown
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Approaches to Drug Discovery and Design book written by Edward J. Glamkowski, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

New Approaches to Natural Anticancer Drugs

New Approaches to Natural Anticancer Drugs Book
Author : Soodabeh Saeidnia
Publisher : Springer
Release : 2015-02-05
ISBN : 3319140272
Language : En, Es, Fr & De

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Book Description :

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery Book
Author : Alexander Hillisch,Rolf Hilgenfeld
Publisher : Birkhäuser
Release : 2012-11-28
ISBN : 3034879970
Language : En, Es, Fr & De

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Book Description :

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

New Approaches to Drug Development

New Approaches to Drug Development Book
Author : Pierre Jollès
Publisher : Unknown
Release : 1989
ISBN : 9780817661298
Language : En, Es, Fr & De

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Book Description :

Download New Approaches to Drug Development book written by Pierre Jollès, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pain

Pain Book
Author : Chas Bountra,Rajesh Munglani,William K. Schmidt
Publisher : CRC Press
Release : 2003-05-13
ISBN : 9780203911259
Language : En, Es, Fr & De

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Book Description :

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery Book
Author : Zoran Rankovic,Richard Morphy
Publisher : John Wiley & Sons
Release : 2010-04-07
ISBN : 9780470584163
Language : En, Es, Fr & De

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Book Description :

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

Dopaminergic Disorders

Dopaminergic Disorders Book
Author : Lynn M. Savage,International Business Communications
Publisher : Unknown
Release : 1998
ISBN : 9781579360719
Language : En, Es, Fr & De

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Book Description :

Download Dopaminergic Disorders book written by Lynn M. Savage,International Business Communications, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hypertension and the Cardiovascular System

Hypertension and the Cardiovascular System Book
Author : Jan M. Kitzen
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hypertension and the Cardiovascular System book written by Jan M. Kitzen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Attrition in the Pharmaceutical Industry

Attrition in the Pharmaceutical Industry Book
Author : Alex,Alexander Alex,C. John Harris,Dennis A. Smith
Publisher : John Wiley & Sons
Release : 2015-12-29
ISBN : 1118679679
Language : En, Es, Fr & De

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Book Description :

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency. Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attrition Tackles a problem that adds billions of dollars to drug development programs and health care costs Guides discovery and development scientists through R&D stages, teaching requirements and reasons why drugs can fail Discusses potential ways forward utilizing new approaches and opportunities to reduce attrition

Pain

Pain Book
Author : Chas Bountra,Rajesh Munglani,William K. Schmidt
Publisher : CRC Press
Release : 2003-05-13
ISBN : 9780824788650
Language : En, Es, Fr & De

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Book Description :

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

New Approaches in Cancer Pharmacology Drug Design and Development

New Approaches in Cancer Pharmacology  Drug Design and Development Book
Author : Paul Workman
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642778747
Language : En, Es, Fr & De

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Book Description :

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.

New Approaches Against Drug Resistant M tuberculosis

New Approaches Against Drug Resistant M  tuberculosis Book
Author : Maria Rosalia Pasca,Yossef Av-Gay,Giorgia Mori
Publisher : Frontiers Media SA
Release : 2021-06-09
ISBN : 288966869X
Language : En, Es, Fr & De

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Book Description :

Download New Approaches Against Drug Resistant M tuberculosis book written by Maria Rosalia Pasca,Yossef Av-Gay,Giorgia Mori, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Innovative Approaches in Drug Research

Innovative Approaches in Drug Research Book
Author : A. F. Harms
Publisher : Elsevier Publishing Company
Release : 1986
ISBN : 9780444426062
Language : En, Es, Fr & De

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Book Description :

Download Innovative Approaches in Drug Research book written by A. F. Harms, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Therapeutic Targets

Therapeutic Targets Book
Author : Luis M. Botana,Mabel Loza
Publisher : John Wiley & Sons
Release : 2012-04-20
ISBN : 1118185528
Language : En, Es, Fr & De

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Book Description :

The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.

New Approaches in Cancer Pharmacology Drug Design and Development

New Approaches in Cancer Pharmacology  Drug Design and Development Book
Author : Paul Workman
Publisher : Springer
Release : 2011-12-13
ISBN : 9783642790904
Language : En, Es, Fr & De

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Book Description :

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.

Fragment based Approaches in Drug Discovery

Fragment based Approaches in Drug Discovery Book
Author : Wolfgang Jahnke,Daniel A. Erlanson
Publisher : John Wiley & Sons
Release : 2006-12-13
ISBN : 3527608605
Language : En, Es, Fr & De

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Book Description :

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Antiepileptic Drug Discovery Novel Approaches

Antiepileptic Drug Discovery  Novel Approaches Book
Author : Alan Talevi,Luisa Rocha
Publisher : Methods in Pharmacology and To
Release : 2018-10-08
ISBN : 9781493981748
Language : En, Es, Fr & De

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Book Description :

Download Antiepileptic Drug Discovery Novel Approaches book written by Alan Talevi,Luisa Rocha, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Rational Drug Design

Rational Drug Design Book
Author : Thomas Mavromoustakos,Tahsin F. Kellici
Publisher : Humana
Release : 2018-07-24
ISBN : 9781493986293
Language : En, Es, Fr & De

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Book Description :

This volume covers several aspects of rational drug design, such as synthesis of novel bioactive drugs; development and application of new methodologies; computational methods valuable for the establishment of new approaches in drug discovery; and the effects of physical-chemical and ADMET properties of the designed potential drugs. Chapters guide readers through amyloid deposits, Saturation Transfer Difference (STD) NMR, methods on bioguided design, the importance of lipophilicity in drug design, ADMET, FRET, structural biology, and homology modeling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Rational Drug Design: Methods and Protocols aims to ensure successful results in the further study of this vital field.