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Neurotherapeutics In The Era Of Translational Medicine

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NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE

NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE  Book
Author : RICHARD A. SMITH
Publisher : Elsevier
Release : 2021
ISBN : 0323907261
Language : En, Es, Fr & De

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Book Description :

Download NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE book written by RICHARD A. SMITH, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery and Development Third Edition

Drug Discovery and Development  Third Edition Book
Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
Publisher : CRC Press
Release : 2019-12-13
ISBN : 1351625136
Language : En, Es, Fr & De

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Book Description :

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Regenerative Pharmacology

Regenerative Pharmacology Book
Author : George J. Christ,Karl-Erik Andersson
Publisher : Cambridge University Press
Release : 2013-04-15
ISBN : 1107354730
Language : En, Es, Fr & De

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Book Description :

Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Sharing Clinical Trial Data

Sharing Clinical Trial Data Book
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Responsible Sharing of Clinical Trial Data
Publisher : National Academies Press
Release : 2015-04-20
ISBN : 0309316324
Language : En, Es, Fr & De

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Book Description :

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research--from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development Book
Author : George G. Nomikos,Douglas E. Feltner
Publisher : Academic Press
Release : 2019-06-18
ISBN : 0128031646
Language : En, Es, Fr & De

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Book Description :

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Drug Discovery and Development

Drug Discovery and Development Book
Author : Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi
Publisher : BoD – Books on Demand
Release : 2020-03-11
ISBN : 1789239753
Language : En, Es, Fr & De

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Book Description :

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

Autoimmune Neurology

Autoimmune Neurology Book
Author : Anonim
Publisher : Elsevier
Release : 2016-03-11
ISBN : 0444634460
Language : En, Es, Fr & De

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Book Description :

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Drug Repurposing

Drug Repurposing Book
Author : Farid A. Badria
Publisher : BoD – Books on Demand
Release : 2020-12-02
ISBN : 1839685204
Language : En, Es, Fr & De

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Book Description :

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

APA Handbook of Psychopharmacology

APA Handbook of Psychopharmacology Book
Author : Suzette M. Evans,Kenneth M. Carpenter
Publisher : APA Handbooks in Psychology(r)
Release : 2019
ISBN : 9781433830754
Language : En, Es, Fr & De

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Book Description :

The APA Handbook of Psychopharmacology provides working knowledge of basic pharmacology and psychopharmacology, examines psychopharmacology for treatment of various emotional and behavioral conditions, and discusses related professional and social issues.

Translational Neuroscience

Translational Neuroscience Book
Author : James E. Barrett,Joseph T. Coyle,Michael Williams
Publisher : Cambridge University Press
Release : 2012-06-28
ISBN : 0521519764
Language : En, Es, Fr & De

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Book Description :

A comprehensive and authoritative analysis of translational neuroscience, covering all major areas of psychiatry, neurology and neurodevelopmental disorders.

Leucine Rich Repeat Kinase 2 LRRK2

Leucine Rich Repeat Kinase 2  LRRK2  Book
Author : Hardy J. Rideout
Publisher : Springer
Release : 2017-03-28
ISBN : 3319499696
Language : En, Es, Fr & De

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Book Description :

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Seizures and Epilepsy

Seizures and Epilepsy Book
Author : Jerome Engel Jr
Publisher : Oxford University Press
Release : 2013-01-31
ISBN : 019532854X
Language : En, Es, Fr & De

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Book Description :

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Rethinking the Clinical Gaze

Rethinking the Clinical Gaze Book
Author : John Gardner
Publisher : Springer
Release : 2017-05-31
ISBN : 3319532707
Language : En, Es, Fr & De

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Book Description :

This book draws on medical sociology and science and technology studies to develop a novel conceptual framework for understanding innovation processes, using the case study of deep brain stimulation in paediatric neurology. It addresses key questions, including: How are promising and potentially disruptive new health technologies integrated into busy resource-constrained clinical contexts? What activities are involved in establishing a new clinical service? How do social and cultural forces shape these services, and importantly, how are understandings of ‘health’ and ‘illness’ reconfigured in the process? The book explores how the ideals of patient-centred medicine influence innovation in the clinic, and it introduces the concept of patient-centred proto-platforms. It argues that patient-centred innovation can constitute an expansion of medical power, as the clinical gaze is directed not only towards the body but also towards the patient as a social being. This will be an innovative and insightful read for academics and advanced students, as well as health service researchers with an interest in technology adoption processes.

Opioids and Their Receptors

Opioids and Their Receptors Book
Author : Mariana Spetea,Helmut Schmidhammer
Publisher : MDPI
Release : 2020-12-18
ISBN : 3036500464
Language : En, Es, Fr & De

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Book Description :

The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Brain Neurotrauma

Brain Neurotrauma Book
Author : Firas H. Kobeissy
Publisher : CRC Press
Release : 2015-02-25
ISBN : 1466565993
Language : En, Es, Fr & De

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Book Description :

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Neuropsychiatric Assessment

Neuropsychiatric Assessment Book
Author : Stuart C. Yudofsky,H. Florence Kim
Publisher : American Psychiatric Pub
Release : 2008-05-20
ISBN : 1585627313
Language : En, Es, Fr & De

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Book Description :

What is neuropsychiatry? This remarkable volume answers that question -- and more. Neuropsychiatry, which focuses on assessment and diagnostic issues at the interface of psychiatry and neurology, is enjoying a renaissance, largely because of the technological innovations detailed in these five chapters. Here, 11 recognized experts have assembled an overview of the essential techniques, current research, and future trends in neuropsychiatric assessment, focusing on clinical applications for psychiatry patients. This eminently practical work begins with the cornerstone of any neuropsychiatric assessment, the physical examination and the medical and psychiatric history. Included here is a head-to-toe compendium of important signs and symptoms to elicit, along with the differential diagnoses of neuropsychiatric disorders to consider when faced with a particular constellation of signs and symptoms. Subsequent chapters discuss The critical importance of the neuropsychological examination, traditionally administered by neuropsychologists and thus often overlooked by psychiatrists in routine workups of their patients. Topics addressed include the clinical approach to the interview process, fixed- and flexible-battery approaches to assessment, interpretation pitfalls, and future trends. The authors illustrate how this essential tool can reveal the major cognitive domains that may be involved in neuropsychiatric disorders and show how specific patterns of deficits in certain domains may help determine a neuropsychiatric diagnosis. The relevance of electrophysiological testing, an underused but invaluable resource, to neuropsychiatric disorders. The authors discuss standard, topographic, and quantitative electroencephalography; cerebral evoked potentials, and polysomnography, providing recommendations for the application of these tools in certain clinical situations (e.g., cognitive decline, rapid-cycling bipolar disorder) and projections for broader uses of electrophysiological testing in the future. The key importance of laboratory testing, especially in view of the complex array of neurological and medical illnesses that may underlie the symptoms of neuropsychiatric patients. The lack of consensus guidelines for the use of conventional laboratory testing, chest X rays, and electrocardiograms in screening patients with neuropsychiatric symptoms continues to constrain our ability to help these patients. The potential of today's increasingly sophisticated neuroimaging approaches -- from structural and functional magnetic resonance imaging and magnetic resonance spectroscopy to diffusion tensor imaging and positron emission tomography -- to reveal the brain and its pathways with unprecedented clarity. The authors provide a fascinating overview of the techniques involved and the current research findings in schizophrenia, major affective disorder, and obsessive-compulsive disorder. Intended to bring us closer to our goals of early detection of, more specific treatments for, and, ultimately, prevention of psychiatric illness, this in-depth yet concise volume on the research and practice of neuropsychiatry will find a wide audience among students, residents, and clinicians.

Neuroprotective Therapy for Stroke and Ischemic Disease

Neuroprotective Therapy for Stroke and Ischemic Disease Book
Author : Paul A. Lapchak,John H. Zhang
Publisher : Springer
Release : 2017-01-12
ISBN : 3319453459
Language : En, Es, Fr & De

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Book Description :

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Emerging Cognitive Neuroscience and Related Technologies

Emerging Cognitive Neuroscience and Related Technologies Book
Author : National Research Council,Division on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Division on Engineering and Physical Sciences,Standing Committee for Technology Insight--Gauge, Evaluate, and Review,Committee on Military and Intelligence Methodology for Emergent Neurophysiological and Cognitive/Neural Science Research in the Next Two Decades
Publisher : National Academies Press
Release : 2008-12-06
ISBN : 0309118948
Language : En, Es, Fr & De

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Book Description :

Emerging Cognitive Neuroscience and Related Technologies, from the National Research Council, identifies and explores several specific research areas that have implications for U.S. national security, and should therefore be monitored consistently by the intelligence community. These areas include: neurophysiological advances in detecting and measuring indicators of psychological states and intentions of individuals the development of drugs or technologies that can alter human physical or cognitive abilities advances in real-time brain imaging breakthroughs in high-performance computing and neuronal modeling that could allow researchers to develop systems which mimic functions of the human brain, particularly the ability to organize disparate forms of data. As these fields continue to grow, it will be imperative that the intelligence community be able to identify scientific advances relevant to national security when they occur. To do so will require adequate funding, intelligence analysts with advanced training in science and technology, and increased collaboration with the scientific community, particularly academia. A key tool for the intelligence community, this book will also be a useful resource for the health industry, the military, and others with a vested interest in technologies such as brain imaging and cognitive or physical enhancers.

Paralysis Resource Guide

Paralysis Resource Guide Book
Author : Sam Maddox
Publisher : Unknown
Release : 2020
ISBN : 9780996095198
Language : En, Es, Fr & De

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Book Description :

Download Paralysis Resource Guide book written by Sam Maddox, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers in Psychiatry

Biomarkers in Psychiatry Book
Author : Judith Pratt,Jeremy Hall
Publisher : Springer
Release : 2019-01-05
ISBN : 3319996428
Language : En, Es, Fr & De

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Book Description :

This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.