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Neuroprotection In Alzheimers Disease

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Neuroprotection in Alzheimer s Disease

Neuroprotection in Alzheimer s Disease Book
Author : Illana Gozes
Publisher : Academic Press
Release : 2016-12-30
ISBN : 0128037121
Language : En, Es, Fr & De

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Book Description :

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Neuroprotection in Autism Schizophrenia and Alzheimer s disease

Neuroprotection in Autism  Schizophrenia and Alzheimer s disease Book
Author : Illana Gozes,Joseph Levine
Publisher : Academic Press
Release : 2019-10-16
ISBN : 0128140380
Language : En, Es, Fr & De

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Book Description :

Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer’s disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry

Molecular Aspects of Neurodegeneration and Neuroprotection

Molecular Aspects of Neurodegeneration and Neuroprotection Book
Author : Akhlaq A. Farooqui,Tahira Farooqui
Publisher : Bentham Science Publishers
Release : 2011-01-26
ISBN : 1608050920
Language : En, Es, Fr & De

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Book Description :

"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Neuroprotection

Neuroprotection Book
Author : Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publisher : BoD – Books on Demand
Release : 2020-11-26
ISBN : 1838804390
Language : En, Es, Fr & De

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Book Description :

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Molecular Mechanisms and Therapeutic Strategies in Alzheimer s Disease

Molecular Mechanisms and Therapeutic Strategies in Alzheimer s Disease Book
Author : Veer Gupta,Vivek Gupta
Publisher : LAP Lambert Academic Publishing
Release : 2012
ISBN : 9783844385847
Language : En, Es, Fr & De

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Book Description :

This book provides an insight into the mechanism on the role of amino acid stereospecificity based amyloid beta aggregation pattern; non-apoptotic amyloid beta peptide induced DNA nicking and neuro-neutraceutical property of garlic and curcumin derivatives. These findings provide a molecular understanding of the neurodegeneration and neuroprotection in Alzheimers Disease brain. Novel neuroprotective strategies to treat various neurodegenrative disorders are discussed.

The Handbook of Neuroprotection

The Handbook of Neuroprotection Book
Author : Kewal K. Jain
Publisher : Springer
Release : 2019-05-15
ISBN : 1493994654
Language : En, Es, Fr & De

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Book Description :

This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Immunomodulation of Glial Cells Towards Neuroprotection in Alzheimer s Disease

Immunomodulation of Glial Cells Towards Neuroprotection in Alzheimer s Disease Book
Author : Natalia Chermoshniuk
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Immunomodulation of Glial Cells Towards Neuroprotection in Alzheimer s Disease book written by Natalia Chermoshniuk, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2020-09-07
ISBN : 0128217014
Language : En, Es, Fr & De

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Book Description :

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection Book
Author : Akinori Akaike,Shun Shimohama,Yoshimi Misu
Publisher : Springer
Release : 2018-04-04
ISBN : 9811084882
Language : En, Es, Fr & De

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Book Description :

This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

Brain Hypoxia and Ischemia New Insights Into Neurodegeneration and Neuroprotection

Brain Hypoxia and Ischemia  New Insights Into Neurodegeneration and Neuroprotection Book
Author : Natalia N Nalivaeva,Elena A Rybnikova
Publisher : Frontiers Media SA
Release : 2019-11-15
ISBN : 2889631176
Language : En, Es, Fr & De

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Book Description :

Download Brain Hypoxia and Ischemia New Insights Into Neurodegeneration and Neuroprotection book written by Natalia N Nalivaeva,Elena A Rybnikova, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuroprotection Methods and Protocols

Neuroprotection Methods and Protocols Book
Author : Tiziana Borsello
Publisher : Springer Science & Business Media
Release : 2007-08-08
ISBN : 1588296660
Language : En, Es, Fr & De

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Book Description :

Neuroprotection is a topic of great importance in current neuroscience, both basic and clinical. The incidence of age-related neurodegenerative diseases could be expected to rise dramatically in the future owing to an aging population. Consequently, finding the means of retarding or preventing the progression of such diseases becomes increasingly important. This book focuses on basic perspective on neuroprotective approaches and scientists well recognized for their work have contributed chapters to this volume. Although findings on neuroprotection in the different pathologies become more and more frequent and detailed, it can be difficult for researchers to orient themselves in such a complicate field. For this reason, this book describes basic science discovery and the application of such research within different laboratories leading to the development of neuroprotective protocols. The main aim of this volume is thus to give an overview of methods used to study neuronal death and neuroprotection and to offer a really comprehensive step-by-step method in order to make clear not just the procedure but also the principles behind the use of it. At this purpose, the “Notes” section of each chapter represents a useful tool to solve technical problems and to help in reproducing the described methods.

Neuroprotection

Neuroprotection Book
Author : Raymond Chuen-Chung Chang,Yuen-Shan Ho
Publisher : BoD – Books on Demand
Release : 2019-08-28
ISBN : 1789847362
Language : En, Es, Fr & De

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Book Description :

Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.

Natural Products and Neuroprotection

Natural Products and Neuroprotection Book
Author : Cristina Angeloni,David Vauzour
Publisher : MDPI
Release : 2020-06-17
ISBN : 303936216X
Language : En, Es, Fr & De

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Book Description :

Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

Melatonin

Melatonin Book
Author : Venkatramanujan Srinivasan,Gabriella Gobbi,Samuel D. Shillcutt,Sibel Suzen
Publisher : CRC Press
Release : 2014-10-15
ISBN : 1482220091
Language : En, Es, Fr & De

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Book Description :

There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.

Neuroprotective Effects of Phytochemicals in Neurological Disorders

Neuroprotective Effects of Phytochemicals in Neurological Disorders Book
Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Release : 2017-02-02
ISBN : 1119155185
Language : En, Es, Fr & De

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Book Description :

Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Frontiers in Clinical Neuroscience

Frontiers in Clinical Neuroscience Book
Author : Laszlo Vecsei
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1441989692
Language : En, Es, Fr & De

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Book Description :

This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.

Glaucoma An Open Window to Neurodegeneration and Neuroprotection

Glaucoma  An Open Window to Neurodegeneration and Neuroprotection Book
Author : Carlo Nucci,Luciano Cerulli,Neville N. Osborne,Giacinto Bagetta
Publisher : Newnes
Release : 2008-11-05
ISBN : 0080932800
Language : En, Es, Fr & De

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Book Description :

Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS), leading researchers to look at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS. This book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma. * Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols * Discusses new strategies for the prevention of neuronal injury in glaucoma patients * Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma

Flavonoids and Neuroprotection

Flavonoids and Neuroprotection Book
Author : Kristopher Beking
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Dementia is a leading contributor to burden of disease in Canada and the world. With an aging population, there are projected increases in its global prevalence. Evidence suggests that some neurodegenerative disorders, such as Alzheimer's disease, that lead to dementia are partly preventable, and that dietary intake of flavonoids may have relevant neuroprotective effects. The purpose of this study was to evaluate such potential for flavonoids using biochemical- and population-based analyses. Among 23 developed nations, negative correlations were found between rates of dementia and intake of all flavonoid groups, especially flavonols (p