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Neuron Glia Interaction In Neuroinflammation

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Neuron Glia Interaction in Neuroinflammation

Neuron Glia Interaction in Neuroinflammation Book
Author : Akio Suzumura,Kazuhiro Ikenaka
Publisher : Springer Science & Business Media
Release : 2013-09-13
ISBN : 1461483131
Language : En, Es, Fr & De

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Book Description :

Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.​

Interaction Between Neurons and Glia in Aging and Disease

Interaction Between Neurons and Glia in Aging and Disease Book
Author : Ana Cristina Rego,Joao Malva,Rodrigo Cunha,Catarina Oliveira
Publisher : Springer Science & Business Media
Release : 2007-08-09
ISBN : 0387708308
Language : En, Es, Fr & De

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Book Description :

A superb source of reference reviews as well as a concise overview of the functional cross-talk between neurons and glial cells, this book also focuses on microglia and inflammation in the aging brain and in neurological disorders. The scientific spectrum covered by this book is of key interest, and is recognized by the scientific community as a major competitive area with critical implications for human health.

Purinergic Signalling in Neuron Glia Interactions

Purinergic Signalling in Neuron Glia Interactions Book
Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Release : 2006-05-01
ISBN : 0470032235
Language : En, Es, Fr & De

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Book Description :

ATP, the intracellular energy source, is also an extremely important cell–cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry of ATP and its derivatives is complex, and the multiple membrane receptors that it activates are linked to many intracellular signalling systems. Purinergic signalling affects a diverse range of cellular phenomena, including ion channel function, cytoskeletal dynamics, gene expression, secretion, cell proliferation, differentiation and cell death. Recently, this class of signalling molecules and receptors has been found to mediate communication between neurons and non-neuronal cells (glia) in the central and peripheral nervous systems. Glia are critical for normal brain function, development and response to injury. Neural impulse activity is detected by glia and purinergic signalling is emerging as a major means of integrating functional activity between neurons, glia and vascular cells in the nervous system. These interactions mediate effects of neural activity on the development of the nervous system and in association with injury, neurodegeneration, myelination and cancer. Bringing together contributions from experts in diverse fields, including glial biologists, neurobiologists and specialists in purinergic receptor structure and pharmacology, this book considers how extracellular ATP acts to integrate communication between different types of glia, and between neurons and glia. Beginning with an overview of glia and purinergic signalling, it contains detailed coverage of purine release, receptors and reagents, purinergic signalling in the neural control of glial development, glial involvement in information processing, and discussion of the interactions between neurons and microglia.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders Book
Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
Publisher : IGI Global
Release : 2020-02-14
ISBN : 1799813185
Language : En, Es, Fr & De

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Book Description :

Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Glial Neuronal Signaling in Neuroendocrine Systems

Glial Neuronal Signaling in Neuroendocrine Systems Book
Author : Jeffrey G. Tasker,Jaideep S. Bains,Julie A. Chowen
Publisher : Springer Nature
Release : 2021-04-01
ISBN : 3030623831
Language : En, Es, Fr & De

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Book Description :

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Jasper s Basic Mechanisms of the Epilepsies

Jasper s Basic Mechanisms of the Epilepsies Book
Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
Publisher : Oxford University Press
Release : 2012-06-01
ISBN : 0199842590
Language : En, Es, Fr & De

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Book Description :

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Neuroinflammation in Neuronal Death and Repair

Neuroinflammation in Neuronal Death and Repair Book
Author : Giacinto Bagetta,M. Tiziana Corasaniti,Stuart A. Lipton
Publisher : Academic Press
Release : 2007
ISBN : 0123739896
Language : En, Es, Fr & De

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Book Description :

A current review of the mechanisms of neuroinflammation and their role in neurodegenerative disorders.

Spectrums of Amyotrophic Lateral Sclerosis

Spectrums of Amyotrophic Lateral Sclerosis Book
Author : Christopher A. Shaw,Jessia R. Morrice
Publisher : John Wiley & Sons
Release : 2021-05-04
ISBN : 1119745519
Language : En, Es, Fr & De

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Book Description :

SPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the field In Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies. In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed. Readers will also benefit from the inclusion of: A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development and clinical trial design Explorations of the genetic basis of ALS, prospective sALS etiologies, and the involvement of microbiome in ALS Discussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cells Examinations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategies Perfect for clinical neurologists, healthcare providers and caretakers, clinicians, and researchers studying motor neuron disease, Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions is also an indispensable resource for the neurodegenerative research community, neurology residents, and graduate-level neuroscience students.

Astrocyte

Astrocyte Book
Author : Maria Teresa Gentile,Luca Colucci D’Amato
Publisher : BoD – Books on Demand
Release : 2018-03-21
ISBN : 9535138855
Language : En, Es, Fr & De

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Book Description :

A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.

Mechanisms of Neuroinflammation

Mechanisms of Neuroinflammation Book
Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Release : 2017-08-23
ISBN : 9535134515
Language : En, Es, Fr & De

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Book Description :

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

The Perioperative Neurocognitive Disorders

The Perioperative Neurocognitive Disorders Book
Author : Roderic G. Eckenhoff,Niccol- Terrando
Publisher : Cambridge University Press
Release : 2019-03-28
ISBN : 1107559200
Language : En, Es, Fr & De

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Book Description :

A practical guide to perioperative cognitive disorders, the most common complications of anesthesia and surgery in older people.

Update on Dementia

Update on Dementia Book
Author : Davide Moretti
Publisher : BoD – Books on Demand
Release : 2016-09-28
ISBN : 9535126547
Language : En, Es, Fr & De

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Book Description :

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration Book
Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Release : 2014-07-08
ISBN : 149391071X
Language : En, Es, Fr & De

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Book Description :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Neuroinflammation in Stroke

Neuroinflammation in Stroke Book
Author : Ulrich Dirnagl,Bernd Elger
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662054264
Language : En, Es, Fr & De

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Book Description :

The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Neuro Immune Interactions in Inflammation and Autoimmunity

Neuro Immune Interactions in Inflammation and Autoimmunity Book
Author : Valentin A. Pavlov,Niccolo Terrando
Publisher : Frontiers Media SA
Release : 2018-07-24
ISBN : 2889455335
Language : En, Es, Fr & De

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Book Description :

The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.

The Role of Apolipoprotein E in Regulating Tau Pathogenesis and Neurodegeneration in a Tauopathy Mouse Model

The Role of Apolipoprotein E in Regulating Tau Pathogenesis and Neurodegeneration in a Tauopathy Mouse Model Book
Author : Yang Shi (Neuroscientist)
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

APOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). APOE4 increases brain amyloid-[beta] (A[beta]) pathology relative to other APOE isoforms. However, whether APOE independently influences tau pathology, the other pathological hallmark of AD and other tauopathies, or tau-mediated neurodegeneration, is not clear. By generating P301S tau transgenic mice on either a human APOE knock in (KI) or APOE knockout (KO) background, we show that the presence of human APOE, regardless of APOE isoforms, leads to various degrees of brain atrophy in 9-month old P301S mice, whereas APOE ablation strongly protects against neurodegeneration. In particular, P301S/E4 mice develop significantly more brain atrophy compared with P301S/E2 and P301S/E3 mice. Concomitantly, APOE-sufficient P301S mice develop ptau staining patterns distinct from P301S/EKO mice, with P301S/E4 mice displaying a yet another different pattern from P301S/E2 and P301S/E3 mice that indicates severe neurodegeneration. In diseased P301S mouse brain, APOE specifically binds to a high-molecular-weight tau species and may affect tau pathogenesis through direct APOE-tau interaction. APOE level strongly correlates with ptau levels, and is associated with less soluble tau and more insoluble tau. In addition to affecting tau pathology and neurodegeneration, APOE has potent immunomodulatory functions. In vitro, E4-expressing microglia produce more proinflammatory cytokines following LPS treatment compared with E2- and E3-expressing microglia. In vivo, P301S/E4 mice show markedly enhanced neuroinflammation compared to P301S/E2 and P301S/E3 mice, whereas P301S/EKO mice are largely protected from the change. Co-culturing P301S tau-expressing neurons with mixed glia (80-90% astrocytes + 10-20% microglia) derived from human APOE KI and APOE KO mice results in a marked neuronal loss in the neuron/E4 co-culture with a concomitant elevation of TNF[alpha] level in the medium compared to neuron/E2 and neuron/E3 co-cultures, whereas neurons co-cultured with EKO glia exhibit the greatest viability with the lowest level of secreted TNF[alpha]. In contrast, treatment of P301S neurons with recombinant APOE (E2, E3, E4) in the absence of glial cells only leads to a mild neuronal impairment compared to the absence of APOE, indicating that APOE regulates neurodegeneration in part through glia-mediated neuroinflammation. The effect of APOE on glia-mediated neuronal loss requires direct contact between neurons and glia cells, and APOE may serve as an opsonin bridging stressed neurons that present 'eat-me' signals on cell surfaces with microglia by binding to triggering receptor expressed on myeloid cells 2 (TREM2) to promote neuronal phagoptosis by microglia. APOE is also required for microglial polarization into a neurodegenerative phenotype characterized by a proinflammatory profile and enhanced phagocytotic activity. Depleting microglia from mouse brain using the colony-stimulating factor 1 receptor (CSF1R) inhibitor - PLX3397, rescues neurodegeneration in TE4 mice, but shows no impact on TEKO mice, indicating critical roles of microglia in neurodegeneration regulated by APOE. Reducing APOE levels in P301S mice by overexpressing an APOE receptor, the low-density lipoprotein receptor (LDLR), significantly attenuates neurodegeneration and shifts the ptau staining towards an early-disease pattern. In addition, LDLR overexpression leads to a significant reduction of ptau levels, similar to that observed in P301S /EKO mice.

Glia in Health and Disease

Glia in Health and Disease Book
Author : Tania Spohr
Publisher : BoD – Books on Demand
Release : 2020-05-20
ISBN : 1789852536
Language : En, Es, Fr & De

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Book Description :

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

Neuroinflammation

Neuroinflammation Book
Author : Alireza Minagar
Publisher : Elsevier
Release : 2010-12-17
ISBN : 9780123849144
Language : En, Es, Fr & De

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Book Description :

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Gap Junctions Hemichannels and Pannexons New Implications in Neuroplasticity and Neuroinflammation

Gap Junctions  Hemichannels and Pannexons  New Implications in Neuroplasticity and Neuroinflammation Book
Author : Juan Andrés Orellana,Eliseo A. Eugenin,Pablo José Sáez
Publisher : Frontiers Media SA
Release : 2022-02-01
ISBN : 2889742180
Language : En, Es, Fr & De

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Book Description :

Download Gap Junctions Hemichannels and Pannexons New Implications in Neuroplasticity and Neuroinflammation book written by Juan Andrés Orellana,Eliseo A. Eugenin,Pablo José Sáez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments

Targeting Neuroinflammation in Central Nervous System Disorders  Uncovering Mechanisms  Pharmacological Targets  and Neuropharmaceutical Developments Book
Author : Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia
Publisher : Frontiers Media SA
Release : 2022-01-20
ISBN : 2889741079
Language : En, Es, Fr & De

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Book Description :

Download Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments book written by Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.