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Neuroinflammation

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Neuroinflammation

Neuroinflammation Book
Author : Alireza Minagar
Publisher : Elsevier
Release : 2010-12-17
ISBN : 9780123849144
Language : En, Es, Fr & De

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Book Description :

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration Book
Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Release : 2014-07-08
ISBN : 149391071X
Language : En, Es, Fr & De

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Book Description :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Neuroinflammation Resolution and Neuroprotection in the Brain

Neuroinflammation  Resolution  and Neuroprotection in the Brain Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2021-10-01
ISBN : 032388461X
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation

Neuroinflammation and CNS Disorders

Neuroinflammation and CNS Disorders Book
Author : Nicola Woodroofe,Sandra Amor
Publisher : John Wiley & Sons
Release : 2014-04-15
ISBN : 1118406540
Language : En, Es, Fr & De

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Book Description :

The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system. Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.

Neuroinflammation and Schizophrenia

Neuroinflammation and Schizophrenia Book
Author : Golam M. Khandaker,Urs Meyer,Peter B. Jones
Publisher : Springer
Release : 2020-01-23
ISBN : 9783030391409
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive summary of the cutting edge scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychotic disorders. It illustrates the role of inflammation and immunity in schizophrenia drawing on both basic science and clinical research. The chapters provide up-to-date summaries of immunological risk factors for schizophrenia and related psychotic disorders, and underlying mechanisms as informed by neuroimaging, genetic, clinical and animal experimental studies. In addition, the book will illuminate the scope for immunological treatment for schizophrenia.

Neuroinflammation

Neuroinflammation Book
Author : Paul L. Wood
Publisher : Springer Science & Business Media
Release : 2002-12-18
ISBN : 159259297X
Language : En, Es, Fr & De

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Book Description :

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Neuroinflammation and Behaviour

Neuroinflammation and Behaviour Book
Author : Luba Sominsky,Adam K. Walker,Deborah M. Hodgson
Publisher : Frontiers Media SA
Release : 2015-07-21
ISBN : 288919602X
Language : En, Es, Fr & De

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Book Description :

The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.

Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives

Neuroinflammation and its Resolution  From Molecular Mechanisms to Therapeutic Perspectives Book
Author : Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes
Publisher : Frontiers Media SA
Release : 2020-07-14
ISBN : 2889638545
Language : En, Es, Fr & De

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Book Description :

Download Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives book written by Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers of Neuroinflammation

Biomarkers of Neuroinflammation Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2018-02-16
ISBN : 0309463688
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Mechanisms of Neuroinflammation

Mechanisms of Neuroinflammation Book
Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Release : 2017-08-23
ISBN : 9535134515
Language : En, Es, Fr & De

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Book Description :

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Neuroinflammation and Cognition

Neuroinflammation and Cognition Book
Author : Ashok Kumar,Brandi K Ormerod,Yogesh Dwivedi,Jakob W Streit
Publisher : Frontiers Media SA
Release : 2019-03-22
ISBN : 2889457605
Language : En, Es, Fr & De

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Book Description :

Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.

Neuroinflammation and the Visual System

Neuroinflammation and the Visual System Book
Author : Gemma Caterina Maria Rossi,Ahmed Toosy,Claudia Angela Michela Gandini Wheeler-Kingshott
Publisher : Frontiers Media SA
Release : 2021-11-23
ISBN : 2889716511
Language : En, Es, Fr & De

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Book Description :

Download Neuroinflammation and the Visual System book written by Gemma Caterina Maria Rossi,Ahmed Toosy,Claudia Angela Michela Gandini Wheeler-Kingshott, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments

Targeting Neuroinflammation in Central Nervous System Disorders  Uncovering Mechanisms  Pharmacological Targets  and Neuropharmaceutical Developments Book
Author : Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia
Publisher : Frontiers Media SA
Release : 2022-01-20
ISBN : 2889741079
Language : En, Es, Fr & De

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Book Description :

Download Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments book written by Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury

Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury Book
Author : Arthur Liesz,Christoph Kleinschnitz
Publisher : Frontiers Media SA
Release : 2015-11-13
ISBN : 2889196917
Language : En, Es, Fr & De

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Book Description :

Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.

Neuron Glia Interaction in Neuroinflammation

Neuron Glia Interaction in Neuroinflammation Book
Author : Akio Suzumura,Kazuhiro Ikenaka
Publisher : Springer Science & Business Media
Release : 2013-09-13
ISBN : 1461483131
Language : En, Es, Fr & De

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Book Description :

Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.​

Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases

Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases Book
Author : Yu Tang,Xuping Li,Xiaobo Mao
Publisher : Frontiers Media SA
Release : 2020-01-15
ISBN : 2889634108
Language : En, Es, Fr & De

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Book Description :

Download Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases book written by Yu Tang,Xuping Li,Xiaobo Mao, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of Neuroinflammation in Chronic Pain Development and Maintenance

The Role of Neuroinflammation in Chronic Pain Development and Maintenance Book
Author : Francesco De Logu,Serena Boccella,Francesca Guida,Gabriela Trevisan
Publisher : Frontiers Media SA
Release : 2022-02-22
ISBN : 2889743217
Language : En, Es, Fr & De

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Book Description :

Download The Role of Neuroinflammation in Chronic Pain Development and Maintenance book written by Francesco De Logu,Serena Boccella,Francesca Guida,Gabriela Trevisan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuroinflammation

Neuroinflammation Book
Author : Paul L. Wood
Publisher : Springer Science & Business Media
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In an unprecedented integration of cutting-edge ideas in immunology with clinical neuropathological findings, Neuroinflammation: Mechanisms and Management reviews and synthesizes our knowledge of the inflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of the role of biochemical mediators in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine research on the design of specific pharmacological agents to inhibit defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and therapeutic actions of first generation agents, as well as their potential clinical relevance to AIDS dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.

Biomarkers of Neuroinflammation

Biomarkers of Neuroinflammation Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2018-03-16
ISBN : 0309463653
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Neuroinflammation in Neuronal Death and Repair

Neuroinflammation in Neuronal Death and Repair Book
Author : Giacinto Bagetta,M. Tiziana Corasaniti,Stuart A. Lipton
Publisher : Academic Press
Release : 2007
ISBN : 0123739896
Language : En, Es, Fr & De

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Book Description :

A current review of the mechanisms of neuroinflammation and their role in neurodegenerative disorders.