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Neurogenic Inflammation In Health And Disease

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Neurogenic Inflammation in Health and Disease

Neurogenic Inflammation in Health and Disease Book
Author : Gábor Jancsó
Publisher : Elsevier
Release : 2009
ISBN : 0444532293
Language : En, Es, Fr & De

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Book Description :

Morphological and functional studies revealed a complex system of primary sensory neurons which parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel which transmits pain. * Neurogenic inflammation in historical perspective * Cardiac protection by nociceptive afferents * Molecular mechanisms of nociception * Sensory mechanisms in migraine pathophysiology * Vagal signalling of visceral inflammation * Neurogenic mechanisms in arthritis * Therapeutic implications of vanilloid-type compounds

Neuroimmune Biology

Neuroimmune Biology Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Neuroimmune Biology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurogenic Inflammation in Health and Disease

Neurogenic Inflammation in Health and Disease Book
Author : Anonim
Publisher : Newnes
Release : 2008-11-11
ISBN : 0080932622
Language : En, Es, Fr & De

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Book Description :

Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. Neurogenic inflammation in historical perspective Cardiac protection by nociceptive afferents Molecular mechanisms of nociception Sensory mechanisms in migraine pathophysiology Vagal signaling of visceral inflammation Neurogenic mechanisms in arthritis Therapeutic implications of vanilloid-type compounds

Insights to Neuroimmune Biology

Insights to Neuroimmune Biology Book
Author : Istvan Berczi
Publisher : Elsevier
Release : 2016-02-03
ISBN : 012801833X
Language : En, Es, Fr & De

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Book Description :

Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms. Provides information on the importance and applicability of the field of neuroimmunology Describes subjects that have shown significant recent developments Introduces a whole new dimension to neuroimmunology by discussing Epigenetic Immunoregulation Investigates the mechanisms and functions of the Neuroimmune Regulatory Supersystem Promotes translational research in the field of neuroimmune biology Covers challenges, such as dealing with problems of e.g., hypothalamic regulation of immune functions, interrelationships of stress and disease, epigenetic immunoregulation, neuroprotection, and neuroimmune regulation in pregnancy.

Frontiers in Clinical Drug Research Anti Allergy Agents

Frontiers in Clinical Drug Research     Anti Allergy Agents Book
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Release : 2016-03-03
ISBN : 1681081598
Language : En, Es, Fr & De

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Book Description :

Frontiers in Clinical Drug Research - Anti-Allergy Agents is an exciting eBook series comprising a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs. The second volume of this series brings 7 reviews which cover neuro- and immunomodulating therapies for asthma and COPD, antioxidant therapies for allergies, allergic rhinitis medications and more. Frontiers in Clinical Drug Research - Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.

The Mast Cell in Health and Disease

The Mast Cell in Health and Disease Book
Author : Kaliner
Publisher : CRC Press
Release : 1992-10-29
ISBN : 9780824787325
Language : En, Es, Fr & De

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Book Description :

Offers coverage of practical and theoretical implications of current research into mast cell biology, emphasizing the role of the mast cell in human diseases. The text covers all aspects of the mast cell from growth and differentiation to its function in such conditions as asthma and skin disease.

The Inflammation Cure

The Inflammation Cure Book
Author : William Joel Meggs,Carol Svec
Publisher : McGraw Hill Professional
Release : 2004
ISBN : 9780071413206
Language : En, Es, Fr & De

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Book Description :

Inflammation is increasingly being seen as the culprit behind many of the diseases associated with aging. This work makes consumers aware of the connection and offers a programme for reducing inflammation and enjoying good health.

Dual Role of Microglia in Health and Disease Pushing the Balance Towards Repair

Dual Role of Microglia in Health and Disease  Pushing the Balance Towards Repair Book
Author : Raquel Ferreira,Liliana Bernardino
Publisher : Frontiers Media SA
Release : 2015-07-23
ISBN : 2889194922
Language : En, Es, Fr & De

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Book Description :

Microglial cells play a vital role in the innate immune response occurring in the Central Nervous System (CNS). Under physiologic conditions, microglia dynamically patrol the brain parenchyma and participate in the remodeling of active neuronal circuits. Accordingly, microglia can boost synaptic plasticity by removing apoptotic cells and by phagocytizing axon terminals and dendritic spines that form inappropriate neural connections. Upon brain and spinal cord injury or infection, microglia act as the first line of immune defense by promoting the clearance of damaged cells or infectious agents and by releasing neurotrophins and/ or proneurogenic factors that support neuronal survival and regeneration. Recently, two main pathways were suggested for microglia activation upon stimuli. Classical activation is induced by Toll-like receptor agonists and Th1 cytokines and polarizes cells to an M1 state, mainly leading to the release of TNF-alpha, IL-6 and nitric oxide and to grave neural damage. Alternative activation is mediated by Th2 cytokines and polarizes cells to an M2a state inducing the release of antiinflammatory factors. These findings have further fueled the discussion on whether microglia has a detrimental or beneficial action (M1 or M2-associated phenotypes, respectively) in the diseased or injured CNS and, more importantly, on whether we can shift the balance to a positive outcome. Although microglia and macrophages share several common features, upon M1 and M2 polarizing conditions, they are believed to develop distinct phenotypic and functional properties which translate into different patterns of activity. Moreover, microglia/macrophages seem to have developed a tightly organized system of maintenance of CNS homeostasis, since cells found in different structures have different morphology and specific function (e.g. meningeal macrophages, perivascular macrophages, choroid plexus macrophages). Nevertheless, though substantial work has been devoted to microglia function, consensus around their exact origin, their role during development, as well as the exact nature of their interaction with other cells of the CNS has not been met. This issue discusses how microglial cells sustain neuronal activity and plasticity in the healthy CNS as well as the cellular and molecular mechanisms developed by microglia in response to injury and disease. Understanding the mechanisms involved in microglia actions will enforce the development of new strategies to promote an efficient CNS repair by committing microglia towards neuronal survival and regeneration.

Nutraceuticals and the Skin Roles in Health and Disease

Nutraceuticals and the Skin  Roles in Health and Disease Book
Author : Jean Christopher Chamcheu,Deeba Nadeem Syed,G. Kerr Whitfield
Publisher : MDPI
Release : 2018-10-08
ISBN : 3038971928
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Nutraceuticals and the Skin: Roles in Health and Disease" that was published in Nutrients

Update in Respiratory Diseases

Update in Respiratory Diseases Book
Author : Jose Carlos Herrera Garcia
Publisher : BoD – Books on Demand
Release : 2020-12-02
ISBN : 1838808949
Language : En, Es, Fr & De

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Book Description :

This edited volume, “Update in Respiratory Diseases”, is a collection of reviewed and relevant research chapters that offer a comprehensive overview of recent developments in the field of respiratory diseases. The book comprises single chapters authored by various researchers and edited by an expert active in the respiratory diseases field. All chapters are separate but are united under a common research topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on respiratory diseases and opening new possible research paths for further novel developments.

The Brain and Host Defense

The Brain and Host Defense Book
Author : Anonim
Publisher : Elsevier
Release : 2009-12-24
ISBN : 9780444535450
Language : En, Es, Fr & De

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Book Description :

It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Eosinophils in Health and Disease

Eosinophils in Health and Disease Book
Author : James J. Lee,Helene F. Rosenberg
Publisher : Academic Press
Release : 2012
ISBN : 012394385X
Language : En, Es, Fr & De

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Book Description :

Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.

Immunoendocrinology in Health and Disease

Immunoendocrinology in Health and Disease Book
Author : Vincent Geenen
Publisher : CRC Press
Release : 2004-08-30
ISBN : 1135539294
Language : En, Es, Fr & De

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Book Description :

One of the first comprehensive references dealing specifically with this new field of interdisciplinary research in medicine, Immunoendocrinology in Health and Disease offers a full scientific picture of where the immune and neuroendocrine systems intersect-placing current understanding of system components, mechanisms, and functions side by side w

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Cyclic Nucleotide Phosphodiesterases in Health and Disease Book
Author : Joseph A. Beavo,Sharron H. Francis,Miles D. Houslay
Publisher : CRC Press
Release : 2006-12-05
ISBN : 1420020846
Language : En, Es, Fr & De

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Book Description :

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

The Inflammation Cure

The Inflammation Cure Book
Author : William Joel Meggs,Carol Svec
Publisher : McGraw Hill Professional
Release : 2003-09-22
ISBN : 0071433368
Language : En, Es, Fr & De

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Book Description :

A powerful new program for preventing the diseases of aging--based on cutting edge research In recent stories, both the New York Times and CNN reported on the vital link between inflammation and the risk of heart disease, as well as diseases associated with aging including arthritis, Alzheimer's disease, frailty, osteoporosis, and some cancers. The Inflammation Cure is on the cutting edge of this research, exposing this connection and showing readers how to protect themselves. In accessible language, Dr. William Meggs, an originator of the inflammation-related theory of neurogenic switching, explains the research and outlines a practical and complete program for controlling inflammation and returning to vibrant good health. The Inflammation Cure: Explains up-to-the-minute thinking on the role inflammation plays in aging and health Reveals what causes inflammation and how you can tell if you have it Presents a comprehensive program to reduce inflammation and promote wellness Provides information on anti-inflammatory foods and supplements, medications, exercise, and more

ATP gated P2X receptors in health and disease

ATP gated P2X receptors in health and disease Book
Author : Andrea Nistri,Geoffrey Burnstock,Baljit S Khakh,Rashid Giniatullin
Publisher : Frontiers Media SA
Release : 2015-01-05
ISBN : 2889194051
Language : En, Es, Fr & De

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Book Description :

Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.

In Vivo Models of Inflammation

In Vivo Models of Inflammation Book
Author : Christopher S. Stevenson,Lisa A. Marshall,Douglas W. Morgan
Publisher : Springer Science & Business Media
Release : 2006-11-09
ISBN : 3764377607
Language : En, Es, Fr & De

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Book Description :

In Vivo Models of Inflammation (Vol. 2) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first, describing and updating the standard models that are most utilized for specific disease areas. New models are included exploring emerging areas of inflammation research.

The Toxicant Induction of Irritant Asthma Rhinitis and Related Conditions

The Toxicant Induction of Irritant Asthma  Rhinitis  and Related Conditions Book
Author : William J. Meggs
Publisher : Springer Science & Business Media
Release : 2014-01-24
ISBN : 1461490448
Language : En, Es, Fr & De

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Book Description :

Untoward reactions to environmental chemicals, particularly when a subject reports difficulties with exposures to chemicals of diverse classes involving more than one organ system, have been poorly understood and an area of great controversy. Studies of airway inflammation induced by respiratory irritants have established neurogenic inflammation as the mechanism for irritant asthma and rhinitis. Remodeling of the airway after an acute irritant exposure can lead to a heightened sensitivity to irritants that persists. Recognition that rhinitis, while sometimes regarded as a trivial disease, is associated with extra-airway manifestations such as fatigue and disturbances of sleep, mood, and cognition, further elucidates how chemical exposures can be serious for susceptible individuals. This book reviews current scientific understanding of irritant airway inflammation and related conditions, including cardiovascular effects of particulate exposures, airborne contact dermatitis and irritant dermatitis, and the brain as a target organ for both allergic and irritant reactions. It is essential reading for physicians and other healthcare workers caring for patients with environmental intolerances. Allergists, toxicologists, occupational and environmental physicians, and pulmonologists will find the materials particularly valuable. Patients and advocates for those with chemical intolerances will also find the book of interest.

The Inflammation Cure

The Inflammation Cure Book
Author : William Joel Meggs,Carol Svec
Publisher : McGraw Hill Professional
Release : 2005-01-21
ISBN : 9780071438711
Language : En, Es, Fr & De

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Book Description :

Outlines simple steps for reversing heart disease, arthritis, diabetes, asthma, Alzheimer's disease, osteoporosis and other diseases of aging.

Environmental Health Perspectives

Environmental Health Perspectives Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Environmental Health Perspectives book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.