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Neurogenic Inflammation In Health And Disease

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Neurogenic Inflammation in Health and Disease

Neurogenic Inflammation in Health and Disease Book
Author : Gabor Jancso
Publisher : Elsevier
Release : 2008-12-10
ISBN : 0444532293
Language : En, Es, Fr & De

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Book Description :

Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. Neurogenic inflammation in historical perspective Cardiac protection by nociceptive afferents Molecular mechanisms of nociception Sensory mechanisms in migraine pathophysiology Vagal signaling of visceral inflammation Neurogenic mechanisms in arthritis Therapeutic implications of vanilloid-type compounds

Neurogenic Inflammation

Neurogenic Inflammation Book
Author : Pierangelo Geppetti,Peter Holzer
Publisher : CRC Press
Release : 1996-03-22
ISBN : 9780849376467
Language : En, Es, Fr & De

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Book Description :

Take advantage of this unique book - the first single-volume resource to explore all important aspects of neurogenic inflammation. An unrivaled compilation of up-to-date information, Neurogenic Inflammation contains chapters written by recognized authorities in their areas of expertise. It covers the basic mechanisms and the pathophysiological implications of neurogenic inflammatory processes and points to novel therapeutic strategies in the field of inflammatory and related diseases. The book highlights the many systems and mechanisms involved in neurogenic inflammation, including vasodilatation, plasma extravasation, leukocyte adhesion, smooth muscle contraction, exocrine gland secretion, and recruitment of inflammatory cells. The authors discuss the contribution of neurogenic inflammation to human diseases, such as migraine, asthma, arthritis, and inflammatory bowel disease, linked to the ubiquitous distribution of sensory nerves to organs and tissues at both the somatic and visceral level. Neurogenic Inflammation is the clear choice for a one-step, authoritative guide to the latest developments in this dynamic field.

The Mast Cell in Health and Disease

The Mast Cell in Health and Disease Book
Author : Kaliner
Publisher : CRC Press
Release : 1992-10-29
ISBN : 9780824787325
Language : En, Es, Fr & De

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Book Description :

Offers coverage of practical and theoretical implications of current research into mast cell biology, emphasizing the role of the mast cell in human diseases. The text covers all aspects of the mast cell from growth and differentiation to its function in such conditions as asthma and skin disease.

Frontiers in Clinical Drug Research Anti Allergy Agents

Frontiers in Clinical Drug Research     Anti Allergy Agents Book
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Release : 2016-03-03
ISBN : 1681081598
Language : En, Es, Fr & De

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Book Description :

Frontiers in Clinical Drug Research - Anti-Allergy Agents is an exciting eBook series comprising a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs. The second volume of this series brings 7 reviews which cover neuro- and immunomodulating therapies for asthma and COPD, antioxidant therapies for allergies, allergic rhinitis medications and more. Frontiers in Clinical Drug Research - Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.

Insights to Neuroimmune Biology

Insights to Neuroimmune Biology Book
Author : Istvan Berczi
Publisher : Elsevier
Release : 2016-02-03
ISBN : 012801833X
Language : En, Es, Fr & De

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Book Description :

Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms. Provides information on the importance and applicability of the field of neuroimmunology Describes subjects that have shown significant recent developments Introduces a whole new dimension to neuroimmunology by discussing Epigenetic Immunoregulation Investigates the mechanisms and functions of the Neuroimmune Regulatory Supersystem Promotes translational research in the field of neuroimmune biology Covers challenges, such as dealing with problems of e.g., hypothalamic regulation of immune functions, interrelationships of stress and disease, epigenetic immunoregulation, neuroprotection, and neuroimmune regulation in pregnancy.

NGF and Related Molecules in Health and Disease

NGF and Related Molecules in Health and Disease Book
Author : L. Aloe,L. Calza
Publisher : Elsevier
Release : 2003-12-10
ISBN : 0080497500
Language : En, Es, Fr & De

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Book Description :

The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.

The Inflammation Cure

The Inflammation Cure Book
Author : William Joel Meggs,Carol Svec
Publisher : McGraw Hill Professional
Release : 2004
ISBN : 9780071413206
Language : En, Es, Fr & De

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Book Description :

Inflammation is increasingly being seen as the culprit behind many of the diseases associated with aging. This work makes consumers aware of the connection and offers a programme for reducing inflammation and enjoying good health.

The MIF Handbook

The MIF Handbook Book
Author : Richard Bucala
Publisher : World Scientific
Release : 2012
ISBN : 9814335355
Language : En, Es, Fr & De

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Book Description :

The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.

Nutraceuticals and the Skin Roles in Health and Disease

Nutraceuticals and the Skin  Roles in Health and Disease Book
Author : Jean Christopher Chamcheu,Deeba Nadeem Syed,G. Kerr Whitfield
Publisher : MDPI
Release : 2018-10-08
ISBN : 3038971928
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Nutraceuticals and the Skin: Roles in Health and Disease" that was published in Nutrients

Update in Respiratory Diseases

Update in Respiratory Diseases Book
Author : Jose Carlos Herrera Garcia
Publisher : BoD – Books on Demand
Release : 2020-12-02
ISBN : 1838808949
Language : En, Es, Fr & De

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Book Description :

This edited volume, “Update in Respiratory Diseases”, is a collection of reviewed and relevant research chapters that offer a comprehensive overview of recent developments in the field of respiratory diseases. The book comprises single chapters authored by various researchers and edited by an expert active in the respiratory diseases field. All chapters are separate but are united under a common research topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on respiratory diseases and opening new possible research paths for further novel developments.

Eosinophils in Health and Disease

Eosinophils in Health and Disease Book
Author : James J. Lee,Helene F. Rosenberg
Publisher : Academic Press
Release : 2012-11-02
ISBN : 012394385X
Language : En, Es, Fr & De

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Book Description :

Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.

The Brain and Host Defense

The Brain and Host Defense Book
Author : Anonim
Publisher : Elsevier
Release : 2009-12-24
ISBN : 9780444535450
Language : En, Es, Fr & De

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Book Description :

It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

In Vivo Models of Inflammation

In Vivo Models of Inflammation Book
Author : Christopher S. Stevenson,Lisa A. Marshall,Douglas W. Morgan
Publisher : Springer Science & Business Media
Release : 2006-11-09
ISBN : 3764377607
Language : En, Es, Fr & De

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Book Description :

In Vivo Models of Inflammation (Vol. 2) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first, describing and updating the standard models that are most utilized for specific disease areas. New models are included exploring emerging areas of inflammation research.

Itch

Itch Book
Author : E. Carstens,Tasuku Akiyama
Publisher : CRC Press
Release : 2014-02-25
ISBN : 1466505435
Language : En, Es, Fr & De

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Book Description :

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

The Inflammation Cure

The Inflammation Cure Book
Author : William Joel Meggs,Carol Svec
Publisher : McGraw Hill Professional
Release : 2003-09-22
ISBN : 0071433368
Language : En, Es, Fr & De

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Book Description :

A powerful new program for preventing the diseases of aging--based on cutting edge research In recent stories, both the New York Times and CNN reported on the vital link between inflammation and the risk of heart disease, as well as diseases associated with aging including arthritis, Alzheimer's disease, frailty, osteoporosis, and some cancers. The Inflammation Cure is on the cutting edge of this research, exposing this connection and showing readers how to protect themselves. In accessible language, Dr. William Meggs, an originator of the inflammation-related theory of neurogenic switching, explains the research and outlines a practical and complete program for controlling inflammation and returning to vibrant good health. The Inflammation Cure: Explains up-to-the-minute thinking on the role inflammation plays in aging and health Reveals what causes inflammation and how you can tell if you have it Presents a comprehensive program to reduce inflammation and promote wellness Provides information on anti-inflammatory foods and supplements, medications, exercise, and more

Migraine A Neuroinflammatory Disease

Migraine  A Neuroinflammatory Disease  Book
Author : Egilius L.H. Spierings,Margarita del Rio Sanchez
Publisher : Springer Science & Business Media
Release : 2002-01-01
ISBN : 9783764362317
Language : En, Es, Fr & De

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Book Description :

This book contains reviews by a renowned group of clinicians and scientists, which consider in great depth the potential involvement of neurogenic inflammation in the pathogenesis of migraine and inhibition of this putative mechanism as a possible mode of action of antimigraine medications. The authors carefully consider current and future potential therapeutic approaches for the abortive as well as preventive treatment of migraine. The pioneering work by Professor Michael A. Moskowitz's group at Harvard gave rise to the "neurogenic hypothesis" of migraine pathogenesis and to an intel­ lectual framework for many aspects of migraine research through a detailed phar­ macological characterization of the trigeminovascular system. This knowledge then spurred detailed research worldwide into the roles of the dural vasculature, trigem­ inal nerve fibers, and sensory neuropeptides, such as substance P and calcitonin gene-related peptide, in migraine. Similar in-depth investigations have not been made of the role of the seventh cranial parasympathetic nerves but this area war­ rants further study because of its potential for interactions with the trigeminovas­ cular system and its clear involvement in cluster headache.

Capillary Fluid Exchange

Capillary Fluid Exchange Book
Author : Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis
Publisher : Morgan & Claypool Publishers
Release : 2010
ISBN : 1615040668
Language : En, Es, Fr & De

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Book Description :

The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease Book
Author : Stephen Sonis,Alessandro Villa
Publisher : Academic Press
Release : 2019-09-14
ISBN : 0128137630
Language : En, Es, Fr & De

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Book Description :

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Perspectives in Basic and Applied Toxicology

Perspectives in Basic and Applied Toxicology Book
Author : Bryan Ballantyne
Publisher : Elsevier
Release : 2016-10-27
ISBN : 1483193535
Language : En, Es, Fr & De

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Book Description :

Perspectives in Basic and Applied Toxicology features a collection of essays on various aspects of toxicology. It aims to relate fundamental knowledge of toxicology to its application in assessing relevance of that information to the causation of adverse health effects, predicting hazardous situations, defining protective and precautionary measures, and the recognition and management of intoxication in humans. Another objective of this volume is to encourage those with responsibility for the training of toxicologists to instill a greater concern about ethical and moral issues as fundamental to the practice of toxicology as a profession with wide-ranging social implications. This book is organized into 14 chapters. The coverage of these chapters include assessment of chemical hazards in the workplace, the relation between animal studies and epidemiology in the context of industrial toxicology, carcinogenicity testing in animals, and biochemical evaluation of neurotoxicity. This book will be of interest to undergraduate and graduate toxicologists, pharmacologists, physicians, industrial hygienists, and other health professionals.

Autonomic Neuroimmunology

Autonomic Neuroimmunology Book
Author : John Bienenstock,M. Blennerhassett,E. Goetzl
Publisher : CRC Press
Release : 2003-02-13
ISBN : 0415306582
Language : En, Es, Fr & De

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Book Description :

While it may appear that the nervous and immune systems exist as two separate entities, groundbreaking observations have positively identified anatomic connections between elements of the nervous system and cells of adaptive immunity. Building on this research, Autonomic Neuroimmunology presents a scientific discussion of the current understanding of these vital neuroimmunological interactions and their implications for normal psychology and disease states. Contributors document the cell biological mechanisms for the neuropeptide activation of mast cells, and analyze how one or more adrenergenic and peptidergic messengers modulate immunity. They also explain the pathways by which cholinergic factors may suppress immunological inflammation. The potential implications of organ system-selective neuroimmunology for host defense and diseases are thoroughly discussed for the skin, the intestines, the bladder, and the lungs. With modern neuroimmunology now firmly established as a scientific discipline, this volume supports this promising science as a pathway to novel diagnostic and therapeutic techniques for diseases of the neural, immune, and endocrine systems.