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Neurochemical Aspects Of Alzheimers Disease

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Neurochemical Aspects of Alzheimer s Disease

Neurochemical Aspects of Alzheimer s Disease Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2017-05-25
ISBN : 0128099380
Language : En, Es, Fr & De

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Book Description :

Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2010-09-02
ISBN : 9781441966520
Language : En, Es, Fr & De

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Book Description :

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

Neurochemical Aspects of Excitotoxicity

Neurochemical Aspects of Excitotoxicity Book
Author : Akhlaq A. Farooqui,Wei-Yi Ong,Lloyd A. Horrocks
Publisher : Springer Science & Business Media
Release : 2007-11-20
ISBN : 0387730230
Language : En, Es, Fr & De

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Book Description :

Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases. In addition, the authors discuss the treatment of these diseases with endogenous and exogenous antioxidants and glutamate receptor antagonists.

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2020-03-20
ISBN : 0128201843
Language : En, Es, Fr & De

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Book Description :

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help in the early detection of insulin resistance related visceral and neurological disorders, but also promote the discovery of new drugs which may block or delay onset in elderly patients. Understanding these processes is important not only for patients, caregivers and health professionals, but also for health policymakers who must plan for national resources. Presents the first comprehensive book dedicated to insulin resistance as a risk factor for neurological disorders Focuses on the molecular mechanisms and signal transduction processes associated with insulin resistance Discusses insulin resistance to heart disease, obesity, diabetes, stroke, Alzheimer’s, Parkinson’s, dementia and depression

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2019-04-15
ISBN : 0128167319
Language : En, Es, Fr & De

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Book Description :

Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia

Ischemic and Traumatic Brain and Spinal Cord Injuries

Ischemic and Traumatic Brain and Spinal Cord Injuries Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2018-03-21
ISBN : 0128135972
Language : En, Es, Fr & De

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Book Description :

Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases. Offers a clearly written, logically organized, comprehensive overview on the molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting-edge research information on the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Presents chapters that are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Neurochemical Mechanisms in Disease

Neurochemical Mechanisms in Disease Book
Author : John P. Blass
Publisher : Springer Science & Business Media
Release : 2010-12-01
ISBN : 9781441971043
Language : En, Es, Fr & De

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Book Description :

This newest volume of Advances in Neurobiology deals with the Neurochemistry of disease, with chapters covering both human diseases and animal “model” diseases.

Alzheimer s Disease Epidemiology Neuropathology Neurochemistry and Clinics

Alzheimer   s Disease  Epidemiology  Neuropathology  Neurochemistry  and Clinics Book
Author : Konrad Maurer,Peter Riederer,Helmut Beckmann
Publisher : Springer Science & Business Media
Release : 2013-03-14
ISBN : 3709133963
Language : En, Es, Fr & De

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Book Description :

The book Alzheimer's Disease - Epidemiology, Neuropathology, Neurochemistry, and Clinics is derived from an International Symposium on the occasion of the 125th Anniversary of the Birth of Alois Alzheimer (14.6.1864-19.12.1915). Over the past decade, as the elderly have become the fastest-growing segment of the population in industrialized countries, Alzheimer's disease has emerged as one of the major mental health problems. The contributors to this book represent internationally recognized authorities in the field of dementia and present new information about epidemiology, neuropathology, neurochemistry, and clinics in Alzheimer's disease. This book is a rich and valuable up-to-date resource for psychiatrists, neurologists, scientists working in the fields of neuropathology, neurochemistry and molecular genetics, behavioral scientists, family physicians and all who share an interest in understanding and treating the older individual with Alzheimer's disease/dementia.

Quantifying Neurochemical Changes in Early Alzheimer s Disease

Quantifying Neurochemical Changes in Early Alzheimer   s Disease Book
Author : Katrina Cruickshank
Publisher :
Release : 2020
ISBN :
Language : En, Es, Fr & De

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Book Description :

"Alzheimer’s disease (AD) is a neurodegenerative disorder that advances through a unique cascade of characteristic neuropathological features. Distinguishing features include the accumulation of amyloid beta plaques and neurofibrillary tangles (NFTs) in the brain, accompanied by learning and memory impairments. The disease is projected to begin years-to-decades before clinical diagnosis. Accordingly, prodromal biomarkers are a necessity with early diagnosis as the goal. Neurochemical measures obtained via non-invasive brain imaging have potential to serve as early, AD biomarkers. Evidence suggests that alterations in the concentrations of certain metabolites are related to inflammation. It is known that while inflammation is ubiquitous in the progressed disease state, it is also apparent during initial stages. Of interest, a paradoxical increase in neuronal activity during early stages of AD has been noted, with a suspected link to an initial inflammatory response via proinflammatory cytokines. Early evidence suggests that alongside their role in immune mediation, cytokines play a critical part in maintaining optimal synaptic activity, and that early deviations from this role may contribute directly to downstream AD pathogenesis. Therefore, as magnetic resonance spectroscopy (MRS) has the capacity to noninvasively quantify neurochemical concentrations, it is an appropriate tool to pinpoint early fluctuations associated with inflammation and elevated cytokine activation.A greater understanding of AD requires an improved appreciation for its initial evolution. This requires, not only investigation into potential preclinical, neurochemical biomarkers, but furthermore, an examination into any parallel cognitive deficits. This project investigated prodromal AD in a transgenic (Tg) rodent model from early adulthood to middle age. It utilized in vivo proton magnetic resonance spectroscopy (1H MRS) to assess longitudinal changes in neurochemistry and the Barnes maze (BM) to evaluate spatial learning and memory. The central research objective was the longitudinal characterization of neurochemistry and behaviour in the TgF344-AD rodent model during the initial disease state, to highlight abnormalities that precede diagnosable AD.The study was conducted from approximately 4 to 10 months of age, in both TgF344-AD rats and their wildtype (WT) controls. Five evenly spaced magnetic resonance (MR) scans were acquired during this time (1 every 6 weeks), in addition to three sessions of behavioural testing (1 every 2 months). The BM was implemented to test spatial learning and memory ability, and longitudinal changes in metabolic levels were evaluated through linear mixed effects modeling.Altered neurochemistry was recorded between genotypes and across time in prodromal stages of AD. More specifically, Tg rats had significantly lower levels of glutamine (Gln), a precursor to glutamate (Glu), following disease initiation and increasing with age. In addition, with time Glu levels fell and myo-inositol (Ins) levels rose, independent of genotype. N-acetyl aspartate (NAA), reportedly reduced at later stages of AD, remained unchanged in Tg relative to WT rats. Neurochemical changes were not accompanied by a significant loss in cognitive ability, and thus appear to precede characteristic cognitive impairments.This research demonstrates that altered neurochemistry materializes in early AD and occurs before the onset of measurable behavioural deficits. A better understanding of preclinical AD requires further investigation into the relationship between neurochemistry, cognition, neuroanatomy, and the concentrations of proinflammatory mediators. Consequently, this could contribute to novel diagnostic and treatment techniques through the identification of reliable, early biomarkers"--

Basic Clinical and Therapeutic Aspects of Alzheimer s and Parkinson s Diseases

Basic  Clinical  and Therapeutic Aspects of Alzheimer   s and Parkinson   s Diseases Book
Author : Toshiharu Nagatsu,Abraham Fisher,Mitsuo Yoshida
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468458442
Language : En, Es, Fr & De

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Book Description :

This two-volume work contains the full text of the oral and poster presentations and the general discussion at the round table discussion of the Second International Conference on Alzheimer's and Parkinson's Diseases: Basic and Therapeutic Strategies, held at the Kyoto Park Hotel in Kyoto, Japan, on November 6-10, 1989. The First Conference was held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. The record of this First Conference was published by Plenum Press in 1986 as Volume 29 in Advances in Behavioral Biology, under the title "Alzheimer's and Parkinson's Diseases: Strategies for Research and Development." We are happy that the comprehensive texts of the oral and poster presentations of the Second Conference could again be published within the framework of this series. Since the First Conference in 1985, rapid progress has been made in both basic and 'therapeutic aspects of these diseases. About 700 scientists from allover the world participated in the Second Conference, and 300 papers were presented in oral and poster sessions. Many people and organizations have helped to organize this multi disciplinary international conference and hence have contributed to the scientific quality of these two volumes. We thank the members of the organizing committee, the organizations that provided financial support, and the contributing scientists for their enthusiastic participation. These two volumes follow the same publishing philosophy as the volume derived from the First Conference. They span a broad spectrum of topics and bridge preclinical and clinical concepts related to these diseases.

Therapeutic Potentials of Curcumin for Alzheimer Disease

Therapeutic Potentials of Curcumin for Alzheimer Disease Book
Author : Akhlaq A Farooqui
Publisher : Springer
Release : 2016-03-05
ISBN : 3319158899
Language : En, Es, Fr & De

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Book Description :

This is the first book on the market that explores the importance of curcumin for the treatment of neurological disorders. It has been estimated that 35.6 million people globally had dementia in 2010 and the prevalence of dementia has been predicted to double every 20 years. Thus, 115.4 million people may be living with dementia in 2050. Alzheimer’s disease (AD) is the leading cause of dementia and is present in 60%–70% of people with dementia. Unless new discoveries are made in the prevention or treatment of AD, the number of cases in the US alone is estimated to increase threefold, to 13.2 million by the year 2050. Thus, it is important to focus on delaying and treating the onset of AD by curcumin may be an important step for controlling AD. Regular consumption of healthy diet containing curcumin enriched foods, moderate exercise, and regular sleep may produce beneficial effects not only on motor and cognitive functions, but also on memory deficits that occur to some extent during normal aging and to a large extent in AD. Delaying the onset and progression of AD and improving its symptoms by few years with regular consumption of curcumin may relieve some of the burden on health care systems. In service of this goal, this volume gives readers a comprehensive and cutting edge description of the importance of curcumin for the treatment of AD in cell culture and animal models in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. It can be used as supplement text for a range of neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists and pharmacologists will find this book useful for understanding molecular aspects of AD treatment by curcumin.

Neurochemistry

Neurochemistry Book
Author : Albert Teelken,Jaap Korf
Publisher : Springer
Release : 2013-11-11
ISBN : 1461554055
Language : En, Es, Fr & De

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Book Description :

Proceedings of the 11th European Society for Neurochemistry Meeting held in Groningen, The Netherlandes, June 15-20, 1996

Metabolic Syndrome

Metabolic Syndrome Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2013-06-14
ISBN : 1461473187
Language : En, Es, Fr & De

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Book Description :

Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.

Inflammation and Oxidative Stress in Neurological Disorders

Inflammation and Oxidative Stress in Neurological Disorders Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2014-01-27
ISBN : 3319041118
Language : En, Es, Fr & De

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Book Description :

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Biological Markers of Alzheimer s Disease

Biological Markers of Alzheimer   s Disease Book
Author : Francois Boller,Robert Katzman,Andre Rascol,Jean-Louis Signoret
Publisher : Springer Science & Business Media
Release : 2013-03-08
ISBN : 3642466907
Language : En, Es, Fr & De

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Book Description :

This volume presents the proceedings of the symposium held in Toulouse on April 24, 1989, on the topic "Biological Markers of Alzheimer's Disease. " This sym posium was the fourth of a continuing and successful series of Colloques Medecine et Recherche organized by the Fondation IPSEN pour la Recherche Therapeutique, addressing various aspects of contemporary research in the field of Alzheimer's disease (AD). The series started in September 1987 with "Im munology and Alzheimer's Disease," followed 6 months later in Paris by "Gene tics and Alzheimer's Disease" and in September 1988 in Montpellier by "Neuronal Grafting and Alzheimer's Disease. " The present symposium was organized for the purpose of gathering the most current ideas concerning biological markers of AD. The papers presented at this symposium may be roughly subdivided into three groups. The first deals with the markers of AD at the level of the brain itself. These markers are studied either through the cerebrospinal fluid or through techniques such as nuclear magnetic resonance (NMR) - approaches which respectively aim at demonstrating the cerebral changes indicated by the debris resulting from the disease, or studying the possible neurochemical abnormalities that occur in the earlier stages of AD.

Concepts of Alzheimer Disease

Concepts of Alzheimer Disease Book
Author : Peter J. Whitehouse,Konrad Maurer,Jesse F. Ballenger
Publisher : JHU Press
Release : 2003-05-27
ISBN : 0801877156
Language : En, Es, Fr & De

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Book Description :

As the essays in this volume show, conceptualizing dementia has always been a complex process. With contributions from noted professionals in psychiatry, neurology, molecular biology, sociology, history, ethics, and health policy, Concepts of Alzheimer Disease looks at the ways in which Alzheimer disease has been defined in various historical and cultural contexts. The book covers every major development in the field, from the first case described by Alois Alzheimer in 1907 through groundbreaking work on the genetics of the disease. Essays examine not only the prominent role that biomedical and clinical researchers have played in defining Alzheimer disease, but also the ways in which the perspectives of patients, their caregivers, and the broader public have shaped concepts.

Phytochemicals Signal Transduction and Neurological Disorders

Phytochemicals  Signal Transduction  and Neurological Disorders Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2012-07-10
ISBN : 1461438047
Language : En, Es, Fr & De

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Book Description :

Phytochemicals Signal Transduction and Neurological Disorders Phytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases. Unlike vitamins and minerals, phytochemicals are not required for sustaining cell viability, but they play an important role in protecting tissues and cells from the harmful effects of oxidative stress and inflammation. Examples of phytochemicals include catechins, resveratrol, ginkgo biloba, curcumin, and sulfur compounds found in garlic. Although, the precise molecular mechanisms associated with beneficial effects of phytochemicals still remain the subject of intense investigations, but it is becoming increasingly evident that phytochemicals mediate their effects by counteracting, reducing, and repairing the damage caused by oxidative stress and neuroinflammation. In addition, phytochemicals also stimulate the synthesis of adaptive enzymes and proteins through the stimulation of a transcription factor called Nrf2 and induction of phase II detoxifying enzymes. Consumption of phytochemicals induces neurohormetic response that results in the expression of adaptive stress-resistance genes that are responsible for encoding antioxidant enzymes, protein chaperones, and neurotrophic factor (BDNF). Based on the stimulation of signal transduction network and adaptive stress-resistance genes, it is proposed that the use of phytochemicals from childhood to old age along with regular exercise is an important strategy for maintaining normal aging and delaying onset of age-related neurological disorders (stroke, Alzheimer disease, and Parkinson disease). Phytochemicals Signal Transduction and Neurological Disorders presents readers with cutting edge and comprehensive information not only on bioavailability, and mechanism of action of phytochemicals in the brain, but also provides the molecular mechanism associated with beneficial effects of phytochemicals in neurotraumatic (stroke, spinal cord trauma, and traumatic brain injury) and neurodegenerative (Alzheimers disease, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis) diseases.

Diet and Exercise in Cognitive Function and Neurological Diseases

Diet and Exercise in Cognitive Function and Neurological Diseases Book
Author : Akhlaq A. Farooqui,Tahira Farooqui
Publisher : John Wiley & Sons
Release : 2015-02-06
ISBN : 1118840569
Language : En, Es, Fr & De

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Book Description :

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Alzheimer s and Parkinson s Diseases

Alzheimer   s and Parkinson   s Diseases Book
Author : Israel Hanin,Mitsuo Yoshida,Abraham Fisher
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475791453
Language : En, Es, Fr & De

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Book Description :

This book represents the third in a series of International Conferences related to Alzheimer's (AD) and Parkinson's (PD) diseases. The first one took place in Eilat, Israel, in 1985; and the second one in Kyoto, Japan, in 1989. This book contains the full text of oral and poster presentations from the Third International Conference on Alzheimer's and Parkinson's Diseases: Recent Developments, held in Chicago, Illinois, U.S.A. on November 1-6, 1993. The Chicago Conference was attended by 270 participants. The Scientific Program was divided into nine oral sessions, a keynote presentation, and a poster session. The conference culminated in a Round Table Discussion involving all of the participants in the conference. The four and one-half day meeting served as an excellent medium for surveying the current status of clinical and preclinical developments in AD and PD. There were 59 oral presentations and 93 posters. This book incorporates a majority of both.