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Neurobiology Of Depression

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Neurobiology of Depression

Neurobiology of Depression Book
Author : Francisco Lopez-Munoz,Cecilio Alamo
Publisher : CRC Press
Release : 2011-09-09
ISBN : 143983850X
Language : En, Es, Fr & De

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Book Description :

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Behavioral Neurobiology of Depression and Its Treatment

Behavioral Neurobiology of Depression and Its Treatment Book
Author : Philip J. Cowen,Trevor Sharp,Jennifer Y . F. Lau
Publisher : Springer Science & Business Media
Release : 2014-04-24
ISBN : 3642354254
Language : En, Es, Fr & De

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Book Description :

The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

Neurobiology of Depression

Neurobiology of Depression Book
Author : Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Publisher : Academic Press
Release : 2019-01-03
ISBN : 0128133341
Language : En, Es, Fr & De

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Book Description :

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Systems Neuroscience in Depression

Systems Neuroscience in Depression Book
Author : Thomas Frodl
Publisher : Academic Press
Release : 2016-09-01
ISBN : 0128026286
Language : En, Es, Fr & De

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Book Description :

Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

Cingulate Neurobiology and Disease

Cingulate Neurobiology and Disease Book
Author : Brent Vogt
Publisher : Oxford University Press
Release : 2009-06-04
ISBN : 0198566964
Language : En, Es, Fr & De

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Book Description :

One of the major neuroscience publications of the past few years, Cingulate Neurobiology and Disease presents the definitive review of the cingulate cortex, explaining its critical role in a host of diseases and illnesses.

Major Depressive Disorder

Major Depressive Disorder Book
Author : Yong-Ku Kim
Publisher : BoD – Books on Demand
Release : 2015-06-11
ISBN : 9535121294
Language : En, Es, Fr & De

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Book Description :

Major depressive disorder (MDD) is a complex and heterogeneous disorder, phenotypically and biologically. MDD may be caused by complex interaction between genes and environment in susceptible individuals. Thus, a combination of certain genetic polymorphism, environmental stress, and personal susceptibility ultimately may induce MDD. Gene-environment interactions in the pathophysiology of MDD lead to advancement in personalized medicine by means of genotyping for inter-individual variability in drug action and metabolism. Gene-environment interactions may explain why some subjects become depressed while others remain unaffected. The aim of this book is to describe current knowledge of MDD from the point of view of neurobiology, molecular genetics and cognition. The authors address a deep understanding of cognitive and neurobiological mechanisms involved in MDD.

Towards the Neurobiology of Depression

Towards the Neurobiology of Depression Book
Author : Erich Seifritz
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Towards the Neurobiology of Depression book written by Erich Seifritz, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurobiology of Mental Illness

Neurobiology of Mental Illness Book
Author : Dennis S. Charney,Eric J. Nestler
Publisher : Oxford University Press
Release : 2005-07-21
ISBN : 0195189809
Language : En, Es, Fr & De

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Book Description :

The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

Neurobiology of Depression and Alzheimer s Disease

Neurobiology of Depression and Alzheimer s Disease Book
Author : Kanwaljit Chopra
Publisher : LAP Lambert Academic Publishing
Release : 2011-06
ISBN : 9783844315189
Language : En, Es, Fr & De

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Book Description :

Depression is one of the most prevalent and life- threatening forms of mental illnesses associated with significant disability and mortality. Stress can be considered as a major contribution for the development of depressive disorder due to dysregulation of HPA-axis. Although there are multiple pathways that are involved in the pathogenesis of depression, the current antidepressants mainly target monoaminergic pathway. However, therapeutic potential of other pathways is still under investigation. Drugs targeting nitric oxide, cytokines and kynurenine acid pathway might be the drugs of choice in near future. Alzheimer s disease is a neurodegenerative disorder with progressive dementia. Although basic research in Alzheimer s disease has made remarkable progress in past 2 decades, currently available drugs are able to improve cognitive symptoms temporarily, and no treatment can reverse, stop, or even slow this inexorable neurodegenerative process. This book dwells on the recently unravelled pathogenetic hypothesis and therapeutics of mental depression and Alzheimer s disease.

Ketamine for Treatment Resistant Depression

Ketamine for Treatment Resistant Depression Book
Author : Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
Publisher : Academic Press
Release : 2020-09-16
ISBN : 0128210346
Language : En, Es, Fr & De

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Book Description :

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

Neurobiology of Depression

Neurobiology of Depression Book
Author : Anonim
Publisher : Unknown
Release : 2022-05-27
ISBN : 9781591763598
Language : En, Es, Fr & De

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Book Description :

Whatever its cause, depression ultimately emerges from biochemical shifts in the brain that provoke aching sadness, loss of pleasure, guilt, thoughts of death, and other symptoms. The search for those neurological underpinnings is intensifying and raising the prospects for better therapies.

Depression in Neurologic Disorders

Depression in Neurologic Disorders Book
Author : Andres Kanner
Publisher : John Wiley & Sons
Release : 2012-06-21
ISBN : 1118348079
Language : En, Es, Fr & De

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Book Description :

The first part of the book begins with an overview of depression, its incidence and manifestations and neurobiological origins; how it's diagnosed; and its relevance to neurology, in particular to suicidality. The second part looks at depression in distinct conditions, in particular: migraine, stroke, epilepsy, Parkinson's Disease, Huntington's Disease, dementia, and traumatic brain injury. This useful guide takes a practical approach, with "tips and tricks" boxes, case studies, points of interest boxes, and take-home summaries.

Neurobiology of Mental Disorders

Neurobiology of Mental Disorders Book
Author : Marcus Lira Brandão
Publisher : Nova Publishers
Release : 2006
ISBN : 9781594549144
Language : En, Es, Fr & De

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Book Description :

In writing this book, the authors have emphasised current perspectives on the neurobiology of mental disorders, not attempting to provide an exhaustive coverage of the field. Each chapter of the book represents a synthesis of the subject's state of the art. The first and third chapters were written by one of the Editors (FGG) and the sixth by the other (MLB). Each of the remaining chapters was extensively revised by one the authors. The book is a single-volume overview on the neurobiology of mental disorders, and was written for a broad audience. The authors aimed at the generally educated reader, who enjoys science and is interested in becoming acquainted with the remarkable new discoveries about how the nervous system executes mental functions. For this reason, they have provided, inside text boxes, background knowledge on the most relevant topics of each field. The authors hope that students from many areas will find here a clear and readable introduction to the present topic.

Charney Nestler s Neurobiology of Mental Illness

Charney   Nestler s Neurobiology of Mental Illness Book
Author : Dennis S. Charney,Pamela B. Sklar
Publisher : Oxford University Press
Release : 2018-01-12
ISBN : 019068142X
Language : En, Es, Fr & De

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Book Description :

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Neurobiology of Addiction and Co Morbid Disorders

Neurobiology of Addiction and Co Morbid Disorders Book
Author : Anonim
Publisher : Academic Press
Release : 2021-03-01
ISBN : 0128203560
Language : En, Es, Fr & De

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Book Description :

Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series Updated release includes the latest information on the Neurobiology of Addiction and Co-Morbid Disorders

                         Book
Author : Anonim
Publisher : Unknown
Release : 1934
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Parkinson s Disease

Parkinson s Disease Book
Author : Steven J. Huber,Jeffrey L. Cummings
Publisher : Oxford University Press, USA
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Behavioral symptoms are an integral part of Parkinson's disease. In the past decade there has been an enormous amount of research on the nature of these disturbances, their underlying neural basis, and methods of assessment. This book provides an up-to-date review of neuropsychological deficits, depression, and treatment-related behavioral disorders associated with Parkinson's disease. Each section is a balanced presentation of both theoretical and practical issues. From a theoretical perspective, study of the neurobehavioral features of Parkinson's disease has contributed to our understanding of the subcortical structures and neurotransmitter systems related to human cognitive and emotional functions. From a practical perspective, behavioral symptoms represent a major treatment challenge. The advent of levodopa has created a population of older and more chronically disabled Parkinson patients, and has made it more imperative to understand the illness. Proper management of patients requires adequate methods for assessing behavioral changes, understanding the relationship of the behavior to the neurobiology of the disease, and being aware of therapeutic options.

Understanding Depression

Understanding Depression Book
Author : Yong-Ku Kim
Publisher : Springer
Release : 2018-01-02
ISBN : 9811065802
Language : En, Es, Fr & De

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Book Description :

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide Book
Author : Yogesh Dwivedi
Publisher : CRC Press
Release : 2012-06-25
ISBN : 1439838828
Language : En, Es, Fr & De

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Book Description :

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment

Towards a Neurobiology of Major Depression

Towards a Neurobiology of Major Depression Book
Author : Poul Videbech
Publisher : Unknown
Release : 2005
ISBN : 9788777881268
Language : En, Es, Fr & De

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Book Description :

Download Towards a Neurobiology of Major Depression book written by Poul Videbech, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.