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Neurobiology Of Depression

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Neurobiology of Depression

Neurobiology of Depression Book
Author : Francisco Lopez-Munoz,Cecilio Alamo
Publisher : CRC Press
Release : 2011-09-09
ISBN : 1439838496
Language : En, Es, Fr & De

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Book Description :

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Neurobiology of Depression

Neurobiology of Depression Book
Author : Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Publisher : Academic Press
Release : 2019-01-03
ISBN : 0128133341
Language : En, Es, Fr & De

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Book Description :

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Behavioral Neurobiology of Depression and Its Treatment

Behavioral Neurobiology of Depression and Its Treatment Book
Author : Philip J. Cowen,Trevor Sharp,Jennifer Y . F. Lau
Publisher : Springer Science & Business Media
Release : 2014-04-24
ISBN : 3642354254
Language : En, Es, Fr & De

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Book Description :

The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

Neurobiology of Depression

Neurobiology of Depression Book
Author : Anonim
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Neurobiology of Depression and Alzheimer s Disease

Neurobiology of Depression and Alzheimer s Disease Book
Author : Kanwaljit Chopra
Publisher : LAP Lambert Academic Publishing
Release : 2011-06
ISBN : 9783844315189
Language : En, Es, Fr & De

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Book Description :

Depression is one of the most prevalent and life- threatening forms of mental illnesses associated with significant disability and mortality. Stress can be considered as a major contribution for the development of depressive disorder due to dysregulation of HPA-axis. Although there are multiple pathways that are involved in the pathogenesis of depression, the current antidepressants mainly target monoaminergic pathway. However, therapeutic potential of other pathways is still under investigation. Drugs targeting nitric oxide, cytokines and kynurenine acid pathway might be the drugs of choice in near future. Alzheimer s disease is a neurodegenerative disorder with progressive dementia. Although basic research in Alzheimer s disease has made remarkable progress in past 2 decades, currently available drugs are able to improve cognitive symptoms temporarily, and no treatment can reverse, stop, or even slow this inexorable neurodegenerative process. This book dwells on the recently unravelled pathogenetic hypothesis and therapeutics of mental depression and Alzheimer s disease.

Towards the Neurobiology of Depression

Towards the Neurobiology of Depression Book
Author : Erich Seifritz
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Towards the Neurobiology of Depression book written by Erich Seifritz, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

                         Book
Author : Anonim
Publisher : Unknown
Release : 1934
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Neurobiology of Depression

Neurobiology of Depression Book
Author : Anonim
Publisher : Unknown
Release : 2021-09-21
ISBN : 9781591763598
Language : En, Es, Fr & De

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Book Description :

Whatever its cause, depression ultimately emerges from biochemical shifts in the brain that provoke aching sadness, loss of pleasure, guilt, thoughts of death, and other symptoms. The search for those neurological underpinnings is intensifying and raising the prospects for better therapies.

Systems Neuroscience in Depression

Systems Neuroscience in Depression Book
Author : Thomas Frodl
Publisher : Academic Press
Release : 2016-09-01
ISBN : 0128026286
Language : En, Es, Fr & De

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Book Description :

Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

Ketamine for Treatment Resistant Depression

Ketamine for Treatment Resistant Depression Book
Author : Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
Publisher : Academic Press
Release : 2020-10-15
ISBN : 0128210338
Language : En, Es, Fr & De

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Book Description :

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

The Neurobiology of Depression

The Neurobiology of Depression Book
Author : Laurent Descarries,Chawki Benkelfat,Paul R Albert
Publisher : Unknown
Release : 2013
ISBN : 9780854039982
Language : En, Es, Fr & De

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Book Description :

Download The Neurobiology of Depression book written by Laurent Descarries,Chawki Benkelfat,Paul R Albert, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Understanding Depression

Understanding Depression Book
Author : Yong-Ku Kim
Publisher : Springer
Release : 2018-01-02
ISBN : 9811065802
Language : En, Es, Fr & De

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Book Description :

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

Exercise and the neurobiology of depression

Exercise and the neurobiology of depression Book
Author : Andrea L. Dunn,Rod K. Dishman
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exercise and the neurobiology of depression book written by Andrea L. Dunn,Rod K. Dishman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder Book
Author : Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Publisher : Academic Press
Release : 2020-11-25
ISBN : 012819183X
Language : En, Es, Fr & De

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Book Description :

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Major Depressive Disorder

Major Depressive Disorder Book
Author : Yong-Ku Kim
Publisher : BoD – Books on Demand
Release : 2015-06-11
ISBN : 9535121294
Language : En, Es, Fr & De

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Book Description :

Major depressive disorder (MDD) is a complex and heterogeneous disorder, phenotypically and biologically. MDD may be caused by complex interaction between genes and environment in susceptible individuals. Thus, a combination of certain genetic polymorphism, environmental stress, and personal susceptibility ultimately may induce MDD. Gene-environment interactions in the pathophysiology of MDD lead to advancement in personalized medicine by means of genotyping for inter-individual variability in drug action and metabolism. Gene-environment interactions may explain why some subjects become depressed while others remain unaffected. The aim of this book is to describe current knowledge of MDD from the point of view of neurobiology, molecular genetics and cognition. The authors address a deep understanding of cognitive and neurobiological mechanisms involved in MDD.

Chromatin Remodeling in Transgenic Mouse Brain

Chromatin Remodeling in Transgenic Mouse Brain Book
Author : Yan Jiang
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chromatin Remodeling in Transgenic Mouse Brain book written by Yan Jiang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurobiology of Depression

Neurobiology of Depression Book
Author : Francisco Lopez-Munoz,Cecilio Alamo
Publisher : CRC Press
Release : 2011-09-09
ISBN : 143983850X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Pharmacotherapy of Depression

Pharmacotherapy of Depression Book
Author : Domenic A. Ciraulo,Richard Shader
Publisher : Humana Press
Release : 2011-04-07
ISBN : 9781607618904
Language : En, Es, Fr & De

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Book Description :

Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on dosing, indications, and metabolism. Augmentation strategies are reviewed, including the use of non-traditional agents. The chapters that follow next address the use of antidepressants in special populations, such as the elderly and depressed individuals with psychosis, bipolar disorder, substance abuse, and post traumatic stress disorder. The complex issues involving the diagnosis and treatment of depression during pregnancy is thoroughly reviewed in Chapter 8 and provides a synthesis of the scientific literature in the area, one that is noted for contradictory and controversial findings, as well as guidelines for prescribing. The next chapter then provides an overview of the treatment of depression in the pediatric population, highlighting clinical concerns such as suicide risk. The book concludes with two chapters at the interface of medicine and psychiatry in the treatment of mood disorders: managing depression in primary care settings and depression associated with medical illnesses. The outstanding clinician-scientists who have contributed to this volume are all leaders in their fields and represent a broad spectrum of renowned institutions. A timely contribution to the literature, The Pharmacotherapy of Depression, Second Edition, offers busy clinicians from many disciplines a strong scientific foundation that seamlessly transitions into practical recommendations for clinical practice. The result is another gold-standard guide to the safe and effective use of the latest antidepressant medications.

Bipolar Depression Molecular Neurobiology Clinical Diagnosis and Pharmacotherapy

Bipolar Depression  Molecular Neurobiology  Clinical Diagnosis  and Pharmacotherapy Book
Author : Carlos A. Zarate Jr.,Husseini K. Manji
Publisher : Springer
Release : 2017-01-28
ISBN : 3319316893
Language : En, Es, Fr & De

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Book Description :

This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allowing clinicians to distinguish between the various mood disorders. Further, they: review the course, outcome, and genetics of this highly heritable condition; offer a thorough overview of the neurobiology of the disorder, including what is known from neuroimaging work; delineate the treatment of bipolar depression in special populations such as children and pregnant women; address suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient’s symptoms and history; and cover acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments. This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.

Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders Book
Author : Thomas E. Schlaepfer,Charles B. Nemeroff
Publisher : Elsevier
Release : 2012
ISBN : 0444520023
Language : En, Es, Fr & De

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Book Description :

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain