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Neuroanatomy Of The Mouse

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Neuroanatomy of the Mouse

Neuroanatomy of the Mouse Book
Author : Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger
Publisher : Springer Nature
Release : 2020-02-28
ISBN : 3030198987
Language : En, Es, Fr & De

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Book Description :

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

The Mouse Nervous System

The Mouse Nervous System Book
Author : Charles Watson
Publisher : Academic Press
Release : 2012
ISBN : 0123694973
Language : En, Es, Fr & De

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Book Description :

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlasesA detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness

Confocal Ultramicroscopy

Confocal Ultramicroscopy Book
Author : Ludovico Silvestri
Publisher : Unknown
Release : 2013*
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Confocal Ultramicroscopy book written by Ludovico Silvestri, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuroanatomy of a Potential Mouse Model for Hemispatial Neglect

Neuroanatomy of a Potential Mouse Model for Hemispatial Neglect Book
Author : Josiah An
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Unilateral lesions in associative areas including medial agranular cortex (AGm), posterior parietal cortex (PPC), dorsocentral striatum (DCS), and thalamus in rats are known to result in hemispatial neglect. We hypothesized that these regions in mice may be similar to rats and might be used as a model to study hemispatial neglect. Cortico efferent projections from AGm to DCS and thalamus were first determined by placing an anterograde tracer in AGm and observing the resulting striatal and thalamic axonal terminal field labeling. Retrograde injections were made in DCS to confirm the results of anterograde tracing results and possibly determine additional projection from other areas of the brain. Axonal labeling for the anterograde study and cell body labeling for the retrograde study were examined at the areas of interest. For the anterograde study, DCS and lateral posterior thalamic nucleus were labeled intensely indicating that there is a strong projection from AGm to striatum and thalamus in mice. Labeling seen in AGm and thalamus in the retrograde study showed that DCS receives input from the cortex and thalamus as seen in rats, likely forming a cortical-striatal-thalamic network that may be important in directed attention. These findings suggest that mice likely have a similar cortico-striatal-thalamic network to that previously described as mediating directed attention in rats, and can possibly be used as a model for hemispatial neglect.

Characterization of Longitudinal Neuroanatomical Effects in a Mouse Model of Alzheimer s Disease Using Deformation based Morphometry

Characterization of Longitudinal Neuroanatomical Effects in a Mouse Model of Alzheimer s Disease Using Deformation based Morphometry Book
Author : Johathan C. Lau
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Characterization of Longitudinal Neuroanatomical Effects in a Mouse Model of Alzheimer s Disease Using Deformation based Morphometry book written by Johathan C. Lau, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Assessment of the Neuroanatomy and Neurochemistry GCPII Mouse Model with Magnetic Resonance Imaging and Spectroscopy

Assessment of the Neuroanatomy and Neurochemistry GCPII    Mouse Model with Magnetic Resonance Imaging and Spectroscopy Book
Author : Weiya Mu
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Assessment of the Neuroanatomy and Neurochemistry GCPII Mouse Model with Magnetic Resonance Imaging and Spectroscopy book written by Weiya Mu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research on MRM Template and Atlas Framework of Mouse Brains

Research on MRM Template and Atlas Framework of Mouse Brains Book
Author : Lan Lin
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research on MRM Template and Atlas Framework of Mouse Brains book written by Lan Lin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Mouse Urocortin 1 CRF Receptor Type 2 System

The Mouse Urocortin 1 CRF Receptor Type 2 System Book
Author : Adam Zachary Weitemier
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Mouse Urocortin 1 CRF Receptor Type 2 System book written by Adam Zachary Weitemier, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Locus Coeruleus

The Locus Coeruleus Book
Author : Jerry Lee Coursen
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Locus Coeruleus book written by Jerry Lee Coursen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Mouse Brain in Stereotaxic Coordinates

The Mouse Brain in Stereotaxic Coordinates Book
Author : Keith B. J. Franklin,George Paxinos
Publisher : Unknown
Release : 2008
ISBN : 9780123694607
Language : En, Es, Fr & De

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Book Description :

The Mouse Brain in Sterotaxic Coordinates is the most comprehensive and accurate atlas of the mouse brain. This complete revised and updated third edition features 100 coronal diagrams and accompanying photographic plates spaced at 120 Ãmu¨m intervals; 32 sagittal diagrams and accompanying photographic plates; new in this edition: 30 horizontal diagrams and accompanying photographic plates; photographic plates scanned directly from the microscopic slides and printed in full color; the most accurate and universally used sterotaxic coordinate system; and a DVD with all drawings in Adobe Acrobat PDF as well as EPS files.

Orienting Behaviours and Attentional Processes in the Mouse and Macaque

Orienting Behaviours and Attentional Processes in the Mouse and Macaque Book
Author : Michael Anthony Savage
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Orienting Behaviours and Attentional Processes in the Mouse and Macaque book written by Michael Anthony Savage, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Hippocampus Book

The Hippocampus Book Book
Author : Division of Neurophysiology Tim Bliss
Publisher : Oxford University Press
Release : 2007
ISBN : 9780195100273
Language : En, Es, Fr & De

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Book Description :

The hippocampus is one of a group of remarkable structures embedded within the brains medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. This volume offers an account of what the hippocampus does, and what happens when things go wrong.--[Source inconnue].

Chemoarchitectonic Atlas of the Mouse Brain

Chemoarchitectonic Atlas of the Mouse Brain Book
Author : Charles Watson,George Paxinos
Publisher : Academic Press
Release : 2010
ISBN : 9780123742384
Language : En, Es, Fr & De

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Book Description :

Until now researchers studying the mouse brain have been forced to consult the existing histochemical atlases of the rat brain & extrapolate from rat data, a strategy which is not very accurate & often unsuccessful. This atlas collects systematic images of the mouse brain stained with a range of key chemical markers.

Neuroanatomy for the XXIst Century

Neuroanatomy for the XXIst Century Book
Author : Kathleen S. Rockland,Javier DeFelipe
Publisher : Frontiers Media SA
Release : 2016-08-15
ISBN : 2889199169
Language : En, Es, Fr & De

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Book Description :

An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the newer techniques. A second goal is to showcase what has become the conspicuous interdisciplinary reach of the field: neuroanatomical standards and the close association of structure-function and underlying circuitry mechanisms are increasingly relevant to investigations in development, physiology, and disease. Another feature of this Research Topic is that it includes a breadth of cross-species contributions from investigators working with rodent, nonhuman primate, and human brains. This is important since most of our current knowledge of brain structure has been obtained from experimental animals. However, recent technical advances, coupled with researcher willingness to use the human tissue available, will undoubtedly lead to major advances in the near future regarding human brain mapping and connectomes. Thus, of particular interest will be the methods that can help to define general wiring principles in the brain, both structural and functional. Overall, the state of the field is: exciting.

Geometric Representation of Neuroanatomical Data Observed in Mouse Brain at Cellular and Gross Levels

Geometric Representation of Neuroanatomical Data Observed in Mouse Brain at Cellular and Gross Levels Book
Author : Wonryull Koh
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This dissertation studies two problems related to geometric representation of neuroanatomical data: (i) spatial representation and organization of individual neurons, and (ii) reconstruction of three-dimensional neuroanatomical regions from sparse two-dimensional drawings. This work has been motivated by nearby development of new technology, Knife-Edge Scanning Microscopy (KESM), that images a whole mouse brain at cellular level in less than a month. A method is introduced to represent neuronal data observed in the mammalian brain at the cellular level using geometric primitives and spatial indexing. A data representation scheme is defined that captures the geometry of individual neurons using traditional geometric primitives, points and cross-sectional areas along a trajectory. This representation captures inferred synapses as directed links between primitives and spatially indexes observed neurons based on the locations of their cell bodies. This method provides a set of rules for acquisition, representation, and indexing of KESMgenerated data. Neuroanatomical data observed at the gross level provides the underlying regional framework for neuronal circuits. Accumulated expert knowledge on neuroanatomical organization is usually given as a series of sparse two-dimensional contours. A data structure and an algorithm are described to reconstruct separating surfaces among multiple regions from these sparse cross-sectional contours. A topology graph is defined for each region that describes the topological skeleton of the region's boundary surface and that shows between which contours the surface patches should be generated. A graph-directed triangulation algorithm is provided to reconstruct surface patches between contours. This graph-directed triangulation algorithm combined together with a piecewise parametric curve fitting technique ensures that abutting or shared surface patches are precisely coincident. This method overcomes limitations in i) traditional surfaces-from-contours algorithms that assume binary, not multiple, regionalization of space, and in ii) few existing separating surfaces algorithms that assume conversion of input into a regular volumetric grid, which is not possible with sparse inter-planar resolution.

Acquisition and Mining of the Whole Mouse Brain Microstructure

Acquisition and Mining of the Whole Mouse Brain Microstructure Book
Author : Jae-Rock Kwon
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Charting out the complete brain microstructure of a mammalian species is a grand challenge. Recent advances in serial sectioning microscopy such as the Knife- Edge Scanning Microscopy (KESM), a high-throughput and high-resolution physical sectioning technique, have the potential to finally address this challenge. Nevertheless, there still are several obstacles remaining to be overcome. First, many of these serial sectioning microscopy methods are still experimental and are not fully automated. Second, even when the full raw data have been obtained, morphological reconstruction, visualization/editing, statistics gathering, connectivity inference, and network analysis remain tough problems due to the unprecedented amounts of data. I designed a general data acquisition and analysis framework to overcome these challenges with a focus on data from the C57BL/6 mouse brain. Since there has been no such complete microstructure data from any mammalian species, the sheer amount of data can overwhelm researchers. To address the problems, I constructed a general software framework for automated data acquisition and computational analysis of the KESM data, and conducted two scientific case studies to discuss how the mouse brain microstructure from the KESM can be utilized. I expect the data, tools, and studies resulting from this dissertation research to greatly contribute to computational neuroanatomy and computational neuroscience.

Comparative Anatomy and Histology

Comparative Anatomy and Histology Book
Author : Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine
Publisher : Academic Press
Release : 2017-06-01
ISBN : 9780128029008
Language : En, Es, Fr & De

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Book Description :

Comparative Anatomy and Histology: A Mouse, Rat, and Human Atlas, Second Edition is aimed at the new mouse investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse anatomy and histology using direct comparison to the human. The side by side comparison of mouse and human tissues highlight the unique biology of the mouse, which has great impact on the validation of mouse models of human disease. This second edition features added comprehensive tables of mouse background strains and lesions for quick comparison with normal anatomy. New imaging modalities (MRI, CT, microCT, Pet/CT, Bioluminescence) have been incorporated into every body system chapter. Offers the only comprehensive source for comparing human and mouse anatomy and histology through over 600 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their mutant mice Includes input from experts from both human and veterinary fields Takes readers through each organ system in a side-by-side comparative approach to anatomy and histology-human Netter anatomy images along with Netter-style mouse images Includes virtual microscope slides of both human and mouse histology from each body system

Computer Techniques in Neuroanatomy

Computer Techniques in Neuroanatomy Book
Author : J.J. Capowski
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468456911
Language : En, Es, Fr & De

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Book Description :

This book is the story of the marriage of a new techl}ology, computers, with an old problem, the study of neuroanatomical structures using the light microscope. It is aimed toward you, the neuroanatomist, who until now have used computers primarily for word processing but now wish to use them also to collect and analyze your laboratory data. Mter reading the book, you will be better equipped to use a computer system for data collection and analysis, to employ a programmer who might develop a system for you, or to evaluate the systems available in the marketplace. To start toward this goal, a glossary first presents commonly used terms in computer assisted neuroanatomy. This, on its own, will aid you as it merges the jargon of the two different fields. Then, Chapter 1 presents a historical review to describe the manual tasks involved in presenting and measuring anatomic structures. This review lays a base line of the tasks that were done before computers and the amount of skill and time needed to perform the tasks. In Chapters 2 and 3, you will find basic information about laboratory computers and programs to the depth required for you to use the machines easily and talk with some fluency to computer engineers, programmers, and salesmen. Chapters 4, 5, and 6 present the use of computers to reconstruct anatomic structures, i.e., to enter them into a computer memory, where they are later displayed and analyzed.