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Neural Stem Cells And Adult Neurogenesis

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Neural Stem Cells and Adult Neurogenesis

Neural Stem Cells and Adult Neurogenesis Book
Author : Arie S. Mobley
Publisher : Academic Press
Release : 2019-02-28
ISBN : 0128110155
Language : En, Es, Fr & De

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Book Description :

Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons’ contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format. Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research Details adult neurogenesis and its role in behavior, stroke and disease Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine Book
Author : Philippe Taupin
Publisher : Nova Publishers
Release : 2008
ISBN : 9781604564723
Language : En, Es, Fr & De

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Book Description :

The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, fetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises adult neurogenesis and neural stem cell research and therapy.

Adult Neurogenesis and Neural Stem Cells in Mammals

Adult Neurogenesis and Neural Stem Cells in Mammals Book
Author : Philippe Taupin
Publisher : Nova Publishers
Release : 2006
ISBN : 9781594548567
Language : En, Es, Fr & De

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Book Description :

This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.

Adult Neurogenesis

Adult Neurogenesis Book
Author : Gerd Kempermann
Publisher : Oxford University Press, USA
Release : 2006
ISBN : 9780195179712
Language : En, Es, Fr & De

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Book Description :

The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.

Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory

Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory Book
Author : Aaron R. Friedman,Daniela Kaufer
Publisher : Biota Publishing
Release : 2013-12-01
ISBN : 1615044779
Language : En, Es, Fr & De

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Book Description :

Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology—that all the neurons of the brain are made during early development—and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.

Neurogenesis in the Adult Brain I

Neurogenesis in the Adult Brain I Book
Author : Tatsunori Seki,Kazunobu Sawamoto,Jack M. Parent,Arturo Alvarez-Buylla
Publisher : Springer Science & Business Media
Release : 2011-06-15
ISBN : 9784431539339
Language : En, Es, Fr & De

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Book Description :

The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine Book
Author : Philippe Taupin
Publisher : Nova Biomedical Books
Release : 2008
ISBN : 9781616685782
Language : En, Es, Fr & De

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Book Description :

Download Stem Cells and Regenerative Medicine book written by Philippe Taupin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neural Stem Cells and Therapy

Neural Stem Cells and Therapy Book
Author : Tao Sun
Publisher : BoD – Books on Demand
Release : 2012-02-15
ISBN : 9533079584
Language : En, Es, Fr & De

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Book Description :

This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 9781604564723
Language : En, Es, Fr & De

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Book Description :

Download Stem Cells and Regenerative Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Adult neurogenesis twenty years later physiological function versus brain repair

Adult neurogenesis twenty years later  physiological function versus brain repair Book
Author : Paolo Peretto,Luca Bonfanti
Publisher : Frontiers Media SA
Release : 2015-05-01
ISBN : 2889194949
Language : En, Es, Fr & De

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Book Description :

The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.

Neural Stem Cells in Development Adulthood and Disease

Neural Stem Cells in Development  Adulthood and Disease Book
Author : H. Georg Kuhn,Amelia J. Eisch
Publisher : Springer
Release : 2014-11-22
ISBN : 1493919083
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others. Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Neural Stem Cells

Neural Stem Cells Book
Author : Luca Bonfanti
Publisher : BoD – Books on Demand
Release : 2013-04-24
ISBN : 9535110691
Language : En, Es, Fr & De

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Book Description :

Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans. On the other side, many problems arise when stem cells encounter the mature brain parenchyma, still hampering the development of efficacious therapeutic approaches with endogenous or exogenously-delivered neural stem cells. This book tries to make the point on these extremely promising, yet unresolved, issues.

Neural Stem Cells in Health and Disease

Neural Stem Cells in Health and Disease Book
Author : Ashok K Shetty
Publisher : World Scientific Publishing Company
Release : 2015-08-28
ISBN : 9814623199
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Stem Cells and Regenerative Medicine Embryonic and adult stem cells

Stem Cells and Regenerative Medicine  Embryonic and adult stem cells Book
Author : Philippe Taupin
Publisher : Nova Publishers
Release : 2008
ISBN : 9781604564730
Language : En, Es, Fr & De

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Book Description :

Annotation. The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, foetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises embryonic and adult stem cells.

Circadian Clocks in Neural Stem Cells and Their Modulation of Adult Neurogenesis Fate Commitment and Cell Death

Circadian Clocks in Neural Stem Cells and Their Modulation of Adult Neurogenesis  Fate Commitment  and Cell Death Book
Author : Astha Malik
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Adult neurogenesis creates new neurons and glial cells from stem cells in the human brain throughout life, and it is best understood in the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ). Recent studies have described possible interactions between the molecular mechanism of circadian clocks and the signaling pathways that regulate stem cell differentiation. Circadian rhythms have been identified in the olfactory bulb and the hippocampus, but the role of any endogenous circadian oscillator cells in neurogenesis and their importance in learning and memory remains unclear. Circadian rhythms have not been examined well in neural stem cells and progenitor cells that produce new neurons and glial cells during adult neurogenesis. To evaluate circadian timing abilities of cells undergoing neural differentiation, neurospheres were prepared from mPer1::luc mouse SVZ and DG. Circadian bioluminescence rhythms were recorded in neurospheres maintained in culture medium that induces neurogenesis but not in one that maintains the stem cell state. Cell types were also characterized by confocal immunofluorescence microscopy at early and late developmental stages in vitro. Evidence was provided that neural stem progenitor cells (NSPCs) derived from the SVZ and DG of adult mice are self-sufficient clock cells capable of producing a circadian rhythm without input from known circadian pacemakers of the organism. Extremely rare percentages of mature neuronal cells were observed during ontogeny of rhythms. The bulk of the neurosphere cells were undifferentiated, indicating that they are the circadian clock cells producing timing signals. This conclusion was supported by immunocytochemistry for mPER1 protein that was localized to the inner, more stem cell-like neurosphere core. To further test whether circadian clocks in NSPCs are necessary for growth, differentiation and cell survival, neurospheres were cultured from Bmal1-/- and Cry1-/-,2-/- knockout mice. Neurosheres from Bmal1-/- knockout mice displayed unusually high differentiation into glia rather than neurons according to GFAP and NeuN expression, respectively, and very few DCX and BetaIII tubulin-positive, immature neurons were observed. The knockout neurospheres also had areas visibly devoid of cells and overall higher cell death. Neurospheres from mice lacking Cry1 and Cry2 showed significantly reduced growth. Altered NSPC proliferation and differentiation in these mice may impede memory formation and could provide a way to identify circadian timing effects in neurodegenerative disorders and impaired brain functions.

Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain

Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain Book
Author : Sara Gil-Perotín,Arturo Alvarez-Buylla,Jose Manuel Garcia-Verdugo
Publisher : Springer Science & Business Media
Release : 2009-04-21
ISBN : 9783540887195
Language : En, Es, Fr & De

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Book Description :

Adult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. In the last century however, new discoveries have demonstrated the real existence of proliferation in the adult brain, and in the last decade, these studies led to the identification of neural stem cells in mammals. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons. Newly formed neurons terminally differentiate into mature neurons in the olfactory bulb and the dentate gyrus of the hippocampus. Since then, a number of new research lines have emerged whose common objective is the phenotypical and molecular characterization of brain stem cells. As a result, new therapies are successfully being applied to animal models for certain neurodegenerative diseases or stroke. At present, and in years to come, this finding extends to the adult human brain, and gives reason and hope to all the previous studies.

Stem Cells in the Nervous System Functional and Clinical Implications

Stem Cells in the Nervous System  Functional and Clinical Implications Book
Author : Fred H. Gage,Anders Björklund,Alain Prochiantz
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642188834
Language : En, Es, Fr & De

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Book Description :

After 40 years of research, scientists have confirmed that persistent neurogenesis occurs in the adult mammalian brain. The obvious next question is: "Are the newly generated neurons functional?" If so, "What are the functions of these new neurons?" This volume intends to clarify both questions by providing the latest data available.

Neural Stem Cells and Cellular Therapy

Neural Stem Cells and Cellular Therapy Book
Author : Philippe Taupin
Publisher : Nova Biomedical
Release : 2010
ISBN : 9781608760176
Language : En, Es, Fr & De

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Book Description :

Over the past-decade or so, studies have revealed and confirmed that new nerve cells are generated in the adult brain of mammals, including humans. These new nerve cells originate from cells, referred as neural stem cells. Neural stem cells have the capacity to generate nerve cells and repair the brain. Hence, contrary to a long-held dogma, neural stem cells reside in the adult brain and therefore the adult brain has the capacity of, and may be amenable to, repair. Adult neurogenesis and neural stem cells offer new avenues and opportunities for the treatment and cure of a broad range of neurological diseases, disorders and injuries. Neural stem cells and cellular therapy aims at providing an overview and in depth analysis of recent developments in neuralstem cell research and therapy. This book is composed of recently published review articles that went through the peer-review process.

Identity and Functional Significance of Adult Neural Stem Cells

Identity and Functional Significance of Adult Neural Stem Cells Book
Author : Anna Denise Resurreccion Garcia
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Identity and Functional Significance of Adult Neural Stem Cells book written by Anna Denise Resurreccion Garcia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

50th Anniversary of Adult Neurogenesis Olfaction Hippocampus and beyond

50th Anniversary of Adult Neurogenesis  Olfaction  Hippocampus and beyond Book
Author : Alino Martinez-Marcos,José L.Trejo,Laura López-Mascaraque
Publisher : Frontiers Media SA
Release : 2016-09-21
ISBN : 2889199630
Language : En, Es, Fr & De

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Book Description :

In the mid-sixties, the discovery by Altman and co-workers of neurogenesis in the adult brain changed the previous conception of the immutability of this organ during adulthood sustained among others by Cajal. This discovery was ignored up to eighty’s when Nottebohm demonstrated neurogenesis in birds. Subsequently, two main neurogenic zones were characterized: the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus. Half century later, the exact role of new neurons in the adult brain is not completely understand. This book is composed by a number of articles by leaders in the filed covering from an historic perspective to potential therapeutic opportunities.