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Netosis

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NETosis At the Intersection of Cell Biology Microbiology and Immunology

NETosis  At the Intersection of Cell Biology  Microbiology  and Immunology Book
Author : Mariana J. Kaplan,Marko Radic
Publisher : Frontiers E-books
Release : 2013-08-08
ISBN : 2889191583
Language : En, Es, Fr & De

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Book Description :

NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflammatory stimuli induce NETosis and the release of NETs requires enzyme activities. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases. NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. While the benefit of NETs in an infection appears clear, NETs also figure prominently at the center of various pathologic states. Therefore, it is important for NETs to be efficiently cleared; else digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions. Recent studies identified aberrant NET synthesis and/or clearance in inflammatory/autoimmune conditions such as systemic lupus erythematosus (SLE), psoriasis, ANCA-positive vasculitis, gout and Felty’s syndrome. In the case of SLE, for example, it appears that LL-37 exposed in the NETs may be a significant trigger of type I Interferon responses in this disease. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we approach the 10-year-anniversary of the initial discovery of NETosis, it is useful and timely to review the so far identified mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their putative importance as inducers of autoimmune responses. We look forward to a rich and rigorous discussion of these and related issues that benefit from interdisciplinary approaches, collaborations and exciting discoveries.

NETosis

NETosis Book
Author : Geeta Rai
Publisher : Academic Press
Release : 2019-09-15
ISBN : 9780128161470
Language : En, Es, Fr & De

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Book Description :

NETosis: Immunity, Pathogenesis and Therapeutic Drug Development takes a focused approach to the clinical aspects of NETosis and drug development, bringing critical findings. Chapters introduce NETosis, consider mechanisms and antimicrobial strategies regulating NETosis, examine NETosis in neonates, explore the role of NETosis in autoimmunity, delve into NETosis and other diseases, and present therapeutic approaches for dysregulated NETosis. Since Brinkamm, et al, discovered an unrecognized neutrophil anti-microbial mechanism responsible for the extracellular killing of invading pathogens in 2004, the novel process in which nuclear chromatin de-condenses and DNA is ejected into the extra cellular environment, trapping and inactivating tissue pathogens has rapidly evolved. Presents an up-to-date and detailed analysis of NETosis Brings together critical findings on NETosis as a comparatively novel immune mechanism Focuses on the clinical aspects of NETosis that lead to drug development Covers the topic with a cogency and passion that is based on years of scientific research

Neutrophil Functions in Host Immunity Inflammation and Tissue Repair

Neutrophil Functions in Host Immunity  Inflammation and Tissue Repair Book
Author : Felix Ellett,Philip Michael Elks,Sonja Vermeren
Publisher : Frontiers Media SA
Release : 2022-01-19
ISBN : 2889740927
Language : En, Es, Fr & De

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Book Description :

Download Neutrophil Functions in Host Immunity Inflammation and Tissue Repair book written by Felix Ellett,Philip Michael Elks,Sonja Vermeren, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Damage Associated Molecular Patterns in Human Diseases

Damage Associated Molecular Patterns in Human Diseases Book
Author : Walter Gottlieb Land
Publisher : Springer
Release : 2018-10-09
ISBN : 3319786555
Language : En, Es, Fr & De

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Book Description :

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

NLRP3 Inflammasome Regulatory Mechanisms Role in Health and Disease and Therapeutic Potential

NLRP3 Inflammasome  Regulatory Mechanisms  Role in Health and Disease and Therapeutic Potential Book
Author : Kuo-Feng Hua,Oleg Chernikov,Ann Chen,Jong-Seok Moon
Publisher : Frontiers Media SA
Release : 2021-11-08
ISBN : 2889716023
Language : En, Es, Fr & De

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Book Description :

Download NLRP3 Inflammasome Regulatory Mechanisms Role in Health and Disease and Therapeutic Potential book written by Kuo-Feng Hua,Oleg Chernikov,Ann Chen,Jong-Seok Moon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Skin Autoimmunity

Skin Autoimmunity Book
Author : Ralf J. Ludwig,Katja Bieber,Christian David Sadik,Michael P. Schön,Gang Wang,Karin Loser
Publisher : Frontiers Media SA
Release : 2021-05-25
ISBN : 2889668096
Language : En, Es, Fr & De

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Book Description :

Download Skin Autoimmunity book written by Ralf J. Ludwig,Katja Bieber,Christian David Sadik,Michael P. Schön,Gang Wang,Karin Loser, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bacterial Virulence

Bacterial Virulence Book
Author : Philippe Sansonetti
Publisher : John Wiley & Sons
Release : 2010-04-05
ISBN : 3527323260
Language : En, Es, Fr & De

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Book Description :

Starting with basic principles, this reference and handbook discusses examples of the most advanced models of bacterial infection with regard to their value as paradigms to understand the molecular cross-talks between microbes and their host and tissue targets. It adopts a very forward-looking, advanced approach, placing special emphasis on the main global challenges facing scientists today, such as pathogenicity vs. commensalisms, infections in immunocompromised hosts and species specificity issues.

Gram Positive Pathogens

Gram Positive Pathogens Book
Author : Vincent A. Fischetti,Richard P. Novick,Joseph J. Ferretti,Daniel A. Portnoy,Mirian Braunstein,Julian I. Rood
Publisher : John Wiley & Sons
Release : 2019-10-01
ISBN : 1683672879
Language : En, Es, Fr & De

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Book Description :

Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease. “This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge.” - William R. Jacobs, Jr., PhD, Professor Microbiology & Immunology, Albert Einstein College of Medicine

Recent Progresses in Amebiasis

Recent Progresses in Amebiasis Book
Author : Anjan Debnath,Mario Alberto Rodriguez,Serge Ankri
Publisher : Frontiers Media SA
Release : 2019-10-14
ISBN : 2889630064
Language : En, Es, Fr & De

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Book Description :

Amebiasis, a parasitic disease transmitted by the unicellular protozoan parasite Entamoeba histolytica, is the cause of at least 100,000 deaths each year. The disease is mostly prevalent in developing countries and is one of the three common causes of death from parasitic diseases. The parasite has two stages in its life cycle in the host: the infective cyst and the invasive trophozoite. In the large intestine, the parasite feeds on bacteria and on cellular debris. No vaccine against amebiasis currently exists. Although metronidazole is the drug of choice for treating amebiasis, adverse effects in patients and potential resistance to metronidazole in other protozoa exist. About nine out of 10 people who are infected with E. histolytica are asymptomatic and in those individuals who develop symptoms, bloody diarrhea (amebic colitis) and liver abscess are the most common symptoms. One possible explanation for this observation is the difference in the gut microbiota between individuals that may significantly influence the host’s immune response in amebiasis and E. histolytica's virulence. Amebiasis is characterized by acute inflammation of the intestine with release of pro-inflammatory cytokines, reactive oxygen species and reactive nitrogen species from activated cells of the host's immune system. In recent years, significant advances on the cell biology of Entamoeba infection have been achieved through the development of new genetic tools to manipulate gene expression in the parasite and through the application of Omics tools. In this Research Topic, we welcome high quality original research articles, as well as review, opinion or method articles, on amebiasis including but not limited to the regulation of gene expression, cell biology and signaling, adaptation and resistance to environmental stresses, metabolism, pathogenesis and immunity, pathogenesis and microbiome, drug discovery and drug resistance.

Role of Neutrophils in Disease Pathogenesis

Role of Neutrophils in Disease Pathogenesis Book
Author : Maitham Khajah
Publisher : BoD – Books on Demand
Release : 2017-06-07
ISBN : 9535131958
Language : En, Es, Fr & De

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Book Description :

This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.

Autophagy Networks in Inflammation

Autophagy Networks in Inflammation Book
Author : Maria Chiara Maiuri,Daniela De Stefano
Publisher : Springer
Release : 2016-08-17
ISBN : 3319300792
Language : En, Es, Fr & De

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Book Description :

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Apoptosis and Beyond

Apoptosis and Beyond Book
Author : James A. Radosevich
Publisher : John Wiley & Sons
Release : 2018-09-18
ISBN : 1119432359
Language : En, Es, Fr & De

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Book Description :

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Apoptosis and Beyond 2 Volume Set

Apoptosis and Beyond  2 Volume Set Book
Author : James A. Radosevich
Publisher : Wiley-Blackwell
Release : 2018-12-18
ISBN : 1119432421
Language : En, Es, Fr & De

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Book Description :

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Advanced Trauma and Surgery

Advanced Trauma and Surgery Book
Author : Xiaobing Fu,Liangming Liu
Publisher : Springer
Release : 2016-11-15
ISBN : 9811024251
Language : En, Es, Fr & De

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Book Description :

This book discusses different aspects of trauma surgery, ranging from the various types of trauma and their management, infection, sepsis and inflammation to tissue injury and repair in trauma. It discusses cellular, molecular and genetic research findings and their role in pathogenesis in trauma and injury. In addition, it highlights the translational application of advanced theories and technologies in the management of trauma patients. This book is a valuable resource for anyone involved in the management of severe trauma damage to tissues wanting to reduce early mortality and improve patients' quality of life.

Neutrophil Communication

Neutrophil Communication Book
Author : Christian Jan Lood,Rohit Jain,Marco A. Cassatella,Jason S. Knight
Publisher : Frontiers Media SA
Release : 2020-06-29
ISBN : 2889638103
Language : En, Es, Fr & De

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Book Description :

Download Neutrophil Communication book written by Christian Jan Lood,Rohit Jain,Marco A. Cassatella,Jason S. Knight, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Inflammation Fundamental Mechanisms

Inflammation  Fundamental Mechanisms Book
Author : Ley Klaus
Publisher : World Scientific
Release : 2018-03-13
ISBN : 9813109459
Language : En, Es, Fr & De

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Book Description :

Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation. Contents: TNF Superfamily in Inflammation (Marisol Veny, Richard Virgen-Slane and Carl F Ware) Complement as a Mediator of Inflammation (B Paul Morgan) Lipids and Inflammation (Valerie B O'Donnell, Robert C Murphy and Garret A FitzGerald) Reactive Oxygen Species (Ulla G Knaus) Leukocyte Adhesion (Klaus Ley and Zhichao Fan) Neutrophil Extracellular Traps (Tobias A Fuchs, Abdul Hakkim and Constantin F Urban) Sepsis (Jamison J Grailer, Matthew J Delano and Peter A Ward) Granulomatous Inflammation (Marc Hilhorst, Gene Hunder, Jörg Goronzy and Cornelia Weyand) Readership: Graduate students, medical doctors/ practitioners, researchers, pathologists and nutritionists in medicine and healthcare. Keywords: Cytokines;IL-1;TNF;Lipid Mediators;Bradykinin and Neuropeptides;Leukocyte Adhesion;Angiogenesis;Degranulation;Antimicrobial Peptides;Neutrophil Extracellular Traps (NETs);Pharmacologic Modulation of Inflammation;Sepsis;Complement;Oxygen Radicals;Reperfusion Injury;Resolution of Inflammation;Atherosclerosis;Granulomatous Inflammation;Inflammatory Bowel DiseaseReview: Key Features: Up-to-date resource Comprehensive review of the various facets of inflammation

Immunity to Fungal Infections Insights from the Innate Immune Recognition and Antifungal Effector Mechanisms

Immunity to Fungal Infections  Insights from the Innate Immune Recognition and Antifungal Effector Mechanisms Book
Author : Rodrigo Tinoco Figueiredo,Allan J. Guimaraes,David L. Moyes
Publisher : Frontiers Media SA
Release : 2021-09-15
ISBN : 2889713253
Language : En, Es, Fr & De

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Book Description :

Download Immunity to Fungal Infections Insights from the Innate Immune Recognition and Antifungal Effector Mechanisms book written by Rodrigo Tinoco Figueiredo,Allan J. Guimaraes,David L. Moyes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology Book
Author : Nancy Guillen
Publisher : Springer Nature
Release : 2020-06-01
ISBN : 3030448266
Language : En, Es, Fr & De

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Book Description :

Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.

Role of Neutrophils in Inflammatory Diseases

Role of Neutrophils in Inflammatory Diseases Book
Author : Laurent Reber,Thomas Marichal,Onur Boyman
Publisher : Frontiers Media SA
Release : 2021-01-20
ISBN : 2889664090
Language : En, Es, Fr & De

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Book Description :

Download Role of Neutrophils in Inflammatory Diseases book written by Laurent Reber,Thomas Marichal,Onur Boyman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Concise Guide to Hematology

Concise Guide to Hematology Book
Author : Hillard M. Lazarus,Alvin H. Schmaier
Publisher : Springer
Release : 2018-11-15
ISBN : 331997873X
Language : En, Es, Fr & De

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Book Description :

This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.