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Drug Delivery to the Central Nervous System

Drug Delivery to the Central Nervous System Book
Author : Kewal K. Jain
Publisher : Humana
Release : 2016-08-23
ISBN : 9781493961597
Language : En, Es, Fr & De

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Book Description :

Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.

Nanomedicines for Brain Drug Delivery

Nanomedicines for Brain Drug Delivery Book
Author : Javier O. Morales,Pieter J. Gaillard
Publisher : Humana
Release : 2020-11-20
ISBN : 9781071608371
Language : En, Es, Fr & De

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Book Description :

This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Thorough and cutting-edge, Nanomedicines for Brain Drug Delivery is a valuable resource that will help researchers guide and advance the field of nanomedicines for the brain and nervous system.

Drug Delivery to the Brain

Drug Delivery to the Brain Book
Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publisher : Springer Science & Business Media
Release : 2013-12-03
ISBN : 1461491053
Language : En, Es, Fr & De

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Book Description :

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Nervous System Drug Delivery

Nervous System Drug Delivery Book
Author : Russell R. Lonser,Malisa Sarntinoranont,Kristof Bankiewicz
Publisher : Academic Press
Release : 2019-06-25
ISBN : 0128139986
Language : En, Es, Fr & De

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Book Description :

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques. Offers an up-to-date, comprehensive resource on drug delivery to the nervous system Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application) Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry

The Nasal Pathway for Drug Delivery to the Central Nervous System

The Nasal Pathway for Drug Delivery to the Central Nervous System Book
Author : Robert G. Thorne
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Nasal Pathway for Drug Delivery to the Central Nervous System book written by Robert G. Thorne, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug and Gene Delivery to the Central Nervous System for Neuroprotection

Drug and Gene Delivery to the Central Nervous System for Neuroprotection Book
Author : Hari S. Sharma,Dafin F. Muresanu,Aruna Sharma
Publisher : Springer
Release : 2017-06-05
ISBN : 3319576968
Language : En, Es, Fr & De

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Book Description :

This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease

Drug Delivery in Central Nervous System Diseases

Drug Delivery in Central Nervous System Diseases Book
Author : Kewal K. Jain
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug Delivery in Central Nervous System Diseases book written by Kewal K. Jain, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Delivery in Central Nervous System Disorders

Drug Delivery in Central Nervous System Disorders Book
Author : Bioportfolio
Publisher : Unknown
Release : 2008
ISBN : 9780000510013
Language : En, Es, Fr & De

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Book Description :

Download Drug Delivery in Central Nervous System Disorders book written by Bioportfolio, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Peptide Transport and Delivery into the Central Nervous System

Peptide Transport and Delivery into the Central Nervous System Book
Author : Laszlo Prokai,Katalin Prokai-Tatrai
Publisher : Birkhäuser
Release : 2012-12-06
ISBN : 3034880499
Language : En, Es, Fr & De

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Book Description :

Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.

New Advances in Drug Delivery to the Central Nervous System

New Advances in Drug Delivery to the Central Nervous System Book
Author : Timothy Tankosic
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Advances in Drug Delivery to the Central Nervous System book written by Timothy Tankosic, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Liposomal Drug Delivery to the Central Nervous System

Liposomal Drug Delivery to the Central Nervous System Book
Author : Rita Nieto Montesinos
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Central nervous system diseases represent a huge world of burden of human suffering with negative economic results. Most therapeutic compounds cannot attain the brain because of the blood-brain barrier and its expression of efflux transporters. Among them, the P-glycoprotein plays a significant role leading to failure of various clinical treatments. A non-invasive strategy to circumvent the blood-brain barrier and P-glycoprotein emphasizes on the encapsulation and therefore masking of therapeutic compounds in drug delivery systems. Up to now, liposomes are the most widely studied drug delivery systems due to their biocompatibility, biodegradability, and less toxicity. The incorporation of polyethylene glycol-lipid derivatives within the bilayer of conventional liposomes significantly prolongs liposomal cargo half-life by steric stabilization. Interestingly, an increased brain accumulation of liposomal cargo is achieved by coupling targeting moieties on liposomes surface. These targeting moieties such as peptides or monoclonal antibodies recognize the biochemical transport systems at the blood-brain barrier and mediate the transport of liposomes and their cargo across this barrier. Moreover, stimuli-sensitive liposomes are programmed for cargo release when exposed to a particular microenvironment. Hence, this chapter highlights the potential liposomal applications for delivery of therapeutic compounds as well as diagnostic tools or both, in major central nervous system diseases.

The Blood brain Barrier and Drug Delivery to the Cns

The Blood brain Barrier and Drug Delivery to the Cns Book
Author : Michael Bradbury,Jorg Kreuter,David Begley
Publisher : CRC Press
Release : 2019-08-30
ISBN : 9780367398668
Language : En, Es, Fr & De

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Book Description :

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery Book
Author : Li Di,Edward H. Kerns
Publisher : John Wiley & Sons
Release : 2015-02-02
ISBN : 1118788354
Language : En, Es, Fr & De

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Book Description :

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Drug Delivery to Central Nervous System CNS

Drug Delivery to Central Nervous System  CNS  Book
Author : Luca Badiali
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug Delivery to Central Nervous System CNS book written by Luca Badiali, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Delivery to the Brain

Drug Delivery to the Brain Book
Author : Margareta Hammarlund-Udenaes,Elizabeth de Lange,Robert G. Thorne
Publisher : Springer
Release : 2013-12-17
ISBN : 9781461491040
Language : En, Es, Fr & De

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Book Description :

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders Book
Author : Jun Chen,Jian Wang,Ling Wei,John H. Zhang
Publisher : Springer
Release : 2019-07-29
ISBN : 3030167151
Language : En, Es, Fr & De

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Book Description :

The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer's, Parkinson's, and others.​

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems Book
Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Release : 2018-09-20
ISBN : 012814002X
Language : En, Es, Fr & De

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Book Description :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery Book
Author : Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais
Publisher : CRC Press
Release : 2021-03-16
ISBN : 1000245632
Language : En, Es, Fr & De

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Book Description :

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

The Blood Brain Barrier and Drug Delivery to the CNS

The Blood Brain Barrier and Drug Delivery to the CNS Book
Author : Michael Bradbury,David Begley,Jorg Kreuter
Publisher : CRC Press
Release : 2000-05-16
ISBN : 9780824703943
Language : En, Es, Fr & De

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Book Description :

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

Teaching an Old Drug New Tricks

Teaching an Old Drug New Tricks Book
Author : Zachary Nielson Warnken
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A major barrier to the treatment of central nervous system delivery is the ability to target drug delivery to the brain. The brain is protected by the blood-brain barrier, making it difficult for both small and especially large molecule drugs to reach their sight of action. With recent advancements in high throughput screening, some already marketed drugs have been found to be active in treating central nervous system diseases such as glioblastoma multiforme (GBM), however, some of these drugs are insufficient in their current forms to reach the brain and treat the disease. Nasal drug delivery is a promising route of delivery for treating central nervous system disease as it has shown the ability to directly transport drugs to the brain, bypassing the blood-brain barrier. Critical aspects to using nasal drug delivery to treat central nervous system diseases are the ability to target the formulation to specific sites in the nasal cavity as well as the ability of formulations to drive transport to the brain. In addition to nasal drug delivery, some drugs can benefit from improvements in bioavailability orally to increase brain exposure. Amorphous solid dispersions are a technique widely used to improve the bioavailability of the poorly-water soluble drugs however they are limited in their use for highly lipophilic drugs due to drug loading limitations. This research focuses on better understanding nasal drug delivery to leverage ways to better target sites in the nasal cavity. In addition to this targeting research, research that supports the in vitro tests for analyzing and assessing nasal drug delivery devices has been performed. Personalized nasal drug delivery in 3D-printed casts is shown to be a superior method for targeting a particular region of the nasal cavity due to the variation in individual’s nasal geometry. A large focus of the research has been to repurpose atovaquone for the treatment of glioblastoma. This research provides evidence of the benefits a new formulation strategy which incorporates a spontaneously emulsifying component into the classical amorphous solid dispersion to overcome its limitations with the highly lipophilic nature of atovaquone. The improved formulation alongside results showing activity of atovaquone against GBM present a promising repurposing strategy for atovaquone to be used in the treatment of GBM