Skip to main content

Natural Products And Drug Discovery

In Order to Read Online or Download Natural Products And Drug Discovery Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Natural Products and Drug Discovery Set

Natural Products and Drug Discovery Set Book
Author : Anonim
Publisher : RSC Publishing
Release : 2014-02-01
ISBN : 9781782620945
Language : En, Es, Fr & De

GET BOOK

Book Description :

Naturally occurring compounds, or natural products, continue to be an important source of commercially successful products and leads in the pharmaceutical, agrochemical and nutritional sectors. This set of books, aimed at medicinal chemists in academia and industry, provides an authoritative reference on natural product chemistry related to drug discovery. Readers will find a broad range of important topics covered in this set from natural product biosynthesis and extraction to their use in pharmaceutical and other industries. The science of their application in both western medicine and traditional Chinese medicine, which is currently poorly understood in the west, is comprehensively covered. This set includes: Drug Discovery from Natural Products Edited by Olga Genilloud and Francisca Vicente (978-1-84973-361-8, 2012, RSC Drug Discovery) Natural Product Extraction: Principles and Applications Edited by Mauricio A Rostagno and Juliana M Prado (978-1-84973-606-0, 2013, RSC Green Chemistry) Natural Product Chemistry for Drug Discovery Edited by Stephen Neidle, Antony D Buss and Mark S Butler (978-0-85404-193-0, 2009, RSC Biomolecular Sciences) Functional Molecules from Natural Sources Edited by Stephen K Wrigley, Robert Thomas, Neville Nicholson and Colin Bedford (978-1-84755-259-4, 2010) Traditional Chinese Medicine: Scientific Basis for Its Use Edited by James D Adams and Eric J Lien (978-1-84973-661-9, 2013, RSC Drug Discovery)

The Role of Natural Products in Drug Discovery

The Role of Natural Products in Drug Discovery Book
Author : J. Mulzer,R. Bohlmann
Publisher : Springer
Release : 2000-09-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Natural Products in Medicinal Chemistry

Natural Products in Medicinal Chemistry Book
Author : Stephen Hanessian
Publisher : John Wiley & Sons
Release : 2013-12-18
ISBN : 3527676562
Language : En, Es, Fr & De

GET BOOK

Book Description :

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

The Changing Role of Natural Products in Drug Discovery

The Changing Role of Natural Products in Drug Discovery Book
Author : Peter Norman
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Natural products remain an underexploited resource despite their historical success in providing valuable drugs. They offer access to novel areas of biologically relevant chemical space, and may help address the industry's innovation challenge.

Chemistry for Pharmacy Students

Chemistry for Pharmacy Students Book
Author : Lutfun Nahar,Professor Satyajit D. Sarker
Publisher : John Wiley & Sons
Release : 2019-08-26
ISBN : 1119394430
Language : En, Es, Fr & De

GET BOOK

Book Description :

Introduces the key areas of chemistry required for all pharmacy degree courses and focuses on the properties and actions of drug molecules This new edition provides a clear and comprehensive overview of the various areas of general, organic, and natural products chemistry (in relation to drug molecules). Structured to enhance student understanding, it places great emphasis on the applications of key theoretical aspects of chemistry required by all pharmacy and pharmaceutical science students. This second edition particularly caters for the chemistry requirements in any ‘Integrated Pharmacy Curricula’, where science in general is meant to be taught ‘not in isolation’, but together with, and as a part of, other practice and clinical elements of the course. Chemistry for Pharmacy Students: General, Organic and Natural Product Chemistry, 2nd Edition is divided into eight chapters. It opens with an overview of the general aspects of chemistry and their importance to modern life, with emphasis on medicinal applications. The text then moves on to discuss the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy in relation to drug action and toxicity. Various aspects of organic functional groups, organic reactions, heterocyclic chemistry, nucleic acids and their pharmaceutical importance are then covered in subsequent chapters, with the final chapter dealing with drug discovery and development, and natural product chemistry. Provides a student-friendly introduction to the main areas of chemistry required by pharmacy degree courses Written at a level suitable for non-chemistry students in pharmacy, but also relevant to those in life sciences, food science, and the health sciences Includes learning objectives at the beginning of each chapter Focuses on the physical properties and actions of drug molecules Chemistry for Pharmacy Students: General, Organic and Natural Product Chemistry, 2nd Edition is an essential book for pharmacy undergraduate students, and a helpful resource for those studying other subject areas within pharmaceutical sciences, biomedical sciences, cosmetic science, food sciences, and health and life sciences.

Bioassay Methods in Natural Product Research and Drug Development

Bioassay Methods in Natural Product Research and Drug Development Book
Author : Lars Bohlin,Jan G. Bruhn
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401148104
Language : En, Es, Fr & De

GET BOOK

Book Description :

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Natural Products in Drug Discovery Development II

Natural Products in Drug Discovery   Development II Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Natural Products in Drug Discovery Development II book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Atta-ur-Rahman
Publisher : Elsevier
Release : 2020-07-03
ISBN : 0128179058
Language : En, Es, Fr & De

GET BOOK

Book Description :

Studies in Natural Products Chemistry: Bioactive Natural Products, Volume 65, the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, provides cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products. This has opened up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Discovery and Development of Anti inflammatory Agents from Natural Products

Discovery and Development of Anti inflammatory Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2019-07-11
ISBN : 0128169931
Language : En, Es, Fr & De

GET BOOK

Book Description :

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery Book
Author : Alexander Hillisch,Rolf Hilgenfeld
Publisher : Springer Science & Business Media
Release : 2002-12-11
ISBN : 9783764360818
Language : En, Es, Fr & De

GET BOOK

Book Description :

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Indole Ring Synthesis

Indole Ring Synthesis Book
Author : Gordon W. Gribble
Publisher : John Wiley & Sons
Release : 2016-08-08
ISBN : 0470512180
Language : En, Es, Fr & De

GET BOOK

Book Description :

Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.

Drug Discovery and Commercial Opportunities in Medicinal Plants and Natural Products

Drug Discovery and Commercial Opportunities in Medicinal Plants and Natural Products Book
Author : International Business Communications
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Drug Discovery and Commercial Opportunities in Medicinal Plants and Natural Products book written by International Business Communications, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2016-10-11
ISBN : 0128096926
Language : En, Es, Fr & De

GET BOOK

Book Description :

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery Book
Author : Zoran Rankovic,Richard Morphy
Publisher : Wiley
Release : 2010-04-07
ISBN : 0470584165
Language : En, Es, Fr & De

GET BOOK

Book Description :

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

Medicinal Plants of South Asia

Medicinal Plants of South Asia Book
Author : Muhammad Asif Hanif,Haq Nawaz,Muhammad Mumtaz Khan,Hugh J. Byrne
Publisher : Unknown
Release : 2019-09-17
ISBN : 9780081026595
Language : En, Es, Fr & De

GET BOOK

Book Description :

Medicinal Plants of South Asia: Novel Sources for Drug Discovery provides a comprehensive review of medicinal plants of this region, highlighting chemical components of high potential and applying the latest technology to reveal the underlying chemistry and active components of traditionally used medicinal plants. Drawing on the vast experience of its expert editors and authors, the book provides a contemporary guide source on these novel chemical structures, thus making it a useful resource for medicinal chemists, phytochemists, pharmaceutical scientists and everyone involved in the use, sales, discovery and development of drugs from natural sources. Provides comprehensive reviews of 50 medicinal plants and their key properties Examines the background and botany of each source before going on to discuss underlying phytochemistry and chemical compositions Links phytochemical properties with pharmacological activities Supports data with extensive laboratory studies of traditional medicines

Plant derived Natural Products

Plant derived Natural Products Book
Author : Anne E. Osbourn,Virginia Lanzotti
Publisher : Springer
Release : 2009-07-28
ISBN : 9780387854977
Language : En, Es, Fr & De

GET BOOK

Book Description :

Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Textbook of Drug Design and Discovery Fifth Edition

Textbook of Drug Design and Discovery  Fifth Edition Book
Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
Publisher : CRC Press
Release : 2016-08-19
ISBN : 1498702791
Language : En, Es, Fr & De

GET BOOK

Book Description :

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding). The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

Natural Products in Drug Discovery Development

Natural Products in Drug Discovery   Development Book
Author : T&F Informa UK Ltd,Taylor & Francis Events
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Natural Products in Drug Discovery Development book written by T&F Informa UK Ltd,Taylor & Francis Events, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Encyclopedia of Drug Discovery and Development

Encyclopedia of Drug Discovery and Development Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 9781632421395
Language : En, Es, Fr & De

GET BOOK

Book Description :

Natural products are a consistent source of potentially effective compounds for the treatment of several disorders. It is believed that the tropical and Middle East regions have the most abundant supplies of natural products across the globe. Secondary metabolites obtained from plants have been employed by humans to treat health disorders, acute infections and chronic illness for a large number of years. Natural products have been greatly replaced by synthetic drugs in the past 100 years. Estimates of 200,000 natural products in plant species have been revised upward as mass spectrometry methodologies have advanced. For advancing countries the recognition and use of endogenous medicinal plants as cures for cancers have become appealing. This book covers important topics such as antibacterial drug discovery, resources for drug discovery, colon cancer: current treatments and preclinical models, etc.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Atta-ur- Rahman
Publisher : Elsevier
Release : 2012-12-06
ISBN : 0444595155
Language : En, Es, Fr & De

GET BOOK

Book Description :

Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry