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Natural Killer Cells

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Natural Killer Cells

Natural Killer Cells Book
Author : Eric Vivier,James Di Santo,Alessandro Moretta
Publisher : Springer
Release : 2016-02-15
ISBN : 3319239163
Language : En, Es, Fr & De

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Book Description :

To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

Role of Natural Killer Cells in Cancer and Autoimmune Diseases

Role of Natural Killer Cells in Cancer and Autoimmune Diseases Book
Author : Noha Mousaad Taha Hassen Elemam
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Natural Killer Cells in Cancer and Autoimmune Diseases book written by Noha Mousaad Taha Hassen Elemam, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Natural Killer Cells

Natural Killer Cells Book
Author : Jacques Zimmer
Publisher : Springer Science & Business Media
Release : 2010-01-12
ISBN : 9783642023095
Language : En, Es, Fr & De

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Book Description :

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.

Natural Killer Cells

Natural Killer Cells Book
Author : Michael T. Lotze,Angus W. Thomson
Publisher : Academic Press
Release : 2009-11-12
ISBN : 9780080919294
Language : En, Es, Fr & De

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Book Description :

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

The Natural Killer Cell

The Natural Killer Cell Book
Author : Claire E. Lewis,James O'Donnell McGee
Publisher : Oxford University Press
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The ability of an organism to combat infection by foreign particles and microbial pathogens is essential for its survival and evolutionary success. Such efforts at immunity can take two forms. A considerable number of works have been published which focus on the central role of antigen recognition and antibody structure and function in the host response to infection. This volume, however, discusses the recent shift in focus towards the "natural" or "innate" immune system which consists of various cell types and factors. These cells and factors can take part in immune responses without prior sensitization, and have important modulatory effects on later, specific responses. This work reviews the biology and function of the natural killer cell, covering such topics as the molecular basis of natural killer cell function and its role in viral infection, tumor biology, and transplantation. Graduate students and researchers in immunology, cell biology, and medicine will find this work a valuable resource on current research in this exciting field.

Natural Killer Cell Protocols

Natural Killer Cell Protocols Book
Author : Kerry S. Campbell,Marco Colonna
Publisher : Springer Science & Business Media
Release : 2000
ISBN : 1592590446
Language : En, Es, Fr & De

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Book Description :

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial migration, in vivo detection of cells migrating into tumors, immunofluorescence staining of intracellular cytokines, and in vitro NK cell development. Valuable techniques for specific applications include vaccinia virus protein expression, soluble KIR-Fc fusions for HLA class I binding assays, calcium mobilization in cell conjugates, and identification of heterodimeric receptor complexes using cDNA library expression cloning. No less important are accounts of such classic methods as hybrid resistance, ADCC, viral defense, target cell cytotoxicity assays, cloning and culturing, tumor immunotherapy, and generation of HLA class I transfected target cells. Natural Killer Cell Protocols: Cellular and Molecular Methods offers immunologists, cancer researchers, virologists, and cell biologists today's most comprehensive collection of both established and cutting-edge techniques, methods that will contribute significantly to advancing our understanding of this fascinating and critically important class of cells.

The Natural Killer Cell Interactome in the Tumor Microenvironment Basic Concepts and Clinical Application

The Natural Killer Cell Interactome in the Tumor Microenvironment  Basic Concepts and Clinical Application Book
Author : Martin Villalba,Régis Thierry Costello,Julian Pardo,Alberto Anel
Publisher : Frontiers Media SA
Release : 2020-07-02
ISBN : 2889638219
Language : En, Es, Fr & De

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Book Description :

Download The Natural Killer Cell Interactome in the Tumor Microenvironment Basic Concepts and Clinical Application book written by Martin Villalba,Régis Thierry Costello,Julian Pardo,Alberto Anel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunobiology of Natural Killer Cells

Immunobiology of Natural Killer Cells Book
Author : Eva Lotzova,Ronald B Herberman
Publisher : CRC Press
Release : 2021-06-02
ISBN : 9780367255558
Language : En, Es, Fr & De

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Book Description :

First published in 1986: This book contributes to the advancing knowledge of reads in the field of NK cells, and will be helpful as a teaching device.

The Second Life of Natural Killer NK Cells

The Second Life of Natural Killer  NK  Cells Book
Author : Chiara Romagnani,Joseph C. Sun,Marco Colonna
Publisher : Frontiers Media SA
Release : 2018-07-16
ISBN : 2889455467
Language : En, Es, Fr & De

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Book Description :

Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of “Innate lymphoid cells” (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications.

Natural Killer Cells

Natural Killer Cells Book
Author : Srinivas S. Somanchi
Publisher : Humana Press
Release : 2016-05-13
ISBN : 9781493936823
Language : En, Es, Fr & De

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Book Description :

This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.

Natural Killer T cells

Natural Killer T cells Book
Author : Masaki Terabe,Jay A. Berzofsky
Publisher : Springer Science & Business Media
Release : 2011-09-22
ISBN : 9781461406136
Language : En, Es, Fr & De

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Book Description :

This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.

Molecular and Cellular Pathways in NK Cell Development

Molecular and Cellular Pathways in NK Cell Development Book
Author : Ewa Sitnicka,Yenan Bryceson,Aharon Freud,Emily Mace
Publisher : Frontiers Media SA
Release : 2020-09-02
ISBN : 2889639770
Language : En, Es, Fr & De

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Book Description :

Download Molecular and Cellular Pathways in NK Cell Development book written by Ewa Sitnicka,Yenan Bryceson,Aharon Freud,Emily Mace, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role of Natural Killer Cells in Cord Blood Transplantation

Role of Natural Killer Cells in Cord Blood Transplantation Book
Author : Takuya Sekine
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Natural Killer Cells in Cord Blood Transplantation book written by Takuya Sekine, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Natural Killer Cells

Human Natural Killer Cells Book
Author : Tuomo Timonen
Publisher : Unknown
Release : 1979
ISBN : 9789519921679
Language : En, Es, Fr & De

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Book Description :

Download Human Natural Killer Cells book written by Tuomo Timonen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tailoring NK Cell Receptor Ligand Interactions an Art in Evolution 2nd Edition

Tailoring NK Cell Receptor Ligand Interactions  an Art in Evolution  2nd Edition Book
Author : Ulrike Koehl,Antoine Toubert,Gianfranco Pittari
Publisher : Frontiers Media SA
Release : 2018-11-13
ISBN : 2889456633
Language : En, Es, Fr & De

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Book Description :

Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.

The Elaborate Interplay of Natural Killer Cells and Vaccinia Virus

The Elaborate Interplay of Natural Killer Cells and Vaccinia Virus Book
Author : Delphine Depierreux
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Elaborate Interplay of Natural Killer Cells and Vaccinia Virus book written by Delphine Depierreux, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Natural Killer Cells

Natural Killer Cells Book
Author : Bernard Serrou,Claude Rosenfeld,Ronald B. Herberman
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Natural Killer Cells book written by Bernard Serrou,Claude Rosenfeld,Ronald B. Herberman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ex Vivo Expansion of Human Natural Killer Cells NK for Adoptive Immunotherapy

Ex Vivo Expansion of Human Natural Killer Cells  NK  for Adoptive Immunotherapy Book
Author : Bryce Andrew Pierson
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Ex Vivo Expansion of Human Natural Killer Cells NK for Adoptive Immunotherapy book written by Bryce Andrew Pierson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.