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Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery Book
Author : João Pedro Martins,Hélder A. Santos
Publisher : Academic Press
Release : 2020-07-30
ISBN : 0128180390
Language : En, Es, Fr & De

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Book Description :

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery Book
Author : Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon
Publisher : Springer Science & Business Media
Release : 2008-10-29
ISBN : 9780387776682
Language : En, Es, Fr & De

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Book Description :

The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery Book
Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Release : 2014-07-25
ISBN : 9535116282
Language : En, Es, Fr & De

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Book Description :

This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Nanotechnology and Drug Delivery Volume One

Nanotechnology and Drug Delivery  Volume One Book
Author : José L. Arias
Publisher : CRC Press
Release : 2014-08-04
ISBN : 1466599472
Language : En, Es, Fr & De

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Book Description :

Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

Nanotechnology and Drug Delivery Volume Two

Nanotechnology and Drug Delivery  Volume Two Book
Author : Jose L. Arias
Publisher : CRC Press
Release : 2016-04-21
ISBN : 1482262738
Language : En, Es, Fr & De

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Book Description :

The recent introduction of nanomedicines in the drug therapy arena is revolutionizing the management of severe diseases. The key advance in the field is the optimization of the biological fate of drug molecules, thus improving the therapeutic effect while keeping to a very minimum the associated toxicity. Volume one of this book series, Nanoplatforms in Drug Delivery, established the basic aspects in the development of drug-loaded nanoplatforms, the so-called nanomedicines or nanodrugs, focusing on representative materials and strategies used in their formulation. Taking advantage of the advanced conceptualizations on nanomedicine engineering that were described in volume one, volume two, Nano-Engineering Strategies and Nanomedicines against Severe Diseases, analyzes in depth special features related to the formulation of nanoplatforms for oral, dental, topical and transdermal, pulmonary and nasal, ocular and otic, vaginal, and brain drug delivery and targeting. Particular aspects of nanomedicine engineering and in vivo fate associated with the routing of drug administration are given special attention. In addition, an up-to-date view is presented on the use of nanomedicines against severe diseases, such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, and metabolic diseases. The chapters analyze the key factors that need to be controlled to achieve the optimum therapeutic effect. Attention is further given to gene delivery and the recent concept of nanotheranosis.

Nanomedicine and Drug Delivery

Nanomedicine and Drug Delivery Book
Author : Mathew Sebastian,Neethu Ninan,A. K. Haghi
Publisher : CRC Press
Release : 2012-07-23
ISBN : 1926895177
Language : En, Es, Fr & De

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Book Description :

This forward-looking book focuses on the recent advances in nanomedicine and drug delivery. It outlines the extraordinary new tools that have become available in nanomedicine and presents an integrated set of perspectives that describe where we are now and where we should be headed to put nanomedicine devices into applications as quickly as possible, while also considering the possible dangers of nanomedicine. The book considers the full range of nanomedicinal applications that employ molecular nanotechnology inside the human body, from the perspective of a future practitioner in an era of widely available nanomedicine. Written by some of the most innnovative minds in medicine and engineering, this unique volume will help professionals understand cutting-edge and futuristic areas of research that can have tremendous payoff in terms of improving human health. Readers will find insightful discussions of nanostructured intelligent materials and devices that are considered technically feasible and which have a high potential to produce advances in medicine in the near future. Topics include: Health benefits of phytochemicals and the application of colloidal delivery systems Study of non-covalent attachment of recombinant targeting proteins to polymer-modified Adenoviral gene delivery vectors The role of nanoparticles as adjuvants for mucosal vaccine delivery Poly(amido-amine)s as delivery styems for biologically active substances Antimicrobial activity of silver nanoparticles Nanomedicine in the use of cancer treatment Dendrimers, capsules based on lipid vesicles for drug delivery Many other recent achievements

Dental Applications of Nanotechnology

Dental Applications of Nanotechnology Book
Author : Ramesh S. Chaughule
Publisher : Springer
Release : 2018-08-29
ISBN : 3319976346
Language : En, Es, Fr & De

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Book Description :

This book discusses current trends and potential areas of nanotechnology applications in dental materials. Dentistry is undergoing yet another change to benefit mankind via the discipline of nanodentistry. A variety of nanostructures such as nanorobots, nanospheres, nanofibers, nanorods, etc., have been studied for various applications in dentistry and medicine. Preventive dentistry has also utilized nanodentistry to develop the nanomaterials for inclusion in a variety of oral health-care products. Methods to prevent and combat dental problems have been devised, discussed, and implemented since ancient times; however, there is a constant need for improved tools and techniques. This book is relevant academically for undergraduate and post-graduate dental students, dental practitioners, researchers, and faculties of dental universities, as this book explores the application of various nanobiomaterials in dentistry, discusses current research in dental nanomaterials and potential future areas of interest, and examines the use of nanotechnology in various fields of dentistry.

Functional Bionanomaterials

Functional Bionanomaterials Book
Author : Devarajan Thangadurai,Jeyabalan Sangeetha,Ram Prasad
Publisher : Springer Nature
Release : 2020-07-08
ISBN : 3030414647
Language : En, Es, Fr & De

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Book Description :

This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with biological molecules at nanoscale level, nanotechnology opens up an immense field of research and applications. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside human cells. Operating at nanoscale allows exploitation of physical properties different from those observed at microscale, such as the volume to surface area ratio. A number of clinical applications of nanobiotechnology, such as disease diagnosis, target-specific drug delivery, and molecular imaging are being investigated. Some promising new products are also undergoing clinical trials. Such advanced applications of this approach to biological systems will undoubtedly transform the foundations of diagnosis, treatment, and prevention of disease in the future. Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested each year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the global economy. This book provides clear, colorful and simple illustrations, tables, and case studies to clearly convey the content to a general audience and reader. This book also discusses the development of nanobiomaterials from biogenic (biological sources) systems for healthcare and disease therapies. This book, therefore, is useful for researchers and academicians in the fields of nanotechnology, medicine, nano-biotechnology and pharmacology.

Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes

Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes Book
Author : Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
Publisher : Academic Press
Release : 2017-05-23
ISBN : 0128097183
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book
Author : Pavan Muttil,Nitesh K. Kunda
Publisher : Springer Nature
Release : 2020-03-18
ISBN : 3030359107
Language : En, Es, Fr & De

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Book Description :

Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Book
Author : Prashant Kesharwani,Umesh Gupta
Publisher : Academic Press
Release : 2018-04-20
ISBN : 0128122498
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery Book
Author : Taylor & Francis Group
Publisher :
Release : 2021-01-21
ISBN : 9789814877312
Language : En, Es, Fr & De

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Book Description :

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico-in vitro-in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Drug Delivery Systems

Drug Delivery Systems Book
Author : N.A
Publisher : Academic Press
Release : 2019-10-23
ISBN : 0128145080
Language : En, Es, Fr & De

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Book Description :

Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Drug Delivery Systems Third Edition

Drug Delivery Systems  Third Edition Book
Author : Vasant V. Ranade,John B. Cannon
Publisher : CRC Press
Release : 2011-04-25
ISBN : 1439806187
Language : En, Es, Fr & De

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Book Description :

Drug delivery technologies represent a vast, vital area of research and development in pharmaceuticals. The demand for innovative drug delivery systems continues to grow, driving a variety of new developments. Drug Delivery Systems, Third Edition provides a comprehensive review of the latest research and development on drug delivery systems. Coverage includes liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery. Each chapter provides a table of marketed and investigational products with numerous practical examples. The book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives. This third edition contains a chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. Written in a straightforward manner, the authors provide a global perspective on current and future advances and market opportunities. Supplying a cogent overview of the field and extensive guidance on where to get more information, it is an essential resource for anyone venturing into this area of drug development.

BioMEMS and Biomedical Nanotechnology

BioMEMS and Biomedical Nanotechnology Book
Author : Tejal Desai,Sangeeta N. Bhatia
Publisher : Springer Science & Business Media
Release : 2007-05-26
ISBN : 0387258442
Language : En, Es, Fr & De

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Book Description :

Volume 3 of the multi-volume reference, BioMEMS and Biomedical Nanotechnology, will be the first comprehensive treatment of the emerging area of therapeutic micro- and nanotechnology. Subjects covered include: cell-based therapeutics, regenerative medicine - merging cells with micro- and nanosystems, and integrating MEMS with cells and tissues; Drug delivery - intravascular nanoparticles for drug targeting and nonvascular delivery (implantable, oral, inhalable); and, molecular surface engineering for the biological interface, biomolecule patterning and cell patterning. This volume is very well illustrated with many of the figures in color.

Lipids in Nanotechnology

Lipids in Nanotechnology Book
Author : Moghis U. Ahmad
Publisher : Elsevier
Release : 2015-08-15
ISBN : 0128043458
Language : En, Es, Fr & De

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Book Description :

Nanotechnology is a rapidly expanding field which includes fundamental nanoscale phenomena and processes, nanomaterials, nanoscale devices and systems, nanomanufacturing, and benefits and risks of nanotechnology. This book serves as a valuable reference and resource for those interested in the field of nanotechnology – from basic research to engineering aspects of nanoparticles. It covers thermodynamics to engineering aspects of nanoparticles or nanoemulsions; synthesis and applications of surface active lipids to food and cosmetics; and pharmaceutical applications to nanomedicine. Lipids in Nanotechnology will be useful to scholars, scientists, and technologists who are interested in the field of lipid nanotechnology. Discusses an overview of the opportunities and challenges of lipids in nanotechnology Presents applications of nanotechnology for use in drug delivery, nanomedicine, and pharmaceutical developments Explores the potential for lipids to act as encapsulation agents or delivery vehicles of bioactive compounds

Emerging Nanotechnologies in Dentistry

Emerging Nanotechnologies in Dentistry Book
Author : Karthikeyan Subramani,Waqar Ahmed
Publisher : William Andrew
Release : 2012
ISBN : 1455778621
Language : En, Es, Fr & De

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Book Description :

Nanotechnology and the future of Dentistry -- Nanoparticles for Dental Materials: Synthesis, analysis and Applications -- Antimicrobial nanoparticles in Restorative Composites -- Nanotechnology in operative dentistry: a perspective approach of history, mechanical behavior and clinical application -- Nanotechnology and dental implants -- Titanium surface modification techniques for dental implants - From microscale to nanoscale -- Titanium nanotubes as carriers of osteogenic growth factors and antibacterial drugs for applications in dental implantology -- Cellular responses to nanoscale surface modifications of titanium implants for dentistry and bone tissue engineering applications -- Corrosion Resistance of Ti6Al4V with Nanostructured TiO2 Coatings -- Multiwalled Carbon Nanotubes/Hydroxyapatite Nanoparticles incorporated GTR membranes -- Fabrication of PEG hydrogel micropatterns by Soft-photolithography and PEG hydrogel as Guided Bone Regeneration membrane in dental implantology -- Na ...

Drug Delivery Systems Advanced Technologies Potentially Applicable in Personalised Treatment

Drug Delivery Systems  Advanced Technologies Potentially Applicable in Personalised Treatment Book
Author : Jorge Coelho
Publisher : Springer Science & Business Media
Release : 2013-03-15
ISBN : 9400760108
Language : En, Es, Fr & De

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Book Description :

This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.

Targeted Drug Delivery Concepts and Design

Targeted Drug Delivery   Concepts and Design Book
Author : Padma V. Devarajan,Sanyog Jain
Publisher : Springer
Release : 2014-12-08
ISBN : 3319113550
Language : En, Es, Fr & De

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Book Description :

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Nanotechnology and Nanomedicine in Diabetes

Nanotechnology and Nanomedicine in Diabetes Book
Author : Lan-Anh Le,Ross J. Hunter,Victor R. Preedy
Publisher : CRC Press
Release : 2012-03-08
ISBN : 1578087295
Language : En, Es, Fr & De

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Book Description :

Understanding the importance of nanosciences in diabetes is problematic as some texts can be too technical for the novice. This book uses a reader–friendly format suitable not only for practitioners but newcomers as well. It begins with general aspects of nanotechnology and nanomedicine in diabetes. It then discusses glucose and glucose sensors based on functional nanocomposites before moving on to a discussion of insulin and the use of nanoprobes to monitor cell processes in the pancreas. Finally, it explores drugs and other treatments, including second-generation sulfonylurea glipizide loaded biodegradable nanoparticles and nanoparticle-mediated delivery of angiogenic inhibitors in diabetic retinopathy.