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Nanostructures For The Engineering Of Cells Tissues And Organs

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Nanostructures for the Engineering of Cells Tissues and Organs

Nanostructures for the Engineering of Cells  Tissues and Organs Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-02-14
ISBN : 0128136669
Language : En, Es, Fr & De

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Book Description :

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Introductory Biomaterials

Introductory Biomaterials Book
Author : Lia Stanciu,Susana Diaz-Amaya
Publisher : Academic Press
Release : 2021-09-23
ISBN : 0128095245
Language : En, Es, Fr & De

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Book Description :

Introductory Biomaterials enables undergraduate students in Biomedical, Chemical, Materials and other relevant Engineering disciplines to become familiar with the key concepts of Biomaterials principles: biocompatibility, structure-property-applications relationships, mechanical response of natural tissues, and cellular pathways for tissue-material ingrowth. Written in a clear, concise manner that weds theory with applications, this book helps students to understand the often intricate relationships between materials the implant devices that are made from them, and how the human body reacts to them. The book includes such concepts as requirements for metals, alloys, and ceramic materials to be used in load bearing implants (corrosion concepts, stress shielding, mechanical properties, composition), what properties of polymers impact their use in medicine (leaching and swelling, creep and stress relaxation); the tissue response to biomaterials, concepts related to drug delivery applications (polymer degradation, encapsulation), and tissue engineering (scaffold porosity, diffusion of nutrients, mechanical properties). Begins with structure-properties, followed immediately by their impact on actual biomaterials classes and devices, thus directly relating theory to applications (e.g. polymers to polymeric stents; metals to fracture fixation devices) Explains concepts in a clear, progressive manner, with numerous examples and figures to enhance student learning Covers all key biomaterials classes: metallic, ceramic, polymeric, composite and biological Includes a timely chapter on medical device regulation

Regenerated Organs

Regenerated Organs Book
Author : Chandra P Sharma
Publisher : Academic Press
Release : 2021-01-13
ISBN : 0128231955
Language : En, Es, Fr & De

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Book Description :

Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field. Discusses recent advances in tissue and organ fabrication Provides translational-research aspects that are often lacking in existing literature Contains chapters that are multi-authored by international experts in the field

Fullerens Graphenes and Nanotubes

Fullerens  Graphenes and Nanotubes Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-05-28
ISBN : 0128136928
Language : En, Es, Fr & De

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Book Description :

Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach shows how carbon nanomaterials are used in the pharmaceutical industry. While there are various books on the carbonaceous nanomaterials available on the market, none approach the subject from a pharmaceutical point-of-view. In this context, the book covers different applications of carbonaceous nanomaterials. Chapters examine different types of carbon nanomaterials and explore how they are used in such areas as cancer treatments, pulse sensing and prosthetics. Readers will find this book to be a valuable reference resource for those working in the areas of carbon materials, nanomaterials and pharmaceutical science. Explains how the unique properties of carbon-based nanomaterials allow them to be used to create effective drug delivery systems Covers how carbon-based nanomaterials should be prepared for use in pharmaceutical applications Discusses the relative toxicity of a range of carbon-based nanomaterials Considers the safety of their use in different types of drugs

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Drug Targeting and Stimuli Sensitive Drug Delivery Systems Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-05-21
ISBN : 0128136901
Language : En, Es, Fr & De

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Book Description :

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Design and Development of New Nanocarriers

Design and Development of New Nanocarriers Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-12-12
ISBN : 0128136286
Language : En, Es, Fr & De

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Book Description :

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Organic Materials as Smart Nanocarriers for Drug Delivery

Organic Materials as Smart Nanocarriers for Drug Delivery Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-03-26
ISBN : 0128136642
Language : En, Es, Fr & De

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Book Description :

Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems

Lipid Nanocarriers for Drug Targeting

Lipid Nanocarriers for Drug Targeting Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-04-16
ISBN : 012813688X
Language : En, Es, Fr & De

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Book Description :

Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment Assesses the pros and cons of using different lipid nanocarriers for different therapies

Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology

Nanoscale Fabrication  Optimization  Scale up and Biological Aspects of Pharmaceutical Nanotechnology Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-12-11
ISBN : 0128136308
Language : En, Es, Fr & De

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Book Description :

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Inorganic Frameworks as Smart Nanomedicines

Inorganic Frameworks as Smart Nanomedicines Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-04-09
ISBN : 0128136626
Language : En, Es, Fr & De

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Book Description :

Inorganic Frameworks as Smart Nanocarriers for Drug Delivery brings together recent research in the area of inorganic frameworks for drug delivery. Different types of nanocarriers are presented and discussed in detail, providing an up-to-date overview on inorganic nanoparticles with pharmaceutical applications. Written by a diverse range of international academics, this book is a valuable reference resource for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of inorganic smart nanocarriers. Includes assembly methods for a variety of smart nanocarrier systems, also showing how they are applied Highlights how metal-oxide nanoparticles are effectively used in drug delivery Assesses the pros and cons of different metallic nanomaterials as drug carriers

Concepts and Misconceptions of Drug Targeting

Concepts and Misconceptions of Drug Targeting Book
Author : Karel Petrak
Publisher : Cambridge Scholars Publishing
Release : 2020-08-05
ISBN : 1527557618
Language : En, Es, Fr & De

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Book Description :

Precision medicine requires precision drugs that match the needs of individual patients. An ideal drug, popularly referred to as the “magic bullet”, should be effective without causing any unwanted side effects. To do this, drugs must act solely on the target of the disease. Despite major efforts in this area over some 50 years, the currently available drugs are far from being “idea”. This book summarizes the key requirements for developing precision drugs and offers a new paradigm for site-specific drug delivery. As such, it will be of interest to personnel involved in drug development at pharmaceutical and biotech companies and academic institutions.

Nanotechnology for Biomedical Applications

Nanotechnology for Biomedical Applications Book
Author : Sreerag Gopi
Publisher : Springer Nature
Release : 2022-06-26
ISBN : 9811674833
Language : En, Es, Fr & De

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Book Description :

Download Nanotechnology for Biomedical Applications book written by Sreerag Gopi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Functional Chitosan

Functional Chitosan Book
Author : Sougata Jana,Subrata Jana
Publisher : Springer Nature
Release : 2020-03-05
ISBN : 9811502633
Language : En, Es, Fr & De

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Book Description :

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

Handbook of Functionalized Nanomaterials for Industrial Applications

Handbook of Functionalized Nanomaterials for Industrial Applications Book
Author : Chaudhery Mustansar Hussain
Publisher : Elsevier
Release : 2020-04-24
ISBN : 0128167882
Language : En, Es, Fr & De

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Book Description :

Functionalized nanomaterials have extremely useful properties, which can outperform their conventional counterparts because of their superior chemical, physical, and mechanical properties and exceptional formability. They are being used for the development and innovation in a range of industrial sectors. However, the use of functionalized nanomaterials is still in its infancy in many industrial settings. Functionalized nanomaterials have the potential to create cheaper and more effective consumer products and industrial processes. However, they also could have adverse effects on the environment, human health, and safety, and their sustainability is questionable, if used incorrectly. This book discusses the opportunities and challenges of using functionalized nanomaterials in a variety of major industrial sectors. Handbook of Functionalized Nanomaterials for Industrial Applications provides a concise summary of the major applications of functionalized nanomaterials in industry today. It covers the enhancements in industrial techniques and processes, due to functionalized nanomaterials, showing how they substantially improve the performance of existing procedures, and how they can deliver exciting consumer products more cheaply. Emphasis is given to greener approaches, leading to more sustainable products and devices. The legal, economical, and toxicity aspects of functionalized nanomaterials are also discussed in detail. Highlights established industrial applications of functionalized nanomaterials and discusses their future potential for a range of industrial sectors Discusses how functionalized nanomaterials are being used to create new types of commercial products and devices Assesses the challenges of using functionalized nanomaterials in industry, setting out major safety and regulatory challenges

Basic Fundamentals of Drug Delivery

Basic Fundamentals of Drug Delivery Book
Author : Anonim
Publisher : Academic Press
Release : 2018-11-30
ISBN : 0128179104
Language : En, Es, Fr & De

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Book Description :

Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The book also covers various approaches involved in optimizing the therapeutic performance of a biomolecule while designing its appropriate advanced formulation. Provides up-to-date information on translating the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as orally, parenterally, transdermally or through inhalation Contains extensive references and further reading for course and self-study

Role of Novel Drug Delivery Vehicles in Nanobiomedicine

Role of Novel Drug Delivery Vehicles in Nanobiomedicine Book
Author : Rajeev K. Tyagi,Neeraj Garg,Rahul Shukla,Prakash Singh Bisen
Publisher : BoD – Books on Demand
Release : 2020-02-26
ISBN : 1789239850
Language : En, Es, Fr & De

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Book Description :

Medical Nanotechnology and Nanomedicine introduces non-experts to the world of nanomedicine and its evolving organizational infrastructure. Considering the fluid nature of nano breakthroughs and the delicate balance between benefits and consequences as they apply to medicine, readers at all levels will gain a practical, understandable base of information on these developments so that they may take the greatest advantage of them. This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects and provides an ideal foundation upon which to plan and make decisions.

Biomaterials and Nanotechnology for Tissue Engineering

Biomaterials and Nanotechnology for Tissue Engineering Book
Author : Emeka Arendse
Publisher : Unknown
Release : 2017-02
ISBN : 9781681177205
Language : En, Es, Fr & De

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Book Description :

Download Biomaterials and Nanotechnology for Tissue Engineering book written by Emeka Arendse, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Engineering Micro and Nanostructured Biomaterials for Cell and Tissue Engineering

Engineering Micro  and Nanostructured Biomaterials for Cell and Tissue Engineering Book
Author : Benjamin Li-Ping Lee
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Tissue engineering has emerged as a well-investigated research area that aims to ultimately create biological substitutes, ranging from skin replacement to artificial blood vessels, for regenerative medicine applications. It is a multidisciplinary field that integrates knowledge and advancements from biology, materials, chemistry, and many others. Although the goal of tissue engineering is to engineer tissues with structure and function that closely mimic those of native tissues for not only diagnostic and drug testing applications but also repair and replacement of diseased and injured tissues, it provides in-depth understanding of tissue development and morphogenesis, including the intricate biological systems in the body that together operate to direct growth, repair, and death. The general approach of tissue engineering is to use cells, biomaterials, bioactive molecules, or a combination thereof to best recapitulate the properties of native tissues and reconstitute function. Specifically, biomaterial scaffolds play a key role in that their main function is to serving as a basis to interact with and support cells, promoting their attachment and migration while providing a porous and biomimetic microenvironment for mass transport and integration of bioactive factors. Therefore, in order to fabricate implantable scaffolds with properties that emulate the natural extracellular matrix (ECM) in terms of structure and organization, we utilize and implement electrospinning technology. Electrospinning is a versatile technique with immense potential to create cell-instructive scaffolds possessing ECM-like fibrous structures. Because of the ability to tune scaffold structure with respect to physical (i.e. geometry and mechanical properties) and chemical (i.e. retention and presentation of bioactive molecules) features, electrospun scaffolds, which are made from synthetic, natural, or a combination of the two polymers, have demonstrated functional success in an array of tissue engineering applications. In fact, the fibrous network, especially in the nanoscale, possesses high surface-area-to-volume ratio that is favorable for surface modifications to facilitate cell attachment as well as immobilization and covalent conjugation of bioactive molecules. However, one major shortcoming of electrospun scaffolds as a result of such densely packed network of fibers is their small pore size, limiting cell infiltration and tissue ingrowth essential for desired angiogenesis and tissue integration. Thus, electrospun scaffolds with dense fibrous structure and small pore size have not had enormous success in the regeneration of large, more complex tissues that require abundant vascularization and mass transport of oxygen and nutrients. In this dissertation, we attempt to address both the physical and chemical elements of electrospun scaffolds as we engineer novel ways to modulate their structural features and surface chemistry for their utilization in different cell and tissue engineering applications. We focus primarily on micro- and nanostructures, topographical cues, and chemical modifications and their role in enhancing cell infiltration and promoting better tissue integration in terms of angiogenesis in and overall functional performance of implanted scaffolds as well as vascular graft. Specifically, we detail the employment of an ultrafast, femtosecond (FS) laser system as a promising post-fabrication technology to pattern structural features (i.e. through-holes) that influence cell behavior and improve the integration electrospun scaffolds in vivo. We also demonstrate that changes in biophysical factors, such as increasing pore size and porosity via incorporation and removal of sacrificial fibers from composite scaffolds, can not only improve cell infiltration but more importantly regulate stem cell differentiation. Lastly, we show that we can fabricate small-diameter, nanofibrous vascular graft made of Carbosil®, a commercially available polycarbonate-urethane (PCU), via electrospinning and subsequently manipulate its surface properties through plasma treatment and reductive amination to effectively end-point immobilize heparin to reduce surface thrombogenicity while enhancing bioactivity and short-term in vivo performance. In summary, we offer novel design and fabrication of electrospun scaffolds with large pore size and highly porous structure, and vascular grafts with tailored surface chemistry and bioactivity optimal for their biological performance. We demonstrate through our studies that physical and chemical features of not only electrospun scaffolds but implantable biomaterials in general can be engineered and manipulated using post-fabrication processing (i.e. FS laser and tunable surface chemistry) and unique fabrication approaches (i.e. multiple polymers with sacrificial components). Only with ample vascularization and tissue integration will such biomaterial scaffolds regenerate native tissue function and demonstrate success in both simple, such as skin substitutes, as well as complicated, such as artificial heart, tissues and organs for applications in regenerative medicine.

Stem Cell Nanoengineering

Stem Cell Nanoengineering Book
Author : H. Baharvand
Publisher : John Wiley & Sons
Release : 2015-03-30
ISBN : 1118540611
Language : En, Es, Fr & De

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Book Description :

Stem-Cell Nanoengineering reviews the applications of nanotechnology in the fields of stem cells, tissue engineering, and regenerative medicine. Topics addressed include various types of stem cells, underlying principles of nanobiotechnology, the making of nanoscaffolds, nanotissue engineering, applications of nanotechnology in stem-cell tracking and molecular imaging, nanodevices, as well as stem-cell nanoengineering from bench to bedside. Written by renowned experts in their respective fields, chapters describe and explore a wide variety of topics in stem-cell nanoengineering, making the book a valuable resource for both researchers and clinicians in biomedical and bioengineering fields. • Synthesizes topics from the active and growing fields of stem-cell research and nanoengineering • Addresses a wide range of subjects that will be of interest to engineers, chemists, biological scientists, clinicians, and biomedicine industry professionals • Includes introduction to the various types of stem cells and the general principles of nanobiotechnology • Chapters cover hot topics including nanoscaffolds, nanotissue engineering, and nanodevices

Long Acting Drug Delivery Systems

Long Acting Drug Delivery Systems Book
Author : Eneko Larraneta,Thakur Raghu Raj Singh,Ryan F. Donnelly
Publisher : Woodhead Publishing
Release : 2021-09-24
ISBN : 0128217596
Language : En, Es, Fr & De

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Book Description :

Long-Acting Drug Delivery Systems: Pharmaceutical, Clinical, and Regulatory Aspects offers a comprehensive overview of the technical, clinical, regulatory and industrial perspectives on these drug delivery systems. The book follows a sequential order, beginning with the current technical state-of-the-field and moving on to more clinical, industrial and regulatory topics. Opening chapters describe the current needs and potential applications of implantable and long-acting therapeutic approaches. The book goes on to describe established and novel long-acting systems, with a focus on the materials used to prepare these systems and their biocompatibility. Importantly, applied topics such as scale-up manufacturing, products under clinical trials and regulatory aspects are covered, offering the reader a holistic view of this rapidly growing field. Brings together technical, clinical, regulatory and industrial perspectives for a complete overview of long acting and implantable drug delivery systems Provides up-to-date coverage of established and novel long-acting and implantable drug delivery systems, both in development and actively in use Appeals to a broad readership, including materials scientists, pharmaceutical scientists, biomedical engineers, clinicians and regulatory experts