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Nanostructures For The Engineering Of Cells Tissues And Organs

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Nanostructures for the Engineering of Cells Tissues and Organs

Nanostructures for the Engineering of Cells  Tissues and Organs Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-02-16
ISBN : 9780128136652
Language : En, Es, Fr & De

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Book Description :

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Nanostructures for the Engineering of Cells Tissues and Organs

Nanostructures for the Engineering of Cells  Tissues and Organs Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-02-14
ISBN : 0128136669
Language : En, Es, Fr & De

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Book Description :

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Biomaterials and Nanotechnology for Tissue Engineering

Biomaterials and Nanotechnology for Tissue Engineering Book
Author : Emeka Arendse
Publisher : Unknown
Release : 2017-02
ISBN : 9781681177205
Language : En, Es, Fr & De

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Book Description :

Download Biomaterials and Nanotechnology for Tissue Engineering book written by Emeka Arendse, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Engineering Micro and Nanostructured Biomaterials for Cell and Tissue Engineering

Engineering Micro  and Nanostructured Biomaterials for Cell and Tissue Engineering Book
Author : Benjamin Li-Ping Lee
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Tissue engineering has emerged as a well-investigated research area that aims to ultimately create biological substitutes, ranging from skin replacement to artificial blood vessels, for regenerative medicine applications. It is a multidisciplinary field that integrates knowledge and advancements from biology, materials, chemistry, and many others. Although the goal of tissue engineering is to engineer tissues with structure and function that closely mimic those of native tissues for not only diagnostic and drug testing applications but also repair and replacement of diseased and injured tissues, it provides in-depth understanding of tissue development and morphogenesis, including the intricate biological systems in the body that together operate to direct growth, repair, and death. The general approach of tissue engineering is to use cells, biomaterials, bioactive molecules, or a combination thereof to best recapitulate the properties of native tissues and reconstitute function. Specifically, biomaterial scaffolds play a key role in that their main function is to serving as a basis to interact with and support cells, promoting their attachment and migration while providing a porous and biomimetic microenvironment for mass transport and integration of bioactive factors. Therefore, in order to fabricate implantable scaffolds with properties that emulate the natural extracellular matrix (ECM) in terms of structure and organization, we utilize and implement electrospinning technology. Electrospinning is a versatile technique with immense potential to create cell-instructive scaffolds possessing ECM-like fibrous structures. Because of the ability to tune scaffold structure with respect to physical (i.e. geometry and mechanical properties) and chemical (i.e. retention and presentation of bioactive molecules) features, electrospun scaffolds, which are made from synthetic, natural, or a combination of the two polymers, have demonstrated functional success in an array of tissue engineering applications. In fact, the fibrous network, especially in the nanoscale, possesses high surface-area-to-volume ratio that is favorable for surface modifications to facilitate cell attachment as well as immobilization and covalent conjugation of bioactive molecules. However, one major shortcoming of electrospun scaffolds as a result of such densely packed network of fibers is their small pore size, limiting cell infiltration and tissue ingrowth essential for desired angiogenesis and tissue integration. Thus, electrospun scaffolds with dense fibrous structure and small pore size have not had enormous success in the regeneration of large, more complex tissues that require abundant vascularization and mass transport of oxygen and nutrients. In this dissertation, we attempt to address both the physical and chemical elements of electrospun scaffolds as we engineer novel ways to modulate their structural features and surface chemistry for their utilization in different cell and tissue engineering applications. We focus primarily on micro- and nanostructures, topographical cues, and chemical modifications and their role in enhancing cell infiltration and promoting better tissue integration in terms of angiogenesis in and overall functional performance of implanted scaffolds as well as vascular graft. Specifically, we detail the employment of an ultrafast, femtosecond (FS) laser system as a promising post-fabrication technology to pattern structural features (i.e. through-holes) that influence cell behavior and improve the integration electrospun scaffolds in vivo. We also demonstrate that changes in biophysical factors, such as increasing pore size and porosity via incorporation and removal of sacrificial fibers from composite scaffolds, can not only improve cell infiltration but more importantly regulate stem cell differentiation. Lastly, we show that we can fabricate small-diameter, nanofibrous vascular graft made of Carbosil®, a commercially available polycarbonate-urethane (PCU), via electrospinning and subsequently manipulate its surface properties through plasma treatment and reductive amination to effectively end-point immobilize heparin to reduce surface thrombogenicity while enhancing bioactivity and short-term in vivo performance. In summary, we offer novel design and fabrication of electrospun scaffolds with large pore size and highly porous structure, and vascular grafts with tailored surface chemistry and bioactivity optimal for their biological performance. We demonstrate through our studies that physical and chemical features of not only electrospun scaffolds but implantable biomaterials in general can be engineered and manipulated using post-fabrication processing (i.e. FS laser and tunable surface chemistry) and unique fabrication approaches (i.e. multiple polymers with sacrificial components). Only with ample vascularization and tissue integration will such biomaterial scaffolds regenerate native tissue function and demonstrate success in both simple, such as skin substitutes, as well as complicated, such as artificial heart, tissues and organs for applications in regenerative medicine.

Design of Nanostructures for Versatile Therapeutic Applications

Design of Nanostructures for Versatile Therapeutic Applications Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-02-03
ISBN : 0128136685
Language : En, Es, Fr & De

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Book Description :

Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry. Assesses the most recently developed nanostructures that have potential antimicrobial properties, explaining their novel mechanical aspects Shows how nanoantibiotics can be used to more effectively treat disease Provides a cogent summary of recent developments in nanoantimicrobial discovery, allowing readers to quickly familiarize themselves with the topic

Regenerated Organs

Regenerated Organs Book
Author : Chandra P Sharma
Publisher : Academic Press
Release : 2021-01-13
ISBN : 0128231955
Language : En, Es, Fr & De

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Book Description :

Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field. Discusses recent advances in tissue and organ fabrication Provides translational-research aspects that are often lacking in existing literature Contains chapters that are multi-authored by international experts in the field

Concepts and Misconceptions of Drug Targeting

Concepts and Misconceptions of Drug Targeting Book
Author : Karel Petrak
Publisher : Cambridge Scholars Publishing
Release : 2020-08-05
ISBN : 1527557618
Language : En, Es, Fr & De

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Book Description :

Precision medicine requires precision drugs that match the needs of individual patients. An ideal drug, popularly referred to as the “magic bullet”, should be effective without causing any unwanted side effects. To do this, drugs must act solely on the target of the disease. Despite major efforts in this area over some 50 years, the currently available drugs are far from being “idea”. This book summarizes the key requirements for developing precision drugs and offers a new paradigm for site-specific drug delivery. As such, it will be of interest to personnel involved in drug development at pharmaceutical and biotech companies and academic institutions.

Fullerens Graphenes and Nanotubes

Fullerens  Graphenes and Nanotubes Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-05-28
ISBN : 0128136928
Language : En, Es, Fr & De

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Book Description :

Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach shows how carbon nanomaterials are used in the pharmaceutical industry. While there are various books on the carbonaceous nanomaterials available on the market, none approach the subject from a pharmaceutical point-of-view. In this context, the book covers different applications of carbonaceous nanomaterials. Chapters examine different types of carbon nanomaterials and explore how they are used in such areas as cancer treatments, pulse sensing and prosthetics. Readers will find this book to be a valuable reference resource for those working in the areas of carbon materials, nanomaterials and pharmaceutical science. Explains how the unique properties of carbon-based nanomaterials allow them to be used to create effective drug delivery systems Covers how carbon-based nanomaterials should be prepared for use in pharmaceutical applications Discusses the relative toxicity of a range of carbon-based nanomaterials Considers the safety of their use in different types of drugs

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Drug Targeting and Stimuli Sensitive Drug Delivery Systems Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-05-21
ISBN : 0128136901
Language : En, Es, Fr & De

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Book Description :

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Design and Development of New Nanocarriers

Design and Development of New Nanocarriers Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-12-12
ISBN : 0128136286
Language : En, Es, Fr & De

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Book Description :

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Organic Materials as Smart Nanocarriers for Drug Delivery

Organic Materials as Smart Nanocarriers for Drug Delivery Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-03-26
ISBN : 0128136642
Language : En, Es, Fr & De

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Book Description :

Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems

Lipid Nanocarriers for Drug Targeting

Lipid Nanocarriers for Drug Targeting Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-04-16
ISBN : 012813688X
Language : En, Es, Fr & De

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Book Description :

Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment Assesses the pros and cons of using different lipid nanocarriers for different therapies

Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology

Nanoscale Fabrication  Optimization  Scale up and Biological Aspects of Pharmaceutical Nanotechnology Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-12-11
ISBN : 0128136308
Language : En, Es, Fr & De

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Book Description :

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Bionanocomposites in Tissue Engineering and Regenerative Medicine

Bionanocomposites in Tissue Engineering and Regenerative Medicine Book
Author : Shakeel Ahmed,Annu Tomer
Publisher : Woodhead Publishing
Release : 2021-06-11
ISBN : 0128216344
Language : En, Es, Fr & De

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Book Description :

Bionanocomposites in Tissue Engineering and Regenerative Medicine explores novel uses of these in tissue engineering and regenerative medicine. This book offers an interdisplinary approach, combining chemical, biomedical engineering, materials science and pharmacological aspects of the characterization, synthesis and application of bionanocomposites. Chapters cover a broad selection of bionanocomposites including chitosan, alginate and more, which are utilized in tissue engineering, wound healing, bone repair, drug formulation, cancer therapy, drug delivery, cartilage regeneration and dental implants. Additional sections of Bionanocomposites in Tissue Engineering and Regenerative Medicine discuss, in detail, the safety aspects and circular economy of bionanocomposites – offering an insight into the commercial and industrial aspects of these important materials. Bionanocomposites in Tissue Engineering and Regenerative Medicine will prove a highly useful text for for those in the fields of biomedical engineering, chemistry, pharmaceutics and materials science, both in academia and industrial R&D groups. Each bionanocomposite type is covered individually, providing specific and detailed information for each material Covers a range of tissue engineering and regenerative medicine applications, from dental and bone engineering to cancer therapy Offers an integrated approach, with contributions from authors across a variety of related disciplines, including biomedical engineering, chemistry and materials science

Inorganic Frameworks as Smart Nanomedicines

Inorganic Frameworks as Smart Nanomedicines Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-04-09
ISBN : 0128136626
Language : En, Es, Fr & De

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Book Description :

Inorganic Frameworks as Smart Nanocarriers for Drug Delivery brings together recent research in the area of inorganic frameworks for drug delivery. Different types of nanocarriers are presented and discussed in detail, providing an up-to-date overview on inorganic nanoparticles with pharmaceutical applications. Written by a diverse range of international academics, this book is a valuable reference resource for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of inorganic smart nanocarriers. Includes assembly methods for a variety of smart nanocarrier systems, also showing how they are applied Highlights how metal-oxide nanoparticles are effectively used in drug delivery Assesses the pros and cons of different metallic nanomaterials as drug carriers

Nano Hydrogels

Nano Hydrogels Book
Author : Jiya Jose
Publisher : Springer Nature
Release : 2021-09-17
ISBN : 9811571384
Language : En, Es, Fr & De

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Book Description :

Download Nano Hydrogels book written by Jiya Jose, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Functional Chitosan

Functional Chitosan Book
Author : Sougata Jana,Subrata Jana
Publisher : Springer Nature
Release : 2020-03-05
ISBN : 9811502633
Language : En, Es, Fr & De

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Book Description :

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

Nanobiotechnology in Diagnosis Drug Delivery and Treatment

Nanobiotechnology in Diagnosis  Drug Delivery and Treatment Book
Author : Mahendra Rai,Mehdi Razzaghi-Abyaneh,Avinash P. Ingle
Publisher : John Wiley & Sons
Release : 2020-11-10
ISBN : 1119671795
Language : En, Es, Fr & De

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Book Description :

Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.

Sustainable Agriculture Reviews 43

Sustainable Agriculture Reviews 43 Book
Author : Ankit Saneja,Amulya K. Panda,Eric Lichtfouse
Publisher : Springer Nature
Release : 2020-05-05
ISBN : 3030418383
Language : En, Es, Fr & De

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Book Description :

This edited book comprises of eight chapters dealing on various aspects of pharmaceutical technology for delivery of natural products. Book chapters deal with the solubility and bioavailability enhancement technologies for natural products. Emphasis has also been given on the significance of delivery strategies for improving the therapeutic efficacy of paclitaxel, galantamine and tea constituents.

Novel Drug Delivery Technologies

Novel Drug Delivery Technologies Book
Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : Springer Nature
Release : 2020-02-12
ISBN : 9811336423
Language : En, Es, Fr & De

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Book Description :

The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.