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Nanoscience In Dermatology

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Nanoscience in Dermatology

Nanoscience in Dermatology Book
Author : Michael R. Hamblin,Pinar Avci,Tarl Prow
Publisher : Academic Press
Release : 2016-08-13
ISBN : 0128029455
Language : En, Es, Fr & De

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Book Description :

Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology Coherently structured book written by experts working in the fields covered

Nanotechnology in Dermatology

Nanotechnology in Dermatology Book
Author : Adnan Nasir,Adam Friedman,Steven Wang
Publisher : Springer Science & Business Media
Release : 2012-12-02
ISBN : 1461450349
Language : En, Es, Fr & De

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Book Description :

Nanotechnology in Dermatology is the first book of its kind to address all of the important and rapidly growing aspects of nanotechnology as it relates to dermatology. In the last few years there has been an explosion in research and development for products and devices related to nanotechnology, including numerous applications for consumers, physicians, patients, and industry. Applications are underway in medicine and dermatology for the early detection, diagnosis, and targeted therapy of disease, and nanodesigned materials and devices are expected to be faster, smaller, more powerful, more efficient, and more versatile than their traditional counterparts. Written by experts working in this exciting field, Nanotechnology in Dermatology specifically addresses nanotechnology in consumer skin care products, in the diagnosis of skin disease, in the treatment of skin disease, and the overall safety of nanotechnology. The book also discusses future trends of this ever-growing and changing field, providing dermatologists, pharmaceutical companies, and consumer cosmetics companies with a clear understanding of the advantages and challenges of nanotechnology today.

Nanotechnology Environmental Health and Safety

Nanotechnology Environmental Health and Safety Book
Author : Matthew Hull,Diana Bowman
Publisher : William Andrew
Release : 2018-08-14
ISBN : 0128135891
Language : En, Es, Fr & De

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Book Description :

Nanotechnology Environmental Health and Safety tackles – in depth and in breadth – the complex and evolving issues pertaining to nanotechnology's environmental health and safety (EHS). The chapters are authored by leaders in their respective fields, providing thorough analysis of their research areas. The diverse spectrum of topics include nanotechnology EHS issues, financial implications, foreseeable risks including exposure, dosage and hazards, and the implications of occupational hygiene precautions and consumer protections. The book includes real-world case studies, wherever practical, to illustrate specific issues and scenarios encountered by stakeholders positioned on the front-lines of nanotechnology-enabled industries. These case studies will appeal to, and resonate with, laboratory scientists, business leaders, regulators, service providers, and postgraduate researchers. Reviews toxicological studies and industrial initiatives, supported by numerous case studies Covers new generation of nanoparticles and significantly expands on existing material from second edition Only edited volume to collect research on the regulatory and risk implications of a wide array of industrial, environmental and consumer nanomaterials

Nanotechnology in Medicine

Nanotechnology in Medicine Book
Author : Mahendra Rai,Mrunali Patel,Rashmin Patel
Publisher : John Wiley & Sons
Release : 2021-12-20
ISBN : 1119769868
Language : En, Es, Fr & De

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Book Description :

Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxicological and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

Nanoscience and Nanotechnology for Human Health

Nanoscience and Nanotechnology for Human Health Book
Author : Bert Müller
Publisher : John Wiley & Sons
Release : 2017-04-10
ISBN : 3527338608
Language : En, Es, Fr & De

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Book Description :

Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.

Applied Nanotechnology

Applied Nanotechnology Book
Author : Jeremy Ramsden
Publisher : William Andrew
Release : 2018-01-30
ISBN : 0128133449
Language : En, Es, Fr & De

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Book Description :

Applied Nanotechnology: The Conversion of Research Results to Products, Third Edition, takes an integrated approach to the scientific, commercial and social aspects of nanotechnology, exploring the relationship between nanotechnology and innovation, the changing economics and business models required to commercialize innovations in nanotechnology, and product design challenges that are investigated through case studies. Applications in various sectors, including composite materials, energy and agriculture are included, as is a section on the role of the government in promoting nanotechnology. In addition, the potential future of molecular self-assembly in industrial production is discussed, along with the ethics and social implications of nanotechnology. This new edition begins a concise introduction to nanotechnology, carefully explaining the relationships between science, technology, wealth and innovation. Next, it focuses on actual products and processes, including the big three areas of application, health, IT and energy. Different types of nanobusiness (upstream, downstream, ancillary etc.), are also carefully delineated, and aspects such as design and realization (e.g., actual fabrication) are also covered, amongst other timely topics. This book offers a vision of the role of nanotechnology in confronting the challenges facing humanity, from healthcare to climate change. Written by an author who has direct, hands-on experience working in a large nanotechnology-based company, in academia as a professor and chair of nanotechnology, and as the co-owner and director of a nanotechnology-based start-up Presents comprehensive coverage in an integrated fashion, not wasting space on trivial details that, if not already known to the reader, can be readily found in generic sources Thoroughly revised, reflecting advances in the field Includes areas that have been expanded into nanotechnology, such as health, and the safety of nano products and processes

Preparation Properties and Photocatalytic Activity of Doped and Undoped Metal Oxide Nanomaterials

Preparation  Properties and Photocatalytic Activity of Doped and Undoped Metal Oxide Nanomaterials Book
Author : Azad Kumar
Publisher : BFC Publications
Release : 2021-07-10
ISBN : 9390675499
Language : En, Es, Fr & De

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Book Description :

In this thesis, describes a proficient method for synthesis of Titania, titania based nanocomposites, Ni:TiO2, Co:Ni:TiO2, Co:La:TiO2, Co:TiO2, Cu-TiO2, TiO2/PAni, TiO2/PAni/GO, TiO2/PPy and TiO2/PPy/GO nanocomposites. The doping of metal ions were made by solution impregnation method in the Titania nanopowder followed by the calcination in the muffle furnace. The polymer based nanocomposites were prepared by one-step in situ deposition oxidative polymerization of Aniline and pyrrole hydrochloride using Ammonium persulphate (APS) as an oxidant in the presence of ultra-fine grade powder of TiO2 nanoparticles cooled in an ice bath. The obtained nanocomposites were characterized by XRD, TEM, SEM and UV-Vis for band gap determination. The Photocatalytic degradation of Eriochrome black-T, Acetic acid, methyl blue, methyl green, Thymol Blue, Rose Bengal and Victoria blue dye was done at different condition viz concentration of dye, time of illumination, pH and dose of the photocatalyst. The maximum photodegradation was found at 7 pH, lowest concentration of compound solution, highest amount of photocatalyst and 120 min irradiation of visible light. Kinetics of photodegradation was investigated for organic dyes were found first order kinetics. The doping of metal ions and coating of Polyaniline and PolyPyrrole and GO has enhanced the photocatalytic activity of Titania.

Essentials of Industrial Pharmacy

Essentials of Industrial Pharmacy Book
Author : Saeed Ahmad Khan
Publisher : Springer Nature
Release : 2022-05-20
ISBN : 3030849775
Language : En, Es, Fr & De

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Book Description :

Download Essentials of Industrial Pharmacy book written by Saeed Ahmad Khan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Microalgae

Microalgae Book
Author : Charis M. Galanakis
Publisher : Academic Press
Release : 2020-10-05
ISBN : 0128232145
Language : En, Es, Fr & De

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Book Description :

Microalgae: Cultivation, Recovery of Compounds and Applications supports the scientific community, professionals and enterprises that aspire to develop industrial and commercialized applications of microalgae cultivation. Topics covered include conventional and emerging cultivation and harvesting techniques of microalgae, design, transport phenomena models of microalgae growth in photobioreactors, and the catalytic conversion of microalgae. A significant focus of the book illustrates how marine algae can increase sustainability in industries like food, agriculture, biofuel and bioprocessing, among others. This book is a complete reference for food scientists, technologists and engineers working in the bioresource technology field. It will be of particular interest to academics and professionals working in the food industry, food processing, chemical engineering and biotechnology. Explores emerging technologies for the clean recovery of antioxidants from microalgae Includes edible oil and biofuels production, functional food, cosmetics and animal feed applications Discusses microalgae use in sustainable agriculture and wastewater treatment Considers the techno-economic aspects of microalgae processing for biofuel, chemicals, pharmaceuticals and bioplastics

Nanocosmetics

Nanocosmetics Book
Author : Arun Nanda,Sanju Nanda,Tuan Anh Nguyen,Susai Rajendran,Yassine Slimani
Publisher : Elsevier
Release : 2020-05-06
ISBN : 0128222859
Language : En, Es, Fr & De

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Book Description :

Nanotechnology is key to the design and manufacture of the new generation of cosmetics. Nanotechnology can enhance the performance and properties of cosmetics, including colour, transparency, solubility, texture, and durability. Sunscreen products, such as UV nano-filters, nano-TiO2 and nano-ZnO particles, can offer an advantage over their traditional counterparts due to their broad UV-protection and non-cutaneous side effects. For perfumes, nano-droplets can be found in cosmetic products including Eau de Toilette and Eau de Parfum. Nanomaterials can also be used in cosmetics as transdermal drug delivery systems. By using smart nanocontainers, active compounds such as vitamins, antioxidants, nutrients, and anti-inflammatory, anti-infective agents, can be delivered effectively. These smart nanocontainers are typically related with the smart releasing property for their embedded active substances. These smart releases could be obtained by using the smart coatings as their outer nano-shells. These nano-shells could prevent the direct contact between these active agents and the adjacent local environments. Nanocosmetics: Fundamentals, Applications and Toxicity explores the formulation design concepts and emerging applications of nanocosmetics. The book also focuses on the mitigation or prevention of their potential nanotoxicity, potential global regulatory challenges, and the technical challenges of mass implementation. It is an important reference source for materials scientists and pharmaceutical scientists looking to further their understanding of how nanotechnology is being used for the new generation of cosmetics. Outlines the major fabrication and formulation design concepts of nanoscale products for cosmetic applications Explores how nanomaterials can safely be used for various applications in cosmetic products Assesses the major challenges of using nanomaterials for cosmetic applications on a large scale

Advances in Applied Microbiology

Advances in Applied Microbiology Book
Author : Geoffrey M. Gadd,Sima Sariaslani
Publisher : Academic Press
Release : 2021-11-04
ISBN : 0323850812
Language : En, Es, Fr & De

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Book Description :

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology. Contains contributions from leading authorities in the field Informs and updates on the latest developments in the field of microbiology Includes discussions on the role of specific molecules in pathogen life stages, interactions, and much more

Nanocellulose Synthesis Structure Properties And Applications

Nanocellulose  Synthesis  Structure  Properties And Applications Book
Author : Guang Yang,Muhammad Wajid Ullah,Shi Zhijun
Publisher : World Scientific
Release : 2021-04-09
ISBN : 1786349485
Language : En, Es, Fr & De

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Book Description :

Nanocellulose, a unique and promising natural material extracted from native cellulose, has received immense interest for its broad spectrum of applications owing to its remarkable physical properties, special surface chemistry, and excellent biological properties (biocompatibility, biodegradability and low toxicity). In attempts to meet the requirements of humanity's well-being, biomaterials scientists taking advantage of the structure and properties of nanocellulose aim to develop new and formerly non-existing materials with novel and multifunctional properties.This book highlights the importance of nanocellulose and reviews its synthesis, types, structure and properties. Further, it discusses various biofabrication approaches and applications of nanocellulose-based biomaterials in various fields such as the environment, biomedicine, optoelectronics, pharmaceutics, paper, renewable energy and the food industry. Devised to have a broad appeal, this book will be useful to beginners, who will appreciate its comprehensive approach, as well as active researchers, who will find the focus on recent advancements highly valuable.

Clay Based Pharmaceutical Formulations and Drug Delivery Systems

Clay Based Pharmaceutical Formulations and Drug Delivery Systems Book
Author : César Viseras
Publisher : MDPI
Release : 2021-01-19
ISBN : 303650186X
Language : En, Es, Fr & De

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Book Description :

This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.

Nanomaterials and Plant Potential

Nanomaterials and Plant Potential Book
Author : Azamal Husen,Muhammad Iqbal
Publisher : Springer
Release : 2019-03-01
ISBN : 3030055698
Language : En, Es, Fr & De

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Book Description :

This book discusses the latest developments in plant-mediated fabrication of metal and metal-oxide nanoparticles, and their characterization by using a variety of modern techniques. It explores in detail the application of nanoparticles in drug delivery, cancer treatment, catalysis, and as antimicrobial agent, antioxidant and the promoter of plant production and protection. Application of these nanoparticles in plant systems has started only recently and information is still scanty about their possible effects on plant growth and development. Accumulation and translocation of nanoparticles in plants, and the consequent growth response and stress modulation are not well understood. Plants exposed to these particles exhibit both positive and negative effects, depending on the concentration, size, and shape of the nanoparticles. The impact on plant growth and yield is often positive at lower concentrations and negative at higher ones. Exposure to some nanoparticles may improve the free-radical scavenging potential and antioxidant enzymatic activities in plants and alter the micro-RNAs expression that regulate the different morphological, physiological and metabolic processes in plant system, leading to improved plant growth and yields. The nanoparticles also carry out genetic reforms by efficient transfer of DNA or complete plastid genome into the respective plant genome due to their miniscule size and improved site-specific penetration. Moreover, controlled application of nanomaterials in the form of nanofertilizer offers a more synchronized nutrient fluidity with the uptake by the plant exposed, ensuring an increased nutrient availability. This book addresses these issues and many more. It covers fabrication of different/specific nanomaterials and their wide-range application in agriculture sector, encompassing the controlled release of nutrients, nutrient-use efficiency, genetic exchange, production of secondary metabolites, defense mechanisms, and the growth and productivity of plants exposed to different manufactured nanomaterials. The role of nanofertilizers and nano-biosensors for improving plant production and protection and the possible toxicities caused by certain nanomaterials, the aspects that are little explored by now, have also been generously elucidated.

Applications of Targeted Nano Drugs and Delivery Systems

Applications of Targeted Nano Drugs and Delivery Systems Book
Author : Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar Mishra,Sabu Thomas
Publisher : Elsevier
Release : 2018-10-05
ISBN : 0128140305
Language : En, Es, Fr & De

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Book Description :

Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields. Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types

Carrier Mediated Dermal Delivery

Carrier Mediated Dermal Delivery Book
Author : Andreia Ascenso,Helena Ribeiro,Sandra Simões
Publisher : CRC Press
Release : 2017-09-01
ISBN : 9814745596
Language : En, Es, Fr & De

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Book Description :

This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management. Photodynamic therapy and melatonin can be used in the photocarcinogenesis context, too. Therefore, the inclusion of this strong antioxidant in sunscreen products could be a promising approach. The book discusses topical formulations, including emulsions (conventional formulations and emulsions stabilized by solid particles), nail films, and nanocarriers used for the delivery of actives in various skin and nail diseases such as acne, psoriasis, atopic dermatitis, fungal diseases, leishmaniasis, and skin cancer. Finally, several nanocarriers are introduced, such as lipid vesicles (ranging from the first-generation conventional liposomes to the more recent deformable vesicles), liquid crystalline nanodispersions, gelatin, and solid lipid nanoparticles. Their composition, formulation, characterization, and topical applications are also discussed. Although this is a broad topic, the most important (nano)pharmaceutical formulations are presented in the book.

Biomedical Applications of Nanoparticles

Biomedical Applications of Nanoparticles Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2019-02-28
ISBN : 0128166304
Language : En, Es, Fr & De

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Book Description :

Biomedical Applications of Nanoparticles describes the most interesting and investigated biomedical applications of nanoparticles, emphasizing their therapeutic impact. Progress made in the therapy of severe diseases, such as cancer and difficult infections is strictly correlated to the scientific progress and technological development in the field of materials science. Nanoparticles have numerous therapeutic applications, starting with the design of new drugs, delivery systems, therapeutic materials, and their contribution to the development of preventive strategies. The book highlights the impact of nanoparticles on the therapy of infections, antimicrobial effect and also anti-cancer strategies. Successful examples are given throughout the book, along with analysis in order to improve future outcomes of novel therapies. Highlights the term nanotherapeutics and presents several classifications of nanotherapeutics from different points-of-view Presents the recent progress related to nanotherapeutics in the oral cavity Provides the recent progress in the field of biomedical nanoparticles

Nanomedicine for the Treatment of Disease

Nanomedicine for the Treatment of Disease Book
Author : Sarwar Beg,Mahfoozur Rahman,Md. Abul Barkat,Farhan Jalees Ahmad
Publisher : CRC Press
Release : 2019-09-25
ISBN : 0429758839
Language : En, Es, Fr & De

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Book Description :

This new volume, Nanomedicine for the Treatment of Disease: From Concept to Application, looks at the application of nanomedicines with a particular focus on their use in the treatment of diseases. The chapters in this volume, contributed by eminent scientists, researchers, and nanotechnologists from across the globe, highlight key advancements, challenges, and opportunities in the area of application of nanomedicines for disease treatment. They explore the design and development of therapeutic nanocarriers for targeting drugs for satiating the demands of disease treatment process. The volume explores the use nanomedicines for the diagnosis and treatment of a multitude various diseases and health conditions, including respiratory diseases, neurological disorders, genetic diseases, pulmonary fungal infections, neuroAIDS, cardiovascular disorders, gastric and colonic diseases, skin disorders, cancer, brain tumors, leishmaniasis and other visceral diseases, hypertension, and ocular diseases.

Inorganic Frameworks as Smart Nanomedicines

Inorganic Frameworks as Smart Nanomedicines Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2018-04-09
ISBN : 0128136626
Language : En, Es, Fr & De

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Book Description :

Inorganic Frameworks as Smart Nanocarriers for Drug Delivery brings together recent research in the area of inorganic frameworks for drug delivery. Different types of nanocarriers are presented and discussed in detail, providing an up-to-date overview on inorganic nanoparticles with pharmaceutical applications. Written by a diverse range of international academics, this book is a valuable reference resource for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of inorganic smart nanocarriers. Includes assembly methods for a variety of smart nanocarrier systems, also showing how they are applied Highlights how metal-oxide nanoparticles are effectively used in drug delivery Assesses the pros and cons of different metallic nanomaterials as drug carriers

Clinical Applications of Magnetic Nanoparticles

Clinical Applications of Magnetic Nanoparticles Book
Author : Nguyen TK Thanh
Publisher : CRC Press
Release : 2018-02-06
ISBN : 1351685422
Language : En, Es, Fr & De

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Book Description :

Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.