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Nanoparticulate Drug Delivery

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Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems Book
Author : Deepak Thassu,Michel Deleers,Yashwant Vishnupant Pathak
Publisher : CRC Press
Release : 2007-03-30
ISBN : 1000654745
Language : En, Es, Fr & De

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Book Description :

With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems Book
Author : Raj K. Keservani,Anil K. Sharma
Publisher : CRC Press
Release : 2019-01-23
ISBN : 1351137247
Language : En, Es, Fr & De

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Book Description :

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Nanoparticulate Drug Delivery

Nanoparticulate Drug Delivery Book
Author : Vandana Patravale,Prajakta Dandekar,Ratnesh Jain
Publisher : Elsevier
Release : 2012-10-31
ISBN : 1908818190
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-based therapeutics, operating at scales of billionths of a metre, have great potential for future expansion in altering the scale and methods of drug delivery. The availability of these novel formulations to once-inaccessible areas of the body has greatly expanded the therapeutic window of existing drug molecules. Nanoparticulate drug delivery highlights and examines the transition of nanoparticulate drug delivery systems from the laboratory into a commercially viable sector. The first chapters of the book provide an overview of the use and characterization of nanoparticulate systems as drug carriers, including the assessment of their morphology, sterility and potential toxicity. In the latter part of the book, chapters cover nanotoxicology, regulatory aspect and clinical trials, ending with an overview of several case studies and a look towards future developments. Discusses the issues surrounding nanoparticulate products, based on personal experience of their formulation Provides an overview of new application areas, including RNA interference Outlines the pros and cons of nanoparticulate products, and discusses how these may influence their route into the commercial sector

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems Book
Author : Yoon Yeo
Publisher : John Wiley & Sons
Release : 2013-02-25
ISBN : 1118570510
Language : En, Es, Fr & De

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Book Description :

Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems. Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acids Multifunctional dendritic nanocarriers Polymer drug nanoconjugates Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulation Drug delivery strategies for combatting multiple drug resistance Toxicological assessment of nanomedicine Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research. With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.

Nanoparticulates as Drug Carriers

Nanoparticulates as Drug Carriers Book
Author : V. P. Torchilin
Publisher : Imperial College Press
Release : 2006
ISBN : 186094907X
Language : En, Es, Fr & De

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Book Description :

Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."

Nanoparticle Drug Delivery Systems for Cancer Treatment

Nanoparticle Drug Delivery Systems for Cancer Treatment Book
Author : Hala Gali-Muhtasib,Racha Chouaib
Publisher : CRC Press
Release : 2020-02-19
ISBN : 1000680878
Language : En, Es, Fr & De

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Book Description :

In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Drug Delivery Nanoparticles Formulation and Characterization

Drug Delivery Nanoparticles Formulation and Characterization Book
Author : Yashwant Pathak,Deepak Thassu
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420078054
Language : En, Es, Fr & De

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Book Description :

Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na

Surface Modification of Nanoparticles for Targeted Drug Delivery

Surface Modification of Nanoparticles for Targeted Drug Delivery Book
Author : Yashwant V Pathak
Publisher : Springer
Release : 2019-03-11
ISBN : 3030061159
Language : En, Es, Fr & De

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Book Description :

This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

Nanotherapeutics

Nanotherapeutics Book
Author : Alf Lamprecht
Publisher : Pan Stanford Publishing
Release : 2009
ISBN : 9814241024
Language : En, Es, Fr & De

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Book Description :

This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g., diabetes, cancer, inflammation) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. From this concise book, readers will gain an insight into the basics of nanoparticle preparation and find a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Nanotechnology and Drug Delivery Volume One

Nanotechnology and Drug Delivery  Volume One Book
Author : José L. Arias
Publisher : CRC Press
Release : 2014-08-04
ISBN : 1466599480
Language : En, Es, Fr & De

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Book Description :

Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

Ocular Drug Delivery Systems

Ocular Drug Delivery Systems Book
Author : Deepak Thassu,Gerald J. Chader
Publisher : CRC Press
Release : 2012-10-02
ISBN : 1439848017
Language : En, Es, Fr & De

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Book Description :

Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Ba

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery Book
Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Release : 2014-07-25
ISBN : 9535116282
Language : En, Es, Fr & De

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Book Description :

This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems Book
Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Release : 2018-09-20
ISBN : 012814002X
Language : En, Es, Fr & De

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Book Description :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Nanoparticle Technology for Drug Delivery

Nanoparticle Technology for Drug Delivery Book
Author : Ram B. Gupta,Uday B. Kompella
Publisher : Informa Health Care
Release : 2006-01-13
ISBN : 9781574448573
Language : En, Es, Fr & De

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Book Description :

Nanoparticles, products of nanotechnology, are of increasing interest to the pharmaceutical community. They can increase drug solubility, enhance bioavailability, allow tissue targeting, offer decreased side-effects, and improve therapeutic efficacy. Presenting the most pertinent and practical issues in the manufacturing and biological application of nanoparticles, this source presents state-of-the-art scientific contributions by seasoned authorities in the field.

A Novel Nanoparticle Formulation for Targeted Drug Delivery in Cardiovascular Diseases

A Novel Nanoparticle Formulation for Targeted Drug Delivery in Cardiovascular Diseases Book
Author : Nikita Lomis
Publisher :
Release : 2020
ISBN :
Language : En, Es, Fr & De

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Book Description :

"Cardiovascular diseases are the leading cause of mortality across the globe. Of the various cardiovascular diseases, congestive heart failure is the most prevalent. Heart failure has no permanent cure, yet certain treatments and lifestyle changes can help enhance the patients’ quality of life. Congestive heart failure is commonly treated by delivering drugs which lower the blood pressure and improve the heart’s pumping action. However, their use has limitations such as lack of specificity, toxicity, low retention time in the body along with side effects such as hypotension, arrhythmia, nausea, vomiting etc. It is anticipated that the targeted delivery of drugs would help address and overcome these limitations. This thesis focuses on the design and development of a nanoparticle-based formulation for the targeted delivery of the drug, milrinone, for congestive heart failure treatment. The action of milrinone helps in improving the contraction ability and functioning of the failing heart. The nanoparticles were prepared from the protein, human serum albumin, which was surface functionalized to bind the angiotensin II type 1 (AT1) peptide. The peptide-tagged nanoparticles were designed to target the AT1 receptors, found to be overexpressed on the myocardium under heart failure conditions, therefore facilitating higher nanoparticle uptake and drug delivery to the heart. The nanoparticles were spherical with a particle size between 100-200 nm and negative surface charge, indicating high physical stability. The in vitro characterization studies showed that the nanoparticle formulation was target-specific, biodegradable, biocompatible and suitable for use in vivo. The in vivo pharmacokinetics and tissue distribution studies of the targeted nanoparticle formulation revealed superior drug delivery and release, with improvement in the retention time of milrinone compared to the non-targeted drug. The treatment efficacy of this formulation was validated using a rat model of congestive heart failure, where it was found to be safe and effective in improving the cardiac function and contractility. Therefore, this targeted nanoparticle formulation delivering milrinone exhibits immense potential for use in congestive heart failure and related cardiovascular disease"--

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery Book
Author : Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon
Publisher : Springer Science & Business Media
Release : 2008-10-29
ISBN : 9780387776682
Language : En, Es, Fr & De

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Book Description :

The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Metal Nanoparticles for Drug Delivery and Diagnostic Applications

Metal Nanoparticles for Drug Delivery and Diagnostic Applications Book
Author : Muhammad Raza Shah,Muhammad Imran,Shafi Ullah
Publisher : Micro & Nano Technologies
Release : 2019-10-22
ISBN : 0128169605
Language : En, Es, Fr & De

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Book Description :

Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science. Illustrates the progression of nanoparticle therapeutics from basic research to applications Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use

Nano Biomaterials For Ophthalmic Drug Delivery

Nano Biomaterials For Ophthalmic Drug Delivery Book
Author : Yashwant Pathak,Vijaykumar Sutariya,Anjali A. Hirani
Publisher : Springer
Release : 2016-11-12
ISBN : 331929346X
Language : En, Es, Fr & De

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Book Description :

This consolidated reference book addresses the various aspects of nano biomaterials used in ophthalmic drug delivery, including their characterization, interactions with ophthalmic system and applications in treatments of the ophthalmic diseases and disorders. In the last decade, a significant growth in polymer sciences, nanotechnology and biotechnology has resulted in the development of new nano- and bioengineered nano-bio-materials. These are extensively explored as drug delivery carriers as well as for implantable devices and scaffolds. At the interface between nanomaterials and biological systems, the organic and synthetic worlds merge into a new science concerned with the safe use of nanotechnology and nano material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions. While it is impossible to describe with certainty all the bio physicochemical interactions at play at the interface, we are at a point where the pockets of assembled knowledge are providing a conceptual framework to guide this exploration, and review the impact on future product development. The book is intended as a valuable resource for academics and pharmaceutical scientists working in the field of polymers, polymers materials for drug delivery, drug delivery systems and ophthalmic drug delivery systems, in addition to medical and health care professionals in these areas.

Nanocarriers for the Delivery of Combination Drugs

Nanocarriers for the Delivery of Combination Drugs Book
Author : Sanjula Baboota,Javed Ali
Publisher : Elsevier
Release : 2021-06-15
ISBN : 9780128207796
Language : En, Es, Fr & De

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Book Description :

Nanocarriers for the Delivery of Combination Drugs focuses on the role of nanocarriers in the delivery of combination drugs for the management and treatment of various diseases. Combination drug therapy success has been limited due to the inability of the individual drugs to achieve the desired therapeutic outcome when they are delivered in the individual form and reasons for this can be the difference in physiochemical and biopharmaceutical characteristics of drugs leading to variable results. Nanocarriers have been used for the co-delivery of drug combinations for delivering drugs at the right place and right time in combinations. Nanocarriers belonging to the category of polymeric nanoparticles, dendrimers, lipidic nanocarriers like nanoemulsions, liposomes, solid lipid nanoparticles, nanostructured lipid carriers, are now being used for drug delivery of combination drugs. The primary focus of Nanocarriers for the Delivery of Combination Drugs is to assimilate all the information available pertaining to the application of various nanocarrier technology for the delivery of combination drugs of synthetic and natural origin and encompassing small and large molecules. It is an important reference source for pharmaceutical scientists and biomaterials scientists, who are looking to gain an increased understanding of how nanotechnology is improving the efficiency of combination drug delivery. Outlines how nanocarriers are used to enhance combination drug delivery systems Assesses the major challenges of delivering combination drugs successfully, and explains how nanocarriers can help meet these challenges Explores the characteristics of a variety of nanocarrier material types

Lipids in Nanotechnology

Lipids in Nanotechnology Book
Author : Moghis U. Ahmad
Publisher : Elsevier
Release : 2015-08-15
ISBN : 0128043458
Language : En, Es, Fr & De

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Book Description :

Nanotechnology is a rapidly expanding field which includes fundamental nanoscale phenomena and processes, nanomaterials, nanoscale devices and systems, nanomanufacturing, and benefits and risks of nanotechnology. This book serves as a valuable reference and resource for those interested in the field of nanotechnology – from basic research to engineering aspects of nanoparticles. It covers thermodynamics to engineering aspects of nanoparticles or nanoemulsions; synthesis and applications of surface active lipids to food and cosmetics; and pharmaceutical applications to nanomedicine. Lipids in Nanotechnology will be useful to scholars, scientists, and technologists who are interested in the field of lipid nanotechnology. Discusses an overview of the opportunities and challenges of lipids in nanotechnology Presents applications of nanotechnology for use in drug delivery, nanomedicine, and pharmaceutical developments Explores the potential for lipids to act as encapsulation agents or delivery vehicles of bioactive compounds