Skip to main content

Nanoparticles And The Immune System

In Order to Read Online or Download Nanoparticles And The Immune System Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Nanoparticles and the Immune System

Nanoparticles and the Immune System Book
Author : Diana Boraschi,Albert Duschl
Publisher : Academic Press
Release : 2013-12-09
ISBN : 9780124080850
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system

Nanoparticles and the Immune System

Nanoparticles and the Immune System Book
Author : Diana Boraschi,Albert Duschl
Publisher : Academic Press
Release : 2013-11-29
ISBN : 0124079210
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system

Interaction of Nanomaterials With the Immune System Role in Nanosafety and Nanomedicine

Interaction of Nanomaterials With the Immune System  Role in Nanosafety and Nanomedicine Book
Author : Paola Italiani,Diana Boraschi,Lucio R. C. Castellano,Paulo Bonan,Eliton S. Medeiros
Publisher : Frontiers Media SA
Release : 2018-04-10
ISBN : 2889453871
Language : En, Es, Fr & De

GET BOOK

Book Description :

The immune system has the double role of maintaining tissue integrity and homeostasis and of protecting the organism from possible dangers, from invading pathogens to environmentally-borne dangerous chemicals. New chemicals recognisable by the immune system are engineered nanomaterials/ nanoparticles, new agents in our environment that are becoming common due to their presence in many products, from constructions and building material (e.g., solar cells, pigments and paints, tilesand masonry materials) to daily products (e.g., food packaging, cosmetics, and cigarettes). Human beings can be accidentally exposed to engineered nanomaterials when these are released from products containing them or during production in workplaces. Furthermore, intentional exposure occurs in medicine, as engineered nanoparticles are used as tools for improving delivery of drugs and vaccines, vaccine adjuvants and contrast agents in therapeutic, preventive and diagnostic strategies. Nanoparticles that come in contact with the immune system after unintentional exposure need to be eliminated from the organism as they represent a potential threat. In this case, however, due to their peculiar characteristics of size, shape, surface charge and persistence, nanoparticles may elicit undesirable reactions and have detrimental effects on the immune system, such as cytotoxicity, inflammation, anaphylaxis, immunosuppression. Conversely, nanomedicines need to escape immune recognition/elimination and must persist in the organism long enough for reaching their target and exerting their beneficial effects. Immune cells and molecules at the body surface (airway and digestive mucosae, skin) are the first that come in contact with nanomaterials upon accidental exposure, while immune effectors in blood are those that more easily come in contact with nanomedical products. Thus, evaluating the interaction of the immune system with nanoparticles/nanomaterials is a topic of key importance both in nanotoxicology and in nanomedicine. Immuno-nanosafety studies consider both accidental exposure to nanoparticles, which may occur by skin contact, ingestion or inhalation (at doses and with a frequency that are not known), and medical exposure, which takes place with a defined administration schedule (route, dose, frequency). Many studies focus on the interaction between the immune system and nanoparticles that, for medical purposes, have been specifically modified to stimulate immunity or to avoid immune recognition, as in the case of vaccine carriers/adjuvants or drug delivery systems, respectively. The aims of this Research Topic is to provide an overview of recent strategies: 1.for assessing the immunosafety of engineered nanomaterials/nanoparticles, in particular in terms of activation of inflammatory responses, such as complement activation and allergic reactions, based on the nanomaterial intrinsic characteristics and on the possible carry-over of bioactive contaminants such as LPS. Production of new nanoparticles taking into account their effects on immune responses, in order to avoid undesirable effects on one hand, and to design particles with desirable effects for medical applications on the other hand; 2.for designing more effective nanomedicines by either avoiding or exploiting their interaction with the immune systems, with particular focus on cancer diagnosis and therapy, and vaccination. This collection of articles gives a comprehensive view of the state-of-the-art of the interaction of nanoparticles with the immune system from the two perspectives of safety and medical use, and aims at providing immunologists with the relevant knowledge for designing improved strategies for immunologically safe nanomaterial applications.

Interactions of Engineered and Endogenous Nanoparticles with Cells in the Immune System

Interactions of Engineered and Endogenous Nanoparticles with Cells in the Immune System Book
Author : Helen Vallhov
Publisher : Unknown
Release : 2010
ISBN : 9789174095449
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanotechnology is a fast developing area, which refers to research and technology development at the nanometer scale, ranging from 0.1-100 nm. The properties of nanomaterials offer the ability to interact with complex biological functions, implying enormous opportunities for novel applications within medicine. However, there is little information available concerning the potential toxicity of nanoparticles and what influence such particles have on the immune system, e.g. on dendritic cells (DCs). DCs are the most efficient antigen presenting cells, having a capacity to initiate and direct immune responses against foreign material. The aim of this thesis was to study effects of differently sized and shaped nanomaterials in the interaction with primary human monocyte derived DCs (MDDCs), thereby obtaining an insight on what impact these materials have on the immune system and their potential use in medical applications. In addition, we wanted to determine if endogenous nanoparticles (exosomes), produced by various cells, are natural targeting vehicles. We show that conventionally produced gold nanoparticles had a maturing effect on human MDDCs, but this was found to be a result of lipopolysaccharide (LPS) contamination. By modification of the production process, clean particles were obtained, which had practically no effect on phenotype or cytokine production of MDDCs. These findings emphasize the importance of retaining high purity during the production of nanoparticles, since possible contaminants may interfere with the assessment of nanoparticles biological effects and result in hazardous particles. To investigate whether various shapes of gold nanoparticles affect MDDC differently, a novel method was developed for the preparation of gold nanorods with high aspect ratios (ARs) based on a self-seeded surfactant-mediated protocol. The biocompatibility of these high AR gold nanorods, with potential use in thermal therapy, was compared with spherical gold nanoparticles

Silver Nanoparticles

Silver Nanoparticles Book
Author : David Pozo
Publisher : IntechOpen
Release : 2010-03-01
ISBN : 9789533070285
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanotechnology will be soon required in most engineering and science curricula. It cannot be questioned that cutting-edge applications based on nanoscience are having a considerable impact in nearly all fields of research, from basic to more problem-solving scientific enterprises. In this sense, books like “Silver Nanoparticles” aim at filling the gaps for comprehensive information to help both newcomers and experts, in a particular fast-growing area of research. Besides, one of the key features of this book is that it could serve both academia and industry. “Silver nanoparticles” is a collection of eighteen chapters written by experts in their respective fields. These reviews are representative of the current research areas within silver nanoparticle nanoscience and nanotechnology.

Interaction of Nanomaterials with the Immune System

Interaction of Nanomaterials with the Immune System Book
Author : James C. Bonner,Jared M. Brown
Publisher : Springer Nature
Release : 2020-01-30
ISBN : 3030339629
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

Handbook Of Immunological Properties Of Engineered Nanomaterials Second Edition In 3 Volumes

Handbook Of Immunological Properties Of Engineered Nanomaterials  Second Edition   In 3 Volumes  Book
Author : Dobrovolskaia Marina A,Mcneil Scott E
Publisher : World Scientific
Release : 2016-01-28
ISBN : 9814699187
Language : En, Es, Fr & De

GET BOOK

Book Description :

This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function . The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called 'corona' around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Nanomaterial mediated Immune Interactions for Disease Diagnosis and Cancer Immunotherapy

Nanomaterial mediated Immune Interactions for Disease Diagnosis and Cancer Immunotherapy Book
Author : Colin G. Buss
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

The body's natural defenses against disease,facilitated by a complex and highly-evolved immune system, eluded the scientific community's understanding for thousands of years following its first description. It wasn't until the mid to late 1900s that we were able to begin robustly describing the mechanisms through which innate and adaptive immune responses function, but numerous revolutionary discoveries over recent decades have since facilitated meaningful clinical advances impacting innumerable lives. From diagnostic techniques for the characterization of disease, to immunotherapies for their treatment, much of modern medicine can trace its roots to the study of immunology. Yet despite advances in immunological knowledge and its clinical applications, much remains to be understood, and many such applications have major limitations. Mechanisms by which to interface with the immune system have thus generated immense interest, and nanotechnologies have emerged as useful tools in pursuit of this goal. Decades of research in a variety of applications have facilitated our capability to exquisitely engineer nanoparticles to incorporate desirable characteristics, allowing us to utilize these unique materials for the study and modulation of immunological activity. The work in this thesis aims to contribute understanding of the role of immunity in disease by using nanoparticle technologies that interact with the immune system to diagnose, monitor, and treat disease. First, we engineer a set of nanoparticles responsive to infection-associated proteolysis driven by the innate immune response to a pathogen as well as by the pathogen itself. We demonstrate that detection of such proteolytic activity allows for the diagnosis of disease and monitoring of its progression as an immune response mounts, and following therapeutic treatment. Then, we design a separate nanoparticle system to deliver immunostimulatory oligonucleotides for cancer immunotherapy. This technology greatly enhances the activity of a model immunostimulant, suppressing tumor progression and powerfully potentiating immune checkpoint inhibitor antibody treatment, all while greatly reducing the dose of immunostimulant required to have such effects. Together, this work elucidates mechanisms by which nanomaterials can be utilized to interface with the immune system for the detection and modulation of its activity, thereby achieving sensitive and specific disease diagnosis and powerful tumor suppression.

Lipid based Nanoparticles for Altering Immune Response

Lipid based Nanoparticles for Altering Immune Response Book
Author : Noha Samir Mohamed Ismail
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Abstract: Since cancer is an extremely heterogeneous disease of origin, scientists are always trying to define novel approaches that can eliminate this disease. Over decades now, surgery, radiotherapy and chemotherapy have been the conventional methods to eradicate cancer. Unfortunately, cancer resistance has developed, in which tumor cells became resistant to the majority of chemotherapeutics. Consequently, people started to use combination therapy as a more intensified protocol to counteract the aggressiveness of cancer. However, the results are not satisfactory till now and lots of optimizations are needed in order to make sure that synergistic not antagonistic effects are happening. That is why scientists started to revisit cancer immunotherapy field after long years of its discovery. They are trying to understand more about the manifestations that occur in case of tumor induced immunosuppression. They are rapidly defining new approaches for harnessing the immune system against cancer. Different methodologies are developed in the last ten years, yet optimizations are still in process. The significant hurdle in the field of cancer immunotherapy is the selectivity towards certain immune cell population. In other words, how selective targeting could be achieved with high affinity to the cell of interest. That led to the evolution of cancer nano-immunotherapy where nanoparticles are engineered in a certain manner that can elicit a selective interaction with the target receptor. Many studies have revealed how nanotechnology is a promising tool in harnessing immune system against cancer. However, targeting as a technique is still paving the way for the optimum particle-cell interaction. In the current study, we are paving the way to target immune cells infiltrating the tumor. The challenge here is that the population of cancer cells themselves are much more than the immune cells. In this study, the response of different immune cell lines towards internalization of different surface charged lipid-based nanoparticles (NPs) was investigated at different time frames. The hypothesis is whether specific immune cell line isolated from melanoma tumor model and lymphoid organ like spleen could be targeted with liposomes having different surface charges, could this be considered a novel approach for targeting immune cells passively depending only on surface charge. In the first part, three sets of fluorescently labelled nano-liposomes were engineered as a model for different surface charges, the cationic DOTAP NP, anionic DOPG NP and near neutral DOPC NP with mean diameter of 220, 190, 210 nm and Zeta Potential of +36, -48 and -17.4 mV respectively. Physical stability of the NPs was evaluated by monitoring the changes in size and zeta potential. B16 melanoma cancer model was induced subcutaneously in C57BL/6 black mice (10 weeks age), divided into four groups each of five mice. CD11c Dendritic Cells (DCs), CD11b macrophages, CD90.2 T-cells and CD49b Natural Killer (NK) cells were isolated from the tumors and spleens of each group. The three sets of NPs were tested against the isolated cell lines. The cellular uptake (internalization) was assessed by normalizing the fluorescence of the cells against their protein concentration, then all samples were acquired to flow cytometry, and shifts in fluorescence histograms on horizontal axis were monitored against PE channel on the vertical axis. Results reveal the presence of preferential internalization of specific surface charge over others in some cell lines in different time frames. For the first time differences in the internalization pattern are reported in the same immune cell line isolated from two different contexts tumor and spleen. These results might serve as a guideline for a rational design of successful nano-carriers that can maximize the targeting, and hence the therapeutic efficacy towards certain population of immune cells. In the second part and in the sense of screening the different pathways that contribute to immunosuppression, STAT3 (Signal Transducer and Activator of Transcription 3) pathway is considered one of the promising targets that when inhibited will reverse the immunosuppressed status of DCs. The molecular STAT3 inhibitor is investigated for the first time for its ability to offer superior properties in terms of specificity of STAT3 without affecting the other STATs and eliciting immunomodulatory effect. Pegylated nano-liposomes were synthesized with size of 190 nm loaded with conjugated form of the drug which is drug-cholesterol in order to maximize the loading efficiency reaching 82±4% and physical stability with minimal changes in size and zeta potential. Cryo-TEM revealed the formation of predominant unilamillar structures. The efficacy of conjugated drug-NP was evaluated in-vitro on different cells: Bone Marrow derived DCs (BMDCs), DC cell line, B16F10, 4T1 and MDA-MB-231. The BMDCs primary cultures were generated from bone marrow of C57BL/6 mice femurs. The purity of CD11c lineage of BMDCs was assessed by flow cytometry and showed 70-80% purity. In order to mimic the tumor microenvironment surrounding DCs in the tumor i.e. induce immunosuppression and downregulation of DCs surface receptors, high levels of phospho-STAT3 (pSTAT3) were induced via conditioning DCs with different conditioning media of B16, LLC, and 4T1. It has been revealed that B16 conditioning media induced the highest amount of pSTAT3 based on western blot, flow cytometry and cytokine analysis. DCs by then showed downregulation of CD80, CD86 and major histocompatibility complex class II (MHCII). Finally, the drug-NP and free drug (5μmole) were added to the immunosuppressed DCs for 24hrs and maturation status was assessed using flow cytometry. Expression of CD86, MHCII and CD80 were evaluated after gating CD11c double positive population. No significant change was observed in case of CD80. Slight increase was observed in case of CD86. However, surprisingly there was a dramatic increase in MHCII with 3 folds higher expression in case of free drug and 1.3 fold with drug-NP in only 24 hrs, this reflects sustained release of the drug from the NP. These results demonstrate the potential of the STAT3 inhibitor in reversing the immunosuppressed status of DCs in tumor microenvironment and its immunomodulatory role for the first time.

Cell Membrane Coated Nanoparticles for Immune Modulation

Cell Membrane Coated Nanoparticles for Immune Modulation Book
Author : Ashley Victoria Kroll
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanotechnology is a cutting edge scientific area that is fundamentally changing the way we design and administer medicines and therapies to patients. One area in which nanomedicine can have a large impact is through immune modulation and "nano-immunoengineering". The size and unique cell-particle interaction patterns enable nanoparticles to interact with the immune system in ways that can impact the immune system in radically new and efficacious ways. This dissertation focuses on demonstrating how cell membrane coating can be merged with nanoparticle design to facilitate immune modulation to improve a variety of pathological conditions. The rationale for cell membrane coating and the use of nanoparticles in immune modulation is discussed in the first chapter of the dissertation. The second portion of the dissertation concentrates on developing cancer cell membrane-coated nanoparticles for anticancer vaccination. Using the membrane of cancer cells serves as an ideal and multivalent antigen source, while coating around the adjuvant-loaded nanoparticle core provide immune stimulation and a codelivery of both components to the lymphatic system. The third portion of the dissertation dives into the use of erythrocyte membrane-coated nanoparticles for antibacterial vaccination. Pore-forming toxins naturally embed into red blood cell membrane, and can be delivered in the nanoparticulate form to provide intact toxin antigens to the immune system. Formation of anti-toxin antibodies then protect from toxin damage and also provide antivirulence immunity against bacterial infections. Finally, the fourth section of this dissertation will focus on a novel "nanosponge" for immune thrombocytopenia purpura. Platelet membrane coated nanoparticles can specifically absorb anti-platelet antibodies, sparing immune destruction of real platelets and reducing disease symptoms. This dissertation will serve as an example of applying rational design and engineering of cell membrane coating and nanoparticle synthesis and loading to enhance immune system intervention in a variety of internal and external pathological challenges. By harnessing these tools, cell membrane-coated nanoparticles can have a great impact in the field of immunotherapy, and have much potential to be expanded upon for new therapeutic and prophylactic modalities.

Nanotechnology in Dermatology

Nanotechnology in Dermatology Book
Author : Adnan Nasir,Adam Friedman,Steven Wang
Publisher : Springer Science & Business Media
Release : 2012-12-02
ISBN : 1461450349
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanotechnology in Dermatology is the first book of its kind to address all of the important and rapidly growing aspects of nanotechnology as it relates to dermatology. In the last few years there has been an explosion in research and development for products and devices related to nanotechnology, including numerous applications for consumers, physicians, patients, and industry. Applications are underway in medicine and dermatology for the early detection, diagnosis, and targeted therapy of disease, and nanodesigned materials and devices are expected to be faster, smaller, more powerful, more efficient, and more versatile than their traditional counterparts. Written by experts working in this exciting field, Nanotechnology in Dermatology specifically addresses nanotechnology in consumer skin care products, in the diagnosis of skin disease, in the treatment of skin disease, and the overall safety of nanotechnology. The book also discusses future trends of this ever-growing and changing field, providing dermatologists, pharmaceutical companies, and consumer cosmetics companies with a clear understanding of the advantages and challenges of nanotechnology today.

Polycarbonate and Polystyrene Nanoparticles Act as Stressors to the Innate Immune System of Fathead Minnows Pimephales Promelas Rafinesque 1820

Polycarbonate and Polystyrene Nanoparticles Act as Stressors to the Innate Immune System of Fathead Minnows  Pimephales Promelas  Rafinesque 1820  Book
Author : Anne-Catherine Greven
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Polycarbonate and Polystyrene Nanoparticles Act as Stressors to the Innate Immune System of Fathead Minnows Pimephales Promelas Rafinesque 1820 book written by Anne-Catherine Greven, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Control Physicochemical Properties of Nanoparticle Surfaces to Modulate Immune Cell Recruitment to Scaffolds

Control Physicochemical Properties of Nanoparticle Surfaces to Modulate Immune Cell Recruitment to Scaffolds Book
Author : Stephen C. Bady
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Although many complex tissue engineering scaffolds have been developed, the number of translated treatments remains stagnant. Successful applications of scaffolds in regenerative medicine often requires scaffolds to elicit minimal host immune response and controlled release of bioactive molecules. Nanoparticles have shown great promise in the controlled release of therapeutics to aid tissue engineering. However, nanoparticles incorporated in tissue engineering scaffolds causes extra inflammatory responses. Although the release of anti-inflammatory drugs has been shown to reduce the foreign body response to scaffolds in vivo, the drugs also interfere with immune cells that are vital for tissue regeneration. Proposed here is a nanoparticle embedded scaffold drug delivery system designed to minimize the host immune response by controlling the physiochemical properties of nanoparticles. This system embeds PLGA nanoparticles with or without encapsulated immunosuppressant drugs in the walls of alginate scaffolds. The effects of surface modification and release of dexamethasone on immune cell recruitment to scaffolds in vivo were explored. Red Blood Cell Membrane (RBCM) coating on PLGA nanoparticles showed a decrease in neutrophil recruitment as well as an increased number of CD4+ T cells in the scaffolds, which are important for tissue regeneration. Our approach is a new strategy in minimizing the induced foreign body inflammatory response of nanoparticles used for tissue regeneration.

Micro and Nanotechnology in Vaccine Development

Micro  and Nanotechnology in Vaccine Development Book
Author : Mariusz Skwarczynski,Istvan Toth
Publisher : William Andrew
Release : 2016-09-20
ISBN : 0323400299
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Therapeutic RNA Nanotechnology

Therapeutic RNA Nanotechnology Book
Author : Kirill A. Afonin,Morgan Chandler
Publisher : CRC Press
Release : 2021-07-22
ISBN : 1000263177
Language : En, Es, Fr & De

GET BOOK

Book Description :

This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures. RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.

Nano Oncologicals

Nano Oncologicals Book
Author : Maria José Alonso,Marcos Garcia-Fuentes
Publisher : Springer
Release : 2014-10-15
ISBN : 3319080849
Language : En, Es, Fr & De

GET BOOK

Book Description :

This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines). Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Nanotechnology in Medicine

Nanotechnology in Medicine Book
Author : Vishnu Kirthi Arivarasan,Karthik Loganathan,Pushpamalar Janarthanan
Publisher : Springer Nature
Release : 2021-01-21
ISBN : 3030610217
Language : En, Es, Fr & De

GET BOOK

Book Description :

Nanomedicine is the field of science that deals with organic applications of medicine at the nano-scale level. It primarily addresses finding, anticipating, and treating sickness, as well as using nanotechnology to assist in controlling human frameworks at the cellular level. The nature of nanotechnology allows it to address numerous medical issues in humans. This book offers comprehensive information to better comprehend and apply multifunctional nanoparticles in nanomedicine, and thus open avenues in the field. Medicating at the nanolevel is an exceptional therapeutic avenue, as it avoids symptoms associated with conventional medicines. This book investigates recent insights into structuring novel drug delivery frameworks. It concentrates on the physical characteristics of drug delivery transporters, and the preliminary procedures involved in their use. The book offers in-depth detail that benefits academics and researchers alike, containing broad research from experts in the field, and serves as a guide for students and researchers in the field of nanomedicine, drug delivery, and nanotechnology.

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377566
Language : En, Es, Fr & De

GET BOOK

Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Nanoparticles in medicine and environment

Nanoparticles in medicine and environment Book
Author : J.C. Marijnissen,Leon Gradon
Publisher : Springer Science & Business Media
Release : 2009-12-01
ISBN : 9789048126323
Language : En, Es, Fr & De

GET BOOK

Book Description :

A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system. Three main themes are discussed: Nanoparticle sources and production Nanoparticle inhalation and deposition Toxicological and medical consequences of nanoparticles Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.