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Nanoparticle Therapeutics

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Nanoparticle Therapeutics

Nanoparticle Therapeutics Book
Author : Prashant Kesharwani,Kamalinder K. Singh
Publisher : Academic Press
Release : 2021-11-06
ISBN : 0128209186
Language : En, Es, Fr & De

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Book Description :

Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states. This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful. Brings together the novel applications of nanotechnology in biological fields Explores perspectives on technologies through highly organized tables, illustrative figures and flow charts Addresses key multidisciplinary challenges faced by nanotechnologists to foster collaboration among biologists, chemists, physicists, engineers and clinicians

Multifunctional Nanoparticles for Drug Delivery Applications

Multifunctional Nanoparticles for Drug Delivery Applications Book
Author : Sonke Svenson,Robert K. Prud'homme
Publisher : Springer Science & Business Media
Release : 2012-02-22
ISBN : 1461423058
Language : En, Es, Fr & De

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Book Description :

This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

Polymeric Nanoparticles as a Promising Tool for Anti cancer Therapeutics

Polymeric Nanoparticles as a Promising Tool for Anti cancer Therapeutics Book
Author : Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye
Publisher : Academic Press
Release : 2019-07-08
ISBN : 0128173319
Language : En, Es, Fr & De

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Book Description :

Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Model Organisms to Study Biological Activities and Toxicity of Nanoparticles

Model Organisms to Study Biological Activities and Toxicity of Nanoparticles Book
Author : Busi Siddhardha,Madhu Dyavaiah,Kaviyarasu Kasinathan
Publisher : Springer Nature
Release : 2020-03-28
ISBN : 9811517029
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.

Colloidal Upconverting Nanoparticle Systems for Integration in Targeting Therapeutics and Imaging Applications

Colloidal Upconverting Nanoparticle Systems for Integration in Targeting  Therapeutics and Imaging Applications Book
Author : Rafik Naccache
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Colloidal Upconverting Nanoparticle Systems for Integration in Targeting Therapeutics and Imaging Applications book written by Rafik Naccache, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Metal Nanoparticles for Drug Delivery and Diagnostic Applications

Metal Nanoparticles for Drug Delivery and Diagnostic Applications Book
Author : Muhammad Raza Shah,Muhammad Imran,Shafi Ullah
Publisher : Elsevier
Release : 2019-10-19
ISBN : 0128169613
Language : En, Es, Fr & De

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Book Description :

Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science. Illustrates the progression of nanoparticle therapeutics from basic research to applications Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use

               Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Novel Approaches for Cancer Therapy

Novel Approaches for Cancer Therapy Book
Author : Zane Barak Starkewolfe
Publisher : Unknown
Release : 2014
ISBN : 9781321023121
Language : En, Es, Fr & De

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Book Description :

This work explores the interaction of X-rays with nanomaterials and examines applications of this interaction for the treatment of cancer. The absorption of X-rays by nanomaterials and the mechanism by which these structures induce the production of radicals is studied. Using nanoparticles of various materials and sizes, we elucidate a mechanism of the interactions between the nanoparticles and the X-ray radiation-generated radical species. We measured the enhanced generation of radicals by nanomaterials irradiated with X-ray-radiation and termed this Nanoparticle Enhanced X-ray Therapy (NEXT). Using this approach we measure an increase in cell death employing various sizes and types of nanoparticles under X-ray radiation. While the enhancement of this cell death has a promising application potential for cancer therapy, the overall benefit will be determined by the overall X-ray absorption and the number of generated radical species. Utilizing the mechanism for radical generation by nanomaterials under X-ray radiation, we devised a novel approach for X-ray Enabled Nanochemistry (XEN) that allows for chemical reactions to take place only on the surface of nanomaterials. These location specific reactions are induced and enhanced by X-ray radiation. Using an approach called X-ray Triggered Chemotherapy (XTC), cancer drug molecules were attached to the oligonucleotide strands bound to the surface of gold nanoparticles and the applications of these nanoparticle drug carriers is explored for the treatment of cancer. In breast cancer cells, we observed an increase in cancer cell death using the XTC approach as compared with the use of either X-ray radiation or chemotherapy alone. We find that nanomaterials can enhance the efficacy of X-rays in cancer treatment and that nanomaterials under X-ray radiation can be used for the remote activation of otherwise dormant cancer drugs at the tumor site.

Trajectory Features as Surrogate Measures of the Nanoparticle microenvironment Interaction Space

Trajectory Features as Surrogate Measures of the Nanoparticle microenvironment Interaction Space Book
Author : Chad Curtis
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The use of nanoparticle platforms in the field of medicine as diagnostic tools and therapeutic agents has been a long-promised hope. Despite some successes, including FDA approval of micelle and liposomal formulations for the delivery of strongly hydrophobic anticancer drugs, the translation of these technologies has slowed; in 1995, the ratio of animal studies to FDA-approved drugs was 19:1 and the ratio of animal studies to clinical studies was 7:1. Fifteen years later in 2010, the ratio of animal studies to FDA-approved drugs was 4000:1, and the ratio of animal studies to clinical studies was 120:1. There are many factors contributing to the slow in translation of nanotherapeutic technologies including bottlenecks in funding and the number of researchers trained in translational and clinical studies. But there are some upstream causes that need to be addressed prior to consideration of clinical trials. In this dissertation, I focus on two in particular: a limited knowledge of nanoparticle-environment interactions at the cell, tissue, and organ levels; and the slowness of existing screening tools to identify potentially successful nanoformulations. This dissertation presents a number of tools that can be used to inform systems-level models of drug-environment interactions and improve the screening of drug candidates. Using in vitro and ex vivo models we demonstrate that nanoparticle colloidal stability can be used as a screening tool for nanoparticle therapeutics to the brain. We also demonstrate the use of trajectory datasets collected via fluorescent microscopy and multiple particle tracking to distinguish nuanced aspects of the nanoparticle-microenvironment interaction space using neural networks, including protein adhesion and nanoparticle cell uptake. We apply similar methods to investigate the role of key nanoparticle features (surface functionality, PEG grafting density, PEG chain length) in determining in vitro and ex vivo transport behavior. This method of analysis highlights the potential of nanoparticles to be used both as pre-clinical diagnostic probes without the use of complex chemistries and to guide nanoparticle design for therapeutic interventions.

RNA Nanotechnology and Therapeutics

RNA Nanotechnology and Therapeutics Book
Author : Peixuan Guo,Farzin Haque
Publisher : CRC Press
Release : 2013-07-09
ISBN : 1466505664
Language : En, Es, Fr & De

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Book Description :

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

Nanomedicine

Nanomedicine Book
Author : Ismail M. Meraz,Victor Segura-Ibarra,Fransisca Leonard,Javier Gonzalez,Sally Ally,Biana Godin,Rita E. Serda
Publisher : Elsevier Inc. Chapters
Release : 2013-09-19
ISBN : 0128055448
Language : En, Es, Fr & De

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Book Description :

Discrete pathologies have unique features that contribute to disease progression. Each lesion contains unique clusters of cells and other factors that make up specific micro-niches. Individual microniches present novel barriers that hamper the delivery of therapeutics, but it also contains characteristic elements that can favour accumulation of therapeutics within the lesion. This chapter discusses the unique biology associated with cancer, cardiovascular disease, and neurological disorders and describes how each unique presentation can be used to optimize nanoparticle design for targeting the lesion.

Design and Evaluation of Plasmonic Magnetic Au MFe2O4 M Fe Co Mn Core Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics

Design and Evaluation of Plasmonic Magnetic Au MFe2O4  M Fe Co Mn  Core Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics Book
Author : Ravichandran Manisekaran
Publisher : Springer
Release : 2017-10-30
ISBN : 3319676091
Language : En, Es, Fr & De

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Book Description :

This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles.

Nanoparticle Mediated Immunotherapy

Nanoparticle Mediated Immunotherapy Book
Author : Tuan Vo-Dinh
Publisher : Springer
Release : 2021-10-31
ISBN : 9783030783372
Language : En, Es, Fr & De

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Book Description :

This book is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in immunotherapy. The combination of nanotechnology and immunotherapy is recognized as a promising treatment modality. In particular, the use of nanoparticles in immunotherapy has attracted increased attention for their unique efficacy and specificity in cancer treatment. A wide variety of nanoparticles, such as polymeric and liposomal nanosystems, carbon nanotubes, and gold nanoparticles have provided important nanoplatforms for immunotherapeutic approaches. They have been shown to improve delivery and efficacy of immunotherapeutic agents such as vaccines or adjuvants. Nanoparticle-mediated thermal therapy has demonstrated the effectiveness for precise tumor cell ablation, radio-sensitization of hypoxic regions, enhancement of drug delivery, activation of thermosensitive agents, and enhancement of the immune system. Plasmonic nanoparticles are a special type of metallic nanoparticles that has received great interest due to their enhanced optical and electromagnetic properties and their superior capacity to convert photon energy into heat for selective photothermal therapy at the nanoscale level. Nanoparticle sizes can also be controlled such that they accumulate preferentially in tumors due to the enhanced permeability and retention effect of tumor vasculature. Various nanosystems such as gold nanoparticles have also been shown to stimulate the immune system. Immunotherapies could thus synergistically benefit from the combination with targeted nanoparticle-mediated photothermal therapies, especially when hyperthermia around immune-checkpoint inhibitors in the tumor bed is combined with precise thermal ablation of cancer cells. Of great importance is the possibility that such an approach can induce long-term immunological memory that can provide protection against tumor recurrence long after treatment of the initial tumors, like an ‘anticancer vaccine’. Nanoparticle-mediated immunotherapy could lead to an entirely new treatment paradigm that challenges traditional surgical resection approaches for many cancers and metastases.

Alzheimer s Disease Theranostics

Alzheimer   s Disease Theranostics Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2019-01-20
ISBN : 0128167394
Language : En, Es, Fr & De

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Book Description :

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

Cell Membrane Cloaked Nanoparticles for Targeted Therapeutics

Cell Membrane Cloaked Nanoparticles for Targeted Therapeutics Book
Author : Brian Luk
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The advent of nanoparticle-based delivery systems has made a significant impact on clinical patient outcomes. In recent decades, myriad nanoparticle-based therapeutic agents have been developed for the treatment and management of ailments such as cancer, diabetes, pain, bacterial infections, and asthma, among many others. Nanotherapeutics offer many distinct advantages over conventional free drug formulations. For example, nanoparticles are able to accumulate at tumor sites by extravasation through leaky vasculature at tumor sites via the enhanced permeability and retention (EPR) effect; nanoparticles can also be tailored to have desirable characteristics, such as prolonged circulation in the blood stream, improved drug encapsulation, and sustained or triggered drug release. Currently, a growing number of nanoformulations with favorable pharmacological profiles and promising efficacy are being used in clinical trials for the treatment of various cancers. Building on the success of these encouraging clinical results, new engineering strategies have emerged that combine synthetic nanoparticles with natural biomaterials to create nature-inspired biomimetic delivery systems. The work presented in this dissertation focuses on the biointerfacing between synthetic and natural materials, namely in the manifestation of cell membrane-coated nanoparticles. By exploiting the natural functionalities of source cell membranes, cell membrane-cloaked nanoparticles have huge potential in the delivery of therapeutic agents for a variety of applications. The first portion of this thesis will focus on understanding the fundamentals underlying cell membrane coating on synthetic nanoparticles. First introduced in 2011, cell membrane-cloaked nanoparticles showed immediate promise in drug delivery applications, but further understanding was necessary to be able to harness the full potential of the membrane coating platform. The first section provides further insight into the interfacial interactions between membranes and synthetic nanoparticles, and how the membrane coating technique faithfully translates the complexities of natural cellular membranes to the nanoscale. The following three sections explore potential therapeutic applications of membrane-coated nanoparticles for targeted drug delivery, biodetoxification, and immunomodulation. Ultimately, cell membrane-cloaked nanoparticles have the potential to significantly change the landscape of nanomedicine. The novel applications presented in this thesis are just a few of many examples currently being researched, with countless more avenues waiting to be explored.

Therapeutic Evaluation of Aminoflavone in Triple Negative Breast Cancer

Therapeutic Evaluation of Aminoflavone in Triple Negative Breast Cancer Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Breast cancer is a heterogeneous disease that is clinically characterized by the expression of estrogen receptor [alpha] (ER[alpha]), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Targeted and effective therapies have been developed against these markers. Triple negative breast cancers (TNBCs) comprise 15-20% of breast cancers, and lack expression of these three proteins. TNBCs are aggressive and correlated with a poor prognosis, thus, the development of novel targeted therapies to improve outcomes in these patients is crucial. It has been shown that the aryl hydrocarbon receptor (AhR) is overexpressed in models of human TNBC, but its role in mammary tumorigenesis or as a potential therapeutic target is unclear. In order to elucidate the role of AhR in TNBC, two human TNBC cell lines were engineered to harbor inducible knockdown of AhR. While growth effects were not observed upon AhR knockdown in these models, they serve as tools to understand the impact of AhR modulation. Based on existing data, it is hypothesized that AhR or AhR ligands may be used to treat breast cancer. AhR activator aminoflavone (AF) was shown to mediate growth inhibitory effects in TNBC models at low doses, which provides evidence against the existing paradigm that ER[alpha] expression correlates with AF responsiveness, suggesting AF could be a therapeutic option for TNBC patients. Despite in vitro efficacy, AF-mediated pulmonary toxicity is dose-limiting in vivo. Therefore, a novel targeted nanoparticle-based AF delivery system was created to take advantage of the benefits associated with nanoparticle therapeutics, including active targeting abilities and increase in therapeutic index. A majority of TNBCs overexpress epidermal growth factor receptor (EGFR), and nanoparticles are conjugated with an EGFR-binding peptide to actively target TNBC tumors. The use of AF-loaded, EGFR-targeted nanoparticles in vivo significantly reduces tumor volume at low doses without evidence of toxicity. Overall, this comprehensive study examines AhR and AhR activator, AF, in the context of TNBC, as well as characterizes a novel method to deliver AF in order to enhance its therapeutic efficacy. The results presented here ultimately provide a basis for further development of targeted nanoparticle-based therapies for treatment of TNBC.

Development of Novel Nanoparticle based Therapeutics for Treatment of Lung Cancer

Development of Novel Nanoparticle based Therapeutics for Treatment of Lung Cancer Book
Author : Deniz Ali Bölükbaş
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Development of Novel Nanoparticle based Therapeutics for Treatment of Lung Cancer book written by Deniz Ali Bölükbaş, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanoparticle NP Based Delivery Vehicles

Nanoparticle  NP  Based Delivery Vehicles Book
Author : Navid Rabiee,Mahsa Kiani,Mojtaba Bagherzadeh,Mohammad Rabiee,Sepideh Ahmadi
Publisher : Morgan & Claypool Publishers
Release : 2019-05-08
ISBN : 164327452X
Language : En, Es, Fr & De

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Book Description :

Gene therapy as a potential method for treatment of genetic disorders and other malignancies as well as treatment of many cancers has attracted a great amount of attention in recent years. Current research focuses on stable and smart drug/gene delivery systems, including controlled release. Smart nanostructures have been considered as a promising approach when applied to drug and gene delivery systems, and could solve the problems related to the inefficient transfer of medication to the affected cells.

Advances in Animal Biotechnology and its Applications

Advances in Animal Biotechnology and its Applications Book
Author : Suresh Kumar Gahlawat,Joginder Singh Duhan,Raj Kumar Salar,Priyanka Siwach,Suresh Kumar,Pawan Kaur
Publisher : Springer
Release : 2018-05-29
ISBN : 9811047022
Language : En, Es, Fr & De

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Book Description :

This book explores the recent advancements in cutting-edge techniques and applications of Biotechnology. It provides an overview of prospects and applications while emphasizing modern, and emerging areas of Biotechnology. The chapters are dedicated to various field of Biotechnology including, genome editing, probiotics, in-silico drug designing, nanoparticles and its applications, molecular diagnostics, tissue engineering, cryopreservation, and antioxidants. It is useful for both academicians and researchers in the various disciplines of life sciences, agricultural sciences, medicine, and Biotechnology in Universities, Research Institutions, and Biotech companies. This book provides the readers with a comprehensive knowledge of topics in Genomics, Bionanotechnology, Drug Designing, Diagnostics, Therapeutics, Food and Environmental Biotechnology. The chapters have been written with special reference to the latest developments in the frontier areas of Biotechnology that impacts the Biotech industries.