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Nanomedicines For Breast Cancer Theranostics

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Nanomedicines for Breast Cancer Theranostics

Nanomedicines for Breast Cancer Theranostics Book
Author : Nanasaheb D. Thorat,Joanna Bauer
Publisher : Elsevier
Release : 2020-03-08
ISBN : 0128200170
Language : En, Es, Fr & De

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Book Description :

Nanomedicines for Breast Cancer Theranostics addresses the translational aspects and clinical perspectives of breast cancer nanomedicine from a multidisciplinary perspective. The book summarizes research efforts at the preclinical and clinical stage of nanostructures and nanomedicine for dealing with the important challenge of nanomedicine translation in breast cancer theranostics. This book is an important resource for those working in both academia and industry, focusing on hot topics in biomaterials, biomedical engineering, drug delivery and oncology. Shows how the discovery of new nanomedicines is leading directly to an increase in the early-stage diagnosis of breast cancer Includes coverage of breast cancer nanomedicine standardization and characterization, highlighting newly developed treatments, diagnostics and treatment monitoring tools Explains why the design of nanobiomaterials make them effective drug carriers when treating breast cancer

Multifunctional Theranostic Nanomedicines in Cancer

Multifunctional Theranostic Nanomedicines in Cancer Book
Author : Malay K. Das
Publisher : Academic Press
Release : 2021-03-26
ISBN : 0128217006
Language : En, Es, Fr & De

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Book Description :

Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment

Handbook of Nanomaterials for Cancer Theranostics

Handbook of Nanomaterials for Cancer Theranostics Book
Author : Joao Conde
Publisher : Elsevier
Release : 2018-06-27
ISBN : 0128133406
Language : En, Es, Fr & De

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Book Description :

Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments

Nanomedicine for Cancer Therapy

Nanomedicine for Cancer Therapy Book
Author : Piyush Kumar,Rohit Srivastava
Publisher : Springer
Release : 2016-11-21
ISBN : 3319458264
Language : En, Es, Fr & De

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Book Description :

This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.

Biogenic Nanoparticles for Cancer Theranostics

Biogenic Nanoparticles for Cancer Theranostics Book
Author : Chittaranjan Patra,Irshad Ahmad,Muhammad Ayaz,Ali Talha Khalil,Sudip Mukherjee,Muhammad Ovais
Publisher : Elsevier
Release : 2021-06-01
ISBN : 0128214686
Language : En, Es, Fr & De

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Book Description :

Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetration in cancerous tissue, its clearance, and its metabolism. Moreover, the in vitro and in vivo toxicological effects of biogenic nanoparticles are discussed. This book is an important reference source for materials scientists and biomedical scientists who are looking to increase their understanding of how biogenic nanoparticles are being used for a range of cancer treatment types. Metal nanoparticles have traditionally been synthesized by classical physico-chemical methods which have many drawbacks, such as high energy demand, high cost and potential ecotoxicity. As a result, the biosynthesis of metal nanoparticles is gaining increasing prominence. Biosynthesis approaches to metal nanoparticles are clean, safe, energy efficient and environment friendly. Explains the synthesis methods and applications of biogenic nanoparticles for cancer theranostics Outlines the distinctive features of biogenic nanoparticles that make them effective cancer treatment agents Assesses the major challenges of using biogenic nanoparticles on a mass scale

Nanomedicine for Cancer Therapy

Nanomedicine for Cancer Therapy Book
Author : Piyush Kumar,Rohit Srivastava
Publisher : Springer
Release : 2016-12-08
ISBN : 9783319458250
Language : En, Es, Fr & De

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Book Description :

This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.

Cancer Theranostics

Cancer Theranostics Book
Author : Xiaoyuan Chen,Stephen Wong
Publisher : Academic Press
Release : 2014-03-20
ISBN : 0124078842
Language : En, Es, Fr & De

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Book Description :

Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Nanotheranostics for Cancer Applications

Nanotheranostics for Cancer Applications Book
Author : Prakash Rai,Stephanie A. Morris
Publisher : Springer
Release : 2018-11-12
ISBN : 3030017753
Language : En, Es, Fr & De

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Book Description :

This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

Hybrid Nanostructures for Cancer Theranostics

Hybrid Nanostructures for Cancer Theranostics Book
Author : Raghvendra Ashok Bohara,Nanasaheb D. Thorat
Publisher : Elsevier
Release : 2018-11-19
ISBN : 0128139072
Language : En, Es, Fr & De

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Book Description :

Hybrid nanostructures are nanoparticles which incorporate two or more structures. These structures may represent organic or inorganic material, but they synergistically improve the application of the material for end users. Hybrid Nanostructures for Cancer Theranostics explores how hybrid nanostructures are used in cancer treatment. Focusing on the properties of hybrid nanostructures, the book demonstrates how their unique characteristics can be used to create more effective treatment techniques. In the second half of the book, the chapters examine how hybrid nanostructures are currently being used in practice, assessing the pros and cons of using different types of nanostructures for different treatments. This valuable resource will allow readers to understand the core and emerging concept of functionalization, bioconjugation, hyperthermia and phototherapy of nanoparticles which allows for the greater use of hybrid nanomaterials in cancer theranostics. Shows how the use of novel hybrid nanostructures can lead to more effective cancer treatments. Explores how hybrid nanostructures are used for different treatment types, including photo thermal therapy and drug delivery. Explains how the use of hybrid nanostructures can lead to more rapid cancer diagnosis.

Nanoparticles in Cancer Therapy Novel Concepts Mechanisms and Applications

Nanoparticles in Cancer Therapy  Novel Concepts  Mechanisms and Applications Book
Author : Qingxin Mu,Bing Yan
Publisher : Frontiers Media SA
Release : 2019-04-03
ISBN : 2889458105
Language : En, Es, Fr & De

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Book Description :

Since the invention of nanomedicine decades ago, considerable progresses have been made, especially with cancer as a target. Nanoparticles have been proven to be powerful imaging tools or potent agents for cancer diagnosis, treatment and prevention. Active research spread from fundamental research to clinical investigations. This topic intends to cover several important aspects in this field including nanocarrier development, gene delivery, intrinsically active nanoparticles, tumor microenvironment, immunology, and toxicity.

Targeted Nanomedicine for Breast Cancer Therapy

Targeted Nanomedicine for Breast Cancer Therapy Book
Author : Shivani Rai Paliwal,Rishi Paliwal
Publisher : Academic Press
Release : 2021-11-29
ISBN : 9780128244760
Language : En, Es, Fr & De

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Book Description :

Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of different and diverse aspects of treatment approaches for breast cancer such as conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. Worldwide, breast cancer is the most common cancer in women; however, breast cancer therapy is always challenging. Reports and new studies are released from different corners of the world and it is interdisciplinary research. This book compiles the most important information on the state-of-the-art breast cancer therapeutics. It contains detailed information on breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, the first part describes basic and receptor mediated targeting approaches and the second part examines tumor microenvironment mediated approaches. Targeted Nanomedicine for Breast Cancer Therapy is a useful book for pharmaceutical scientists, basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry. Highlights promising breast cancer targets to help design nanomedicines and stimuli-triggered methods for cancer imaging and treatment Provides in-depth exploration of targeted breast cancer therapy as well as highlights to understand the most important points quickly Explores cutting edge research in the area of targeted nanomedicine and drug delivery including nanotheranostics for breast cancer therapy

Nanomedicine for Cancer Diagnosis and Therapy

Nanomedicine for Cancer Diagnosis and Therapy Book
Author : Arshi Malik,Sarah Afaq,Mohammed Tarique
Publisher : Springer Nature
Release : 2021-08-01
ISBN : 9811575649
Language : En, Es, Fr & De

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Book Description :

This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.

Intracellular Delivery III

Intracellular Delivery III Book
Author : Aleš Prokop,Volkmar Weissig
Publisher : Springer
Release : 2016-10-31
ISBN : 3319435256
Language : En, Es, Fr & De

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Book Description :

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.

Nanoparticle Drug Delivery Systems for Cancer Treatment

Nanoparticle Drug Delivery Systems for Cancer Treatment Book
Author : Hala Gali-Muhtasib,Racha Chouaib
Publisher : CRC Press
Release : 2020-02-19
ISBN : 1000681416
Language : En, Es, Fr & De

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Book Description :

In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine Book
Author : Yusuf Tutar
Publisher : Bentham Science Publishers
Release : 2020-06-08
ISBN : 9811456895
Language : En, Es, Fr & De

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Book Description :

Nanotheranostics is a recent medical field which integrates diagnostic imaging protocols and therapeutic functions to monitor real time drug release in the body and distribution to the target site. The combined processes allow technicians to observe the effectiveness of a specifically designed drug candidate and predict its possible side effects. All these features help clinicians in optimizing treatment options for cancer and other diseases for the individual patient. Current research is tailored to individual therapy because each drug may display a variety of responses depending on variations in an individual’s genetics and subsequently, their clinical biochemistry. Many tumors are still challenging for therapists in terms of available treatment and nanotheranostic strategies may help them to combat cancer more efficiently. Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine presents information about current theranostic technologies in use at clinics and recent research on nanotheranostic applications, with a focus on cancer treatment. Information is presented in seven organized chapters that cover the basics of cancer nanotheranostics, tumor microenvironmental factors, gene therapy and gene delivery concepts, and the combined application of diagnostic imaging with cancer chemotherapy. A chapter focusing on the role of non-coding MRNAs in breast cancer carcinogenesis is also included, giving readers a glimpse of the complexities in the molecular biology of cancer which drive the need for new theranostic technologies. The book is of interest to medical professionals (including oncologists and specialists in internal medicine), diagnostic imaging technicians, and researchers in the fields of pharmacology, molecular biology and nuclear medicine.

Nanomedicines

Nanomedicines Book
Author : Martin Braddock
Publisher : Royal Society of Chemistry
Release : 2016-04-14
ISBN : 1782622535
Language : En, Es, Fr & De

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Book Description :

Nanomedicines and nanopharmacology is a rapidly developing and evolving field with new techniques and applications under constant development. This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine. Providing an understanding of the relationship of nanocarrier, drug and targetting moieties and physico-chemical properties, this title will provide an accurate and current representation of the field by addressing the promises, prospects and pitfalls of nanomedicine. Covering a wide range of areas in detail, this book will provide an excellent companion for medicinal chemists, pharmacologists and biochemists working in industry or academia.

Nano Oncologicals

Nano Oncologicals Book
Author : Maria José Alonso,Marcos Garcia-Fuentes
Publisher : Springer
Release : 2014-10-15
ISBN : 3319080849
Language : En, Es, Fr & De

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Book Description :

This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines). Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Cancer Nanotheranostics What Have We Learned So Far

Cancer Nanotheranostics  What Have We Learned So Far  Book
Author : João Conde,Pedro Viana Baptista,Jesús M De La Fuente,Furong Tian
Publisher : Frontiers Media SA
Release : 2016-03-17
ISBN : 288919776X
Language : En, Es, Fr & De

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Book Description :

After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.

Block Copolymer Based Magnetic Nanoclusters for Cancer Theranostics Synthesis Characterization and In Vitro Evaluation

Block Copolymer Based Magnetic Nanoclusters for Cancer Theranostics  Synthesis  Characterization and In Vitro Evaluation Book
Author : Hemant Motiram Vishwasrao
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"There is plenty of room at the bottom". In this visionary lecture in 1959 Prof. Richard Feynman spoke of the interesting ramifications of working with matter at the atomic scale. Since then, scientists have worked relentlessly towards realizing his vision. The influence of nanobiotechnology on material science and polymer chemistry has given rise to a new field called 'theranostics', combining drug delivery and diagnostics within the same nanostructures, thereby enabling simultaneous diagnosis, targeted drug delivery and continued therapy monitoring. Iron oxide nanoparticles (MNPs) are one such class of MRI contrast agents that can be converted into theranostic nanomedicines for cancer therapy. However, development of a stable theranostic contrast system comprising of MNPs is complex and requires a careful balance between the therapeutic diagnostic components. We explored the potential of biodegradable hydrophilic block ionomers such as anionic poly (glutamic acid-b-ethylene glycol) and cationic poly (l-lysine-b-ethylene glycol) in formulating stable magnetic nanoclusters (MNCs). These MNCs were extensively characterized for their composition, colloidal stability and factors influencing their MRI capability. Extensive in vitro studies revealed that the anionic cisplatin-loaded MNCs showed minimal non-specific uptake, a highly preferred feature for targeted cancer therapy. Luteinizing hormone releasing hormone receptor (LHRHr) targeting significantly enhanced the uptake of these formulations in LHRHr-positive ovarian cancer cells. LHRHr targeting also helped improve the theranostic efficacy in cisplatin resistant ovarian cancer cells. One the other hand, cationic MNCs were used to demonstrate the potential of MNCs to function as stimuli-responsive theranostic systems capable of releasing the payload in the acidic milieu breast and ovarian cancer cells. These cationic MNCs also exhibited significantly enhanced T2-weighted MRI contrasts at much lower concentrations than the anionic counterparts. Finally, we successfully evaluated the feasibility of kinetically controlled flash nanoprecipitation technique using multi-inlet vortex mixer (MIVM) to formulate well-defined MNCs from non-ionic amphiphilic Pluronic tri-block copolymers. In comparison to self-assembly techniques, flash nanoprecipitation resulted in significant reduction in polydispersity. It was observed that the hydrophobic block-length of the copolymer dictates the extent of encapsulation hydrophobic therapeutic agents along with the MNPs. exhibited the potential to function as both T1 and T2 contrast agents. In summary, looking at the bigger picture, the work presented here emphasizes on the importance of product development in establishing a critical balance between the therapeutic and imaging functionalities when designing an efficient targeted theranostic nanosystems.

Advanced Theranostic Nanomedicine in Oncology

Advanced Theranostic Nanomedicine in Oncology Book
Author : Gianni Ciofani,Attilio Marino,Christos Tapeinos
Publisher : Frontiers Media SA
Release : 2020-03-18
ISBN : 2889636216
Language : En, Es, Fr & De

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Book Description :

Download Advanced Theranostic Nanomedicine in Oncology book written by Gianni Ciofani,Attilio Marino,Christos Tapeinos, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.