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Nanomedicine For Ischemic Cardiomyopathy

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Nanomedicine for Ischemic Cardiomyopathy

Nanomedicine for Ischemic Cardiomyopathy Book
Author : Morteza Mahmoudi
Publisher : Academic Press
Release : 2020-05-05
ISBN : 0128174358
Language : En, Es, Fr & De

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Book Description :

Nanomedicine for Ischemic Cardiomyopathy: Progress, Opportunities, and Challenges provides an overview on the recent advances in diagnostic and treatment of ischemic cardiomyopathy diseases including myocardial infarction. Shortcomings of the current methods and how nanomedicine can address those obstacles in the field are discussed including the limitations of newly developed cell therapy approaches to clinical translation and how nanomedicine may overcome crucial issues and facilitate the successful and efficient clinical translation of cell therapy. Biomolecular therapy is also explored as another powerful approach for regeneration of heart tissue including available methods and systematic delivery of biomolecules using nanocarriers to the injured part of myocardium through active targeting. Finally, coverage of major tissue engineering advances for myocardial regeneration, including use of epicardial nanostructured patches for regeneration of injured epicardium and the highly conductive patches for enhancing cross talks between the cardiomyocytes, is explored. This concise, yet rigorous coverage, of the field of cardiac nanotechnology outlines the innovative and necessary role of nanomedicine in regenerative medicine for cardiac repair allowing researchers, clinicians, and nanotechnologists to examine the strengths and limitations of current findings and predict future trends to advance the applications of nanotechnology in cardiovascular biomedical research. Introduces concepts of the unique capacities of cardiac-nanotechnology Points to potential and promising applications of engineering nanotechnologies on revolutionizing cell therapy and biomolecular therapy approaches for cardiac regeneration Bridges the knowledge gap between cardiologists and cardiac regenerative nanomedicine experts

Cardiovascular Regenerative Medicine

Cardiovascular Regenerative Medicine Book
Author : Vahid Serpooshan,Sean M. Wu
Publisher : Springer
Release : 2019-06-29
ISBN : 3030200477
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Cardiovascular Disease I Contemporary Cover

Cardiovascular Disease I  Contemporary Cover  Book
Author : Iconcept Press
Publisher : Iconcept Press
Release : 2014-09-12
ISBN : 9781922227898
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease is a class of diseases that involve the heart or blood vessels, such as arteries, capillaries and veins. Cardiovascular diseases remain the biggest cause of deaths worldwide, though over the last two decades, cardiovascular mortality rates have declined in many high-income countries. At the same time, cardiovascular deaths and disease have increased at a fast rate in low- and middle-income countries. The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common ones. This book is targeted for researchers, scholars or other health care providers who need a ready reference for cardiovascular disease ranging from causes, signs and symptoms, and diagnosis through treatment and special considerations. There are two volumes. This book is the first volume. There are totally 12 chapters in this book. Chapter 1 proposes that the renal artery diameter could represents a marker of non-traditional cardiovascular risk factors in selected populations. A pathophysiological explanation, including main biophysical background, and clinical implication of this new finding has been critically discussed. Bicuspid aortic valve (BAV) is the commonest congenital cardiac disease and is characterized by the aortic valve only having two leaflets rather than the usual three. Chapter 2 provides a comprehensive review of the condition, from epidemiology and etiology to diagnosis and management. In the case of coronary artery disease, cardiomyocytes' oxygen supply and thus the heart's contractility diminishes with the consequence that the oxygen demands of the whole organism are no longer fulfilled. Chapter 3 focuses on retroperfusion and it is shown that it is possible to perform a regional venous retrobypass in a long term pig model. Chapter 4 discusses the FGF23/Klotho system, which is a new biological system with a pivotal role in normal regulation of phosphorus homeostasis.. Chapter 5 assesses the effect of high-intensity and moderate intensity exercise on the exercise efficiency of ischaemic heart disease patients. Although ischemic heart disease patients were more inefficient during high-intensity exercise, this type of exercise may provide greater benefits for this population group due to eliciting a higher physiological response and energy expenditure. Chapter 6 presents the characteristics of cardiovascular manifestations, including cardiac manifestations, cerebrovascular disease, pulmonary vascular involvement, renal vascular involvement, intestinal vasculitis, and cutaneous vasculitis. All of them are analyzed and described using a retrospective review of the medical records of 1125 SLE patients examined in Juntendo University Hospital between 1955 and 2002. Chapter 7 shows that serotonin, angiotensin II, urotensin II, cardiotrophin-1 and salusin-B exert proatherogenic effects, whereas adiponectin, GLP-1, GIP, heregulin-B1 and salusin-a have antiatherogenic effects. Chapter 8 highlights the role mutations of mitochondrial genome in atherosclerosis. Chapter 9 reviews the relationship between thiamine and MI. Genetic studies provide opportunities to determine which proteins link thiamine to MI pathology. Chapter 10 illustrates a variety types of peripheral vascular disease including from etiology to endovascular treatment. Especially, venous vascular disease are shown as not only endovascular treatment but pharmaceutical therapy. Chapter 11 proposes conventional and new techniques/methods for diagnosis and treatment of the cardiovascular disease. In addition, the chapter explain the comparison of conventional formulation and new nanomedicine therapy of cardiovascular disease. Chapter 12 describes all aspects of cardiogenic shock, especially as the complication of acute myocardial infarction.

Cardiovascular Disease I

Cardiovascular Disease I Book
Author : Iconcept Press
Publisher : Iconcept Press
Release : 2014-09-12
ISBN : 9781922227546
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease is a class of diseases that involve the heart or blood vessels, such as arteries, capillaries and veins. Cardiovascular diseases remain the biggest cause of deaths worldwide, though over the last two decades, cardiovascular mortality rates have declined in many high-income countries. At the same time, cardiovascular deaths and disease have increased at a fast rate in low- and middle-income countries. The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common ones. This book is targeted for researchers, scholars or other health care providers who need a ready reference for cardiovascular disease ranging from causes, signs and symptoms, and diagnosis through treatment and special considerations. There are two volumes. This book is the first volume. There are totally 12 chapters in this book. Chapter 1 proposes that the renal artery diameter could represents a marker of non-traditional cardiovascular risk factors in selected populations. A pathophysiological explanation, including main biophysical background, and clinical implication of this new finding has been critically discussed. Bicuspid aortic valve (BAV) is the commonest congenital cardiac disease and is characterized by the aortic valve only having two leaflets rather than the usual three. Chapter 2 provides a comprehensive review of the condition, from epidemiology and etiology to diagnosis and management. In the case of coronary artery disease, cardiomyocytes' oxygen supply and thus the heart's contractility diminishes with the consequence that the oxygen demands of the whole organism are no longer fulfilled. Chapter 3 focuses on retroperfusion and it is shown that it is possible to perform a regional venous retrobypass in a long term pig model. Chapter 4 discusses the FGF23/Klotho system, which is a new biological system with a pivotal role in normal regulation of phosphorus homeostasis.. Chapter 5 assesses the effect of high-intensity and moderate intensity exercise on the exercise efficiency of ischaemic heart disease patients. Although ischemic heart disease patients were more inefficient during high-intensity exercise, this type of exercise may provide greater benefits for this population group due to eliciting a higher physiological response and energy expenditure. Chapter 6 presents the characteristics of cardiovascular manifestations, including cardiac manifestations, cerebrovascular disease, pulmonary vascular involvement, renal vascular involvement, intestinal vasculitis, and cutaneous vasculitis. All of them are analyzed and described using a retrospective review of the medical records of 1125 SLE patients examined in Juntendo University Hospital between 1955 and 2002. Chapter 7 shows that serotonin, angiotensin II, urotensin II, cardiotrophin-1 and salusin-B exert proatherogenic effects, whereas adiponectin, GLP-1, GIP, heregulin-B1 and salusin-a have antiatherogenic effects. Chapter 8 highlights the role mutations of mitochondrial genome in atherosclerosis. Chapter 9 reviews the relationship between thiamine and MI. Genetic studies provide opportunities to determine which proteins link thiamine to MI pathology. Chapter 10 illustrates a variety types of peripheral vascular disease including from etiology to endovascular treatment. Especially, venous vascular disease are shown as not only endovascular treatment but pharmaceutical therapy. Chapter 11 proposes conventional and new techniques/methods for diagnosis and treatment of the cardiovascular disease. In addition, the chapter explain the comparison of conventional formulation and new nanomedicine therapy of cardiovascular disease. Chapter 12 describes all aspects of cardiogenic shock, especially as the complication of acute myocardial infarction.

Resveratrol and Health

Resveratrol and Health Book
Author : Ole Vang,John Michael Pezzuto
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Resveratrol, a naturally occurring polyphenol found in red grapes (wine), peanuts, and berries, has been linked to health and disease prevention because of its demonstrated cardioprotective, antioxidative, anti-inflammatory, and anticancer effects. However, because of limitations including rapid metabolism and low bioavailability, only limited clinical trials of resveratrol have been possible. To share recent findings on the biological effects of resveratrol and its derivatives and discuss new directions for resveratrol research, the conference "Resveratrol 2014, the Third International Conference on Resveratrol and Health" was convened from November 30 to December 3, 2014 in Hawaii. This Annals volume presents a collection of papers stemming from this conference and covers a range of topics, including the mechanisms of action and therapeutic potential of resveratrol in pancreatic cancer, prostate cancer, heart failure, dystrophic cardiomyopathy, ischemic heart disease, atrial fibrillation, osteoporosis, and polycystic ovary syndrome. Also discussed are the challenges in analyzing the biological effects of resveratrol; new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation; dendrimer nanotechnology for enhanced formulation and controlled delivery of resveratrol; resveratrol metabolite profiling in clinical nutrition research; and lastly, resveratrol and health from a consumer perspective."--Society website.

Cardiovascular Diseases

Cardiovascular Diseases Book
Author : Nilanjana Maulik, Ph.D.
Publisher : CRC Press
Release : 2013-04-09
ISBN : 1439882002
Language : En, Es, Fr & De

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Book Description :

With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases. Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect. Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.

NanoCellBiology

NanoCellBiology Book
Author : Bhanu P. Jena,Douglas J. Taatjes
Publisher : CRC Press
Release : 2014-04-23
ISBN : 9814411809
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive understanding of the discovery of a new cellular structure the "porosome," which is the universal secretory machinery in cells; the protein assembly, biomineralization, and biomolecular interactions; the molecular evolution of protein structure; the use of magnetic nanoparticles for transformative application in medicine and therapy, and the new and novel imaging approach of electrical impedance spectroscopy in biology. It be used for college courses in nanomedicine, nano cell biology, advanced nanotechnology, and biotechnology at the undergraduate and graduate level.

Gold Nanoparticles for Stem Cell Delivery in Myocardial Infarction

Gold Nanoparticles for Stem Cell Delivery in Myocardial Infarction Book
Author : Jeffrey C. Henson
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In this work, the potential for PEGylated gold nanoparticles for use as a platform for stem cell delivery in treatment of myocardial infarction (MI) is preliminarily investigated. Cardiovascular disease is currently the leading cause of death worldwide, with majority of mortality resulting from coronary artery disease and associated MI. The ensuing ischemic conditions resulting from MI cause substantial heart muscle tissue loss and scarring in the heart. Adverse tissue remodeling creates a significant loss in heart function that can result in the formation of cardiac hypertrophy, ventricular dilation and arrythmias. The long-term prognosis of patients who have suffered MI is poor, with conditions developing into chronic heart failure. Nanotechnology based stem cell delivery could be used as a novel method to alleviate these conditions. The heart possesses poor regenerative capacity and the ability to deliver stem cells to the infarcted myocardium has already been shown to return limited functionality to the heart. Current methods, although promising have yet to show significant long-term results improving patient prognosis. Herein we present a novel idea for the use of gold nanoparticles as a means of directing stem cell delivery in-vivo through targeted and specific delivery with the hopes of improving patient conditions over current methodologies. The work involved in this THESIS is related to the establishment of protocols, investigation into particle toxicity, and the development of a perfusion bioreactor system capable of testing such a platform in-vitro.

Regenerative Medicine from Protocol to Patient

Regenerative Medicine   from Protocol to Patient Book
Author : Gustav Steinhoff
Publisher : Springer
Release : 2016-06-14
ISBN : 3319283863
Language : En, Es, Fr & De

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Book Description :

​Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 5 contains clinical science and translation surveys on the circulatory system, visceral, musculoskeletal and skin. The state-of-the-art descriptions involve concepts for clinical diagnosis, stem cell and gene therapy, biomaterials for tissue replacement and pharmacological/biomolecule treatment strategies.

Multi parameter Mueller Matrix Microscopy for the Expert Assessment of Acute Myocardium Ischemia

Multi parameter Mueller Matrix Microscopy for the Expert Assessment of Acute Myocardium Ischemia Book
Author : Victor Bachinsky,Oleh Ya Vanchulyak,Alexander G. Ushenko,Yurii A. Ushenko,Alexander V. Dubolazov,Alexander Bykov,Benjamin Hogan,Igor Meglinski
Publisher : Springer
Release : 2021-04-14
ISBN : 9789811614491
Language : En, Es, Fr & De

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Book Description :

This book provides an essential overview of the basic principles of imaging modalities, accompanied by examples of their applications in modern clinical and associated pre-clinical studies. The monograph is based on the original results of investigation of the efficiency use of laser light and Mueller-matrix polarimetry approach for assessment of myocardial tissues towards confirmation the cause of death. A morphological analysis of necrotic changes in the myocardial tissue of patients that died due to heart attack, coronary heart disease and acute coronary insufficiency was carried out and the data and histological sections of the myocardium inspected utilizing Mueller-matrix mapping of tissue samples with polarized light. A unified optical model of polycrystalline structure of the myocardium is proposed, and the principles and regulations of Mueller-matrix description of its polarization manifestations are explored and developed. The book also provides a statistical and scale-selective wavelet analysis of polarization and Mueller-matrix maps. Finally, the key forensic medical criteria for the differential diagnosis of the cause of death due to necrotic and pathological changes in the morphological structure of the myocardium have been established

Goldfrank s Toxicologic Emergencies Ninth Edition

Goldfrank s Toxicologic Emergencies  Ninth Edition Book
Author : Lewis S. Nelson,Neal A. Lewin,Mary Ann Howland,Robert S. Hoffman,Lewis R. Goldfrank,Neal E. Flomenbaum
Publisher : McGraw Hill Professional
Release : 2010-05-31
ISBN : 0071605940
Language : En, Es, Fr & De

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Book Description :

The most trusted, rigorous, and up-to-date toxicology resource and educational companion available – now in full color Goldfrank’s Toxicologic Emergencies continues to be the source you can turn to first for any poisoning or overdose. The text provides clear information on every aspect of toxicologic emergencies, from pharmacology to clinical presentation to management. Fully referenced and featuring a consistent organization, Goldfrank’s begins with an in-depth examination of general principles of medical toxicology. It then progresses to the biochemical principles and molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital signs, organs, and systems throughout the body. Next, a wide spectrum of clinically important exposures -- including drugs, plants, metals, household products, occupational and environmental xenobiotics are covered within logical categories for easy access to information. Finally, the book concludes with sections on principles of practicing clinical toxicology in today’s challenging healthcare environment. NEW TO THIS EDITION Full-color design and uniformly drawn figures clarify key concepts Special Considerations focus on decision-making in unique toxicologic circumstances, that influence clinical practice and have the potential to improve patient care Antidotes in Depth, following pertinent chapters, place each antidote in its proper context to ensure immediate availability of essential information relevant for clinical use More clinically-relevant figures and quick-reference tables Online learning center, available at www.goldfrankstoxicology.com, includes case studies, and a database of multiple choice questions that allow you to create a custom test for review and study. Every chapter is thoroughly rewritten and new chapters are added to reflect the very latest thinking in the field Here's why Goldfrank's is known worldwide as the field's leading text: General Approach to Medical Toxicology; The Biochemical and Molecular Basis of Medical Toxicology; The Pathophysiologic Basis of Medical; Toxicology: The Organ System Approach; The Clinical Basis of Medical Toxicology: Analgesics and Nonprescription Medications; Prescription Medications Psychopharmacologic Medications; Alcohols and Drugs of Abuse; Food Poisoning; Botanicals; Heavy Metals; Household Toxins; Pesticides; Occupational and Environmental Toxins; Toxic Envenomations; V. Special Populations; Preventive, Psychosocial, Nursing, Epidemiologic, Research & Legal Perspectives.

Experimental Biology and Medicine

Experimental Biology and Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Experimental Biology and Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endothelial Progenitor Cells

Endothelial Progenitor Cells Book
Author : Carmela Rita Balistreri
Publisher : Springer
Release : 2017-05-25
ISBN : 3319551078
Language : En, Es, Fr & De

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Book Description :

This book explores the role of endothelial progenitor cells (EPCs) in the context of regenerative medicine (RegMed). In particular, it reveals the value of RegMed as a new TM branch intended to improve the health and quality of life, by restoring, maintaining or enhancing tissue and functions of organs. The book is divided into three chapters, the first of which describes the relevance of translational medicine (TM) as a new research approach to counteract the imposing challengeof age-related diseases. Of the diverse RegMed approaches, particular attention is paid to stem/progenitor cell-based therapies, their benefits and shortcomings, as well as to the description of types of stem and progenitor cells considered for regenerative cell therapies, such as EPCs as emerging candidates for RegMed applications. In turn, the second chapter outlines the clinical relevance of EPCs as both potential predictors, diagnostic and prognostic biomarkers of age-related diseases and therapeutic agents,discussing their advantages, disadvantages, and conflicting data. Chapter three proposes a potential roadmap for revising the findings and creating a clearer picture of valid data, which can provide support for various important aspects, i.e.isolating and characterizing EPCs by establishing standardized criteria for EPC research, identifying appropriate sub-populations for cell therapy, timing, dosing, priming of cells,and defining delivery modes for different applications. The book concludes with an overview of innovative strategies that could improve the efficacy of cell therapy at all levels, including cell priming, bio-nanotechnology, and tissue engineering.

Innovative Diagnostics and Treatment Nanorobotics and Stem Cells

Innovative Diagnostics and Treatment  Nanorobotics and Stem Cells Book
Author : Tomasz Jadczyk,Ewa Bryndza Tfaily,Sachin Mishra,Marek Jędrzejek,Marta Bołoz,Parasuraman Padmanabhan,Wojciech Wojakowski,Zdeněk Stárek,Sylvain Martel,Balázs Gulyás
Publisher : Springer
Release : 2017-04-09
ISBN : 9811045275
Language : En, Es, Fr & De

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Book Description :

This book focuses on nanorobotic agents and stem cells for biomedical applications.It is intended for researchers and clinicians interested in innovative diagnostic and therapeutic strategies based on nanorobots and stem cells.It presents current advances in the field of molecular machines, which could be applied to generate novel therapeutic-diagnostic systems.

Nanotechnology Enabled Biomedical Fluorescence Imaging in the Second Near infrared Window

Nanotechnology Enabled Biomedical Fluorescence Imaging in the Second Near infrared Window Book
Author : Guosong Hong
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Fluorescence imaging in the second near-infrared window (NIR-II, 1.0-1.7 microns) has many salient advantages over the visible (400-750 nm) and the traditional near-infrared (NIR-I, 750-900 nm) windows owing to the reduced photon scattering and negligible tissue autofluorescence. However, NIR-II fluorescence imaging has been limited by the scarcity of materials with sufficient NIR-II fluorescence quantum efficiency, and single-walled carbon nanotube (SWNT) had been the only fluorophore for biological imaging in the NIR-II window. This work aims to enhance the intrinsic NIR-II fluorescence of SWNTs, apply SWNTs for in vivo imaging of real-world medical problems in animal models and develop new NIR-II fluorophores other than SWNTs. First, a plasmonic gold substrate is used to enhance the intrinsically low NIR-II fluorescence of SWNTs and to improve the sensitivity of cancer cell imaging using SWNTs as molecular targeting probes. The sensitive distance dependence of fluorescence enhancement of SWNTs is then exploited to probe the trans-membrane motion of single nanotube molecules and reveal the internalization pathway as receptor-mediated endocytosis. The biocompatible SWNTs are further applied to an in vivo animal model of lower limb ischemia, where we demonstrate microvascular imaging and hemodynamic measurement using NIR-II fluorescence, with improved spatial resolution over X-ray computer tomography (CT) and broader dynamic range of blood flowmetry than ultrasound. In a rationally chosen sub-region of NIR-II in the 1.3-1.4 micron range, chemically separated SWNTs allow for non-invasive brain vascular imaging through intact scalp and skull with sub-10 micron resolution at millimeter depth of penetration. Lastly, two new materials, Ag2S quantum dots (QDs) and conjugated copolymers are developed to expand the toolbox of NIR-II fluorophores. The Ag2S QDs afford in vitro targeted cancer cell imaging and in vivo mouse imaging with high tumor uptake. The high fluorescence quantum yield of the conjugated copolymer allows for ultrafast dynamic NIR-II imaging of the arterial blood flow with waveform cardiac cycles revealed in hemodynamic analysis. The many benefits of NIR-II fluorescence imaging demonstrated in this work based on the development of a handful of biocompatible NIR-II nanomaterials bode well for future biological research and clinical applications with this new imaging technique.

Horizons in World Cardiovascular Research

Horizons in World Cardiovascular Research Book
Author : Eleanor H. Bennington
Publisher : Nova Science Pub Incorporated
Release : 2013-01-01
ISBN : 9781626189843
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease refers to the class of diseases that involve the heart or blood vessels. While the term technically refers to any disease that affects the cardiovascular system, it is usually used to refer to those related to atherosclerosis. Chronic heart failure (CHF) has emerged as a major worldwide epidemic. This book gathers the latest research in cardiovascular disease with a focus on such topics as cardiac connexin gap junction channels; the impact of alternative splicing on cardiovascular biology; gender aspects in septic patients receiving QTc prolonging drugs; nanotechnology for cardiovascular therapy; ineffective endocarditis associated to oral bacteremia; neonatal echocardiography; endocarditis symptoms, treatment and prevention; metabolomics in aortic stenosis; mid-term outcome of mitral valve repair and coronary artery bypass grafting for ischemic or degenerative mitral regurgitation; and early repolarisation and ventricular fibrillation in a young Tunisian woman.

Progenitor and Stem Cell Technologies and Therapies

Progenitor and Stem Cell Technologies and Therapies Book
Author : Anthony Atala
Publisher : Elsevier
Release : 2012-03-15
ISBN : 0857096079
Language : En, Es, Fr & De

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Book Description :

Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application. Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair. With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology. Reviews the range of progenitor and stem cells available and outlines their therapeutic application Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies

Different Strokes Everything You Never Wanted to Need to Know

Different Strokes    Everything You Never Wanted to Need to Know Book
Author : Richard Douglas Bouslough
Publisher : Trafford Publishing
Release : 2005-12-20
ISBN : 1412081610
Language : En, Es, Fr & De

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Book Description :

Stroke. More than 500,000 Americans will suffer its silent attack this year. The number has epidemic proportions, but add to it the newly estimated 11 million victims each year whose strokes go undetected and America shakes its collective head and wonders, am I next? One third of those detected will die in a short period of time, over 160,000 fatalities, making stroke the number three killer in the US behind only heart disease and cancer. It leaves another 200,000 victims with permanent disability. In spite of the numbers, brain attack strikes intimately and personally. Its shadow of death spreads quickly over living tissue in the brain, violating personality and disrupting life. This graphic contrast, huge numbers of victims versus the unique intimacy of each stroke, draws into focus the one common by-product of all attacks, fear - fear of the unknown, fear of death or livelihood lost. The perception is evil incarnate, destroying the sanctity of one's life and home. I know, stroke left me blinded, with short-term memory wiped clean and sensory input distorted and disorienting. Only the divine touch could bring the light of hope into this darkness. The good news - much can be done to fan this hope into a fire of restoration. The better news - remarkable advancements available today include "miracle" clot busters, surgical procedures that listen to the differences in sounds made by healthy cells and dead ones, probes that travel through the body to apply medicines directly on affected areas of the brain,, and the vision for tomorrow that moves microscopic nanotechnology out of science fiction directly into the brain to both repair and replace damaged brain cells. Different Strokes... unwraps the fear of stroke, revealing possibilities for healing and hope - hope birthed by the insight of experience and supported by research collected from leading edge resources.

Horizons in World Cardiovascular Research

Horizons in World Cardiovascular Research Book
Author : Eleanor H. Bennington
Publisher : Unknown
Release : 2014-05-14
ISBN : 9781626189850
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease refers to the class of diseases that involve the heart or blood vessels. While the term technically refers to any disease that affects the cardiovascular system, it is usually used to refer to those related to atherosclerosis. Chronic heart failure (CHF) has emerged as a major worldwide epidemic. This book gathers the latest research in cardiovascular disease with a focus on such topics as cardiac connexin gap junction channels; the impact of alternative splicing on cardiovascular biology; gender aspects in septic patients receiving QTc prolonging drugs; nanotechnology for cardiovascular therapy; ineffective endocarditis associated to oral bacteremia; neonatal echocardiography; endocarditis symptoms, treatment and prevention; metabolomics in aortic stenosis; mid-term outcome of mitral valve repair and coronary artery bypass grafting for ischemic or degenerative mitral regurgitation; and early repolarisation and ventricular fibrillation in a young Tunisian woman.