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Nanobiomaterials In Medical Imaging

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Nanobiomaterials in Medical Imaging

Nanobiomaterials in Medical Imaging Book
Author : Alexandru Grumezescu
Publisher : William Andrew
Release : 2016-04-13
ISBN : 0323417388
Language : En, Es, Fr & De

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Book Description :

Nanobiomaterials in Medical Imaging presents the latest developments in medical exploratory approaches using nanotechnology. Leading researchers from around the world discuss recent progress and state-of-the-art techniques. The book covers synthesis and surface modification of multimodal imaging agents, popular examples of nanoparticles and their applications in different imaging techniques, and combinatorial therapy for the development of multifunctional nanocarriers. The advantages and potential of current techniques are also considered. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A valuable resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A detailed guide to recent scientific progress, along with the latest application methods Presents innovative opportunities and ideas for developing or improving technologies in nanomedicine and medical imaging

Nanomaterials and Their Biomedical Applications

Nanomaterials and Their Biomedical Applications Book
Author : Tuhin Subhra Santra,Loganathan Mohan
Publisher : Springer Nature
Release : 2021-04-16
ISBN : 9813362529
Language : En, Es, Fr & De

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Book Description :

This book highlights the evolution of, and novel challenges currently facing, nanomaterials science, nanoengineering, and nanotechnology, and their applications and development in the biological and biomedical fields. It details different nanoscale and nanostructured materials syntheses, processing, characterization, and applications, and considers improvements that can be made in nanostructured materials with their different biomedical applications. The book also briefly covers the state of the art of different nanomaterials design, synthesis, fabrication and their potential biomedical applications. It will be particularly useful for reading and research purposes, especially for science and engineering students, academics, and industrial researchers.

Nanomaterials for Medical Applications

Nanomaterials for Medical Applications Book
Author : Zoraida Aguilar
Publisher : Newnes
Release : 2012
ISBN : 0123850894
Language : En, Es, Fr & De

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Book Description :

This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application. It presents the main types of nanomaterial used in medical application today: semiconductor nanomaterials, Magnetic nanomaterials, metal nanoparticles, Carbon nanomaterials, Hydrogel nanocomposites, Liposomes, Dendrimers, Polymer nanocomposites, and Biodegradable polymers. Structurally the work is demarcated into the six most popular areas of research: (1) biocompatibility of nanomaterials with living organisms in their various manifestations (2) nanobiosensors for clinical diagnostics, detecting biomolecules which are useful in the clinical diagnosis of genetic, metabolically acquired, induced or infectious disease (3) targeted drug delivery for nanomaterials in their various modifications (4) nanomedical devices and structures which are used in the development of implantable medical devices and structures such as nanorobots (5) nanopharmacology, as novel nanoparticles are increasingly engineered to diagnose conditions and recognize pathogens, identify ideal pharmaceutical agents to treat the condition or pathogens,fuel high-yield production of matched pharmaceuticals (potentially in vivo), locate, attach or enter target tissue, structures or pathogens; and dispense the ideal mass of matched biological compound to the target regions (6) nanotoxicology and remediation, which focuses on finished and on-going various toxicity evaluations on various nanomaterials that are used and currently being developed for medical applications Discusses the most important biomedical applications and devices of nanomaterials: drug delivery, medical imaging, gene therapy, nanorobots, biosensors and diagnostics Focuses on current commercialized techniques and applications, ensuring the work is entirely relevant to a rapidly evolving field Reviews the most recent studies on nanomaterial toxicity, thereby responding to the widescale private, policy and public interest in nanoscience

Nanotechnology for Biomedical Imaging and Diagnostics

Nanotechnology for Biomedical Imaging and Diagnostics Book
Author : Mikhail Y. Berezin
Publisher : John Wiley & Sons
Release : 2015-02-02
ISBN : 1118873173
Language : En, Es, Fr & De

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Book Description :

Nanotechnology for Biomedical Imaging and Diagnostics: FromNanoparticle Design to Clinical Applications reflects upon theincreasing role of nanomaterials in biological and medical imaging,presenting a thorough description of current research as wellas future directions. With contributions from experts innanotechnology and imaging from academia, industry, andhealthcare, this book provides a comprehensive coverage of thefield, ranging from the architectural design of nanomaterials totheir broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology andbioimaging Provides comprehensive coverage of the field, ranging from thearchitectural design of nanomaterials to their broad imagingapplications in medicine Written by well-recognized experts in academia, industry, andhealthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research anddiagnostic topics, this book will appeal to students, scientiests,and healthcare professionals alike

Nanoparticles in Analytical and Medical Devices

Nanoparticles in Analytical and Medical Devices Book
Author : Fang Gang
Publisher : Elsevier
Release : 2020-09-01
ISBN : 0128225548
Language : En, Es, Fr & De

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Book Description :

Nanoparticles in Analytical and Medical Devices presents the latest information on the use of nanoparticles for a diverse range of analytical and medical applications. Covers basic principles, proper use of nanoparticles in analytical and medical applications, and recent progress in the field. This comprehensive reference helps readers grasp the full potential of nanoparticles in their analytical research or medical practice. Chapters on cutting-edge topics bring readers up to date on the latest research and usage of nanoparticles, and a chapter on commercially available devices that utilize nanoparticles guides readers in overcoming issues with marketing biodevices. Synthesizes nanoparticle conjugation and other critical methods Covers nanoparticles in analytical methods and real analytical devices currently used in the medical field Provides useful new information not covered in the current literature in chapters on surface chemical functionalization for bio-immobilization and nanoparticle production from natural sources

Nanomaterials in Diagnostic Tools and Devices

Nanomaterials in Diagnostic Tools and Devices Book
Author : Suvardhan Kanchi,D. Sharma
Publisher : Elsevier
Release : 2020-06-04
ISBN : 0128179244
Language : En, Es, Fr & De

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Book Description :

Nanomaterials in Diagnostic Tools and Devices provides a complete overview of the significance of nanomaterials in fabricating selective and performance enhanced nanodevices. It is an interdisciplinary reference that includes contributing subjects from nanomaterials, biosensors, materials science, biomedical instrumentation and medicinal chemistry. This book is authored by experts in the field of nanomaterial synthesis, modeling, and biosensor applications, and provides insight to readers working in various science fields on the latest advancements in smart and miniaturized nanodevices. These devices enable convenient real-time diagnosis of diseases at clinics rather than laboratories, and include implantable devices that cause less irritation and have improved functionality. Research in the field of nanomaterials is growing rapidly, creating a significant impact across different science disciplines and nanotechnology industries. This synthesis and modeling of nanomaterials has led to many technology breakthroughs and applications, especially in medical science. Provides a distinctive platform for the latest trends in the synthesis of smart nanomaterials for nanodevices in disease diagnostics Presents a broad range of advancements and applications of lateral-flow nanostrip for point-of-care applications Examines smart-phone based nanodevices for field-based diagnosis with accurate information Comprises more than 70 figures and illustrations that will help readers visualize and easily understand the role of nanodevices in the field of nanomedicine Serves as an ideal reference for those studying smart nanomaterials, biosensors, and nanodevices for real-time and in-situ clinical diagnosis and drug delivery

Nanomaterials for Medical Applications

Nanomaterials for Medical Applications Book
Author : Zoraida Aguilar
Publisher : Newnes
Release : 2012-12-31
ISBN : 0123850908
Language : En, Es, Fr & De

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Book Description :

This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application. It presents the main types of nanomaterial used in medical application today: semiconductor nanomaterials, Magnetic nanomaterials, metal nanoparticles, Carbon nanomaterials, Hydrogel nanocomposites, Liposomes, Dendrimers, Polymer nanocomposites, and Biodegradable polymers. Structurally the work is demarcated into the six most popular areas of research: (1) biocompatibility of nanomaterials with living organisms in their various manifestations (2) nanobiosensors for clinical diagnostics, detecting biomolecules which are useful in the clinical diagnosis of genetic, metabolically acquired, induced or infectious disease (3) targeted drug delivery for nanomaterials in their various modifications (4) nanomedical devices and structures which are used in the development of implantable medical devices and structures such as nanorobots (5) nanopharmacology, as novel nanoparticles are increasingly engineered to diagnose conditions and recognize pathogens, identify ideal pharmaceutical agents to treat the condition or pathogens,fuel high-yield production of matched pharmaceuticals (potentially in vivo), locate, attach or enter target tissue, structures or pathogens; and dispense the ideal mass of matched biological compound to the target regions (6) nanotoxicology and remediation, which focuses on finished and on-going various toxicity evaluations on various nanomaterials that are used and currently being developed for medical applications Discusses the most important biomedical applications and devices of nanomaterials: drug delivery, medical imaging, gene therapy, nanorobots, biosensors and diagnostics Focuses on current commercialized techniques and applications, ensuring the work is entirely relevant to a rapidly evolving field Reviews the most recent studies on nanomaterial toxicity, thereby responding to the widescale private, policy and public interest in nanoscience

Magnetic Nanoheterostructures

Magnetic Nanoheterostructures Book
Author : Surender Kumar Sharma,Yasir Javed
Publisher : Springer Nature
Release : 2020-03-02
ISBN : 3030399230
Language : En, Es, Fr & De

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Book Description :

This book contains most updated information on synthesis of magnetic nanohybrids, their physio-chemical properties, and key biological applications. It highlights the complexity of nanoheterostructures, especially magnetic metal oxides, ferrites and doped magnetic nanomaterials, and discusses their potential applications in the early detection, imaging and treatment of cancer. It also covers the toxicity and risk assessment of multifunctional nanomaterials. Providing an overview of magnetic nanoheterostructures, it appeals to a wide audience, from beginners and graduate-level students to experts in academia and industry.

Principles of Nanomedicine

Principles of Nanomedicine Book
Author : Sourav Bhattacharjee
Publisher : CRC Press
Release : 2019-10-18
ISBN : 0429632053
Language : En, Es, Fr & De

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Book Description :

The scope of nanotechnology in medical applications has expanded fast in the last two decades. With their unprecedented material properties, nanoscale materials present with unorthodox opportunities in a wide range of domains, including drug delivery and medical imaging. This book assembles the various facets of nanomedicine while discussing key issues such as physicochemical properties that enhance the appeal of nanomedicine. The book is an excellent resource for physicians, PhDs, and postdocs involved in nanomedicine research to learn and understand the scope and complexity of the subject. It begins with a short history of nanotechnology, followed by a discussion on the fundamental concepts and extraordinary properties of nanoscale materials, and then slowly unfolds into multiple chapters illustrating the uses of various nanomaterials in drug delivery, sensing, and imaging.

Nanotechnology and Nanomaterials in the Treatment of Life threatening Diseases

Nanotechnology and Nanomaterials in the Treatment of Life threatening Diseases Book
Author : Narenda Kumar,Rajiv Kumar
Publisher : William Andrew
Release : 2013-12-05
ISBN : 0323264506
Language : En, Es, Fr & De

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Book Description :

Nanotechnology and Nanomaterials in the Treatment of Life-threatening Diseases takes a scientific approach to nanotechnology and nanomaterials applications in medicine, while also explaining the core biological principles for an audience of biomedical engineers, materials scientists, pharmacologists, and medical diagnostic technicians. The book is structured by major disease groups, offering a practical, application-based focus for scientists, engineers, and clinicians alike. The spectrum of medical applications is explored, from diagnostics and imaging to drug delivery, monitoring, therapies, and disease prevention. It also focuses specifically on the synthesis of nanomaterials and their potential health risks (particularly toxicity). Nanomedicine — the application of nanomaterials and devices for addressing medical problems — has demonstrated great potential for enabling improved diagnosis, treatment, and monitoring of many serious illnesses, including cancer, cardiovascular and neurological disorders, HIV/AIDS, and diabetes, as well as many types of inflammatory and infectious diseases. Gain an understanding of how nanotechnologies and nanomaterials can be deployed in the fight against the major life-threatening diseases: cancer, neurological disorders (including Alzheimer's and Parkinson's), cardiovascular diseases, and HIV/AIDS Discover the latest developments in nanomedicine, from therapies and drug delivery to diagnostics and disease prevention The authors cover the health risks of nanomaterials as well as their benefits, considering toxicity and potential carcinogens

Mesoporous Silica based Nanomaterials and Biomedical Applications

Mesoporous Silica based Nanomaterials and Biomedical Applications   Book
Author : Anonim
Publisher : Academic Press
Release : 2018-09-20
ISBN : 0128155213
Language : En, Es, Fr & De

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Book Description :

Cancer Therapy and Diagnosis, Part A, Volume 43 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series Updated release includes the latest information on Cancer Therapy and Diagnosis

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications Book
Author : Krishnan Anand,Muthupandian Saravanan,Balakumar Chandrasekaran,Suvardhan Kanchi,Sarojini Jeeva Panchu,Quan-Sheng Chen
Publisher : Elsevier
Release : 2021-03-18
ISBN : 0128219149
Language : En, Es, Fr & De

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Book Description :

Handbook of Nano-biomaterials for Therapeutics and Diagnostic Applications covers in-depth topics on nano-biomaterials and nano drug delivery systems (biosensors and bioimaging) involving polymer nanocomposites, metal nanocomposites, and other carbon family fibers and proteins. The book covers the current application of tiny machines or nanodevices and their use as early detection systems for life threatening diseases, giving detailed literature on the development of nanodevices, their use as diagnostic tools, and their present trend in the industry and market. In addition, their synthesis, potential applications and future of smart nanodevices in diagnosis of diseases and their use as smart clinical devices is covered. Users will find sections on recent advances in interdisciplinary research on the processing, morphology, structure and properties of nanostructured materials and their applications in drug delivery for various diseases such as cancer, tuberculosis, Alzheimer disease, ophthalmic diseases, and more. Offers a comprehensive coverage of the therapeutics and smart nanodevices as diagnostic tools and their potential clinical applications in biosensing and bioimaging Includes a glimpse into the nano-biomaterials that are essential components in nanomedicines Describes nanodevices in the early diagnosis of the diseases Explains the nano-drug delivery system for the treatment of various diseases, including cancer, tuberculosis, Alzheimer disease, and ophthalmic diseases Encompasses all information, starting from the design of nano-biomaterials to their applications in theranostics

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy Book
Author : James C L Chow
Publisher : Mdpi AG
Release : 2022-03-21
ISBN : 9783036535135
Language : En, Es, Fr & De

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Book Description :

To mark the recent advances in nanomaterials and nanotechnology in biomedical imaging and cancer therapy, this book, entitled Application of Nanomaterials in Biomedical Imaging and Cancer Therapy includes a collection of important nanomaterial studies on medical imaging and therapy. The book covers recent works on hyperthermia, external beam radiotherapy, MRI-guided radiotherapy, immunotherapy, photothermal therapy, and photodynamic therapy, as well as medical imaging, including high-contrast and deep-tissue imaging, quantum sensing, super-resolution microscopy, and three-dimensional correlative light and electron microscopy. The significant research results and findings explored in this work are expected to help students, researchers and teachers working in the field of nanomaterials and nanotechnology in biomedical physics, to keep pace with the rapid development and the applications of nanomaterials in precise imaging and targeted therapy.

Development of Novel Nanomaterials for Multimodal Biomedical Imaging

Development of Novel Nanomaterials for Multimodal Biomedical Imaging Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The second section examines the potential for applying the polyethylene glycol-bisphosphonate coating to other inorganic nanomaterials. CdZnSeS alloyed quantum dots were successfully synthesised, with the resulting particles exhibiting red emission ( rv604.0 nm) and no significant shift after phase transfer into aqueous solution. Preliminary in vitro cell studies revealed particle emission at the expected wavelength. Finally, the synthesised nanoparticles were successfully coated with the amphiphilic protein (hydrophobin). The resulting nanoparticles exhibited no change in core size or morphologyas determined by transmission electron microscopy, as well as no shift in emission ("-'627.0 nm). In vitro studies were performed allowing for visualisation of the quantum dots in a biological environment after incubation at physiological temperature. In addition, particles were injected intratumourly into a live mouse model, with emission detected up to 24 h post injection. Lastly, radiolabelling with iodine-131 was achieved; confirming the possibility of utilising exposed residues on the protein to further functionalise the surface. In conclusion, the described methods and nanoparticles synthesised represent a promising platform for the development of targeted agents for multimodal medical imaging and other bio-applications.

Magnetic Nanoparticles in Human Health and Medicine

Magnetic Nanoparticles in Human Health and Medicine Book
Author : Costica Caizer,Mahendra Rai
Publisher : John Wiley & Sons
Release : 2021-09-08
ISBN : 1119754747
Language : En, Es, Fr & De

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Book Description :

Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Functionalized Carbon Nanomaterials for Theranostic Applications

Functionalized Carbon Nanomaterials for Theranostic Applications Book
Author : Shadpour Mallakpour,Chaudhery Mustansar Hussain
Publisher : Elsevier
Release : 2022-09-15
ISBN : 012824366X
Language : En, Es, Fr & De

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Book Description :

Functionalized Carbon Nanomaterials for Theranostic Applications offers insights into the developments and trends that are progressing fast in the field of functionalized carbon nanomaterials-based devices as diagnostic tools for early stage detection of human diseases. The book provides information on how functionalized carbon nanomaterials are being used as the basis for products, such as early disease diagnostic kits, quantum dots for medical imaging and a growing list of other applications. Sections cover different mechanical, absorption, optical and electrical properties than those found in original nanomaterials. This is an important reference source that will be valuable to materials scientists, biomedical engineers and pharmaceutical scientists who are looking to increase their understanding on how functionalized carbon nanomaterials are being used for a variety of theranostic applications. Provides readers with information on how to develop functionalized carbon nanomaterials based diagnostic devices and tools Identifies fabrication and characterization methods for integrated devices for use in theranostic applications Assesses major challenges for manufacturing functionalized carbon nanomaterial materials for theranostic devices on an industrial scale

Medical Imaging Methods

Medical Imaging Methods Book
Author : Ashutosh Kumar Shukla
Publisher : CRC Press
Release : 2021-12-27
ISBN : 1000528154
Language : En, Es, Fr & De

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Book Description :

This volume presents pedagogical content to understand theoretical and practical aspects of diagnostic imaging techniques. It provides insights to current practices, and also discusses specific practical features like radiation exposure, radiation sensitivity, signal penetration, tissue interaction, and signal confinement with reference to individual imaging techniques. It also covers relatively less common imaging methods in addition to the established ones. It serves as a reference for researchers and students working in the field of medical, biomedical science, physics, and instrumentation. Key Features • Focusses on the clinical applications while ensuring a steady understanding of the underlying science • Follows a bottom-up approach to cover the theory, calculations, and modalities to aid students and researchers in biomedical imaging, radiology and instrumentation • Covers unique concepts of nanoparticle applications along with ethical issues in medical imaging

Nanotechnology in Medicine and Biology

Nanotechnology in Medicine and Biology Book
Author : Huinan Liu,Tolou Shokuhfar,Sougata Ghosh
Publisher : Elsevier
Release : 2021-11-13
ISBN : 0128226714
Language : En, Es, Fr & De

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Book Description :

Nanotechnology in Medicine and Biology brings together a multidisciplinary team of experts from the fields of materials science, nanotechnology, medicine and biomedical engineering to introduce new nanoscale biomaterials and their applications, diagnosis and treatment of disorders of the human body. The book presents the fundamentals for understanding the design, properties and selection of nanobiomaterials as well as their real-world applications in medicine. Each chapter addresses current regulations, manufacturing processes, and translation issues of nanobiomaterials for key applications. A discussion of current protocols and their benefits and disadvantages is also included. This book provides comprehensive background and knowledge in the field of nanobiomaterials that is suitable for academics, scientists and clinicians. Provides fundamental understanding on the design, properties and selection of biomaterials for applications in medicine and biology Reviews current regulations, protocols, manufacturing processes and translation issues of nanobiomaterials for medical applications Discusses tissue repair, wound healing, regenerative medicine, drug delivery, imaging and medical device applications

Nanomaterials for Biological Imaging and Biomedical Diagnostic Applications

Nanomaterials for Biological Imaging and Biomedical Diagnostic Applications Book
Author : Scott Michael Tabakman
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis describes the use of inorganic nanomaterials for spectroscopic applications in biomedical imaging in vitro and ex vivo as well as in diagnostic sensor applications. Nanomaterials exhibit unique electronic, optical, magnetic, and chemical properties due to their small size and low dimensionality compared with their bulk counterparts. Exploitation of these phenomena has been the subject of much research in the past few decades, since Feynman famously informed us that there is "Plenty of Room at the Bottom." Components of relatively large chemical systems, quantum physical systems, and biomolecules converge in the nanometer size range, the so-called "nano-bio interface." Control of objects on this length scale affords a wealth of potential applications in biomedicine. However, inorganic nanomaterials and biological systems are not without their incompatibilities. Chemical modification and surface engineering are necessary to successfully employ nanomaterials in biological applications. To exploit the inherent optical properties of single-walled carbon nanotubes (SWNTs) in sensitive and multiplexed medical imaging and diagnostic applications, they must be rendered biocompatible by non-covalent modification. Indeed, it is shown that a suspension of SWNTs via functional amphiphiles affords a supramolecular complex that may be interfaced with biological systems. Resonance Raman scattering molecular imaging of cancer in vitro is demonstrated. The simple chemical structure and high Raman scattering cross section of SWNTs is exploited to prepare a library of SWNT labels for Raman-based immunostaining of ex vivo cancer tissue. Furthermore, the benefits and pitfalls of Raman scattering compared with traditional fluorescence methodologies are discussed. In addition to the optical properties of SWNTs, gold (and silver) nanoparticles possess unique localized surface plasmon resonances in the visible and near-infrared. Coupling of electromagnetic radiation to these plasmon modes effectively increases the local field strength within several nanometers from the nanoparticle surface, enhancing proximal optical phenomena, producing the surface-enhanced Raman scattering (SERS) effect, as well as plasmon-enhanced fluorescence. In order to prepare plasmonic films for SERS and fluorescence-enhancing applications, novel chemical and physical approaches will be presented. Biocompatible SWNTs conjugated to target-specific biomolecules are employed as Raman scattering labels in a SERS-based immunoassay. The combination of the SERS effect with the large Raman scattering intensity of SWNTs affords a protein assay capable of fM detection in microarray format. In addition to SERS, fluorescence-enhancement owing to chemically prepared plasmonic gold films was also realized. The enhancement of both the local electric field and NIR fluorescence emission rate via the coupling of scattering nanoparticle plasmon modes can lead to NIR fluorescence enhancement (NIR-FE) under appropriate conditions. Here, those conditions are optimized to yield the NIR-FE effect in the context of microarray immunoassays. The rapid and simple methodology developed affords high sensitivity detection of cancer and autoimmune disease biomarkers, offering a broad dynamic range applicable to a wide variety of assays. Comparisons are drawn between the SERS and NIR-FE methodologies, along with a discussion of their merits and future research directions.

Nanomedicine Manufacturing and Applications

Nanomedicine Manufacturing and Applications Book
Author : Francis Verpoort,Ikram Ahmad,Awais Ahmad,Anish Khan,Ching Yern Chee
Publisher : Elsevier
Release : 2021-06-22
ISBN : 0128209429
Language : En, Es, Fr & De

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Book Description :

Nanomedicine explores the modification and enhancement of the properties and performances of typical drugs to treat various diseases. Nano-based medicines have advantages in several ways, such as in nanotherapeutics, nanotheranostics, and nanodiagnostics. Nanomedicine Manufacturing and Applications effectively explores the major manufacturing techniques and applications of nanomaterial-based medicine in the areas of chemotherapy, biochips, insulin pumps, and other treatment methods. This book explains how nanomedicines are developed from nanoparticles as well as their biomedical and other applications related to healthcare. This book is an important reference source for nanoscientists, biomaterials scientists, and biomedical engineers who want to learn more about how nano-based medicines are made and used. Outlines the process of making nanomedicine as well as nanodrug carriers, with a focus on nanomedicine for cancer treatment. Explains the formulation and manufacturing process of nanomedicines, showing how to build these materials. Demonstrates how nano-based medicines are being used to tackle a range of diseases in a way that conventional medicines cannot.