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Mutagenicity

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Mutagenicity Assays and Applications

Mutagenicity  Assays and Applications Book
Author : Ashutosh Kumar,Vasily N. Dobrovolsky,Alok Dhawan,Rishi Shanker
Publisher : Academic Press
Release : 2017-09-26
ISBN : 0128092602
Language : En, Es, Fr & De

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Book Description :

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Handbook of Mutagenicity Test Procedures

Handbook of Mutagenicity Test Procedures Book
Author : B.J. Kilbey,M. Legator,W. Nicholson,C. Ramel
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0444600981
Language : En, Es, Fr & De

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Book Description :

The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

Mutagenicity

Mutagenicity Book
Author : John A. Heddle
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483271226
Language : En, Es, Fr & De

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Book Description :

Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.

Mutagenic Screening of Diamine Monomers

Mutagenic Screening of Diamine Monomers Book
Author : Anonim
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Residue Reviews

Residue Reviews Book
Author : Anonim
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Mutagenic Impurities

Mutagenic Impurities Book
Author : Andrew Teasdale
Publisher : John Wiley & Sons
Release : 2022-02-01
ISBN : 1119551250
Language : En, Es, Fr & De

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Book Description :

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

Quantitative Relationship Between Mutagenic and Carcinogenic Potencies

Quantitative Relationship Between Mutagenic and Carcinogenic Potencies Book
Author : Anonim
Publisher : National Academies Press
Release : 1983-01-01
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Carcinogenic and Mutagenic N substituted Aryl Compounds

Carcinogenic and Mutagenic N substituted Aryl Compounds Book
Author : Anonim
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Non Mutagenic Carcinogens

Non Mutagenic Carcinogens Book
Author : Nordic Council Of Ministers Staff
Publisher : Nordic Council of Ministers
Release : 1998
ISBN : 9789289301176
Language : En, Es, Fr & De

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Non-Mutagenic Carcinogens

Carcinogenic and Mutagenic Metal Compounds

Carcinogenic and Mutagenic Metal Compounds Book
Author : E. Merian
Publisher : CRC Press
Release : 1985
ISBN : 9782881240225
Language : En, Es, Fr & De

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Book Description :

This book contains selected papers presented at the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal compounds held in Follinica, Italy in April 1988. This workship discussed the areas of research which link chemistry and biology, difining real problems for further research, and was attended by experts from different fields including analytical chemistry, speciation, environmental chemistry, biochemistry, short-term testing and risk assessment.

Carcinogenic and Mutagenic Metal Compounds 3

Carcinogenic and Mutagenic Metal Compounds 3 Book
Author : Ernest Merian,Giorgio L. Bronzetti,Werner Haerdi
Publisher : CRC Press
Release : 1991
ISBN : 9782881247811
Language : En, Es, Fr & De

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Book Description :

Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR

The Mutagenicity of Pesticides

The Mutagenicity of Pesticides Book
Author : Samuel S. Epstein,Marvin S. Legator
Publisher : MIT Press (MA)
Release : 1971
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is the first book to present recently developed mammalian methodologies for evaluating mutagenic hazards of chemicals such as pesticides.

Agricultural and Biological Chemistry

Agricultural and Biological Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Toxicology Abstracts

Toxicology Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Includes annual author and subject indexes.

Real World Drug Discovery

Real World Drug Discovery Book
Author : Robert M. Rydzewski
Publisher : Elsevier
Release : 2010-07-07
ISBN : 9780080914886
Language : En, Es, Fr & De

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Book Description :

Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Environmental Health Perspectives

Environmental Health Perspectives Book
Author : Anonim
Publisher : Unknown
Release : 2022-12-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Use of the Ames Test for Investigating the Mutagenicity of Air Pollutants

Use of the Ames Test for Investigating the Mutagenicity of Air Pollutants Book
Author : Katarina Victorin
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Use of the Ames Test for Investigating the Mutagenicity of Air Pollutants book written by Katarina Victorin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Quantitative Relationship Between Mutagenic and Carcinogenic Potencies

Quantitative Relationship Between Mutagenic and Carcinogenic Potencies Book
Author : Anonim
Publisher : National Academies
Release : 1983-01-01
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Quantitative Relationship Between Mutagenic and Carcinogenic Potencies book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mutagenicity Testing in Environmental Pollution Control

Mutagenicity Testing in Environmental Pollution Control Book
Author : Friedrich K. Zimmermann,R. E. Taylor-Mayer
Publisher : Halsted Press
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mutagenicity Testing in Environmental Pollution Control book written by Friedrich K. Zimmermann,R. E. Taylor-Mayer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.