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Multiscale Biomechanics

Multiscale Biomechanics Book
Author : Jean-Francois Ganghoffer
Publisher : Elsevier
Release : 2018-02-03
ISBN : 0081021151
Language : En, Es, Fr & De

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Book Description :

Multiscale Biomechanics provides new insights on multiscale static and dynamic behavior of both soft and hard biological tissues, including bone, the intervertebral disk, biological membranes and tendons. The physiological aspects of bones and biological membranes are introduced, along with micromechanical models used to compute mechanical response. A modern account of continuum mechanics of growth and remodeling, generalized continuum models to capture internal lengths scales, and dedicated homogenization methods are provided to help the reader with the necessary theoretical foundations. Topics discussed include multiscale methods for fibrous media based on discrete homogenization, generalized continua constitutive models for bone, and a presentation of recent theoretical and numerical advances. In addition, a refresher on continuum mechanics and more advanced background related to differential geometry, configurational mechanics, mechanics of growth, thermodynamics of open systems and homogenization methods is given in separate chapters. Numerical aspects are treated in detail, and simulations are presented to illustrate models. This book is intended for graduate students and researchers in biomechanics interested in the latest research developments, as well as those who wish to gain insight into the field of biomechanics. Provides a clear exposition of multiscale methods for fibrous media based on discrete homogenization and the consideration of generalized continua constitutive models for bone Presents recent theoretical and numerical advances for bone remodeling and growth Includes the necessary theoretical background that is exposed in a clear and self-contained manner Covers continuum mechanics and more advanced background related to differential geometry, configurational mechanics, mechanics of growth, thermodynamics of open systems and homogenization methods

Multiscale Biomechanics and Tribology of Inorganic and Organic Systems

Multiscale Biomechanics and Tribology of Inorganic and Organic Systems Book
Author : Georg-Peter Ostermeyer
Publisher : Springer Nature
Release : 2021-04-16
ISBN : 3030601242
Language : En, Es, Fr & De

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Book Description :

Download Multiscale Biomechanics and Tribology of Inorganic and Organic Systems book written by Georg-Peter Ostermeyer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Multiscale Modeling in Biomechanics and Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology Book
Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publisher : Springer
Release : 2014-10-10
ISBN : 1447165993
Language : En, Es, Fr & De

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Book Description :

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Biomechanics

Biomechanics Book
Author : Manuel Doblare,Jose Merodio
Publisher : EOLSS Publications
Release : 2015-12-30
ISBN : 178021023X
Language : En, Es, Fr & De

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Book Description :

Biomechanics is a component of Encyclopedia of Physical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The enormous progress in the field of health sciences that has been achieved in the 19th and 20th centuries would have not been possible without the enabling interaction and support of sophisticated technologies that progressively gave rise to a new interdisciplinary field named alternatively as bioengineering or biomedical engineering. Although both terms are synonymous, the latter is less general since it limits the field of application to medicine and clinical practice, while the former covers semantically the whole field of interaction between life sciences and engineering, thus including also applications in biology, biochemistry or the many '-omics'. We use in this book the second, with more general meaning, recalling the very important relation between fundamental science and engineering. And this also recognizes the tremendous economic and social impacts of direct application of engineering in medicine that maintains the health industry as one with the fastest growth in the world economy. Biomechanics, in particular, aims to explain and predict the mechanics of the different components of living beings, from molecules to organisms as well as to design, manufacture and use of any artificial device that interacts with the mechanics of living beings. It helps, therefore, to understand how living systems move, to characterize the interaction between forces and deformation along all spatial scales, to analyze the interaction between structural behavior and microstructure, with the very important particularity of dealing with adaptive systems, able to adapt their internal structure, size and geometry to the particular mechanical environment in which they develop their activity, to understand and predict alterations in the mechanical function due to injuries, diseases or pathologies and, finally, to propose methods of artificial intervention for functional diagnosis or recovery. Biomechanics is today a very highly interdisciplinary subject that attracts the attention of engineers, mathematicians, physicists, chemists, material specialists, biologists, medical doctors, etc. They work in many different topics from a purely scientific objective to industrial applications and with an increasing arsenal of sophisticated modeling and experimental tools but always with the final objectives of better understanding the fundamentals of life and improve the quality of life of human beings. One purpose in this volume has been to present an overview of some of these many possible subjects in a self-contained way for a general audience. This volume is aimed at the following major target audiences: University and College Students, Educators, Professional Practitioners, and Research Personnel.

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering Book
Author : Amit Gefen
Publisher : Springer Science & Business Media
Release : 2014-07-08
ISBN : 3642364829
Language : En, Es, Fr & De

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Book Description :

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

Handbook of Imaging in Biological Mechanics

Handbook of Imaging in Biological Mechanics Book
Author : Corey P. Neu,Guy M. Genin
Publisher : CRC Press
Release : 2014-10-24
ISBN : 1466588144
Language : En, Es, Fr & De

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Book Description :

Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens

Multiscale Biomechanical Modeling of the Brain

Multiscale Biomechanical Modeling of the Brain Book
Author : Raj K. Prabhu,Mark F. Horstemeyer
Publisher : Academic Press
Release : 2021-11-15
ISBN : 9780128181447
Language : En, Es, Fr & De

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Book Description :

Multiscale biomechanical modeling of the brain presents a robust description of the constitutive modeling of the brain at the various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book goes through to the state-of-the- experimental and computational tools used to quantify critical deformational information at that length scale. Then, at the structural scale, several user-based constitutive material models are presented along with its real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design framework. This book is useful for both academia and industry where there is focus on the basic science aspects or the applied research of head and brain protection. The multiscale approach to this topic is unique, and cannot be found in other books. This book includes meticulously selected materials that aim at interconnecting the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels, and is an excellent reference for students, researchers, and clinicians in the field of brain mechanics and trauma. Presents concepts in the theoretical and thermodynamic framework for each length scale Teaches readers how to use an existing multiscale model for the brain, or develop a new multiscale model for the brain Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems

Multiscale Simulations and Mechanics of Biological Materials

Multiscale Simulations and Mechanics of Biological Materials Book
Author : Shaofan Li,Dong Qian
Publisher : John Wiley & Sons
Release : 2013-03-19
ISBN : 1118402944
Language : En, Es, Fr & De

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Book Description :

Multiscale Simulations and Mechanics of BiologicalMaterials A compilation of recent developments in multiscalesimulation and computational biomaterials written by leadingspecialists in the field Presenting the latest developments in multiscale mechanics andmultiscale simulations, and offering a unique viewpoint onmultiscale modelling of biological materials, this book outlinesthe latest developments in computational biological materials fromatomistic and molecular scale simulation on DNA, proteins, andnano-particles, to meoscale soft matter modelling of cells, and tomacroscale soft tissue and blood vessel, and bone simulations.Traditionally, computational biomaterials researchers come frombiological chemistry and biomedical engineering, so this isprobably the first edited book to present work from these talentedcomputational mechanics researchers. The book has been written to honor Professor Wing Liu ofNorthwestern University, USA, who has made pioneering contributionsin multiscale simulation and computational biomaterial in specificsimulation of drag delivery at atomistic and molecular scale andcomputational cardiovascular fluid mechanics via immersed finiteelement method. Key features: Offers a unique interdisciplinary approach to multiscalebiomaterial modelling aimed at both accessible introductory andadvanced levels Presents a breadth of computational approaches for modellingbiological materials across multiple length scales (molecular towhole-tissue scale), including solid and fluid basedapproaches A companion website for supplementary materials plus links tocontributors’ websites (www.wiley.com/go/li/multiscale)

Multi scale Extracellular Matrix Mechanics and Mechanobiology

Multi scale Extracellular Matrix Mechanics and Mechanobiology Book
Author : Yanhang Zhang
Publisher : Springer
Release : 2019-07-12
ISBN : 3030201821
Language : En, Es, Fr & De

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Book Description :

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Materiomics Multiscale Mechanics of Biological Materials and Structures

Materiomics  Multiscale Mechanics of Biological Materials and Structures Book
Author : Markus J. Buehler,Roberto Ballarini
Publisher : Springer Science & Business Media
Release : 2013-11-18
ISBN : 3709115744
Language : En, Es, Fr & De

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Book Description :

Multiscale mechanics of hierarchical materials plays a crucial role in understanding and engineering biological and bioinspired materials and systems. The mechanical science of hierarchical tissues and cells in biological systems has recently emerged as an exciting area of research and provides enormous opportunities for innovative basic research and technological advancement. Such advances could enable us to provide engineered materials and structure with properties that resemble those of biological systems, in particular the ability to self-assemble, to self-repair, to adapt and evolve, and to provide multiple functions that can be controlled through external cues. This book presents material from leading researchers in the field of mechanical sciences of biological materials and structure, with the aim to introduce methods and applications to a wider range of engineers.

Composition dependent Mechanisms of Multiscale Tendon Mechanics

Composition dependent Mechanisms of Multiscale Tendon Mechanics Book
Author : Fei Fang (Materials scientist)
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Tendons serve as an integral part of the musculoskeletal system by transferring loads from muscle to bone and providing joint mobility and stability. From the physiologically-loading perspective, while progress has been made in evaluating mechanical behavior of different types of tendons in tension, further work is needed to relate tendon mechanics to compositional and microstructural properties, particularly under non-tensile loading modalities (i.e., shear, compression). This information is vital to explore mechanisms of how mechanical signals lead to changes in tendon structure and composition to enable these tissues to function properly, including in in vivo multiaxial loading conditions. From the structural perspective, tendon exhibits a hierarchical organization as collagen is bundled into fibrils, fibers, fascicles, and finally full tissue. Within this hierarchy, linking components are believed to act as connections to maintain mechanical integrity. Three linking components have been proposed, namely elastic fibers, proteoglycans, and collagen crosslinks, however conclusions about their specific mechanical roles, assessed using experimental and computational approaches, are inconsistent. In addition, it remains unknown whether/how these linking components regulate tendon microscale behavior (i.e., at the level of cells) and mechanical signal transfer across length scales.Therefore, this study aimed to (1) develop a protocol that combined a biomechanical test device with two-photon microscopy to measure tendon mechanical strength and multiscale deformation; (2) apply this experimental approach to evaluate region-dependent biomechanics of tendons and related physical mechanisms governing their microscale behavior; (3) determine the role of proteoglycans and elastic fibers in tendon multiscale mechanical behavior using enzyme-treated tendons; and (4) elucidate the contribution of collagen crosslinks to tendon mechanics using in vivo treatment and in vitro culture. We found that different regions of bovine flexor tendon exhibited distinct elasticity, but not viscosity, when subjected to shear and compression, and that fiber sliding and reorganization were the primary modes of microscale deformation. Elastic fibers contributed to supraspinatus tendon (SST) mechanical strength in shear, while proteoglycans appeared to not contribute to SST multiscale biomechanics. Rat SST with decreased collagen crosslink density showed inferior mechanical properties, demonstrating the role of collagen crosslinks on tendon mechanical behavior. Taken together, these results have illustrated tendon composition-mechanics relationships by evaluating mechanical contribution of specific linking components at different length scales. In addition, this work provides insight into mechanical consequences that may accompany extracellular matrix changes during tissue injury/degeneration, and as well provides useful data to aid the design of biomimetic engineered tissues with appropriate structure and composition.

Forensic Biomechanics

Forensic Biomechanics Book
Author : Jules Kieser,Michael Taylor,Debra Carr
Publisher : John Wiley & Sons
Release : 2012-09-20
ISBN : 111840422X
Language : En, Es, Fr & De

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Book Description :

Biomechanics is the application of mechanical principles to living organisms, and it is one of the most exciting and fastest growing research areas. In forensic science, it is biomechanics that explains trauma to the body at a crime scene or the fracture of fibers and textiles, and helps interpret blood spatter. Forensic Biomechanics is a comprehensive overview of the role of biomechanics in forensics. Well-illustrated with real-life case studies, and using a multidisciplinary approach, this unique book is an invaluable reference for practicing forensic scientists, lawyers, and researchers.

Orthopaedic Biomechanics

Orthopaedic Biomechanics Book
Author : Donald L. Bartel,Dwight T. Davy,Tony M. Keaveny
Publisher : Prentice Hall
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book addresses the mechanical and structural aspects of the skeletal system - along with the analysis and design of orthopaedic implants that are used to repair the system when it is damaged. KEY TOPICS: Focuses on applications of mechanical engineering in orthopaedic biomechanics, quantitatative modeling, and improving the reader's understanding of mechanics. Introduces the musculoskeletal system, determining loads and motions, the structure and properties of bone and soft tissue, and stress analysis of biomechanical systems), as well as introducing applications of the material (including a basic introduction to bone-implant systems, fracture fixation devices, hip replacements, knee replacements, and articulating surfaces). MARKET: For those interested in orthopaedic biomechanics, as well as orthopedic surgeons who wish to learn more about mechanics and design in the musculoskeletal system.

Innovative Approaches to Cell Biomechanics

Innovative Approaches to Cell Biomechanics Book
Author : Kennedy Omondi Okeyo,Hiromi Miyoshi,Taiji Adachi
Publisher : Springer
Release : 2015-02-10
ISBN : 4431551638
Language : En, Es, Fr & De

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Book Description :

This book covers topics on mechanosensing, mechanotransduction, and actin cytoskeletal dynamics in cell motility. It will contribute to a better understanding of how cells functionally adapt to their mechanical environment as well as highlighting fundamental concepts for designing material niches for cell manipulation. With topics from multidisciplinary fields of the life sciences, medicine and engineering, the book is the first of its kind, providing comprehensive, integrated coverage of innovative approaches to cell biomechanics. It provides a valuable resource for seniors and graduate students studying cell biomechanics and is also suitable for researchers interested in the application of methods and strategies in connection with the innovative approaches discussed. Each section of the book has been supplemented with concrete examples and illustrations to facilitate understanding even for readers unfamiliar with cell biomechanics.

Computational Modeling in Biomechanics

Computational Modeling in Biomechanics Book
Author : Suvranu De,Farshid Guilak,Mohammad Mofrad
Publisher : Springer Science & Business Media
Release : 2010-03-10
ISBN : 9789048135752
Language : En, Es, Fr & De

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Book Description :

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Multiscale Mechanobiology of Bone Remodeling and Adaptation Book
Author : Peter Pivonka
Publisher : Springer
Release : 2017-07-27
ISBN : 3319588451
Language : En, Es, Fr & De

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Book Description :

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Cell and Matrix Mechanics

Cell and Matrix Mechanics Book
Author : Roland Kaunas,Assaf Zemel
Publisher : CRC Press
Release : 2014-10-23
ISBN : 1466553820
Language : En, Es, Fr & De

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Book Description :

Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.

Orthopaedic Biomechanics

Orthopaedic Biomechanics Book
Author : Beth A. Winkelstein
Publisher : CRC Press
Release : 2012-12-18
ISBN : 1439860947
Language : En, Es, Fr & De

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Book Description :

Given the strong current attention of orthopaedic, biomechanical, and biomedical engineering research on translational capabilities for the diagnosis, prevention, and treatment of clinical disease states, the need for reviews of the state-of-art and current needs in orthopaedics is very timely. Orthopaedic Biomechanics provides an in-depth review of the current knowledge of orthopaedic biomechanics across all tissues in the musculoskeletal system, at all size scales, and with direct relevance to engineering and clinical applications. Discussing the relationship between mechanical loading, function, and biological performance, it first reviews basic structure-function relationships for most major orthopedic tissue types followed by the most-relevant structures of the body. It then addresses multiscale modeling and biologic considerations. It concludes with a look at applications of biomechanics, focusing on recent advances in theory, technology and applied engineering approaches. With contributions from leaders in the field, the book presents state-of-the-art findings, techniques, and perspectives. Much of orthopaedic, biomechanical, and biomedical engineering research is directed at the translational capabilities for the "real world". Addressing this from the perspective of diagnostics, prevention, and treatment in orthopaedic biomechanics, the book supplies novel perspectives for the interdisciplinary approaches required to translate orthopaedic biomechanics to today’s real world.

Computer Models in Biomechanics

Computer Models in Biomechanics Book
Author : Gerhard A. Holzapfel,Ellen Kuhl
Publisher : Springer Science & Business Media
Release : 2012-10-16
ISBN : 9400754647
Language : En, Es, Fr & De

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Book Description :

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics