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Multiscale Biomechanical Modeling Of The Brain

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Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering Book
Author : Amit Gefen
Publisher : Springer Science & Business Media
Release : 2014-07-08
ISBN : 3642364829
Language : En, Es, Fr & De

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Book Description :

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

Multiscale Modeling in Biomechanics and Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology Book
Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publisher : Springer
Release : 2014-10-10
ISBN : 1447165993
Language : En, Es, Fr & De

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Book Description :

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Computer Models in Biomechanics

Computer Models in Biomechanics Book
Author : Gerhard A. Holzapfel,Ellen Kuhl
Publisher : Springer Science & Business Media
Release : 2012-10-16
ISBN : 9400754647
Language : En, Es, Fr & De

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Book Description :

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Tumors of the Central Nervous System Volume 12

Tumors of the Central Nervous System  Volume 12 Book
Author : M.A. Hayat
Publisher : Springer Science & Business Media
Release : 2013-11-12
ISBN : 9400772173
Language : En, Es, Fr & De

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Book Description :

As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children’s Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.

Explosion and Blast Related Injuries

Explosion and Blast Related Injuries Book
Author : Nabil M. Elsayed, Ph.D.,James L. Atkins, MD, Ph.D.
Publisher : Academic Press
Release : 2010-07-26
ISBN : 9780080878027
Language : En, Es, Fr & De

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Book Description :

Explosion and Blast-Related Injuries is an authoritative text that brings together diverse knowledge gained from both the experience of clinicians treating blast casualties and the insights of scientists obtained from research and modeling of blast exposures. By providing information on explosion and blast injury patterns, as well as the mechanism of blast-induced injuries, it is a useful reference for both physicians and researchers. With contributions by experts from around the globe, the book covers topics such as the epidemiology of blast and explosion injury, pathology and pathophysiology, and the modeling and mechanism of injury. Finally, this book might stimulate additional studies into ways to improve our current mass casualty response systems. * Contains contributions from experts who had first hand experience dealing with explosion and blast injuries. * Provides a diverse global experience derived from both military operations and terrorist attacks in civilian settings from the US, Europe and the Middle East. * Covers such topics as epidemiology of blast and explosion injury, pathology and pathophysiology, modeling and mechanism of injury, and finally presents the global experiences of blast injury and mass casualty management.

Biomedical Technology

Biomedical Technology Book
Author : Peter Wriggers,Thomas Lenarz
Publisher : Springer
Release : 2017-08-29
ISBN : 3319595482
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015.

Handbook of Medical Image Processing and Analysis

Handbook of Medical Image Processing and Analysis Book
Author : Isaac Bankman
Publisher : Elsevier
Release : 2008-12-24
ISBN : 9780080559148
Language : En, Es, Fr & De

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Book Description :

The Handbook of Medical Image Processing and Analysis is a comprehensive compilation of concepts and techniques used for processing and analyzing medical images after they have been generated or digitized. The Handbook is organized into six sections that relate to the main functions: enhancement, segmentation, quantification, registration, visualization, and compression, storage and communication. The second edition is extensively revised and updated throughout, reflecting new technology and research, and includes new chapters on: higher order statistics for tissue segmentation; tumor growth modeling in oncological image analysis; analysis of cell nuclear features in fluorescence microscopy images; imaging and communication in medical and public health informatics; and dynamic mammogram retrieval from web-based image libraries. For those looking to explore advanced concepts and access essential information, this second edition of Handbook of Medical Image Processing and Analysis is an invaluable resource. It remains the most complete single volume reference for biomedical engineers, researchers, professionals and those working in medical imaging and medical image processing. Dr. Isaac N. Bankman is the supervisor of a group that specializes on imaging, laser and sensor systems, modeling, algorithms and testing at the Johns Hopkins University Applied Physics Laboratory. He received his BSc degree in Electrical Engineering from Bogazici University, Turkey, in 1977, the MSc degree in Electronics from University of Wales, Britain, in 1979, and a PhD in Biomedical Engineering from the Israel Institute of Technology, Israel, in 1985. He is a member of SPIE. Includes contributions from internationally renowned authors from leading institutions NEW! 35 of 56 chapters have been revised and updated. Additionally, five new chapters have been added on important topics incluling Nonlinear 3D Boundary Detection, Adaptive Algorithms for Cancer Cytological Diagnosis, Dynamic Mammogram Retrieval from Web-Based Image Libraries, Imaging and Communication in Health Informatics and Tumor Growth Modeling in Oncological Image Analysis. Provides a complete collection of algorithms in computer processing of medical images Contains over 60 pages of stunning, four-color images

Mechanics of Biological Systems and Materials Volume 2

Mechanics of Biological Systems and Materials  Volume 2 Book
Author : Tom Proulx
Publisher : Springer Science & Business Media
Release : 2011-05-20
ISBN : 9781461402190
Language : En, Es, Fr & De

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Book Description :

Mechanics of Biological Systems and Materials represents one of eight volumes of technical papers presented at the Society for Experimental Mechanics Annual Conference & Exposition on Experimental and Applied Mechanics, held at Uncasville, Connecticut, June 13-16, 2011. The full set of proceedings also includes volumes on Dynamic Behavior of Materials, Mechanics of Time-Dependent Materials and Processes in Conventional and Multifunctional Materials, MEMS and Nanotechnology; Optical Measurements, Modeling and, Metrology; Experimental and Applied Mechanics, Thermomechanics and Infra-Red Imaging, and Engineering Applications of Residual Stress.

Biomechanics of Cells and Tissues

Biomechanics of Cells and Tissues Book
Author : Paola Lecca
Publisher : Springer Science & Business Media
Release : 2013-01-18
ISBN : 9400758901
Language : En, Es, Fr & De

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Book Description :

The application of methodological approaches and mathematical formalisms proper to Physics and Engineering to investigate and describe biological processes and design biological structures has led to the development of many disciplines in the context of computational biology and biotechnology. The best known applicative domain is tissue engineering and its branches. Recent domains of interest are in the field of biophysics, e.g.: multiscale mechanics of biological membranes and films and filaments; multiscale mechanics of adhesion; biomolecular motors and force generation. Modern hypotheses, models, and tools are currently emerging and resulting from the convergence of the methods and phylosophycal apporaches of the different research areas and disciplines. All these emerging approaches share the purpose of disentangling the complexity of organisms, tissues, and cells and mimiking the function of living systems. The contributions presented in this book are current research highlights of six challenging and representative applicative domains of phyisical, engineering, and computational approaches in medicine and biology, i.e tissue engineering, modelling of molecular structures, cell mechanics and cell adhesión processes, cancer physics, and physico-chemical processes of metabolic interactions. Each chapter presents a compendium or a review of the original results achieved by authors in the last years. Furthermore, the book also wants to pinpoint the questions that are still open and that could propel the future research.

Medical Image Analysis

Medical Image Analysis Book
Author : Atam P. Dhawan
Publisher : John Wiley & Sons
Release : 2011-03-29
ISBN : 0470922893
Language : En, Es, Fr & De

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Book Description :

The expanded and revised edition will split Chapter 4 to include more details and examples in FMRI, DTI, and DWI for MR image modalities. The book will also expand ultrasound imaging to 3-D dynamic contrast ultrasound imaging in a separate chapter. A new chapter on Optical Imaging Modalities elaborating microscopy, confocal microscopy, endoscopy, optical coherent tomography, fluorescence and molecular imaging will be added. Another new chapter on Simultaneous Multi-Modality Medical Imaging including CT-SPECT and CT-PET will also be added. In the image analysis part, chapters on image reconstructions and visualizations will be significantly enhanced to include, respectively, 3-D fast statistical estimation based reconstruction methods, and 3-D image fusion and visualization overlaying multi-modality imaging and information. A new chapter on Computer-Aided Diagnosis and image guided surgery, and surgical and therapeutic intervention will also be added. A companion site containing power point slides, author biography, corrections to the first edition and images from the text can be found here: ftp://ftp.wiley.com/public/sci_tech_med/medical_image/ Send an email to: [email protected] to obtain a solutions manual. Please include your affiliation in your email.

Concussion in Sports An Issue of Clinics in Sports Medicine E Book

Concussion in Sports  An Issue of Clinics in Sports Medicine   E Book Book
Author : William P. Meehan,Lyle J. Micheli
Publisher : Elsevier Health Sciences
Release : 2010-12-20
ISBN : 1455709565
Language : En, Es, Fr & De

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Book Description :

This issue of Clinics in Sports Medicine will explore all aspects of sports-related concussion, such as the biomechanics and epidemiology of concussions,as well as special considerations for female and pediatric athletes. The issue will also include articles on return-to-play and retiring decisions after sports-related concussions.

IEEE Workshop on Mathematical Methods in Biomedical Image Analysis

IEEE Workshop on Mathematical Methods in Biomedical Image Analysis Book
Author : Lawrence Staib
Publisher : IEEE
Release : 2001
ISBN :
Language : En, Es, Fr & De

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Book Description :

Specialists in biomedical image analysis participated in a workshop held in December 2001 in Kauai, Hawaii. The papers were grouped into the themes of mammography, registration, acquisition-based image analysis, detection, probabilistic methods, shape, and segmentation. Individual topics include: 3D

Medical Image Computing and Computer Assisted Intervention MICCAI 2003

Medical Image Computing and Computer Assisted Intervention   MICCAI 2003 Book
Author : Randy E. Ellis,Terry M. Peters
Publisher : Springer Science & Business Media
Release : 2003-10-29
ISBN : 3540204628
Language : En, Es, Fr & De

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Book Description :

The 6th International Conference on Medical Imaging and Computer-Assisted Intervention,MICCAI2003,washeldinMontr ́ eal,Qu ́ ebec,CanadaattheF- rmont Queen Elizabeth Hotel during November 15–18, 2003. This was the ?rst time the conference had been held in Canada. The proposal to host MICCAI 2003 originated from discussions within the Ontario Consortium for Ima- guided Therapy and Surgery, a multi-institutional research consortium that was supported by the Government of Ontario through the Ontario Ministry of E- erprise, Opportunity and Innovation. The objective of the conference was to o?er clinicians and scientists a - rum within which to exchange ideas in this exciting and rapidly growing ?eld. MICCAI 2003 encompassed the state of the art in computer-assisted interv- tions, medical robotics, and medical-image processing, attracting experts from numerous multidisciplinary professions that included clinicians and surgeons, computer scientists, medical physicists, and mechanical, electrical and biome- cal engineers. The quality and quantity of submitted papers were most impressive. For MICCAI 2003 we received a record 499 full submissions and 100 short c- munications. All full submissions, of 8 pages each, were reviewed by up to 5 reviewers, and the 2-page contributions were assessed by a small subcomm- tee of the Scienti?c Review Committee. All reviews were then considered by the MICCAI 2003 Program Committee, resulting in the acceptance of 206 full papers and 25 short communications. The normal mode of presentation at MICCAI 2003 was as a poster; in addition, 49 papers were chosen for oral presentation.

Advances in Medical Engineering

Advances in Medical Engineering Book
Author : Thorsten M. Buzug
Publisher : Springer Science & Business Media
Release : 2007-07-19
ISBN : 3540687645
Language : En, Es, Fr & De

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Book Description :

This book offers a lucid and comprehensive account of research and development trends of physics, engineering, mathematics and computer sciences in biomedical engineering. Contributions from industry, clinics, universities and research labs are reviewed. Coverage focuses on medical imaging, medical image processing, computer-assisted surgery, biomechanics, biomedical optics and laser medicine. The book is designed and written to give insight to recent engineering, clinical and mathematical studies.

Glaucoma E Book

Glaucoma E Book Book
Author : Tarek M. Shaarawy,Mark B. Sherwood,Roger A. Hitchings,Jonathan G. Crowston
Publisher : Elsevier Health Sciences
Release : 2014-09-05
ISBN : 0702055417
Language : En, Es, Fr & De

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Book Description :

As the irreversible effects of glaucoma can lead to blindness, there is high demand for early diagnosis and an ongoing need for practitioners to adopt new and evolving medical and surgical treatment options to improve patient outcomes. Glaucoma, Second Edition is the most comprehensive resource in the field delivering expert guidance for the most timely and effective diagnosis and treatment of glaucoma – aimed at specialists, fellows and general ophthalmologists. More than 300 contributors from six continents provide a truly global perspective and explore new approaches in this user friendly reference which has been updated with enhanced images, more spotlights, new videos, and more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Get all the accuracy, expertise, and dependability you could ask for from leading specialists across six continents, for expert guidance and a fresh understanding of the subject. Develop a thorough, clinically relevant understanding of all aspects of adult and pediatric glaucoma and the latest diagnostic imaging techniques including ultrasound biomicroscopy and optical coherence tomography. Broaden your surgical repertoire with the latest surgical techniques - such as trabeculectomy, gonio-surgery, combined surgeries, and implant procedures. Glean all essential, up-to-date, need-to-know information about stem cell research, gene transfer, and implants. Find answers fast thanks to a well-organized, user-friendly full-color layout. Stay at the forefront of your field with 10 brand new chapters on trending topics including: new surgical approaches such as trabectome and canoplasty; glaucoma implications in cataract and ocular surface disease; and, updates in the costs-effectiveness of medical management. Avoid pitfalls and achieve the best outcomes thanks to more than 40 brand new spotlight commentaries from key leaders providing added insight, tips and pearls of wisdom across varying hot topics and advances in the field. Refine and improve your surgical skills by watching over 50 video clips depicting the latest techniques and procedures including: new trabeculectomy methods, needling, implants, valve complications, and more. Prevent and plan for complications in advance by examining over 1,600 illustrations, photos and graphics (1,250 in color) capturing essential diagnostics techniques, imaging methods and surgical approaches. Grasp each procedure and review key steps quickly with chapter summary boxes that provide at-a-glance quick comprehension of the key take away points.