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Multicomponent Reactions in Organic Synthesis

Multicomponent Reactions in Organic Synthesis Book
Author : Jieping Zhu,Qian Wang,Meixiang Wang
Publisher : John Wiley & Sons
Release : 2015-02-09
ISBN : 3527332375
Language : En, Es, Fr & De

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Book Description :

Comprehensive and up–to–date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene–promoted MCRs and frequently applied metal–catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a "who′s who" in multicomponent reaction chemistry, this is definitely a must–have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.

Multicomponent Reactions

Multicomponent Reactions Book
Author : Jieping Zhu,Hugues Bienaymé
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604243
Language : En, Es, Fr & De

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Book Description :

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.

Multicomponent Reactions

Multicomponent Reactions Book
Author : Raquel P. Herrera,Eugenia Marqués-LÃ3pez
Publisher : John Wiley & Sons
Release : 2015-04-27
ISBN : 1118016009
Language : En, Es, Fr & De

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Book Description :

Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions – including key routes for synthesizing complex molecules. • Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic syntheses • Compiles novel and efficient synthetic multicomponent procedures to give readers a complete picture of this class of organic reactions • Helps readers to design efficient and practical transformations using multicomponent reaction strategies • Describes reaction background, applications to synthesize complex molecules and drugs, and reaction mechanisms

Synthesis of Heterocycles via Multicomponent Reactions II

Synthesis of Heterocycles via Multicomponent Reactions II Book
Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer
Release : 2010-07-26
ISBN : 3642154557
Language : En, Es, Fr & De

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Book Description :

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Science of Synthesis Multicomponent Reactions Vol 1

Science of Synthesis  Multicomponent Reactions Vol  1 Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2014-05-14
ISBN : 313176581X
Language : En, Es, Fr & De

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Book Description :

The two volumes "Science of Synthesis: Multicomponent Reactions" critically review the state of the art of domino, sequential, and consecutive multicomponent reactions in what is a highly dynamic field. They serve as the basis for practical application to reach the goals of diversity-oriented synthesis, reaction design, and novel synthetic concepts. As is typical for the Science of Synthesis series, the reference work on multicomponent reactions presents the best synthetic methods as judged by experts in the field and includes typical and general experimental procedures. The volume "Reactions Involving a Carbonyl Compound as Electrophilic Component" covers the following topics: - Biginelli Reaction - Strecker Reaction - Hantzsch Pyridine Synthesis - Mannich Reaction - Petasis Reaction - Willgerodt-Kindler Reaction - Kabachnik-Fields Reaction - Passerini Reaction - Ugi Reaction - Gewald Reaction

Multicomponent Reactions

Multicomponent Reactions Book
Author : K.L. Ameta, Ph.D.,Anshu Dandia
Publisher : CRC Press
Release : 2017-09-20
ISBN : 1498734197
Language : En, Es, Fr & De

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Book Description :

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.

Synthesis of Heterocycles via Multicomponent Reactions I

Synthesis of Heterocycles via Multicomponent Reactions I Book
Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer
Release : 2010-07-20
ISBN : 3642126758
Language : En, Es, Fr & De

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Book Description :

Contents: L. Banfi ∙ A. Basso ∙ R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov ∙ K. A. Gura ∙ S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang ∙ K. Khoury ∙ A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders ∙ E. Ruijter ∙ V.G. Nenajdenko ∙ R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic ∙ J.-C.M.R. Monbaliu ∙ C.V. Stevens: Microreactor Technology as an Efficient Tool for Multicomponent Reactions.- L.A. Wessjohann ∙ C.R.B. Rhoden ∙ D.G. Rivera ∙ O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque ∙ C. Allais ∙ N. Isambert ∙ T. Constantieux ∙ J. Rodriguez: ß-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles

Isocyanide based Multicomponent Reactions

Isocyanide based Multicomponent Reactions Book
Author : Jonathan G. Rudick,Alexander Dömling,Shabnam Shaabani
Publisher : Frontiers Media SA
Release : 2020-02-20
ISBN : 2889634841
Language : En, Es, Fr & De

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Book Description :

Download Isocyanide based Multicomponent Reactions book written by Jonathan G. Rudick,Alexander Dömling,Shabnam Shaabani, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis of Heterocycles Via Multicomponent Reactions II

Synthesis of Heterocycles Via Multicomponent Reactions II Book
Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer Science & Business Media
Release : 2010-09-05
ISBN : 3642154549
Language : En, Es, Fr & De

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Book Description :

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Copper Catalyzed Multi Component Reactions

Copper Catalyzed Multi Component Reactions Book
Author : Yusuke Ohta
Publisher : Springer
Release : 2011-01-30
ISBN : 9783642154720
Language : En, Es, Fr & De

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Book Description :

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.

Multicomponent Reactions Volume 2

Multicomponent Reactions  Volume 2 Book
Author : Anonim
Publisher : Georg Thieme Verlag
Release : 2014-05-14
ISBN : 3131766018
Language : En, Es, Fr & De

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Book Description :

"The two volumes ""Science of Synthesis: Multicomponent Reactions"" critically review the state of the art of domino, sequential, and consecutive multicomponent reactions in what is a highly dynamic field. They serve as the basis for practical application to reach the goals of diversity-oriented synthesis, reaction design, and novel synthetic concepts. As is typical for the Science of Synthesis series, the reference work on multicomponent reactions presents the best synthetic methods as judged by experts in the field and includes typical and general experimental procedures. The volume ""Reactions Involving an alpha,beta-Unsaturated Carbonyl Compound as Electrophilic Component"" covers the following topics: Michael Additions, Wittig Reactions, Cycloadditions, Reactions Involving an alpha,beta-Unsaturated Carbonyl Compound as Electrophilic Component with Electron-Deficient Alkynes as Electrophiles, Boron-Mediated Multicomponent Reactions, Silicon-Mediated Multicomponent Reactions, "

Recent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions Book
Author : Majid M. Heravi,Vahideh Zadsirjan
Publisher : Elsevier
Release : 2020-05-29
ISBN : 0128196955
Language : En, Es, Fr & De

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Book Description :

Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs

Exploring Multicomponent Reactions

Exploring Multicomponent Reactions Book
Author : Edwin Kroon
Publisher : Unknown
Release : 2017
ISBN : 9789036795432
Language : En, Es, Fr & De

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Book Description :

Download Exploring Multicomponent Reactions book written by Edwin Kroon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Recent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions Book
Author : Majid M. Heravi,Vahideh Zadsirjan
Publisher : Elsevier
Release : 2020-06-19
ISBN : 0128185848
Language : En, Es, Fr & De

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Book Description :

Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs

Multicomponent Reactions

Multicomponent Reactions Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Multicomponent Reactions book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis of Densely Functionalized Heterocyclic Compounds by Combining Multicomponent Reactions with Click Chemistry

Synthesis of Densely Functionalized Heterocyclic Compounds by Combining Multicomponent Reactions with Click Chemistry Book
Author : Isabelle Françoise Clémençon
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synthesis of Densely Functionalized Heterocyclic Compounds by Combining Multicomponent Reactions with Click Chemistry book written by Isabelle Françoise Clémençon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Multi component Reactions in Molecular Diversity

Multi component Reactions in Molecular Diversity Book
Author : Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
Publisher : John Wiley & Sons
Release : 2020-01-09
ISBN : 1786305119
Language : En, Es, Fr & De

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Book Description :

While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.

Advancements in Isocyanide Based Multicomponent Reactions

Advancements in Isocyanide Based Multicomponent Reactions Book
Author : Jerry Calhoun Isaacson
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Isocyanide based multicomponent reactions, including the Ugi four-component and Passerini three-component reactions, offer chemists a powerful tool for quickly constructing complex molecules. A particular form of the Ugi reaction, in which two of the four reacting components are introduced into a single molecule, is useful for synthesizing cyclic products. Using a newly developed convertible isocyanide, known as indole isocyanide, in the Ugi reaction allowed for the mild synthesis of various pyroglutamic acids. This effort led first to a racemic total synthesis of the natural product dysibetaine. A project to achieve the stereoselective synthesis of the same natural product led to the discovery of a unique Ugi reaction. Usually a carboxylic acid is one of the four reacting components in this reaction, however in this unusual case an ester acts as the carboxylic acid component. In addition to the natural product syntheses, a detailed explanation of the scope and mechanism of the new convertible indole isocyanide is presented. Finally, we reveal a new stereoselective, Brønsted-acid catalyzed Passerini-type reaction.

Pot Atom and Step Economy PASE Synthesis

Pot  Atom  and Step Economy  PASE  Synthesis Book
Author : Wei Zhang,Wen-Bin Yi
Publisher : Springer
Release : 2019-08-01
ISBN : 3030225968
Language : En, Es, Fr & De

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Book Description :

This book emphasizes the atom economy aspect of multicomponent reactions. It describes how this methodology has been applied to several named reactions. Among the “twelve principles of green chemistry”, atom economy addresses ‘synthetic efficiency’. A multicomponent reaction can be defined as an energy, cost, and time efficient method for organic synthesis. Instead of making one or two bonds in a chemical transformation, multicomponent reactions generate several chemical bonds in a single operation. This book presents a series of detailed reaction mechanisms that beautifully illustrate this principle. Multicomponent reactions are widely applied to the preparation of complex and diverse molecular structures in academic and industrial research laboratories. As such, this book is targeted at researchers involved in green organic chemistry.

Studies on Multicomponent Reactions

Studies on Multicomponent Reactions Book
Author : Christopher Allen Simoneau
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Multicomponent reactions (MCRs) provide a convenient route to structurally diverse compounds in a single step. The increased demand for high-throughput screening of compounds and the biological relevance of most MCR products has led to a renaissance in MCR research. Towards this end, a retrosynthetic intermediate analysis (RIA) approach was developed with the goal of creating new, and improving known, MCRs.