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Multi Functional Role Of Stem Cells In Disease

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Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 1977
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Research Awards Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cells and Human Diseases

Stem Cells and Human Diseases Book
Author : Rakesh K. Srivastava,Sharmila Shankar
Publisher : Springer Science & Business Media
Release : 2012-02-01
ISBN : 940072800X
Language : En, Es, Fr & De

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Book Description :

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Multifunctional Role of Pancreatic Differentiation 2 PD2 in Pancreatic Cancer

Multifunctional Role of Pancreatic Differentiation 2  PD2  in Pancreatic Cancer Book
Author : Arokia Priyanka Vaz
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cancer is a devastating disease that claims the lives of countless people due to its uncontrolled growth pattern. Among various cancers, pancreatic cancer is one of the most lethal cancers due to its aggressive nature, lack of early symptoms and resistance to chemotherapy. The molecular profile of this deadly malignancy is not completely understood. Malignancy arises due to loss or gain of function in genes involved in cell cycle progression leading to disruption of tightly regulated transitions. In addition the evolving concept of cancer throws light on a small population of cells within the tumor known as the cancer stem cells (CSCs) or tumor-initiating cells that are resistant to all drugs treatment and contributes towards tumor initiation and recurrence. Several studies have been carried out to identify specific markers for the cancer stem cell population including that of pancreatic cancer. Pancreatic Differentiation 2 (PD2) or human Polymerase Associated Factor 1 (hPaf1) is an important component of the multifunctional PAF1 complex initially identified to play a crucial role in transcriptional elongation of genes. During the last decade, several papers on PD2 showed that it is a multifaceted molecule playing roles in cell cycle regulation, stem cell maintenance, histone methylation, chromatin remodeling and acinar-to-ductal metaplasia. In this dissertation, the first goal was to investigate the role of PD2 in pancreatic cancer stem cells. Initially, we analyzed the expression and function of PD2 in pancreatic cancer stem cells isolated from pancreatic cancer cell lines, Kras (G12D); Pdx1 (Cre)(KC), Kras (G12D); Trp53 (R172H/+.); Pdx1(Cre) (KPC) mouse models and human pancreatic tumors. Furthermore, the expression of PD2 was significantly higher in CSCs isolated from pancreatic cancer cells along with CSC markers. These cells were shown to exhibit a cobblestone appearance, increased tumorsphere formation and significant tumor growth, characteristic of the CSC phenotype. interestingly, PD2 was found to be specifically overexpressed in a subpopulation of cells within mouse KC, KPC and human pancreatic tumors, which co-express CSC markers. The drug resistance property was impaired upon knockdown of PD2 with simultaneous alteration in the CSC phenotype and reduction in CD133 and MDR2 gene expression. Overall, my study identified that PD2 has a role in self-renewal and drug resistance of pancreatic CSCs. The second part of my dissertation was primarily focused at exploring the functional role of PD2 in pancreatic cancer cells. The ectopic overexpression of PD2 resulted in increased growth rate of tumor cells both in vitro and in vivo. Overexpression of PD2 led to increased growth, colony formation and migration. Interestingly, elevated expression of PD2 also increased the percentage of CSCs. Furthermore, in vivo studies revealed that PD2 overexpression leads to increased tumor volume and metastasis to distant secondary sites. These results were corroborated at the protein level where elevated expression of PD2 led to the up-regulation of c-Myc which is an important player in tumorigenesis and metastasis. In addition, the expression of PD2 in pancreatic cancer tissues and in vitro pancreatic progression model was elucidated. We demonstrated that the expression of PD2 was increased in the ducts present in the pancreatic cancer tissues when compared to the normal tissues. Likewise, the expression of PD2 was elevated in the transformed Human Pancreatic Nestin expressing (HPNE) cells when compared to the untransformed HPNE cells. Understanding the role of PD2 through cell lines led to my next aim to generate PD2 conditional knockout mice in order to substantiate our earlier work in cancer stem cells and acinar to ductal metaplasia during PC initiation. The animal model would be an important resource for understanding the role of PD2 in detail. Taken together, our findings demonstrate that PD2 is an essential member of the oncogene family that plays a significant role in facilitating drug resistance and cancer stem cell maintenance thereby acting as a positive regulator of cancer.

Stem Cells as Targeted Drug Delivery Vehicles

Stem Cells as Targeted Drug Delivery Vehicles Book
Author : Rebecca Lim,Jessica E. Frith,Gina D. Kusuma,Christopher G. Sobey
Publisher : Frontiers Media SA
Release : 2021-02-03
ISBN : 2889664481
Language : En, Es, Fr & De

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Book Description :

Topic Editor RL is a patent inventor on exosome-related patents, PCT/AU2017/050821 and PCT/AU2016/050468. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Forum

Forum Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Forum book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Use of Multipotent Adult Progenitor Cells to Derive Functional Smooth Muscle Cells and Explore Smooth Muscle Development

The Use of Multipotent Adult Progenitor Cells to Derive Functional Smooth Muscle Cells and Explore Smooth Muscle Development Book
Author : Jeffrey James Ross
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Use of Multipotent Adult Progenitor Cells to Derive Functional Smooth Muscle Cells and Explore Smooth Muscle Development book written by Jeffrey James Ross, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemical Abstracts

Chemical Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Chemical Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

CD23 a Novel Multifunctional Regulator of the Immune System that Binds IgE

CD23  a Novel Multifunctional Regulator of the Immune System that Binds IgE Book
Author : John Gordon
Publisher : S Karger Ag
Release : 1991
ISBN : 9783805553582
Language : En, Es, Fr & De

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Book Description :

Download CD23 a Novel Multifunctional Regulator of the Immune System that Binds IgE book written by John Gordon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell Transplantation

Cell Transplantation Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Cell Transplantation book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Laboratory Reference

Clinical Laboratory Reference Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Laboratory products and services currently available in the United States. Product information section arranged alphabetically by companies. Entries include description and ordering information. Indexes by manufactures; brand names; and test, equipment, and services. Product photograph section.

Frontiers in Stem Cell Research

Frontiers in Stem Cell Research Book
Author : Julia M. Spanning
Publisher : Nova Biomedical
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book brings together leading research from throughout the world in this frontier field.

Thymosins in Health and Disease

Thymosins in Health and Disease Book
Author : Allan L. Goldstein,Enrico Garaci
Publisher : Wiley-Blackwell
Release : 2010-06
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"This volume presents manuscripts stemming from the "Second International Symposium on Thymosins in Health and Disease," held on September 30 to October 2, 2009 in Catania, Italy."--P. v.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Book
Author : Asbmr
Publisher : Rittenhouse Book Distributors
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism book written by Asbmr, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Imaging and monitoring astrocytes in health and disease

Imaging and monitoring astrocytes in health and disease Book
Author : Carole Escartin, Keith Murai
Publisher : Frontiers Media SA
Release : 2014-11-25
ISBN : 2889193934
Language : En, Es, Fr & De

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Book Description :

Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells.

Inflammatory Bowel Disease

Inflammatory Bowel Disease Book
Author : Joseph B. Kirsner
Publisher : W.B. Saunders Company
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

World-renowned experts present state-of-the-art information in the clinical understanding of inflammatory bowel disease in the 5th Edition of this best-selling text. Scholarly and pragmatic, this text features authoritative information on the medical and surgical management of IBD with the support of over 390 illustrations. Features many new chapters, including those covering intestinal permeability in health and disease, the intestinal response to acute inflammation and injuries, and current concepts of IBD etiology and pathogenesis.

RNAi and MicroRNA Mediated Gene Regulation in Stem Cells

RNAi and MicroRNA Mediated Gene Regulation in Stem Cells Book
Author : Baohong Zhang,Edmund J. Stellwag
Publisher : Humana
Release : 2010-08-16
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This cutting-edge text will be a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and exciting areas of research such as regenerative medicine and cancer.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Russian Journal of Developmental Biology

Russian Journal of Developmental Biology Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Russian Journal of Developmental Biology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Middleton s Allergy

Middleton s Allergy Book
Author : John W. Yunginger,William W. Busse,Bruce S. Bochner,Stephen T. Holgate
Publisher : Mosby Incorporated
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Provides coverage of state-of-the-art basic science as well as guidance on the practical aspects of day-to-day diagnosis and management.

Stem Cells Basics and Clinical Translation

Stem Cells  Basics and Clinical Translation Book
Author : Robert Chunhua Zhao
Publisher : Springer
Release : 2015-09-14
ISBN : 9401772738
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (“973 Program”). He also serves as Regional Editor of Stem Cells and Development.