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Multi Functional Role Of Stem Cells In Disease

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Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases Book
Author : Ahmed El-Hashash
Publisher : Academic Press
Release : 2020-01-06
ISBN : 0128197137
Language : En, Es, Fr & De

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Book Description :

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Stem Cells

Stem Cells Book
Author : Christine Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers
Publisher : Academic Press
Release : 2014-05-23
ISBN : 0124115675
Language : En, Es, Fr & De

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Book Description :

The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

Stem Cells and the Future of Regenerative Medicine

Stem Cells and the Future of Regenerative Medicine Book
Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Publisher : National Academies Press
Release : 2002-01-25
ISBN : 9780309170420
Language : En, Es, Fr & De

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Book Description :

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush’s watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Dental Stem Cells Regenerative Potential

Dental Stem Cells  Regenerative Potential Book
Author : Barbara Zavan,Eriberto Bressan
Publisher : Humana Press
Release : 2016-07-25
ISBN : 3319332996
Language : En, Es, Fr & De

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Book Description :

This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.

Proteoglycans in Stem Cells

Proteoglycans in Stem Cells Book
Author : Martin Götte,Karin Forsberg-Nilsson
Publisher : Springer Nature
Release : 2021-06-07
ISBN : 3030734536
Language : En, Es, Fr & De

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Book Description :

This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Release : 2010-12-16
ISBN : 9780123814234
Language : En, Es, Fr & De

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Book Description :

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Frontiers in Stem Cell and Regenerative Medicine Research Volume 8

Frontiers in Stem Cell and Regenerative Medicine Research  Volume 8 Book
Author : Atta-ur- Rahman,Shazia Anjum
Publisher : Bentham Science Publishers
Release : 2018-08-13
ISBN : 1681085895
Language : En, Es, Fr & De

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Book Description :

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. This volume includes reviews on the following topics: -the role of microvesicles and exosomes in mesenchymal stem cell (MSCs) in treating diseases while overcoming side effects -alternative models for understanding cancer stem cell biology -stem cells treatments for orthopaedic injury and endocrine disorders -wound healing biomaterials -theoretical models of hematopoietic cell dynamics (with implications for bone marrow transplants)

Brain Repair

Brain Repair Book
Author : Mathias Bähr
Publisher : Springer Science & Business Media
Release : 2007-03-06
ISBN : 0387301283
Language : En, Es, Fr & De

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Book Description :

Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts.

Stem Cells and Aging

Stem Cells and Aging Book
Author : Surajit Pathak,Antara Banerjee
Publisher : Academic Press
Release : 2021-03-17
ISBN : 0128204133
Language : En, Es, Fr & De

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Book Description :

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Plasticity and Reconstruction of Neural Network in Brain Injury

Plasticity and Reconstruction of Neural Network in Brain Injury Book
Author : Zhang Pengyue,Yuchuan Ding,Yulong Bai,Xiangjian Zhang,Yunping Deng
Publisher : Frontiers Media SA
Release : 2021-08-24
ISBN : 2889712206
Language : En, Es, Fr & De

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Book Description :

Download Plasticity and Reconstruction of Neural Network in Brain Injury book written by Zhang Pengyue,Yuchuan Ding,Yulong Bai,Xiangjian Zhang,Yunping Deng, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cells and Human Diseases

Stem Cells and Human Diseases Book
Author : Rakesh K. Srivastava,Sharmila Shankar
Publisher : Springer Science & Business Media
Release : 2012-02-01
ISBN : 940072800X
Language : En, Es, Fr & De

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Book Description :

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Exosomes as Therapeutic Systems

Exosomes as Therapeutic Systems Book
Author : Robert Steven Conlan,Deyarina Gonzalez,Bruna Corradetti,Ines Mendes Pinto
Publisher : Frontiers Media SA
Release : 2021-10-01
ISBN : 2889713768
Language : En, Es, Fr & De

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Book Description :

Download Exosomes as Therapeutic Systems book written by Robert Steven Conlan,Deyarina Gonzalez,Bruna Corradetti,Ines Mendes Pinto, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Pulmonary Neuroepithelial Body Microenvironment

The Pulmonary Neuroepithelial Body Microenvironment Book
Author : Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen
Publisher : Springer Nature
Release : 2021-05-05
ISBN : 3030658171
Language : En, Es, Fr & De

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Book Description :

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors

Gap Junctions Hemichannels and Pannexons New Implications in Neuroplasticity and Neuroinflammation

Gap Junctions  Hemichannels and Pannexons  New Implications in Neuroplasticity and Neuroinflammation Book
Author : Juan Andrés Orellana,Eliseo A. Eugenin,Pablo José Sáez
Publisher : Frontiers Media SA
Release : 2022-02-01
ISBN : 2889742180
Language : En, Es, Fr & De

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Book Description :

Download Gap Junctions Hemichannels and Pannexons New Implications in Neuroplasticity and Neuroinflammation book written by Juan Andrés Orellana,Eliseo A. Eugenin,Pablo José Sáez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cells as Targeted Drug Delivery Vehicles

Stem Cells as Targeted Drug Delivery Vehicles Book
Author : Rebecca Lim,Jessica E. Frith,Gina D. Kusuma,Christopher G. Sobey
Publisher : Frontiers Media SA
Release : 2021-02-03
ISBN : 2889664481
Language : En, Es, Fr & De

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Book Description :

Topic Editor RL is a patent inventor on exosome-related patents, PCT/AU2017/050821 and PCT/AU2016/050468. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

The Role of Metabolism in Stem Cell Fates

The Role of Metabolism in Stem Cell Fates Book
Author : Anthony Scimè,Mireille Khacho
Publisher : Frontiers Media SA
Release : 2022-01-21
ISBN : 2889741346
Language : En, Es, Fr & De

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Book Description :

Download The Role of Metabolism in Stem Cell Fates book written by Anthony Scimè,Mireille Khacho, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells Book
Author : Khalid Ahmed Al-Anazi
Publisher : BoD – Books on Demand
Release : 2020-04-22
ISBN : 1789238072
Language : En, Es, Fr & De

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Book Description :

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Engineering Neural Tissue from Stem Cells

Engineering Neural Tissue from Stem Cells Book
Author : Stephanie Willerth
Publisher : Academic Press
Release : 2017-07-05
ISBN : 0128113863
Language : En, Es, Fr & De

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Book Description :

Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications. Provides readers entering the field with a strong basis of neural tissue engineering processes and real-world applications Discusses the most current clinical trials and their importance of treating nervous system disorders Reviews the structure and immune response of the nervous system, including the brain, spinal cord and their present cells Offers a necessary overview of the natural and synthetic biomaterials used to engineer neural tissue

Lung Stem Cells in Development Health and Disease

Lung Stem Cells in Development  Health and Disease Book
Author : Nikolic, Marko Z.,Hogan, Brigid L.M.
Publisher : European Respiratory Society
Release : 2021-04-01
ISBN : 1849841349
Language : En, Es, Fr & De

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Book Description :

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Stem Cells

Stem Cells Book
Author : Khawaja H. Haider
Publisher : Springer Nature
Release : 2022-01-01
ISBN : 3030770524
Language : En, Es, Fr & De

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Book Description :

In this volume, the contributing authors from top labs involved in stem cell theranostics share the latest advances in the field of stem cell research. The book covers many aspects of stem cell-based therapy and the progress made toward stem cell therapy for liver, ocular, and cardiovascular diseases as well as cancer. This volume serves as a continuation of Prof. Khawaja Husnain Haider’s previously edited books pertaining to stem cells-based therapnostics. This is an ideal book for researchers involved in drug development as well as regenerative medicine and stem cell-based therapy. The secondary audience includes graduate and postgraduate medical students, doctors, cellular pharmacology, drug industry, and researchers involved in using stem cells as ex-vivo disease models for drug development.