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Mucosal Vaccines

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Mucosal Vaccines

Mucosal Vaccines Book
Author : Hiroshi Kiyono
Publisher : Elsevier
Release : 1996-10-23
ISBN : 9780080537054
Language : En, Es, Fr & De

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Book Description :

This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

Mucosal Vaccines

Mucosal Vaccines Book
Author : David W. Pascual
Publisher : Academic Press
Release : 2019-10-19
ISBN : 012811925X
Language : En, Es, Fr & De

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Book Description :

Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format. Provides the latest views on mucosal vaccines Applies basic and current principles in the field of mucosal immunology and related scientific fields (e.g., microbiology, infectious diseases, systems biology, medicine, dentistry, veterinary medicine and translational research) to the development of new vaccines Links basic, clinical and practical aspects of mucosal vaccines to different infectious diseases Presents user-friendly organization using attractive illustrations

Mucosal Vaccines

Mucosal Vaccines Book
Author : Pamela A. Kozlowski
Publisher : Springer Science & Business Media
Release : 2012-01-11
ISBN : 3642236936
Language : En, Es, Fr & De

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Book Description :

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Mucosal Health in Aquaculture

Mucosal Health in Aquaculture Book
Author : Benjamin H. Beck,Eric Peatman
Publisher : Academic Press
Release : 2015-02-17
ISBN : 0124171931
Language : En, Es, Fr & De

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Book Description :

Mucosal Health in Aquaculture is an essential reference on mucosal health for the diverse aquaculture community. Rich in explanatory figures and schematics, the book includes important concepts such as structural and cellular composition of mucosal surfaces in fish and shellfish, known functional roles of molecular and cellular actors during pathogen invasion, impacts of nutrition on the mucosal barriers, impacts of chemical treatments on mucosal surfaces, mucosal vaccines and vaccination strategies, and more. The health of cultured aquaculture species is critical in establishing the sustainable growth of the aquaculture industry worldwide, and mucosal health is of particular interest to those working in aquaculture because mucosal surfaces (skin, gill, intestine, reproductive tissues) constitute the first line of defense against pathogen invasion. Mucosal Health in Aquaculture captures the latest research on mucosal barriers in aquaculture species and their impacts on nutrition and immunity to ensure sustainable aquaculture development. Includes research case studies to exhibit the importance of various integrated approaches to mucosal health Examines the latest scientific methods and technologies to maximize efficiencies for healthy fish production for farming Brings together the latest knowledge and research on mucosal barriers and mechanisms from world-wide experts in mucosal health Utilizes detailed diagrams and figures to enhance comprehension

Mucosal Vaccination Strategies to Induce and Evaluate Mucosal Immunity

Mucosal Vaccination  Strategies to Induce and Evaluate Mucosal Immunity Book
Author : Andreas Frey,Pam Kozlowski,Nicholas J. Mantis
Publisher : Frontiers Media SA
Release : 2022-05-25
ISBN : 2889762165
Language : En, Es, Fr & De

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Book Description :

Download Mucosal Vaccination Strategies to Induce and Evaluate Mucosal Immunity book written by Andreas Frey,Pam Kozlowski,Nicholas J. Mantis, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanovaccines

Nanovaccines Book
Author : Sergio Rosales-Mendoza,Omar González-Ortega
Publisher : Springer Nature
Release : 2019-11-07
ISBN : 3030316688
Language : En, Es, Fr & De

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Book Description :

This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient ́s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development.

Principles of Mucosal Immunology

Principles of Mucosal Immunology Book
Author : Phillip D. Smith,Richard S. Blumberg,Thomas T. MacDonald,Society for Mucosal Immunology
Publisher : Garland Science
Release : 2020-04-21
ISBN : 1000754499
Language : En, Es, Fr & De

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Book Description :

This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.

Handbook of Mucosal Immunology

Handbook of Mucosal Immunology Book
Author : Anonim
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0323138527
Language : En, Es, Fr & De

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Book Description :

Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae. The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis. Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians.Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.

Mucosal Vaccines

Mucosal Vaccines Book
Author : Pamela A. Kozlowski
Publisher : Springer
Release : 2012-01-26
ISBN : 9783642236945
Language : En, Es, Fr & De

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Book Description :

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Mucosal Immunology

Mucosal Immunology Book
Author : Jiri Mestecky,Warren Strober,Michael W. Russell,Hilde Cheroutre,Bart N. Lambrecht,Brian L Kelsall
Publisher : Academic Press
Release : 2015-03-06
ISBN : 0124159753
Language : En, Es, Fr & De

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Book Description :

Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. The most comprehensive text on mucosal immunology from internationally recognized experts in the field Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases Contains nine new chapters and an expanded appendix

Canadian Immunization Guide

Canadian Immunization Guide Book
Author : Canada. National Advisory Committee on Immunization,Canada. Comité consultatif national de l'immunisation
Publisher : Unknown
Release : 2006
ISBN : 9780660193922
Language : En, Es, Fr & De

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Book Description :

The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization.

Veterinary Vaccines and Diagnostics

Veterinary Vaccines and Diagnostics Book
Author : Anonim
Publisher : Elsevier
Release : 1998-10-27
ISBN : 0080526837
Language : En, Es, Fr & De

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Book Description :

This volume of Advances in Veterinary Medicine, derived in part from the First Veterinary Vaccines and Diagnostic Conferences, deals with vaccines, an especially active area of veterinary research and controversy.

Gram Positive Bacteria

Gram Positive Bacteria Book
Author : Gianni Pozzi,Jeremy M. Wells
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3662075482
Language : En, Es, Fr & De

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Book Description :

This book gives a very timely account of recent - partly unpublished - research on the development of gram-positive bacteria as vaccine delivery vehicles for mucosal immunization. The practical and theoretical considerations are discussed and the basic concepts behind the different approaches are compared by giving specific examples of the use of different non-pathogenic bacteria as vaccine vehicles. Thus, a common framework of concepts for a new generation of mucosal vaccines is provided.

Vaccinology

Vaccinology Book
Author : W. John W. Morrow,Nadeem A. Sheikh,Clint S. Schmidt,D. Huw Davies
Publisher : John Wiley & Sons
Release : 2012-09-04
ISBN : 1405185740
Language : En, Es, Fr & De

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Book Description :

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Intracellular Bacterial Vaccine Vectors

Intracellular Bacterial Vaccine Vectors Book
Author : Yvonne Paterson
Publisher : Wiley-Liss
Release : 1999-05-26
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Host defense against infectious microorganisms is becoming an intensively studied topic; recent advances in immunology and microbiology have resulted in a substantially improved understanding of the pathways used by a variety of microorganisms to infect humans. This resource provides up-to-date reviews of the invasion strategies utilized by selected bacteria and then shows how these microorganisms can be manipulated to generate potential vaccines. The book begins with a comprehensive review of the relationship between bacterial life-styles and immune responsiveness to bacterial antigens. The book is divided into two parts: Part 1 describes basic research intended primarily for academic scientists. Included in this section are chapters describing the use of Listeria monocytogenes, Salmonella typhimurium and Bacillus Calmette-Guerin (BCG) to invoke different types of immune response. Part 2 describes the application of the engineered Listeria monocytogenes as a vaccine against specific tumors and the use of recombinant Salmonella and BCG in clinical trials for HIV and TB

Fish Vaccination

Fish Vaccination Book
Author : Roar Gudding,Atle Lillehaug,Oystein Evensen
Publisher : John Wiley & Sons
Release : 2014-05-05
ISBN : 0470674555
Language : En, Es, Fr & De

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Book Description :

Fish farming, in seawater and in freshwater, in cages, tanks or ponds, makes an ever-increasing and significant contribution to the production of aquatic food in many regions of the world. During the last few decades there has been significant progress and expansion in the aquaculture sector, characterized by intensified production and the exploitation of many new species. Aquaculture must be a sustainable bio-production, environmentally as well as economically. Disease prevention in order to reduce losses, and the use of antimicrobials is crucial in this perspective. Vaccination has, in a few years, become the most important method for disease prevention in aquaculture, and effective prophylaxis based on stimulation of the immune system of the fish is essential for further development of the industry. This book provides general information about disease prevention in fish by vaccination, as well as specific descriptions of the correct use of vaccines against the most important bacterial and viral infectious diseases of aquatic animals. The book is written by some of the world’s leading experts in the subject, drawn from many countries where aquaculture is a significant and expanding part of the economy. Fish Vaccination is an encyclopedia of fish vaccinology for every present and future aquaculturist. Professionals in the aquaculture sector, including fish veterinarians and fish biologists, within the industry, in scientific institutions and regulatory authorities will all find a huge wealth of commercially important knowledge within this book. Libraries in all universities where aquaculture, biological and veterinary sciences are studied and taught should have copies of this important book on their shelves.

Defense of Mucosal Surfaces Pathogenesis Immunity and Vaccines

Defense of Mucosal Surfaces  Pathogenesis  Immunity and Vaccines Book
Author : Jean-Pierre Kraehenbuhl,Marian R. Neutra
Publisher : Springer
Release : 2011-12-13
ISBN : 9783642641947
Language : En, Es, Fr & De

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Book Description :

Mucosal immunity encompasses a broad field of research that includes areas of epithelial cell and molecular biology, molecular and cellular immunology, microbiology, virology, and vaccinology. This volume presents up to date and concise discussions of concepts as well as recent advances. It provides an overview of the components of the mucosal immune system, and the basic science relevant to mucosal vaccination. The authors assess current research in critical areas including: Organization of mucosal lymphoid tissue; antigen sampling and presentation in mucosal tissues; mucosalimmune responses and tolerance; immune effectors at mucosal sites; microbial-host interactions at mucosal sites; mucosal vaccines and adjuvants. This multi-disciplinary effort will be a valuable resource for researchers, clinicians and students who need a clear understanding of concepts and a guide to the wide-ranging literature in this very active research area.

Laboratory Correlates of Immunity to Influenza

Laboratory Correlates of Immunity to Influenza Book
Author : Fred Brown
Publisher : S Karger Ag
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

For some 30 years it has been a rule of thumb that antibody to influenza haemagglutinin, induced by natural infection or vaccination, is a universal and useful marker of immunity to influenza. It now seems important to re-examine this hypothesis. Knowledge of the mechanisms of acquired influenza immunity and correlations with measurable laboratory parameters is clearly of importance in understanding influenza epidemiology and vaccine-induced immunity. While immunity is certainly multi-factorial, involving both B and T cell responses, any comprehensive assessment is complicated by the capacity of the virus to undergo extensive and frequent antigenic variation. The aim of this workshop was to review the methods available for assessing immune responses and their advantages and disadvantages; to present information on immune responses to the various vaccine types and attempt to draw possible conclusions on their value in assessing protective immunity; to address the question of standardization and validation of assays and the appropriate use of reference materials; to identify appropriate themes for international collaborative studies.

Periparturient Diseases of Dairy Cows

Periparturient Diseases of Dairy Cows Book
Author : Burim N. Ametaj
Publisher : Springer
Release : 2017-12-21
ISBN : 3319430335
Language : En, Es, Fr & De

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Book Description :

This book summarizes the results achieved so far by application of various biological systems (including genomics, transcriptomics, proteomics, and metabolomics) involved in the pathomechanisms and early diagnosis of periparturient diseases as specific biomarkers of disease in cattle. These emerging technologies help to extensively enhance our understanding of the etiology and pathogenesis of periparturient diseases of transition dairy cows. The book includes a chapter dedicated to ‘omics’ sciences and one that discusses the myths established in animal and veterinary sciences in recent decades and emerging, new paradigms. The diseases discussed include metritis, mastitis, laminitis, ketosis, rumen acidosis, periparturient immunosuppression, gastrointestinal microbiota and their involvement in disease, infertility, fatty liver, milk fever, and retained placenta. This book is intended for academics, veterinarians, animal nutritionists, researchers, and graduate students working in the field of ‘omics sciences’ with a special interest in dairy cattle health.

Vaccines for the 21st Century

Vaccines for the 21st Century Book
Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development
Publisher : National Academies Press
Release : 2001-02-21
ISBN : 9780309174985
Language : En, Es, Fr & De

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Book Description :

Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.