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Mouse Brain Development

Mouse Brain Development Book
Author : Andre M. Goffinet,Pasko Rakic
Publisher : Springer Science & Business Media
Release : 2012-08-10
ISBN : 3540480021
Language : En, Es, Fr & De

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Book Description :

Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

The Role of Glypican 4 During Mouse Brain Development

The Role of Glypican 4 During Mouse Brain Development Book
Author : Stefan Johann Andreas Weiß
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role of Glypican 4 During Mouse Brain Development book written by Stefan Johann Andreas Weiß, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Prenatal Mouse Brain Atlas

Prenatal Mouse Brain Atlas Book
Author : Uta Schambra
Publisher : Springer Science & Business Media
Release : 2008-05-07
ISBN : 038747093X
Language : En, Es, Fr & De

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Book Description :

This is the only book available for studies of the mouse brain before birth. It presents a complete mapping of the developing mouse brain that features imaging of whole brain sections. Users will be able to compare structure shown in the Atlas to what they see in the microscope. This new, greatly expanded edition provides an easily accessible tool for researchers in the fields of normal and abnormal brain development.

Effects of Essential Fatty Acid Deficiency on Mouse Brain Development

Effects of Essential Fatty Acid Deficiency on Mouse Brain Development Book
Author : Judy Hannah
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Effects of Essential Fatty Acid Deficiency on Mouse Brain Development book written by Judy Hannah, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Regulation of Endothelin 1 During Mouse Brain Development and Perinatal Cerebral Ischemia

The Regulation of Endothelin 1 During Mouse Brain Development and Perinatal Cerebral Ischemia Book
Author : 曾昭雪,Chiu-Suet Margaret Tsang
Publisher : Open Dissertation Press
Release : 2017-01-27
ISBN : 9781374745117
Language : En, Es, Fr & De

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Book Description :

This dissertation, "The Regulation of Endothelin-1 During Mouse Brain Development and Perinatal Cerebral Ischemia" by 曾昭雪, Chiu-suet, Margaret, Tsang, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3122174 Subjects: Endothelins Neurophysiology

Effect of Insults Associated with Preterm Birth on Mouse Brain Development

Effect of Insults Associated with Preterm Birth on Mouse Brain Development Book
Author : Eamon Fitzgerald
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Effect of Insults Associated with Preterm Birth on Mouse Brain Development book written by Eamon Fitzgerald, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Reeler Mouse as a Model of Brain Development

The Reeler Mouse as a Model of Brain Development Book
Author : Catherine Lambert de Rouvroit,Andre M. Goffinet
Publisher : Springer Science & Business Media
Release : 2013-03-12
ISBN : 3642722571
Language : En, Es, Fr & De

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Book Description :

Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.

The Regulation of Endothelin 1 During Mouse Brain Development and Perinatal Cerebral Ischemia

The Regulation of Endothelin 1 During Mouse Brain Development and Perinatal Cerebral Ischemia Book
Author : Chiu-suet Tsang (Margaret),University of Hong Kong
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Regulation of Endothelin 1 During Mouse Brain Development and Perinatal Cerebral Ischemia book written by Chiu-suet Tsang (Margaret),University of Hong Kong, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemoarchitectonic Atlas of the Developing Mouse Brain

Chemoarchitectonic Atlas of the Developing Mouse Brain Book
Author : David M. Jacobowitz,Louise C. Abbott
Publisher : CRC Press
Release : 1997-12-29
ISBN : 1466593415
Language : En, Es, Fr & De

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Book Description :

Representing the state-of-the-art in neurochemical mapping, Chemoarchitectonic Atlas of the Developing Mouse Brain provides a complete, full-color look at the developing mouse brain. Hundreds of coronal sections are presented, clearly illustrating structures at progressive stages of brain development.

The Mouse Nervous System

The Mouse Nervous System Book
Author : Charles Watson
Publisher : Academic Press
Release : 2012
ISBN : 0123694973
Language : En, Es, Fr & De

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Book Description :

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlasesA detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness

Mapping Astrocyte Development in the Dorsal Cortex of the Mouse Brain

Mapping Astrocyte Development in the Dorsal Cortex of the Mouse Brain Book
Author : Maria Civita Smith
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Astrocytes are the most abundant cell in the mammalian central nervous system (CNS) where they play essential roles in brain development and neuronal function. It is generally accepted that astrocytes first appear in the developing brain after most neurons have already been generated. The prevailing understanding is that cortical astrocytes are largely generated from two sources: 1) bipotential radial glia (RG) that first produce projection neurons and 2) progenitor cells in the postnatal subventricular zone (SVZ). When astrocytes first begin to differentiate and colonize the developing cerebral cortex and whether bipotential embryonic RG and postnatal SVZ progenitors belong to a single astrocyte lineage or represent two distinct populations remain to be determined. Our lab has previously described a subset of primitive neuroepithelial-like cells in the human central nervous system (CNS) express the beta-IV isoform of tubulin (BT4). Here, the development of these cells is followed, both in vivo and in vitro, by crossing BT4-Cre transgenic mice with Cre-dependent ROSA reporter mouse lines. These studies mainly focus on BT4-Cre/ROSA (mT/mG) bigenic mice, though observations, technical considerations and overall interpretations using other ROSA reporters are addressed and discussed in Chapters 2, 3 and 5. In BT4-Cre/ROSA (mT/mG) mice, EGFP+ NE cells appear as early as embryonic day (E) 7.5. BT4-Cre/EGFP+ NE cells become RG that do not appear to generate EGFP-positive neuronal progenitors or neurons. During neurogenesis (E14.5), BT4-Cre/EGFP RG divide asymmetrically in the SVZ to generate EGFP-positive APCs that migrate into the developing cortex and multiply by symmetrical division. BT4-Cre/EGFP APCs continue to colonize the developing cortex through the second postnatal week. In addition to astrocytes in the gray and white matter of the brain and spinal cord, BT4-Cre/EGFP cells generate and/or become astrocytes in the olfactory bulb, Bergmann glia in the cerebellum and Muller cells in the retina. Through use of an inducible BT4-Cre construct (BT4-CreERT2), it was unequivocally established that this (BT4-Cre/CreERT2-derived) astrocyte lineage originates during a restricted developmental window, between E6.5 and E8.5; it cannot be induced at later embryonic ages or any postnatal timepoint. These studies identify a subpopulation of primitive neural plate cells that generate astrocytes through RG and APC intermediates. These intermediate cells first appear during embryonic neurogenesis. In contrast to the prevalent view that astrocytes are generated after neurogenesis these findings show that a prominent population of cortical astrocytes is derived from a lineage that appears at the earliest stages of brain development. Our studies also demonstrate that APCs first appear in the embryonic neocortex around the mid-point (E14.5) of neocortical neurogenesis. Importantly, these studies also demonstrate that BT4-Cre/EGFP RG and APCs have electrophysiological properties that are consistent with both progenitor cell and astrocyte identities, including presence of potassium currents. Further, environment appears to be a major component in the fate of embryonic BT4-Cre/EGFP cells, as they easily differentiate into cells with molecular and morphological properties of neurons in vitro, but appear distinct from neurons and neuronal progenitors during cortical development, in vivo.

Atlas of the Developing Mouse Brain

Atlas of the Developing Mouse Brain Book
Author : George Paxinos,Glenda Halliday,Charles Watson,Mustafa S Kassem
Publisher : Academic Press
Release : 2020-05
ISBN : 9780128185438
Language : En, Es, Fr & De

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Book Description :

The second edition of Atlas of the Developing Mouse Brain at E17.5, P0, and P6 builds on the features of the successful first edition. The second edition is a comprehensive and convenient reference for all the areas of the mouse brain at Fetal-Day 17.5 (E17.5), Day-of-Birth (P0), and Day-Six postnatal (P6). It also delineates the parts of the eye, features of the skull, ganglia, nerves, arteries, veins, bones and foramina. This atlas is an essential tool for researchers and students who study the development of the mouse brain, or who interpret the findings from genetic manipulation.

Grundlagen Der Massage Und Physikalischen Therapie

Grundlagen Der Massage Und Physikalischen Therapie Book
Author : Michael Fritzsche
Publisher : Unknown
Release : 1992-04-01
ISBN : 9780387523019
Language : En, Es, Fr & De

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Book Description :

Download Grundlagen Der Massage Und Physikalischen Therapie book written by Michael Fritzsche, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Brain Development in the Trisomy 19 Mouse

Brain Development in the Trisomy 19 Mouse Book
Author : Gregory Dean Mieden
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Brain Development in the Trisomy 19 Mouse book written by Gregory Dean Mieden, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lysine Acetyltransferase and Deacetylase in Normal and Abnormal Brain Development

Lysine Acetyltransferase and Deacetylase in Normal and Abnormal Brain Development Book
Author : Lin Li
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Lysine acetyltransferases and deacetylases are not only important for regulating cellular programs (such as cell proliferation, differentiation and gene transcription), but also involved in developmental control and different diseases. As the most complex organ in mammals, the brain is controlled by intracellular and extracellular signaling pathways to maintain its developmental homeostasis. In these pathways, lysine acetylation plays an essential role. To understand the functions of this modification during brain development, I have investigated the roles of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 3 (HDAC3) during mouse brain development. Moreover, we have identified four clinical cases with heterozygous de novo HDAC3 mutations associated with a novel neurodevelopmental disorder and determined the pathogenicity, establishing the first link of this enzyme to a genetic disease.ATAT1 is an [alpha]-tubulin acetyltransferase responsible for acetylation of lysine 40 of [alpha]-tubulin on microtubules. Identified in the 1980s, the acetylation is conserved from protists to humans and the only posttranslational modification in the lumen of microtubules. Although it has been implied in regulating microtubule assembly and motor-based transport in vitro, the real biological function of this modification remains controversial. The function in vivo was largely unknown until ATAT1 was identified a few years ago. We examined the role of tubulin acetylation in mouse development using a mouse strain carrying an inactivated Atat1 gene (Chapter II). We show that loss of Atat1 does not affect mouse survival but leads to hypoplasia of the striatum and septum in the brain. However, development of many other tissues such as the hematopoietic system is normal. While proliferation, differentiation, apoptosis and autophagy are not affected in the mutant brain, our data suggest that the hypoplasia in the striatum and septum is due to defective neuronal migration. Further behavioral tests indicate that mice lacking ATAT1 display a mild motor coordination deficit.HDAC3 is a class I deacetylase that forms tetrameric complexes containing two small subunits and the nuclear receptor co-repressor NCoR or SMRT, either of which is essential for embryonic brain development. Although some evidence indicates that HDAC3 is important in the adult mouse brain, its roles in the embryonic mouse brain and the human brain are entirely unclear. To investigate this, we have adopted two strategies. In the first one, we engineered and analyzed a mouse model with Hdac3 specifically deleted in the cerebrum (Chapter III). In the second strategy, we identified and analyzed HDAC3 germline mutations in human patients (Chapter IV). In Chapter III, we show that mouse Hdac3 inactivation affects embryonic development of the neocortex and hippocampus and induces anxiety and hyperactivity in the resulting pups. We found that the defects are due to abnormal development of neural stem and progenitor cells. Moreover, inhibition of HDAC3 activity by a selective small-molecule inhibitor in cell-based assays in vitro confirmed that the enzymatic activity is essential for neural stem cell development. Using transcriptomic analysis of neurospheres originated from Hdac3-deficient cerebral cortices and neural stem cells, we observed altered expression of multiple genes, including increased transcription of neurogenesis-promoting genes (such as Dlx family genes) and decreased mRNA levels of neurogenesis-inhibiting genes (such as Id and Hes family genes). By transcriptomic analysis and co-immunoprecipitation, we demonstrated that multiple transcription factors, such as NFIB, COUP-TFI, RP58 and SOX4, are highly expressed in the cerebrum and interact with HDAC3. In Chapter IV, we present data on HDAC3 mutations identified in 4 patients with a new neurodevelopmental disorder." --

Atlas of the Prenatal Mouse Brain

Atlas of the Prenatal Mouse Brain Book
Author : Uta B. Schambra,Jerry Silver
Publisher : Academic Press
Release : 2016-04-19
ISBN : 1483289087
Language : En, Es, Fr & De

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Book Description :

The Atlas of the Prenatal Mouse Brain is the latest addition to Academic Press' list of atlases for neuroscientists and neuroscience students. It fills an urgent need for a comprehensive atlas of the developing mouse brain for use in studies of both normal and abnormal development. High-quality photomicrographs of brain sections are depicted in sagittal, coronal, and horizontal planes for four gestational age groups. Each photomicrograph is accompanied by a fully labeled, precision-drawn diagram for easy identification of brain structures. Researchers and students using normal, transgenic, or mutant mouse preparations in developmental neurobiology, neurotoxicology, and biotechnology will welcome this meticulously assembled and accessible guide. Presents 153 photomicrographs of serial brain sections Represents four gestational ages (GD 12 and 14 embryos; GD 16 and 18 fetuses), each depicted in sigittal, coronal, and horizontal planes Includes fully labeled diagrams identifying brain structures for each photomicrograph Provides complete alphabetical lists of brain structures and abbreviations Presents a full description of tissue preparation method Large format, 8-1/2 x 11" pages in a sturdy hardcover case

The Reeler Mouse As a Model of Brain Development

The Reeler Mouse As a Model of Brain Development Book
Author : Catherine Lambert De Rouvroit,Andre M Goffinet
Publisher : Unknown
Release : 1998-09-28
ISBN : 9783642722585
Language : En, Es, Fr & De

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Book Description :

Download The Reeler Mouse As a Model of Brain Development book written by Catherine Lambert De Rouvroit,Andre M Goffinet, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nitric Oxide in Brain Development Plasticity and Disease

Nitric Oxide in Brain Development  Plasticity  and Disease Book
Author : R. Ranney Mize
Publisher : Elsevier Science Limited
Release : 1998
ISBN : 9780444828859
Language : En, Es, Fr & De

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Book Description :

Nitric oxide, "Molecule of the Year" in 1995, continues to be one of the most widely studied molecules in brain research. This excellent volume elucidates the implications of this gas in a variety of brain processes. The volume is divided into five sections, describing: the mechanisms underlying the release and action of Nitric Oxide in the CNS, and the distribution of Nitric Oxide in the brain using various techniques; how Nitric Oxide interacts with and regulates the N-methyl-D-aspartate receptor; the role of Nitric Oxide in pathway refinement and synapse stabilization in the developing CNS; the role of Nitric Oxide in adult brain plasticity including long-term potentiation and depression; and the role of Nitric Oxide in brain injury such as occurs during ischemia and other events produced by glutamate neurotoxicity, and in neuroprotective mechanisms that promote neuron survival. Nitric Oxide in Brain Development, Plasticity, and Disease is the first Progress in Brain Research volume to be published in abstracted form on the World Wide Web. It includes title pages, abstracts, selected figures, and complete references. It also includes a digital brain atlas for readers to view a mouse brain in a three-dimensional full-color rendition, and much more.

Neuroanatomy of Human Brain Development

Neuroanatomy of Human Brain Development Book
Author : Hao Huang,Julia P. Owen,Pratik Mukherjee
Publisher : Frontiers Media SA
Release : 2017-03-07
ISBN : 2889451208
Language : En, Es, Fr & De

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Book Description :

The human brain is extraordinary complex and yet its origin is a simple tubular structure. Rapid and dramatic structural growth takes place during the fetal and perinatal period. By the time of birth, a repertoire of major cortical, subcortical and white matter structures resembling the adult pattern has emerged, however there are continued maturational changes of the gray matter and white matter throughout childhood and adolescence and into adulthood. The maturation of neuronal structures provides the neuroanatomical basis for the acquisition and refinement of cognitive functions during postnatal development. Histological imaging has been traditionally dominant in understanding neuroanatomy of early brain development and still plays an unparalleled role in this field. Modern magnetic resonance imaging (MRI) techniques including diffusion MRI, as noninvasive tools readily applied to in vivo brains, have become an important complementary approach in revealing the detailed brain anatomy, including the structural connectivity between brain regions. In this research topic, we presented the most recent investigations on understanding the neuroanatomy and connectivity of human brain development using both histology and MRI. Modern advances in mapping normal developmental brain anatomy and connectivity should elucidate many neurodevelopmental disorders, ranging from rare congenital malformations to common disorders such as autism and attention deficit hyperactivity disorder (ADHD), which is a prerequisite for better diagnosis and treatment of these currently poorly understood diseases.