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Mouse Behavioral Testing

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Mouse Behavioral Testing

Mouse Behavioral Testing Book
Author : Douglas Wahlsten
Publisher : Academic Press
Release : 2010-11-25
ISBN : 9780123756756
Language : En, Es, Fr & De

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Book Description :

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

What s Wrong With My Mouse

What s Wrong With My Mouse  Book
Author : Jacqueline N. Crawley
Publisher : John Wiley & Sons
Release : 2007-05-11
ISBN : 0470119047
Language : En, Es, Fr & De

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Book Description :

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

The Mouse in Biomedical Research

The Mouse in Biomedical Research Book
Author : Anonim
Publisher : Elsevier
Release : 2006-12-15
ISBN : 9780080469072
Language : En, Es, Fr & De

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Book Description :

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

An Introduction to Textile Printing

An Introduction to Textile Printing Book
Author : Jacqueline N. Crawley, PhD
Publisher : Wiley-Liss
Release : 2010-03-08
ISBN : 9780470653432
Language : En, Es, Fr & De

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Book Description :

Learn how to conduct behavioral tests to phenotype mutant mice Dr. Jacqueline N. Crawley, author of the first and second editions of "What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice," continues to field hundreds of calls and e-mails from molecular geneticists who ask just that: How do I run behavioral assays to find out what's wrong with my mouse? This book answers that question and many more, including what tests are available to discover an aberrant behavioral phenotype? Turn to "What's Wrong With My Mouse?" to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the second edition up to date with the latest science. In addition, the second edition includes two new chapters: Neurodevelopment and Neurodegeneration discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Putting It All Together recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, The Next Generation, examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor Web sites, suggestions for expert behavioral neuroscientist collaborators, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Behavioral Testing of the Trap shy Trap prone Phenomena in Peromyscus Leucopus Noveborancensis white footed Deer Mouse

Behavioral Testing of the Trap shy  Trap prone Phenomena in Peromyscus Leucopus Noveborancensis  white footed Deer Mouse  Book
Author : Barry J. Beaty
Publisher : Unknown
Release : 1972
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Behavioral Testing of the Trap shy Trap prone Phenomena in Peromyscus Leucopus Noveborancensis white footed Deer Mouse book written by Barry J. Beaty, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Behavioral Genetics of the Mouse

Behavioral Genetics of the Mouse Book
Author : Susanna Pietropaolo,Frans Sluyter,Wim E. Crusio
Publisher : Cambridge University Press
Release : 2014-09-25
ISBN : 1107044456
Language : En, Es, Fr & De

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Book Description :

A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.

Behavioral Genetics of the Mouse Volume 2 Genetic Mouse Models of Neurobehavioral Disorders

Behavioral Genetics of the Mouse  Volume 2  Genetic Mouse Models of Neurobehavioral Disorders Book
Author : Susanna Pietropaolo,Frans Sluyter,Wim E. Crusio
Publisher : Cambridge University Press
Release : 2014-09-25
ISBN : 131606140X
Language : En, Es, Fr & De

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Book Description :

The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders; from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Standards of Mouse Model Phenotyping

Standards of Mouse Model Phenotyping Book
Author : Martin Hrabé de Angelis,Pierre Chambon,Steve Brown
Publisher : John Wiley & Sons
Release : 2009-09-03
ISBN : 3527608702
Language : En, Es, Fr & De

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Book Description :

This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.

Model Behavior

Model Behavior Book
Author : Nicole C. Nelson
Publisher : University of Chicago Press
Release : 2018-04-04
ISBN : 022654611X
Language : En, Es, Fr & De

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Book Description :

Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.

Molecular Biology of Neurodegenerative Diseases Visions for the Future Part B

Molecular Biology of Neurodegenerative Diseases  Visions for the Future   Part B Book
Author : Anonim
Publisher : Academic Press
Release : 2021-01-14
ISBN : 0128241446
Language : En, Es, Fr & De

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Book Description :

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Frontiers in Behavioral Neuroscience Editor s Pick 2021

Frontiers in Behavioral Neuroscience   Editor   s Pick 2021 Book
Author : Nuno Sousa
Publisher : Frontiers Media SA
Release : 2021-07-21
ISBN : 2889710564
Language : En, Es, Fr & De

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Book Description :

Download Frontiers in Behavioral Neuroscience Editor s Pick 2021 book written by Nuno Sousa, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Extramural Research and Training Program

Extramural Research and Training Program Book
Author : National Institute on Aging
Publisher : Unknown
Release : 1974
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Extramural Research and Training Program book written by National Institute on Aging, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Extramural Research and Training Program Grant and Contract Summaries

Extramural Research and Training Program  Grant and Contract Summaries Book
Author : National Institute on Aging
Publisher : Unknown
Release : 1974
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Extramural Research and Training Program Grant and Contract Summaries book written by National Institute on Aging, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurotoxicology Third Edition

Neurotoxicology  Third Edition Book
Author : G. Jean Harry,Hugh A. Tilson
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420054880
Language : En, Es, Fr & De

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Book Description :

This new edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.

Animal Models for Human Cancer Volume 69

Animal Models for Human Cancer  Volume 69 Book
Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Publisher : John Wiley & Sons
Release : 2016-08-15
ISBN : 3527339973
Language : En, Es, Fr & De

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Book Description :

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2020-04-03
ISBN : 012817529X
Language : En, Es, Fr & De

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Book Description :

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment Book
Author : Edward D. Levin,Jerry J. Buccafusco
Publisher : CRC Press
Release : 2006-06-22
ISBN : 1420004336
Language : En, Es, Fr & De

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Book Description :

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

Handbook of Developmental Neurotoxicology

Handbook of Developmental Neurotoxicology Book
Author : William Slikker, Jr.,Merle G. Paule,Cheng Wang
Publisher : Academic Press
Release : 2018-01-04
ISBN : 0128093943
Language : En, Es, Fr & De

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Book Description :

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Handbook of Molecular Genetic Techniques for Brain and Behavior Research

Handbook of Molecular Genetic Techniques for Brain and Behavior Research Book
Author : Wim E. Crusio,R.T. Gerlai
Publisher : Elsevier
Release : 1999-10-18
ISBN : 9780080536866
Language : En, Es, Fr & De

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Book Description :

The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.