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Mouse Behavioral Testing

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Mouse Behavioral Testing

Mouse Behavioral Testing Book
Author : Douglas Wahlsten
Publisher : Academic Press
Release : 2010-11-25
ISBN : 9780123756756
Language : En, Es, Fr & De

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Book Description :

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

Methods of Behavior Analysis in Neuroscience

Methods of Behavior Analysis in Neuroscience Book
Author : Jerry J. Buccafusco
Publisher : CRC Press
Release : 2000-08-29
ISBN : 1420041819
Language : En, Es, Fr & De

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Book Description :

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Mouse Behavioral Testing

Mouse Behavioral Testing Book
Author : D. Wahlsten
Publisher : Academic Press
Release : 2011
ISBN : 9780123756749
Language : En, Es, Fr & De

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Book Description :

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully A companion website will provide access to statistical utilities in Excel and test protocols, examples of real documents used for published studies, and video clips of the mice behaviors resulting from various tests

Mood and Anxiety Related Phenotypes in Mice

Mood and Anxiety Related Phenotypes in Mice Book
Author : Todd D Gould
Publisher : Humana Press
Release : 2011-09-02
ISBN : 9781617793127
Language : En, Es, Fr & De

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Book Description :

Preclinical research related to mood and anxiety disorders relies extensively upon mouse behavioral tests and models, the use of which continues to increase as a greater number of underlying susceptibility genes are discovered, new targets for medications are identified, and clinical studies reveal novel neurobiological risk factors. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II serves as a complement to the previous volume in order to offer a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications. As a collection presented in the Neuromethods series, each chapter provides a brief background and review of the test or model as well as a complete and up-to-date protocol narrative. Authoritative and comprehensive, Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II is an ideal resource for scientists actively pursuing or interested in establishing vital behavioral protocols in their laboratories.

Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment Book
Author : Edward D. Levin,Jerry J. Buccafusco
Publisher : CRC Press
Release : 2006-06-22
ISBN : 1420004336
Language : En, Es, Fr & De

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Book Description :

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

What s Wrong With My Mouse

What s Wrong With My Mouse  Book
Author : Jacqueline N. Crawley
Publisher : John Wiley & Sons
Release : 2007-05-11
ISBN : 0470119047
Language : En, Es, Fr & De

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Book Description :

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Book
Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publisher : National Academies Press
Release : 2003-08-22
ISBN : 9780309167857
Language : En, Es, Fr & De

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Book Description :

Expanding on the National Research Council’s Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal’s well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Rodent Models of Stroke

Rodent Models of Stroke Book
Author : Ulrich Dirnagl
Publisher : Humana Press
Release : 2010-07-08
ISBN : 9781607617495
Language : En, Es, Fr & De

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Book Description :

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes

Behavioral Genetics of the Mouse  Volume 1  Genetics of Behavioral Phenotypes Book
Author : Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo
Publisher : Cambridge University Press
Release : 2013-04-25
ISBN : 1107355575
Language : En, Es, Fr & De

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Book Description :

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Animal Models in Psychopharmacology

Animal Models in Psychopharmacology Book
Author : Olivier,Slangen,Mos
Publisher : Birkhäuser
Release : 2013-11-21
ISBN : 3034864191
Language : En, Es, Fr & De

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Book Description :

Download Animal Models in Psychopharmacology book written by Olivier,Slangen,Mos, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research Book
Author : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
Publisher : National Academies Press
Release : 1988-02-01
ISBN : 0309038391
Language : En, Es, Fr & De

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Book Description :

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Animal Models of Neurological Disorders

Animal Models of Neurological Disorders Book
Author : Puneet Kumar Bansal,Rahul Deshmukh
Publisher : Springer
Release : 2018-01-17
ISBN : 9811059810
Language : En, Es, Fr & De

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Book Description :

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Pre Clinical Models

Pre Clinical Models Book
Author : Paul C. Guest
Publisher : Humana Press
Release : 2019-02-04
ISBN : 9781493989935
Language : En, Es, Fr & De

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Book Description :

This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models in a number of medical areas, including metabolic disorders, longevity, cancer, heart disease and psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context of specific disease or therapeutic areas.

Pituitary Adenylate Cyclase Activating Polypeptide

Pituitary Adenylate Cyclase Activating Polypeptide Book
Author : Hubert Vaudry,Akira Arimura
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461502438
Language : En, Es, Fr & De

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Book Description :

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Recognition and Alleviation of Distress in Laboratory Animals

Recognition and Alleviation of Distress in Laboratory Animals Book
Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Distress in Laboratory Animals
Publisher : National Academies Press
Release : 2008-04-10
ISBN : 0309108179
Language : En, Es, Fr & De

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Book Description :

Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.

The Behavior of the Laboratory Rat

The Behavior of the Laboratory Rat Book
Author : Ian Q. Whishaw,Bryan Kolb,Both Professors of Psychology and Neuroscience at Canadian Center for Behavioral Neuroscience Bryan Kolb
Publisher : Oxford University Press
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This text provides a practical overview of all rat behaviour as it has been studied in laboratory conditions. It includes sections on natural history, sensory systems, motor systems, regulatory systems, development and parental behaviour, social behaviour, cognitive functions and models.

Animal Models of Behavioral Analysis

Animal Models of Behavioral Analysis Book
Author : Jacob Raber
Publisher : Humana Press
Release : 2010-10-11
ISBN : 9781607618829
Language : En, Es, Fr & De

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Book Description :

Despite the difficulty in comparing clinic-based human tests with animal model testing, there is still great value in pursuing translational approaches, as tests and treatment strategies might be developed to improve brain function in humans suffering from neurological conditions and knowledge obtained from human behavioral studies can be used to further improve the animal models of behavioral analysis. In Animal Models of Behavioral Analysis, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with those used in humans not only to increase our understanding of brain function across species but also to provide objective performance measures and bridge the gap between behavioral alterations in humans with cognitive disorders and the correlating animal models of these conditions. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. Provocative and cutting-edge, Animal Models of Behavioral Analysis seeks to aid researchers in further developing these vital techniques in an effort to advance studies in both the clinic and the laboratory.

Behavioral Genetics of the Mouse

Behavioral Genetics of the Mouse Book
Author : Wim E. Crusio,Frans Sluyter,Susanna Pietropaolo,R. T. Gerlai
Publisher : Cambridge University Press
Release : 2014-09-25
ISBN : 1107044456
Language : En, Es, Fr & De

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Book Description :

A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.

Motor Activity and Movement Disorders

Motor Activity and Movement Disorders Book
Author : Paul Sanberg,Klaus-Peter Ossenkopp,Martin Kavaliers
Publisher : Springer Science & Business Media
Release : 1995-11-06
ISBN : 1592594697
Language : En, Es, Fr & De

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Book Description :

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders. The contributors emphasize motor asymmetries, turning behavior, and dyskinetic movements. They also present a variety of quantitative approaches designed to assess specific aspects of motor activity and illustrate numerous computerized measuring techniques that permit detailed and objective approaches to quantifying motor behavior. Motor Activity and Movement Disorders will contribute to a greater understanding of brain-behavior relationships through its focus on methodology and its application to current animal models and to human disorders.

A Study of the Rat s Behavior in a Field

A Study of the Rat s Behavior in a Field Book
Author : Calvin Springer Hall,Egerton L. Ballachey
Publisher : Unknown
Release : 1932
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Study of the Rat s Behavior in a Field book written by Calvin Springer Hall,Egerton L. Ballachey, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.