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Molecules to Medicine with MTOR

Molecules to Medicine with MTOR Book
Author : Department of Neurology School of Medicine Kenneth Maiese,Kenneth Maiese
Publisher : Academic Press
Release : 2016-05-15
ISBN : 9780128027332
Language : En, Es, Fr & De

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Book Description :

Download Molecules to Medicine with MTOR book written by Department of Neurology School of Medicine Kenneth Maiese,Kenneth Maiese, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecules to Medicine with mTOR

Molecules to Medicine with mTOR Book
Author : Kenneth Maiese
Publisher : Academic Press
Release : 2016-02-21
ISBN : 012802755X
Language : En, Es, Fr & De

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Book Description :

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

mTOR Inhibition for Cancer Therapy Past Present and Future

mTOR Inhibition for Cancer Therapy  Past  Present and Future Book
Author : Monica Mita,Alain Mita,Eric K. Rowinsky
Publisher : Springer
Release : 2015-11-18
ISBN : 2817804929
Language : En, Es, Fr & De

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Book Description :

This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease  Treating Neurodegenerative Diseases as Metabolic Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-01
ISBN : 012823122X
Language : En, Es, Fr & De

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Book Description :

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

Resveratrol

Resveratrol Book
Author : Farid A. Badria
Publisher : BoD – Books on Demand
Release : 2019-02-06
ISBN : 1789849942
Language : En, Es, Fr & De

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Book Description :

This book intends to strike a balance between developments in research and the fact that researchers must absorb and link to scientific advances with clinical practice so that the management of diseases can be based on sound physiological concepts. This book addresses several controversial issues regarding a natural molecule with fascinating pharmacological and therapeutic effects. The book contains three sections: Section 1: Pharmacology and Therapeutic Applications of Resveratrol; Section 2: Bioavailability, Metabolism, and Mode of Action of Resveratrol; Section 3: Resveratrol and Its Role in Chronic and Degenerative Diseases. Does it Add Life to Years or Years to Life? It is our hope that this book will motivate readers to approach the evidence on the use resveratrol and thereby spark an interest in making further contributions to the current scientific debate and treatment development efforts.

Autophagy and Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases Book
Author : Jun Ren,James R. Sowers,Yingmei Zhang
Publisher : Academic Press
Release : 2018-04-12
ISBN : 0128054425
Language : En, Es, Fr & De

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Book Description :

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Molecules and Medicine

Molecules and Medicine Book
Author : E. J. Corey,Barbara Czakó,László Kürti
Publisher : John Wiley & Sons
Release : 2012-02-28
ISBN : 1118361733
Language : En, Es, Fr & De

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Book Description :

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Translating Molecules into Medicines

Translating Molecules into Medicines Book
Author : Shobha N. Bhattachar,John S. Morrison,Daniel R. Mudra,David M. Bender
Publisher : Springer
Release : 2017-04-21
ISBN : 3319500422
Language : En, Es, Fr & De

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Book Description :

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease Book
Author : Kenneth Maiese
Publisher : Elsevier
Release : 2021-02-20
ISBN : 0128224843
Language : En, Es, Fr & De

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Book Description :

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Issues in Cardiovascular Medicine 2011 Edition

Issues in Cardiovascular Medicine  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464964157
Language : En, Es, Fr & De

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Book Description :

Issues in Cardiovascular Medicine / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cardiovascular Medicine. The editors have built Issues in Cardiovascular Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cardiovascular Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Small Molecules in Oncology

Small Molecules in Oncology Book
Author : Uwe M. Martens
Publisher : Springer Science & Business
Release : 2014-04-22
ISBN : 3642544908
Language : En, Es, Fr & De

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Book Description :

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Developmental Epilepsy From Clinical Medicine To Neurobiological Mechanisms

Developmental Epilepsy  From Clinical Medicine To Neurobiological Mechanisms Book
Author : Stafstrom Carl E,Velisek Libor
Publisher : World Scientific
Release : 2019-06-24
ISBN : 9813277742
Language : En, Es, Fr & De

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Book Description :

This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well understood. This lag in research is reflected in the challenges of treating developmental epilepsy. The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy.The book is introduced by a chapter on brain development to provide a background for understanding when and how seizures and epilepsy can emerge. Recent clinical research indicates strong relationship between childhood epilepsy and developmental cognitive impairment. This connection can be studied in experimental animals and can uncover developmental mechanisms common to both conditions. Targeting those mechanisms might reveal disease-modifying treatments. Febrile seizures are very common in the pediatric population and their impact on further epilepsy development is explored. The link between immunity, inflammation and epileptogenesis in the developing brain is explored. Many developmental epilepsies arise from brain malformations or neuronal migration deficits; some juvenile epilepsies have a clear genetic basis while the etiology of others is less certain. Recently, the involvement of the mTOR pathway in certain childhood epilepsy syndromes was recognized, prompting the repurposing of drugs used in cancer treatment for therapy of these specific epilepsy syndromes. Steroid hormones have significant hormonal effects on neurotransmitter receptors and function, and therefore have an impact on childhood epilepsy; sex steroids may have long term organizational effects on brain structure and epilepsy development. Stress, even early in development, may affect the developing brain and lead to behavioral changes as well as increased susceptibility to seizures.

Current Challenges in Personalized Cancer Medicine

Current Challenges in Personalized Cancer Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123984831
Language : En, Es, Fr & De

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Book Description :

For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy

The Potential Effect and Mechanism of Chinese Traditional Medicine on Vascular Homeostasis and Remodeling

The Potential Effect and Mechanism of Chinese Traditional Medicine on Vascular Homeostasis and Remodeling Book
Author : Yuliang Wang,Zhang Yuefan,Tie-Jun Li,Ismail Laher,Hongbin Wang
Publisher : Frontiers Media SA
Release : 2021-02-02
ISBN : 288966435X
Language : En, Es, Fr & De

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Book Description :

Download The Potential Effect and Mechanism of Chinese Traditional Medicine on Vascular Homeostasis and Remodeling book written by Yuliang Wang,Zhang Yuefan,Tie-Jun Li,Ismail Laher,Hongbin Wang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Issues in Allied Fields of Medicine 2011 Edition

Issues in Allied Fields of Medicine  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 146496582X
Language : En, Es, Fr & De

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Book Description :

Issues in Allied Fields of Medicine / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Allied Fields of Medicine. The editors have built Issues in Allied Fields of Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Allied Fields of Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Allied Fields of Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Frailty and Herbal Medicines From Molecular Mechanisms to Clinical Efficacy

Frailty and Herbal Medicines  From Molecular Mechanisms to Clinical Efficacy Book
Author : Akio Inui,Jiang Bo Li,Koji Ataka,Ryuji Takahashi,Noiro Iizuka
Publisher : Frontiers Media SA
Release : 2020-05-28
ISBN : 2889637611
Language : En, Es, Fr & De

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Book Description :

Download Frailty and Herbal Medicines From Molecular Mechanisms to Clinical Efficacy book written by Akio Inui,Jiang Bo Li,Koji Ataka,Ryuji Takahashi,Noiro Iizuka, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Small Molecules in Oncology

Small Molecules in Oncology Book
Author : Uwe M. Martens
Publisher : Springer
Release : 2018-09-02
ISBN : 9783319914411
Language : En, Es, Fr & De

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Book Description :

This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.

The HLA Complex in Biology and Medicine

The HLA Complex in Biology and Medicine Book
Author : Narinder K Mehra
Publisher : Boydell & Brewer Ltd
Release : 2010-11-26
ISBN : 9788184488708
Language : En, Es, Fr & De

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Book Description :

A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

HEROLD s Internal Medicine Second Edition Vol 1

HEROLD s Internal Medicine  Second Edition    Vol  1 Book
Author : Gerd Herold
Publisher : Lulu.com
Release : 2014-06-20
ISBN : 1291727337
Language : En, Es, Fr & De

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Book Description :

"Herold: Internal Medicine" is a lecture oriented representation taking account of the topic catalogue for the medical examination for physicians. It is one of the leading textbooks of internal medicine in Germany, if not the leading one. Its enormous popularity is based on the facts that it represents the topics of internal medicine in an accurate and systematic form and that it has been updated every year since 1982. For further information please refer www.herold-internal-medicine.com and read the disclaimer.

Anti aging Drugs

Anti aging Drugs Book
Author : Alexander M Vaiserman
Publisher : Royal Society of Chemistry
Release : 2017-01-18
ISBN : 1782629858
Language : En, Es, Fr & De

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Book Description :

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.