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Molecular Neurology

Molecular Neurology Book
Author : Stephen Waxman
Publisher : Elsevier
Release : 2010-07-26
ISBN : 9780080546186
Language : En, Es, Fr & De

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Book Description :

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

From Neuroscience to Neurology

From Neuroscience to Neurology Book
Author : Stephen Waxman
Publisher : Elsevier
Release : 2004-11-05
ISBN : 9780080506982
Language : En, Es, Fr & De

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Book Description :

The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field

Rosenberg s Molecular and Genetic Basis of Neurological and Psychiatric Disease

Rosenberg s Molecular and Genetic Basis of Neurological and Psychiatric Disease Book
Author : Roger N. Rosenberg,Juan M. Pascual
Publisher : Elsevier
Release : 2014-10-28
ISBN : 0124105491
Language : En, Es, Fr & De

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Book Description :

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Applications of Biotechnology in Neurology

Applications of Biotechnology in Neurology Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2013-01-05
ISBN : 162703272X
Language : En, Es, Fr & De

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Book Description :

Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases

Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases Book
Author : Jean-Louis Junien,B. Staels
Publisher : IOS Press
Release : 2008
ISBN : 1586038575
Language : En, Es, Fr & De

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Book Description :

Focuses on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders. This book also focuses on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders, and on the aspects of drug finding.

Molecular Neuroscience

Molecular Neuroscience Book
Author : Patricia Revest,Alan Longstaff
Publisher : Garland Science
Release : 1998
ISBN : 9781859962503
Language : En, Es, Fr & De

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Book Description :

Molecular Neuroscience takes an interesting and original approach to explaining the present and future impact of molecular biology on the study of neuroscience. It provides the reader with a level of understanding which will allow them to delve deeper into the ever expanding neuroscience literature. A good balance is achieved between a didactic style and well-selected examples of experimental approaches. This book is written for 2nd and 3rd year life science undergraduates and MSc students on a range of courses. Medical students and researchers requiring a concise introduction to neuroscience, particularly the latest molecular approaches, will also find it an essential read.

The Neurosciences Paths of Discovery I

The Neurosciences  Paths of Discovery  I Book
Author : F. WORDEN,J. SWAZEY,G. ADELMAN
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468468170
Language : En, Es, Fr & De

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Book Description :

To commemorate properly the 70th birthday of a man who, by his very nature, is too busy to pause for any kind of ceremonial event unless it has a concomitant functional output was a difficult problem for the Staff and Associates of the Neurosciences Research Program. Frank (F. O. S. ) has always dreaded the prospect that sometime it might be appropriate for his colleagues to present him a Fest schrift. In fact, "Fest me no Schriften" became his battle cry, expressing his feeling that the idea of testimonials clustered into a book was anathema. So the "break through" idea for the planners was to organize a symposium around the theme of discovery in neuroscience that would be valuable scientifically and, in its demon stration of interdisciplinary interaction, would support that emphasis in Frank's career. After much planning a program was developed, beginning with a birthday party the evening before, followed by the two-day symposium, and closing with the first F. O. Schmitt Lecture in Neuroscience. We hope that publication of the scientific proceedings in this volume will be of interest not only to the neuroscience community, but also to a broad general readership interested in discovery, under standing, and the creative processes in scientific work. An organizing committee, chaired by Fred Worden, collected advice and guidance leading to the selection of speakers whose scientific careers have played an important part in the recent history of modern neuroscience.

Neuroscience From the Molecular to the Cognitive

Neuroscience  From the Molecular to the Cognitive Book
Author : Floyd E. Bloom
Publisher : Elsevier
Release : 1994-07-19
ISBN : 008086225X
Language : En, Es, Fr & De

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Book Description :

This hundredth volume is a commemorative milestone in the prestigeous Progress in Brain Research series. Accordingly, authors were invited to write on any topic, given that their choice represented the topic most near and dear to their own efforts over a significant period of the recent past, and to which they would likely continue to be devoted in the future. In that sense, this volume does not represent a scientific meeting, but rather an overview sample of problems and methodologies that epitomize brain research broadly at this special moment in the maturation of the field. The chapters comprising this volume assort themselves readily into five or six established categories of topics: developmental brain research, molecular brain research, integrative brain research, neuroplasticity, and neuro-psychiatric conditions. This volume reports through a sample of recognized leaders in the neuroscientific community at a significant instant in the history and evolution of the field.

Neuroscience for Neurologists

Neuroscience for Neurologists Book
Author : Patrick F Chinnery
Publisher : World Scientific
Release : 2006-11-14
ISBN : 1908979860
Language : En, Es, Fr & De

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Book Description :

The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the future career? Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area. Many of the chapters are co-written by a clinician and a basic scientist, and each has been subject to peer review — both by experts in the field and a “jobbing” general neurologist. This has ensured that the contributions reflect contemporary scientific thinking which is presented in a way that is easy to digest. The book includes generous use of diagrams to help explain difficult concepts, a glossary explaining the terminology, and provides information on links to web-based resources for further information. Contents:Neurogenetics — Single Gene DisordersNeurogenetics II: Complex DisordersFunctional Genomics and Proteomics: Application in NeurosciencesMitochondriaNanotechnology for Neuronal Ion ChannelsMolecular and Cellular Pathways of Neurodegeneration in Motor Neurone DiseaseNeurodegenerative Disorders: Parkinson's Disease and Huntington's DiseaseMolecular Pathogenesis of NeuroinflammationNeurovirologyMolecular Neurology of Prion DiseaseMonitoring and Interpretation of Intracranial PressureCerebral Perfusion and StrokeA Review of Structural Magnetic Resonance NeuroimagingApplications of Positron Emission Tomography (PET) in NeurologyFunctional Magnetic Resonance ImagingHow to Spot Bias and Other Potential Problems in Randomised Controlled Trials Readership: Neurologists, trainees/interns in neurology and related disciplines, neurobiologists. Keywords:Neuroscience;Neurology;Neurobiology;Clinical Neurology;Clinical InvestigationKey Features:A single volume describing the scientific principles that underpin the clinical practice of neurology from experts in each fieldCovers a broad range of topics from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trialsSuccinct chapters that will be easily accessible by neurologists and trainees who have no expertise in the areaIdeal for general neurologists who wish to keep up to date with clinically relevant scientific advancesEssential reading for trainee neurologists preparing for their future careerEffective use of diagrams to help explain difficult conceptsMany of the reviews co-written by a clinician and a basic scientist, in addition subjected to peer review — both by experts in the field and also by a “jobbing” general neurologistIncludes a glossary explaining the terminology, and providing links to web-based resources for further information

The Molecular Biology of Neurological Disease

The Molecular Biology of Neurological Disease Book
Author : Roger N. Rosenberg,A. E. Harding
Publisher : Butterworth-Heinemann
Release : 2013-10-22
ISBN : 148316330X
Language : En, Es, Fr & De

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Book Description :

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Molecular Imaging

Molecular Imaging Book
Author : Shankar Vallabhajosula
Publisher : Springer Science & Business Media
Release : 2009-07-13
ISBN : 3540767355
Language : En, Es, Fr & De

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Book Description :

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Epilepsy and Movement Disorders

Epilepsy and Movement Disorders Book
Author : Renzo Guerrini,Jean Aicardi,Frederick Andermann,Mark Hallett
Publisher : Cambridge University Press
Release : 2002
ISBN : 9780521771108
Language : En, Es, Fr & De

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Book Description :

This book examines the clinical, neurophysiological, genetic, pharmacological and molecular factors which relate epilepsy and movement disorders.

Molecular and Cellular Approaches to the Treatment of Neurological Disease

Molecular and Cellular Approaches to the Treatment of Neurological Disease Book
Author : Stephen G. Waxman
Publisher : Lippincott Williams & Wilkins
Release : 1993
ISBN :
Language : En, Es, Fr & De

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Book Description :

This volume demonstrates how recent discoveries in molecular and cellular neurobiology can be used to develop new therapies for stroke, brain and spinal cord injury, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and other neurological disorders. More than fifty outstanding basic and clinical neuroscientists detail the molecular and cellular mechanisms of neuronal death and injury, examine these mechanisms in specific diseases, and explore new strategies for treatment by pharmacological intervention or by cellular and molecular replacement. The book highlights important interrelationships between clinical investigation and research using the incisive methods of molecular biology, membrane biophysics and ion channel physiology, optical imaging, positron emission tomography scanning, magnetic resonance imaging and spectroscopy, and computational neuroscience. The contributors analyze the roles of ion channels and exchangers, intracellular calcium, excitatory transmitters, and excitotoxicity in neuronal death and injury and describe how these mechanisms operate in stroke, spinal cord injury, and hereditodegenerative diseases such as Alzheimer's and Huntington's disease. Close attention is given to the therapeutic implications of the ischemic penumbra in stroke and to the prospects for analyzing the ischemic penumbra by nuclear magnetic resonance spectroscopy. A noted expert in neurosurgical research explains how recent clinical trials of high-dose methylprednisolone in spinal cord injury have shed new light on the cellular mechanisms of neuronal injury. The wide variety of new therapeutic strategies explored includes pharmacological modulation of ion channel properties in demyelinating disorders; treatment of ischemic brain injury by calcium channel and postsynaptic receptor blockade and hypothermia; manipulation of neuronal and glial cells using antisense nucleotides; grafting of genetically engineered cells into the central nervous system; and intracerebral transplantation of neurons in neurodegenerative diseases such as Parkinson's disease. This volume is an essential resource for neurologists, neurosurgeons, psychiatrists, and pharmacologists, as well as for scientists investigating the nervous system at the molecular and cellular levels. It offers direction for utilizing the latest findings from basic neuroscience in the search for new neurological therapies.

Mitochondria the cell powerhouse and nexus of stress

Mitochondria  the cell powerhouse and nexus of stress Book
Author : Sabzali Javadov,Andrey V. Kuznetsov
Publisher : Frontiers E-books
Release : 2014-09-23
ISBN : 2889192830
Language : En, Es, Fr & De

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Book Description :

Mitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and pathological conditions through their participation in many intracellular signaling pathways. Studies over the last 30 years provide strong evidence that mitochondria are the nexus of various stresses which initiate cell death through apoptosis, oncosis, necrosis and autophagy depending on the severity of the stress and cellular energy status. The release of several pro-apoptotic proteins such as cytochrome c, Smac/DIABLO, AIF, endonuclease G from intermembrane space initiates both caspase-dependent and caspase-independent apoptosis. The formation of the mitochondrial permeability transition pore in the IMM promotes cell death mostly through necrosis whereas a mild stress activates autophagy. Due to their critical roles in both cell death and survival mitochondria have been widely considered as an important target for various pharmacological and conditional therapeutic approaches. Currently, a large number of mitochondria-targeted agents are suggested to prevent (in ischemia reperfusion injury, cardiovascular, neurodegenerative and other diseases) or stimulate (in various cancers) cell death. This Research Topic focuses on the role of mitochondria in the regulation of cell metabolism and signaling under physiological and pathological conditions. Studies performed on cultured cells and isolated organs/tissues using different animal and cellular models of various diseases are also included and discussed.

Epilepsy

Epilepsy Book
Author : Jerome Engel, MD, PhD
Publisher : Demos Medical Publishing
Release : 2005-04-01
ISBN : 9781934559123
Language : En, Es, Fr & De

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Book Description :

This volume is the second in a series developed under the auspices of the World Federation of Neurology to meet the needs of neurologists who must practice medicine without many of the advantages that are often taken for granted in the industrialized world. It is targeted to neurologists practicing in low-resource environments and those who wish to practice cost-effective neurology, and addresses issues important for neurologists in developing countries that are not covered in standard textbooks. The series will update the reader in currently accepted diagnostic and management practice. Material is presented in a user-friendly, interactive manner, with abundant case material. Epilepsy is one of the most common serious primary brain disorders, affecting forty million people worldwide. According to the World Health Organization, epilepsy accounts for 1% of the Global Burden of Disease, equivalent to lung cancer in men and to breast cancer in women. It is not surprising, therefore, that ten to twenty texts on epilepsy are published annually. These texts contain the very latest information on diagnosis and treatment of various aspects of epilepsy; however, approximately 80% of people with epilepsy in the world live in developing countries, where modern diagnostic and treatment approaches do not exist. Upwards of 90% of people with epilepsy in these areas receive no treatment at all. This is the first text to address the issues faced by neurologists who must deliver care with limited resources, often in a setting of tropical diseases and malnutrition, that characterize practice in developing countries.

Molecular Neuroscience

Molecular Neuroscience Book
Author : Colton Easton
Publisher :
Release : 2019-06-20
ISBN : 9781632428455
Language : En, Es, Fr & De

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Book Description :

Molecular neuroscience is a subfield of neuroscience. It focuses on the examination of the concepts in molecular biology in relation to the nervous system. The communication between neurons usually takes place with the help of chemical transmission across gaps between the cells, known as synapses. The topics that are covered under this discipline include molecular neuroanatomy, the molecular basis for neuroplasticity and the effects of genetics and epigenetics on neuronal development. It also focuses on the molecular mechanisms of neurodegenerative diseases. Some of the common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease and Huntington's disease. The transmitted chemicals, called neurotransmitters, are responsible in the regulation of a significant fraction of vital body functions. The ever-growing need of advanced technology is the reason that has fueled the research in the field of molecular neuroscience in recent times. It strives to provide a fair idea about this discipline and to help develop a better understanding of the latest advances within this field. As this field is emerging at a rapid pace, the contents of this book will help the readers understand the modern concepts and applications of the subject.

First Aid for the Neurology Boards

First Aid for the Neurology Boards Book
Author : Michael Rafii,Thomas Cochrane
Publisher : McGraw Hill Professional
Release : 2010-05-07
ISBN : 9780071742887
Language : En, Es, Fr & De

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Book Description :

The Insider's Guide to Acing the Neurology Boards-- Written by Physicians Who Passed! Apply the proven First Aid formula for Neurology Board success! 4 STAR DOODY'S REVIEW! "This is a nice, concise review of high-yield neurology and psychiatry topics focused on preparing for neurology board examinations. It can easily be read or reviewed in a short period of time, and the tables and graphics are also helpful. 4 Stars."--Doody's Review Service First Aid for the Neurology Boards is a unique guide for success on the Neurology Boards, in-training exams, and recertification. You will find hundreds of frequently-tested facts based on feedback from students who just passed the exam along with mini-cases essential for oral board preparation.The books is written by recent test-takers and reviewed by top faculty so you know you are studying the most up-to-date, relevant information possible. Features Hundreds of high-yield facts, mnenomics, clinical images, and summary tables help you ace the boards and in-service exams Covers must-know neurology AND psychiatry topics in one complete volume Written by recent, successful test-takers and reviewed by faculty so you know you're studying the most relevant, up-to-date material possible Integrated mini-cases highlight frequently tested scenarios and classic patient presentations Great for in-service and board exams and the perfect refresher before recertification The Content You Need to Excel on the Boards: Guide to the ABPN Examination, Neurology Topics: Neuroanatomy, Neuropharmacology, Neuroimmunology, Neurodegenerative Disorders, Headache and Pain, Neuro-oncology, Neuro-ophthalomology and Neuro-otology, Stroke and Neurocritical Care, Neurological Infections, Neuromuscular Disease, Pediatric Neurology and Neurogenetics, Seizures, Epilepsy, and Sleep Disorders, Psychiatry Topics: Substance Abuse and Dependence, Delirium, Anxiety Disorders, Somatoform Disorders, Bipolar Disorder, Major Depressive Disorder, Primary Psychotic Disorders. Visit www.FirstAidfortheBoards.com and www.FirstAidTeam.com