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Molecular Genetic And Statistical Techniques For Behavioral And Neural Research

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Molecular Genetic and Statistical Techniques for Behavioral and Neural Research

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2018-04-24
ISBN : 0128041161
Language : En, Es, Fr & De

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Book Description :

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2020-04-03
ISBN : 012817529X
Language : En, Es, Fr & De

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Book Description :

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Translational Research in Cancer

Translational Research in Cancer Book
Author : Sivapatham Sundaresan,Yeun-Hwa Gu
Publisher : BoD – Books on Demand
Release : 2021-02-03
ISBN : 1838805346
Language : En, Es, Fr & De

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Book Description :

Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Genetics and the Psychology of Motor Performance

Genetics and the Psychology of Motor Performance Book
Author : Sigal Ben-Zaken,Véronique Richard,Gershon Tenenbaum
Publisher : Routledge
Release : 2019-02-01
ISBN : 1351628429
Language : En, Es, Fr & De

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Book Description :

Despite the prevalence of behavioral research conducted through genetic studies, there is an absence of literature pertaining to the genetics of motor behavior. Genetics and the Psychology of Motor Performance is the first book to integrate cutting-edge genetic research into the study of the psychological aspects of motor learning and control. The book’s central line of enquiry revolves around the extent to which psychological factors central to motor proficiency – including personality, emotion, self-regulation, motivation, and perceptual-cognitive skills – are acquired or inherited. It explains how these factors affect motor performance, distilling the latest research into their genetic underpinnings and, in doing so, assessing the magnitude of the role genetics plays in the stages of motor development, from early proficiency through to expertise. Written by leading experts in the genetics of human performance and exercise psychology, and thoroughly illustrated throughout, Genetics and the Psychology of Motor Performance is a crucial resource for any upper-level student or researcher seeking a deeper understanding of motor learning. It is an important book for anyone studying or working in exercise psychology, motor development, exercise genetics, or exercise physiology more broadly.

Knowledge Modelling and Big Data Analytics in Healthcare

Knowledge Modelling and Big Data Analytics in Healthcare Book
Author : Mayuri Mehta,Kalpdrum Passi,Indranath Chatterjee,Rajan Patel
Publisher : CRC Press
Release : 2021-12-09
ISBN : 1000477762
Language : En, Es, Fr & De

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Book Description :

Knowledge Modelling and Big Data Analytics in Healthcare: Advances and Applications focuses on automated analytical techniques for healthcare applications used to extract knowledge from a vast amount of data. It brings together a variety of different aspects of the healthcare system and aids in the decision-making processes for healthcare professionals. The editors connect four contemporary areas of research rarely brought together in one book: artificial intelligence, big data analytics, knowledge modelling, and healthcare. They present state-of-the-art research from the healthcare sector, including research on medical imaging, healthcare analysis, and the applications of artificial intelligence in drug discovery. This book is intended for data scientists, academicians, and industry professionals in the healthcare sector.

Handbook of Molecular Genetic Techniques for Brain and Behavior Research

Handbook of Molecular Genetic Techniques for Brain and Behavior Research Book
Author : Wim E. Crusio,R.T. Gerlai
Publisher : Elsevier
Release : 1999-10-18
ISBN : 9780080536866
Language : En, Es, Fr & De

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Book Description :

The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

Neurobehavioral Genetics

Neurobehavioral Genetics Book
Author : Byron C. Jones,Pierre Mormede
Publisher : CRC Press
Release : 2006-08-30
ISBN : 1420003569
Language : En, Es, Fr & De

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Book Description :

A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: De

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology Book
Author : Anonim
Publisher : Academic Press
Release : 2019-11-20
ISBN : 0128160764
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Behavior Genetics of Cognition Across the Lifespan

Behavior Genetics of Cognition Across the Lifespan Book
Author : Deborah Finkel,Chandra A. Reynolds
Publisher : Springer Science & Business Media
Release : 2013-07-09
ISBN : 1461474477
Language : En, Es, Fr & De

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Book Description :

Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

Methods in Genomic Neuroscience

Methods in Genomic Neuroscience Book
Author : Hemin R. Chin,Steven O. Moldin
Publisher : CRC Press
Release : 2001-09-26
ISBN : 1420038478
Language : En, Es, Fr & De

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Book Description :

The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco

Handbook of Stress and the Brain Part 2 Stress Integrative and Clinical Aspects

Handbook of Stress and the Brain Part 2  Stress  Integrative and Clinical Aspects Book
Author : T. Steckler,N.H. Kalin,J.M.H.M. Reul
Publisher : Elsevier
Release : 2005-04-07
ISBN : 0444518231
Language : En, Es, Fr & De

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Book Description :

The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry. Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality. Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders. * Provides an overview of recent advances made in stress research * Includes timely discussion of stress and its effect on the immune system * Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms.

Neurobehavioral Genetics

Neurobehavioral Genetics Book
Author : Byron C. Jones,Pierre Mormede
Publisher : CRC Press
Release : 2002-01-01
ISBN : 9781420048384
Language : En, Es, Fr & De

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Book Description :

Neurobehavioral Genetics: Methods and Applications covers classic and contemporary approaches to the study of the brain and behavior, including basic and clinical research. This book is designed as a reference for investigators wishing to incorporate genetic methods into neurobehavioral research. A broad spectrum of methods are integrated, unlike any other publication currently in print. Neurobehavioral Genetics: Methods and Applications presents different models, from invertebrates to genetically defined mammals. Introductory chapters demonstrate the scope and power of genetic methods that can be applied to neurobehavioral research from statistical methods and linkage analysis to contemporary molecular genetic approaches to search for candidate genes. The second half of the book covers the applications of quantitative and molecular genetics in basic and clinical research. Topics covered include animal behavior and neurobiology and human clinical problems including neurodegenerative diseases and psychiatric disorders.

Developmental behavioral Pediatrics

Developmental behavioral Pediatrics Book
Author : Anonim
Publisher : Elsevier Health Sciences
Release : 2008
ISBN : 032304025X
Language : En, Es, Fr & De

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Book Description :

Based on the Diagnostic and Statistical Manual for Primary Care: Child and Adolescent Version (DSM-PC), this state-of-the-art reference expertly guides you through normal and abnormal development and behavior for all pediatric age groups. See how neurobiological, environmental, and human relationship factors all contribute to developmental and behavioral disorders and know how to best diagnose and treat each patient you see. Accurately identify developmental and behavioral problems using the Diagnostic and Statistical Manual for Primary Care criteria, and evidence-based guidelines. Gain a clear understanding of the "normal" boundaries and variations within specific disorders. Make informed therapeutic decisions with the integration of basic science and practical information and recommendations from the Society of Developmental and Behavioral Pediatrics and the American Academy of Pediatrics. Avoid legal and ethical implications by consulting the Law, Policy, and Ethics chapter. Download the DSM PC criteria from the included CD, as well as tables and illustrations for use in electronic presentations.

Handbook of the Psychology of Aging

Handbook of the Psychology of Aging Book
Author : K Warner Schaie,Sherry L. Willis
Publisher : Academic Press
Release : 2010-12-21
ISBN : 9780123808837
Language : En, Es, Fr & De

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Book Description :

The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals. It also provides perspectives on the behavioral science of aging for researchers and professionals from other disciplines. The book is organized into four parts. Part 1 reviews key methodological and analytical issues in aging research. It examines some of the major historical influences that might provide explanatory mechanisms for a better understanding of cohort and period differences in psychological aging processes. Part 2 includes chapters that discuss the basics and nuances of executive function; the history of the morphometric research on normal brain aging; and the neural changes that occur in the brain with aging. Part 3 deals with the social and health aspects of aging. It covers the beliefs that individuals have about how much they can control various outcomes in their life; the impact of stress on health and aging; and the interrelationships between health disparities, social class, and aging. Part 4 discusses the emotional aspects of aging; family caregiving; and mental disorders and legal capacities in older adults. Contains all the main areas of psychological gerontological research in one volume Entire section on neuroscience and aging Begins with a section on theory and methods Edited by one of the father of gerontology (Schaie) and contributors represent top scholars in gerontology

Psychopathology

Psychopathology Book
Author : James E. Maddux,Barbara A. Winstead
Publisher : Routledge
Release : 2015-08-27
ISBN : 1317697995
Language : En, Es, Fr & De

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Book Description :

The fourth edition of Psychopathology is the most up-to-date text about the etiology and treatment of the most important psychological disorders. Intended for first-year graduate students in clinical psychology, counseling psychology, and related programs, this new edition, revised to be consistent with the DSM-5, continues to focus on research and empirically-supported information while also challenging students to think critically. The first part of the book covers the key issues, ideas, and concepts in psychopathology, providing students with a set of conceptual tools that will help them read more thoroughly and critically the second half of the book, which focuses on specific disorders. Each chapter in the second and third sections provides a definition, description, and brief history of the disorder it discusses, and outlines theory and research on etiology and empirically-supported treatments. This edition also features a companion website hosting lecture slides, a testbank, an instructor’s manual, case studies and exercises, and more.

Insect Molecular Genetics

Insect Molecular Genetics Book
Author : Marjorie A. Hoy
Publisher : Academic Press
Release : 2018-09-12
ISBN : 0128152311
Language : En, Es, Fr & De

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Book Description :

Describes how molecular tools solve problems in insect behaviour, ecology, systematics and evolution, and pest management

Genes Brain Function and Behavior

Genes  Brain Function  and Behavior Book
Author : Douglas Wahlsten
Publisher : Academic Press
Release : 2019-03-14
ISBN : 012812833X
Language : En, Es, Fr & De

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Book Description :

Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources

Handbook of Anxiety and Fear

Handbook of Anxiety and Fear Book
Author : D. Caroline Blanchard,Guy Griebel,David J Nutt
Publisher : Elsevier
Release : 2011-09-02
ISBN : 9780080559520
Language : En, Es, Fr & De

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Book Description :

This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena. • Integrates animal and human research on fear and anxiety • Presents emerging and developing fields of human anxiety research including imaging of anxiety disorders, the genetics of anxiety, the pharmacology of anxiolysis, recent developments in classification of anxiety disorders, linking these to animal work • Covers basic research on innate and conditioned responses to threat • Presents work from the major laboratories, on fear learning and extinction • Reviews research on an array of neurotransmitter and neuromodulator systems related to fear and anxiety • Compares models, and neural systems for learned versus unlearned responses to threat • Relates the findings to the study, diagnostics, and treatment of anxiety disorders, the major source of mental illness in modern society (26 % of Americans are affected by anxiety disorders!)

Handbook of Microdialysis

Handbook of Microdialysis Book
Author : Anonim
Publisher : Elsevier
Release : 2007-02-02
ISBN : 0080469663
Language : En, Es, Fr & De

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Book Description :

Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience. * Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods * Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology * Includes clinical applications of microdialysis

Handbook of Episodic Memory

Handbook of Episodic Memory Book
Author : Ekrem Dere,Alexander Easton,Lynn Nadel,Joe P Huston
Publisher : Elsevier
Release : 2008-09-04
ISBN : 9780080932361
Language : En, Es, Fr & De

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Book Description :

Episodic memory is the name of the kind of memory that records personal experiences instead of the mere remembering of impersonal facts and rules. This type of memory is extremely sensitive to ageing and disease so an understanding of the mechanisms of episodic memory might lead to the development of therapies suited to improve memory in some patient populations. Episodic memory is unique in that it includes an aspect of self-awareness and helps us to remember who we are in terms of what we did and what we have been passed through and what we should do in the future. This book brings together a renowned team of contributors from the fields of cognitive psychology, neuropsychology and behavioural and molecular neuroscience. It provides a detailed and comprehensive overview of recent developments in understanding human episodic memory and animal episodic-like memory in terms of concepts, methods, mechanisms, neurobiology and pathology. The work presented within this book will have a profound effect on the direction that future research in this topic will take. - The first and most current comprehensive handbook on what we know about episodic memory, the memory of events, time, place, and emotion, and a key feature of awareness and consciousness - Articles summarize our understanding of the mechanisms of episodic memory as well as surveying the neurobiology of epsidodic memory in patients, animal studies and functional imaging work - Includes 34 heavily illustrated chapters in two sections by the leading scientists in the field