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Molecular Genetic And Statistical Techniques For Behavioral And Neural Research

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Molecular Genetic and Statistical Techniques for Behavioral and Neural Research

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2018-04-26
ISBN : 9780128040782
Language : En, Es, Fr & De

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Book Description :

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2018-04-24
ISBN : 0128041161
Language : En, Es, Fr & De

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Book Description :

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Handbook of Molecular Genetic Techniques for Brain and Behavior Research

Handbook of Molecular Genetic Techniques for Brain and Behavior Research Book
Author : Wim E. Crusio,R.T. Gerlai
Publisher : Elsevier
Release : 1999-10-18
ISBN : 9780080536866
Language : En, Es, Fr & De

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Book Description :

The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2020-04-03
ISBN : 012817529X
Language : En, Es, Fr & De

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Book Description :

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Translational Research in Cancer

Translational Research in Cancer Book
Author : Sivapatham Sundaresan,Yeun-Hwa Gu
Publisher : BoD – Books on Demand
Release : 2021-02-03
ISBN : 1838805346
Language : En, Es, Fr & De

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Book Description :

Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Genetics and the Psychology of Motor Performance

Genetics and the Psychology of Motor Performance Book
Author : Sigal Ben-Zaken,Véronique Richard,Gershon Tenenbaum
Publisher : Routledge
Release : 2019-02-01
ISBN : 1351628429
Language : En, Es, Fr & De

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Book Description :

Despite the prevalence of behavioral research conducted through genetic studies, there is an absence of literature pertaining to the genetics of motor behavior. Genetics and the Psychology of Motor Performance is the first book to integrate cutting-edge genetic research into the study of the psychological aspects of motor learning and control. The book’s central line of enquiry revolves around the extent to which psychological factors central to motor proficiency – including personality, emotion, self-regulation, motivation, and perceptual-cognitive skills – are acquired or inherited. It explains how these factors affect motor performance, distilling the latest research into their genetic underpinnings and, in doing so, assessing the magnitude of the role genetics plays in the stages of motor development, from early proficiency through to expertise. Written by leading experts in the genetics of human performance and exercise psychology, and thoroughly illustrated throughout, Genetics and the Psychology of Motor Performance is a crucial resource for any upper-level student or researcher seeking a deeper understanding of motor learning. It is an important book for anyone studying or working in exercise psychology, motor development, exercise genetics, or exercise physiology more broadly.

Neuroscience of Social Stress

Neuroscience of Social Stress Book
Author : Klaus A. Miczek
Publisher : Springer Nature
Release : 2022-11-26
ISBN : 3031042565
Language : En, Es, Fr & De

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Book Description :

Social stress has emerged as a research front in the neurosciences, and this volume highlights recent insights in brain mechanisms and methodological advances. The topics range from the evolutionary origins of coping with social challenges to neural mechanism-driven focus on novel treatment targets. The parallel presentation of work with animal models and human subjects is bound to be useful to a broad research community.

Nanotherapeutic Strategies and New Pharmaceuticals Part 2

Nanotherapeutic Strategies and New Pharmaceuticals  Part 2  Book
Author : Shahid Khan
Publisher : Bentham Science Publishers
Release : 2021-12-07
ISBN : 9815036734
Language : En, Es, Fr & De

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Book Description :

Advances in technology have enabled medicinal chemists to discover and formulate several highly specific, biocompatible, and non-toxic therapeutic agents for clinical applications. Nanotechnology has achieved significant progress in the last few decades and is crucial in every field of science and technology. Nanotechnology-based pharmaceuticals offer multifaceted and alternative methodologies in comparison to the limitations of many conventional clinical therapies. Expertise in designing and developing nanoformulations has helped in targeted drug delivery. Recently, the use of innovative therapeutic agents, particularly in nanomedicine, has accounted for a significant portion of the global pharmaceutical market and is predicted to continue to grow rapidly in the near future. Nanotherapeutic Strategies and New Pharmaceuticals is an accessible multi-part reference which informs the reader about several new techniques based on nanotechnology. The chapters explain relevant topics in detail. The book is designed to encourage and help undergraduate, graduate and post-graduate students in the field of nanotherapeutics, pharmaceuticals and bio-organic chemistry through the use of didactic language and simple illustrations. Part 2 of this book covers the potential of nanotherapeutics and natural therapies for treating neurological diseases, targeting ion channels, signal transduction therapy, gene therapy of single gene mutation diseases and for nanoformulations for special purposes such as wound healing and stimuli-responsive drug delivery. The book also features a chapter that summarizes the types of nanoparticles tailored for specific molecular targets that mediate different diseases. The book set serves as a textbook for students in pharmacology and medical biochemistry, as well as a quick reference for researchers on bio-organic chemistry, as well as general readers interested in nanomedicine.

Knowledge Modelling and Big Data Analytics in Healthcare

Knowledge Modelling and Big Data Analytics in Healthcare Book
Author : Mayuri Mehta,Kalpdrum Passi,Indranath Chatterjee,Rajan Patel
Publisher : CRC Press
Release : 2021-12-09
ISBN : 1000477762
Language : En, Es, Fr & De

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Book Description :

Knowledge Modelling and Big Data Analytics in Healthcare: Advances and Applications focuses on automated analytical techniques for healthcare applications used to extract knowledge from a vast amount of data. It brings together a variety of different aspects of the healthcare system and aids in the decision-making processes for healthcare professionals. The editors connect four contemporary areas of research rarely brought together in one book: artificial intelligence, big data analytics, knowledge modelling, and healthcare. They present state-of-the-art research from the healthcare sector, including research on medical imaging, healthcare analysis, and the applications of artificial intelligence in drug discovery. This book is intended for data scientists, academicians, and industry professionals in the healthcare sector.

Neurobehavioral Genetics

Neurobehavioral Genetics Book
Author : Byron C. Jones,Pierre Mormede
Publisher : CRC Press
Release : 2006-08-30
ISBN : 1420003569
Language : En, Es, Fr & De

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Book Description :

A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: De

Methods in Genomic Neuroscience

Methods in Genomic Neuroscience Book
Author : Hemin R. Chin,Steven O. Moldin
Publisher : CRC Press
Release : 2001-09-26
ISBN : 1420038478
Language : En, Es, Fr & De

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Book Description :

The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology Book
Author : Anonim
Publisher : Academic Press
Release : 2019-11-20
ISBN : 0128160764
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Behavior Genetics of Cognition Across the Lifespan

Behavior Genetics of Cognition Across the Lifespan Book
Author : Deborah Finkel,Chandra A. Reynolds
Publisher : Springer Science & Business Media
Release : 2013-07-09
ISBN : 1461474477
Language : En, Es, Fr & De

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Book Description :

Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

Handbook of the Psychology of Aging

Handbook of the Psychology of Aging Book
Author : K Warner Schaie,Sherry L. Willis
Publisher : Academic Press
Release : 2010-12-21
ISBN : 9780123808837
Language : En, Es, Fr & De

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Book Description :

The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals. It also provides perspectives on the behavioral science of aging for researchers and professionals from other disciplines. The book is organized into four parts. Part 1 reviews key methodological and analytical issues in aging research. It examines some of the major historical influences that might provide explanatory mechanisms for a better understanding of cohort and period differences in psychological aging processes. Part 2 includes chapters that discuss the basics and nuances of executive function; the history of the morphometric research on normal brain aging; and the neural changes that occur in the brain with aging. Part 3 deals with the social and health aspects of aging. It covers the beliefs that individuals have about how much they can control various outcomes in their life; the impact of stress on health and aging; and the interrelationships between health disparities, social class, and aging. Part 4 discusses the emotional aspects of aging; family caregiving; and mental disorders and legal capacities in older adults. Contains all the main areas of psychological gerontological research in one volume Entire section on neuroscience and aging Begins with a section on theory and methods Edited by one of the father of gerontology (Schaie) and contributors represent top scholars in gerontology

Insect Molecular Genetics

Insect Molecular Genetics Book
Author : Marjorie A. Hoy
Publisher : Elsevier
Release : 2003-03-17
ISBN : 0080489044
Language : En, Es, Fr & De

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Book Description :

Insect Molecular Genetics, 2nd edition, is a succinct book that briefly introduces graduate and undergraduate students to molecular genetics and the techniques used in this well established and important discipline. The book is written for two converging audiences: those familiar with insects that need to learn about molecular genetics, and those that are familiar with molecular genetics but not familiar with insects. Thus, this book is intended to fill the gap between two audiences that share a common middle ground. * Up-to-date references to important review articles, websites, and seminal citations in the disciplines * Well crafted and instructive illustrations integral to explaining the techniques of molecular genetics * Glossary of terms to help beginners learn the vocabulary of molecular biology

Encyclopedia of Applied Developmental Science

Encyclopedia of Applied Developmental Science Book
Author : Celia B Fisher,Richard M. Lerner
Publisher : SAGE Publications
Release : 2004-10-16
ISBN : 1452265224
Language : En, Es, Fr & De

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Book Description :

The Encyclopedia of Applied Developmental Science is an important and timely contribution to this burgeoning field. This four-volume set is the authoritative source that encompasses the entire range of concepts and topics involved in the study of applied developmental science. Its contents and levels have broad appeal for those interested in how the application of knowledge about human development can be used to enhance the lives of individuals, families, and communities.

Biomedical Index to PHS supported Research pt A Subject access A H

Biomedical Index to PHS supported Research  pt  A  Subject access A H Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research pt A Subject access A H book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Psychopathology

Psychopathology Book
Author : James E. Maddux,Barbara A. Winstead
Publisher : Routledge
Release : 2015-08-27
ISBN : 1317697995
Language : En, Es, Fr & De

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Book Description :

The fourth edition of Psychopathology is the most up-to-date text about the etiology and treatment of the most important psychological disorders. Intended for first-year graduate students in clinical psychology, counseling psychology, and related programs, this new edition, revised to be consistent with the DSM-5, continues to focus on research and empirically-supported information while also challenging students to think critically. The first part of the book covers the key issues, ideas, and concepts in psychopathology, providing students with a set of conceptual tools that will help them read more thoroughly and critically the second half of the book, which focuses on specific disorders. Each chapter in the second and third sections provides a definition, description, and brief history of the disorder it discusses, and outlines theory and research on etiology and empirically-supported treatments. This edition also features a companion website hosting lecture slides, a testbank, an instructor’s manual, case studies and exercises, and more.

Developmental behavioral Pediatrics

Developmental behavioral Pediatrics Book
Author : Mark Wolraich
Publisher : Elsevier Health Sciences
Release : 2008-01-01
ISBN : 032304025X
Language : En, Es, Fr & De

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Book Description :

Based on the Diagnostic and Statistical Manual for Primary Care: Child and Adolescent Version (DSM-PC), this state-of-the-art reference expertly guides you through normal and abnormal development and behavior for all pediatric age groups. See how neurobiological, environmental, and human relationship factors all contribute to developmental and behavioral disorders and know how to best diagnose and treat each patient you see. Accurately identify developmental and behavioral problems using the Diagnostic and Statistical Manual for Primary Care criteria, and evidence-based guidelines. Gain a clear understanding of the "normal" boundaries and variations within specific disorders. Make informed therapeutic decisions with the integration of basic science and practical information and recommendations from the Society of Developmental and Behavioral Pediatrics and the American Academy of Pediatrics. Avoid legal and ethical implications by consulting the Law, Policy, and Ethics chapter. Download the DSM PC criteria from the included CD, as well as tables and illustrations for use in electronic presentations.

Modeling the Psychopathological Dimensions of Schizophrenia

Modeling the Psychopathological Dimensions of Schizophrenia Book
Author : Mikhail Pletnikov,John Waddington
Publisher : Academic Press
Release : 2015-11-05
ISBN : 012801184X
Language : En, Es, Fr & De

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Book Description :

Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia Edited and authored by leading researchers in the field of schizophrenia and related psychoses