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Molecular Aspects Of Neurodegeneration Neuroprotection And Regeneration In Neurological Disorders

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Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2020-09-07
ISBN : 0128217014
Language : En, Es, Fr & De

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Book Description :

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

The Handbook of Neuroprotection

The Handbook of Neuroprotection Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2011-02-14
ISBN : 9781617790492
Language : En, Es, Fr & De

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Book Description :

Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Ischemic and Traumatic Brain and Spinal Cord Injuries

Ischemic and Traumatic Brain and Spinal Cord Injuries Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2018-03-21
ISBN : 0128135972
Language : En, Es, Fr & De

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Book Description :

Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases. Offers a clearly written, logically organized, comprehensive overview on the molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting-edge research information on the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Presents chapters that are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Molecular Diagnostics in the Detection of Neurodegenerative Disorders

Molecular Diagnostics in the Detection of Neurodegenerative Disorders Book
Author : Megha Agrawal,William C. Cho
Publisher : Frontiers Media SA
Release : 2017-07-04
ISBN : 2889451941
Language : En, Es, Fr & De

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Book Description :

Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.

Neuroprotection

Neuroprotection Book
Author : Mathias Bähr
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604316
Language : En, Es, Fr & De

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Book Description :

In this first book to cover model systems, molecular mechanisms and clinical trials all in one volume internationally renowned scientists and clinicians provide a comprehensive treatment of neuroprotective strategies for all important neurological disorders. Following an overview of neurodegenerative, traumatic, and ischemic disorders, the book goes on to cover in vitro and animal model systems as well as cellular and molecular mechanisms. An extremely helpful analysis of clinical studies explains reasons for their success and failure, and the whole is rounded off with a look at the current challenges and hopes for the development of effective treatment strategies in the future.

Natural Products for Neurodegenerative Diseases

Natural Products for Neurodegenerative Diseases Book
Author : Y. H. Wong,Joseph T. Y. Wong
Publisher : S Karger Ag
Release : 2005
ISBN : 9783805579339
Language : En, Es, Fr & De

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Book Description :

Natural products have long been used for the relief of neurological symptoms, yet their mechanisms of action remain elusive. Recent investigations have started to unveil the complex molecular events associated with the therapeutic effects of natural products in neurodegenerative diseases. In this publication, leading experts share their perspectives and latest research findings on the roles of natural products in neuroprotection and neuronal regeneration. Multifunctional properties of constituents of botanicals and their derivatives are discussed to illustrate the possibilities towards the development of effective multitarget therapeutics. Researchers in the fields of neuroscience, molecular biology, alternative medicine and pharmacology will find that this issue provides a useful overview of the various mechanisms underlying the therapeutic effects of natural products in neurodegenerative diseases.

Advances in Research on Neurodegeneration

Advances in Research on Neurodegeneration Book
Author : P. Riederer,D.B. Calne,R. Horowski,Y. Mizuno,C.W. Olanow,W. Poewe,M.B.H. Youdim
Publisher : Springer Science & Business Media
Release : 2013-03-14
ISBN : 3709163013
Language : En, Es, Fr & De

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Book Description :

The 8th International Winter Conference on Neurodegeneration from Febru ary 9 to 13, 2000 took place in Tegernsee, Bavaria, Germany. The interest shown in this symposium, which was carried by invited speakers only, was striking. 28 lectures in 5 sessions dealt with themes on basic science and therapy strategies for neurodegenerative illness. This time especially basic mechanism of cell death and resulting causal treatment possibilities were centre themes of the lectures and lively discussions. In accordance with tradi tion 5 lectures on Multiple Sclerosis finished the convention. 60 scientists from 13 countries discussed current questions to these themes. The Symposium started with a lecture on the history of the develop ment of modern-L-DOPA-therapy. Lectures on cell death of dopaminergic nerve cells, new valuation regarding assembly, built up and function of neuromelanin of Substantia nigra and with this, the question of the physio logic and pathobiochemical role of dopamine and neuromelanin built the first block of themes which consequently extended to molecular and genetic aspects of cell death. Highlights of the symposium were neuroprotective and neuroregenerative future therapy strategies together with discussions on the difficulties of clinical neuroprotection. Developmental biological aspects on nerve cells, reorganisation and neurodegeneration showed a stimulating point of view of momentary and future development possibilities of new and more causal forms of therapy of neurodegenerative illness.

Neuroprotective Natural Products

Neuroprotective Natural Products Book
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Release : 2017-04-24
ISBN : 3527341862
Language : En, Es, Fr & De

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Book Description :

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Brain Damage and Repair

Brain Damage and Repair Book
Author : T. Herdegen,J. Delgado-Garcia
Publisher : Springer Science & Business Media
Release : 2007-05-08
ISBN : 1402025416
Language : En, Es, Fr & De

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Book Description :

This book builds a novel bridge from molecular research to clinical therapy. This approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology Book
Author : Naren L. Banik,Swapan K. Ray,Abel Lajtha
Publisher : Springer Science & Business Media
Release : 2008-11-25
ISBN : 038730343X
Language : En, Es, Fr & De

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Book Description :

Therapeutic approaches in spinal cord injury.- Cell death and tissue degeneration in traumatic brain injury.- neurotransmitters and electrophysiology in brain injury.- neurotransmitters and electrophysiology in brain injury.- Parkinsonism in the MPTP model.- EAE Demyelination.- EAE Neurodegeneration.- Cataract.- Uveitis.- Optic neuritis.- GBS/peripherial neuropathy, paraproteinemia.- Brain Tumor(Tumor Mechanisma).- Brain Tumor and angiogenesis.- SCIDS.- Phenylketone urea and mental retardation.- Neurofibromatosis.- BBB.- Muscular dystrophy.- Stracher.- Diabetic neuropathy/retinopathy/cataract.- Peroxisomes and adrenoleukodystrophy ALD.- Neuroprotection.- NFkB (Inflammation and spinal cord injury).- spinal cord injury and traumatic brain injury.- free radicals and neuroprotection.- Traumatic brain injury.- white matter degeneration.- Mitochondrial membrane defects.- Encephalomyopathies.- metal induced neurodegenaration.- neurometals in protein misfolding neurodegenerative diseases.- hyperammonemia.- kyneurenines in the brain preclinical and clinical studies, therapeutic condiserations.

Opportunities and Challenges of the Therapies Targeting CNS Regeneration

Opportunities and Challenges of the Therapies Targeting CNS Regeneration Book
Author : H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publisher : Springer Science & Business Media
Release : 2007-01-19
ISBN : 3540276262
Language : En, Es, Fr & De

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Book Description :

The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Neuroinflammation

Neuroinflammation Book
Author : Samuel David
Publisher : John Wiley & Sons
Release : 2015-03-10
ISBN : 1118732774
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field. neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two chapters that look at some fundamental aspects of neuroinflammationin humans and rodents. The remainder of the book is divided into two sections whichexamine both the detrimental and beneficial aspects of inflammation on the brain, spinalcord and peripheral nerves, on various disease states, and in normal aging. Thesesections provide a broad picture of the role neuroinflammation plays in the physiologyand pathology of various neurological disorders.Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficialand Detrimental Functions will be an essential volume for neuroimmunologists,neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development andprogression of Multiple Sclerosis. In recent years, the field has expanded to look at therole of inflammatory processes in a wide range of neurological conditions and cognitivedisorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers havealso started to note the beneficial impacts of neuroinflammation in certain diseases.Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides acomprehensive view of both the detriments and benefits of neuroinflammation inhuman health.Neuroinflammation: New Insights into Beneficial and Detrimental Functionsopens with two

Metallothioneins and Related Chelators

Metallothioneins and Related Chelators Book
Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Publisher : Royal Society of Chemistry
Release : 2009
ISBN : 1847558992
Language : En, Es, Fr & De

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Book Description :

Chapters 3 to 5 give an account of bacterial MTs, MTs in yeast and fungi, and MTs in plants. Most astonishingly, the MTs of bacteria and plants contain next to cysteine also histidine residues and thus, metal ions are not only sulfur- but also imidazole-coordinated which gives rise to zinc finger-like structures. Remarkably, yeast and fungal MTs are Cu(I) rather than Zn(II) or Cd(II) binding proteins. Next, Chapters 6 through 9 discuss the MTs of dipteran insects, including the model organism Drosophila melanogaster, earthworms and nematodes, as well as echinoderms, crustaceans, molluscs, and fish. Actually, aquatic animals, both vertebrates and invertebrates, have the potential to be used for monitoring metal contamination in aquatic ecosystems. Interestingly, in Chapter 9 the remarkable speculation is presented that under chronic natural exposure conditions the animals establish a trade-off between the "cost" of detoxifying non-essential metals and the "cost" of allowing some of these metals to spill over onto metal-sensitive sites. This contrasts with laboratory experiments involving aquatic animals, where the toxicity of non-essential metals normally exhibits a threshold response: at low exposure concentrations the organisms can detoxify the incoming metal and thus, tolerate the exposure, whereas at concentrations above the threshold, the detoxification mechanism is no longer able to protect the organism completely.

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2010-09-02
ISBN : 9781441966520
Language : En, Es, Fr & De

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Book Description :

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

Oxidative Stress in Vertebrates and Invertebrates

Oxidative Stress in Vertebrates and Invertebrates Book
Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Release : 2011-10-24
ISBN : 1118148118
Language : En, Es, Fr & De

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Book Description :

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Neurodegenerative Disorders as Systemic Diseases

Neurodegenerative Disorders as Systemic Diseases Book
Author : Keiji Wada
Publisher : Springer
Release : 2015-10-21
ISBN : 4431545417
Language : En, Es, Fr & De

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Book Description :

This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

Molecular and Cellular Biology of Neuroprotection in the CNS

Molecular and Cellular Biology of Neuroprotection in the CNS Book
Author : Christian Alzheimer
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461501237
Language : En, Es, Fr & De

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Book Description :

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

Applications of Biotechnology in Neurology

Applications of Biotechnology in Neurology Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2013-01-05
ISBN : 162703272X
Language : En, Es, Fr & De

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Book Description :

Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging Book
Author : Marco Malavolta,Eugenio Mocchegiani
Publisher : Academic Press
Release : 2016-04-15
ISBN : 0128018275
Language : En, Es, Fr & De

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Book Description :

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition