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Molecular Approach To Cancer Management

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Molecular Approach to Cancer Management

Molecular Approach to Cancer Management Book
Author : Gajanan V. Sherbet
Publisher : Academic Press
Release : 2017-06-15
ISBN : 0128128976
Language : En, Es, Fr & De

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Book Description :

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

Breast Cancer Management and Molecular Medicine

Breast Cancer Management and Molecular Medicine Book
Author : Martine Piccart,William C. Wood,Chie-Mien Hung,Lawrence J. Solin,Fatima Cardoso
Publisher : Springer Science & Business Media
Release : 2007-03-07
ISBN : 3540282653
Language : En, Es, Fr & De

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Book Description :

Tailoring treatment for individual breast cancers is no longer a dream and is now the main goal for current research. This book gives an overview of the most recent techniques, agents and approaches for breast cancer and the individualization of treatment. Particular attention is given to organ-specific tailored approaches, specific populations, patients’ preferences and rehabilitation. Contributions from experts focus on the biomedical research behind the transfer of molecular biology knowledge into the clinical management of patients. This has led to increased survival as well as improved quality of life. The book gives an overview of the latest achievements in breast cancer and their use in clinical practice.

Current Advances in Breast Cancer Research A Molecular Approach

Current Advances in Breast Cancer Research  A Molecular Approach Book
Author : Shankar Suman,Garima Suman,Sanjay Mishra
Publisher : Bentham Science Publishers
Release : 2020-04-30
ISBN : 9811451427
Language : En, Es, Fr & De

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Book Description :

Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine Book
Author : Dongfeng Tan,Henry T. Lynch
Publisher : Lippincott Williams & Wilkins
Release : 2013-01-01
ISBN : 9781451131970
Language : En, Es, Fr & De

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Book Description :

Principles of Molecular Diagnostics and Personalized Cancer Medicine The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today's subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care. Improve your understanding of… • The basic mechanisms of carcinogenesis—including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors. • The most current molecular techniques—including polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics, whole-genome assessments, and next- generation sequencing. • Molecular tests—including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment. • Imaging and screening technologies—including molecular imaging, genetic tests, biostatistics, and bioinformatics. • The molecular basis of therapy—including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles. • Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management. • Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!

The Cancer Handbook 2 Volume Set

The Cancer Handbook  2 Volume Set Book
Author : Malcolm Alison
Publisher : John Wiley & Sons
Release : 2007-07-30
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Cancer Handbook provides a comprehensive overview of scientific and clinical information in cancer research and medicine (oncology). This area is one of the most intensively studied in biology and medicine, resulting in a huge amount of new information being published every year. This book summarizes and explains key facts and recent developments. It is aimed at a wide variety of readers who need easy access to knowledge concerning all major aspects of cancer biology, without too much clinical detail or specialist research material. The Cancer Handbook stands out from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment. As more and more laboratory research is applied to clinical management, e.g. the use of monoclonal antibodies as drugs, it is important that clinicians understand the aetiology of the disease and the molecular basis of the new therapeutic approaches. It is also important for laboratory scientists to appreciate the potential applications of their research and the practical issues involved in translating it to clinical practice. For this second edition, all the sections have been fully revised and updated, with new chapters addressing important topics that have gained prominence in recent years. New editors and authors have brought additional expertise to the project. For example, in the section on the Molecular and Cellular Basis of Cancer, there are new chapters on stem cells, epigenetics, and microRNAs, as well as chapters on the links between cancer and development and inflammation. In the Treatment section, the emphasis is now on multidisciplinary team management of different cancers, plus there are new chapters on clinical trial design, RNA interference and rational drug design. The page design and the quality of the diagrams has been improved, with all illustrations now in full colour. The glossary has been made more informative and easy to use.

Molecular Pathology of Breast Cancer

Molecular Pathology of Breast Cancer Book
Author : Sunil Badve,Yesim Gökmen-Polar
Publisher : Springer
Release : 2016-11-26
ISBN : 3319417614
Language : En, Es, Fr & De

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Book Description :

The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

Chondrosarcoma

Chondrosarcoma Book
Author : Francis J. Hornicek
Publisher : Springer Nature
Release : 2021-06-17
ISBN : 3030745724
Language : En, Es, Fr & De

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Book Description :

Chondrosarcoma, a rare cancer that develops from cartilage cells, occurs mainly in the bones but can also appear in the soft tissue of the pelvis, hip and shoulder. Unfortunately, these cancers are highly resistant to both chemotherapy and radiation, and no successful adjuvant therapies currently exist. As such, surgical treatment and resection remain the mainstays of management for patients with these tumors. This concise text is a comprehensive presentation of the current knowledge regarding the development, diagnosis and management of chondrosarcomas. Part I discusses pathology, molecular biology and imaging features of chondrosarcomas. The different types of skeletal and extraskeletal tumors are presented in detail in part II, including conventional and secondary tumors. Management approaches are outlined and described in part III - limb salvage surgery is the most common, and although less effective, radiation and chemotherapy are indicated in certain cases. Part IV examines the future of chondrosarcoma management and development of novel adjuvant therapies, as well as the relationship of this disease to similar types (e.g., chordoma). Bringing together the most up-to-date information on this rare cancer, Chondrosarcoma will be a valuable resource for orthopedic oncologists, researchers and all medical professionals treating these challenging tumors.

Molecular Biology and Pathology of Paediatric Cancer

Molecular Biology and Pathology of Paediatric Cancer Book
Author : Catherine J. Cullinane,Jeremy A. Squire
Publisher : Oxford Medical Publications
Release : 2003
ISBN : 0192630792
Language : En, Es, Fr & De

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Book Description :

There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focused on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behavior of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge. An international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.

Introduction to the Cellular and Molecular Biology of Cancer

Introduction to the Cellular and Molecular Biology of Cancer Book
Author : Leonard Maurice Franks,Natalie M. Teich
Publisher : Unknown
Release : 1997
ISBN : 9780198548546
Language : En, Es, Fr & De

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Book Description :

The third edition of this repected textbook has been extensively revised and updated by the authors and editors to achieve the same objectives as the two earlier editions -- to provide a relatively brief but comprehensive introduction to the initiation, development, and treatment of cancer.After an introduction describing the pathology and natural history of the disease, subsequent chapters survey particular areas of research, concentrating on the principles involved and recent developments. Each topic is reviewed authoritatively by acknowledged experts, in a way that will beunderstood by non-experts in the field.The chapters on epidemiology, genetic and chromosome changes, oncogenes, chemical and radiation carcinogenesis, growth factors, the biology of human leukaemia, and hormones and cancer have been rewritten and/or extensively revised and new developments resulting from the wide application of currenttechniques in cellular and molecular biology to the study of cancer are included. Other chapters have been revised and brought up to date, and new chapters are inclueed on cytokines and cancer, the molecular pathology of cancer, and cancer prevention and screening.Introduction to the Molecular and Celluar Bilogy of Cancer provides a general survey of the whole field of cancer as a basis for research and will serve as a valuable introduction to students and scientists new to the field.

Current Advances in Breast Cancer Research A Molecular Approach

Current Advances in Breast Cancer Research  A Molecular Approach Book
Author : Shankar Suman
Publisher : Unknown
Release : 2020-06
ISBN : 9781681087719
Language : En, Es, Fr & De

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Book Description :

Download Current Advances in Breast Cancer Research A Molecular Approach book written by Shankar Suman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology Book
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release : 2013-07-26
ISBN : 0124165907
Language : En, Es, Fr & De

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Book Description :

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

Ovarian Cancers

Ovarian Cancers Book
Author : Eric Pujade-Lauraine,Isabelle Ray-Coquard,Fabrice Lécuru
Publisher : Springer
Release : 2016-10-17
ISBN : 3319321102
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations. Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives. All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.

Endocrine Problems in Cancer

Endocrine Problems in Cancer Book
Author : Roland T. Jung,Karol Sikora
Publisher : Butterworth-Heinemann
Release : 2013-10-22
ISBN : 1483141330
Language : En, Es, Fr & De

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Book Description :

Endocrine Problems in Cancer: Molecular Basis and Clinical Management reviews endocrine and metabolic problems that can be attributed to the production of hormones by neoplastic cells, or by the interference of normal physiological systems by malignant cells. The book emphasizes the clinical aspects of the diagnosis and management of the endocrine problems in cancer. The text starts by studying the biological basis of cancer, its secreted products, and its relationship to the genetics of the cell and the individual. Cell metabolism and the individual clinical endocrine syndromes that occur are then discussed in the chapters that follow. Several chapters describe the physiological basis and the diagnostic approach to cancer. Finally, the clinical management of cancer is outlined in detail. Oncologists, endocrinologists, physicians, researchers, and medical students will find this text useful.

Bladder Cancer

Bladder Cancer Book
Author : Konstantinos N. Syrigos,Donald G. Skinner
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Bladder cancer represents a significant cause of morbidity and mortality worldwide and presents major problems in detection and management. This book will review comprehensively the current understanding of the biology, pathophysiology and urological oncology of the disease, looking at the problems and potential solutions. Fully illustrated including a colour plate section, it will include chapters on both the scientific and clinical principles, emphasizing molecular biology, pathogenesis, detection and experimental therapeutics, and focusing on new developments in clinical research. The contributors are international and well known in the area.

Management of Bladder Cancer

Management of Bladder Cancer Book
Author : Badrinath R. Konety,Sam S. Chang
Publisher : Springer
Release : 2014-11-17
ISBN : 1493918818
Language : En, Es, Fr & De

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Book Description :

Management of bladder cancer provides a single, comprehensive reference source that incorporates all the latest information regarding bladder cancer. The text covers epidemiology and natural history of bladder cancer as well as latest findings regarding the genetics and molecular biology of the disease. Diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer is discussed. The text incorporates chapters summarizing new findings regarding markers for the diagnosis of bladder cancer and new diagnostic techniques to enhance traditional methods such as cystoscopy. Risk stratified treatment of non muscle invasive bladder cancer including various approaches to intravesical therapy are reviewed. Current guideline based approaches to management and new data regarding diagnosis and prognostication of muscle invasive bladder cancer is analyzed and summarized. The application of chemotherapy for muscle invasive and advanced disease is discussed and the evidence based application of multimodality therapy highlighted. Finally, gaps in current knowledge and areas for future research are highlighted. Ongoing important clinical trials which could imminently yield significant new knowledge is discussed. Authored by experts in their respective fields, Management of Bladder Cancer will serve as a easy and complete reference source for clinicians, researchers, individuals in training, allied health professionals and medical students in the fields of Urology, Medical Oncology, Radiation Oncology, Basic and Translational Science and Epidemiology.

Ovarian Cancer

Ovarian Cancer Book
Author : Frank Sharp
Publisher : CRC Press
Release : 1998-06-01
ISBN : 9781899066230
Language : En, Es, Fr & De

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Book Description :

This reference details recent knowledge of ovarian cancer. Areas covered include: the genetic basis and molecular biology of ovarian cancer, analytic approaches to diagnosis and management, experimental therapeutics - gene therapy, methodology for dose intensification, new drugs, and quality of life and ethical issues.

Management of Castration Resistant Prostate Cancer

Management of Castration Resistant Prostate Cancer Book
Author : Fred Saad,Mario A. Eisenberger
Publisher : Springer
Release : 2014-08-20
ISBN : 1493911767
Language : En, Es, Fr & De

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Book Description :

This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine. As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.

Esophageal Cancer

Esophageal Cancer Book
Author : Nabil F. Saba,Bassel F. El-Rayes
Publisher : Springer
Release : 2015-08-12
ISBN : 3319200682
Language : En, Es, Fr & De

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Book Description :

​This book reviews the recent progress made in the prevention, diagnosis, and treatment of esophageal cancer. Epidemiology, molecular biology, pathology, staging, and prognosis are first discussed. The radiologic assessment of esophageal cancer and the role of endoscopy in diagnosis, staging, and management are then described. The principles of surgical resection, radiation therapy, and systemic chemotherapy for esophageal cancer are explained, and particular attention is paid to the multidisciplinary management of early-stage cervical, thoracic, distal, and junctional tumors. Up-to-date information is also provided on the treatment of metastatic and recurrent disease and on approaches that may affect future care, such as chemoprevention. Esophageal cancer remains one of the least studied cancers although it accounts for more than 400,000 deaths across the globe each year. The majority of esophageal cancers worldwide are squamous cell carcinomas, yet in the past few decades major epidemiologic changes have occurred affecting the incidence of adenocarcinomas in Western countries. Despite the advances in surgical and non-surgical therapies, overall survival has not changed significantly. It is hoped that Esophageal Cancer: Prevention, Diagnosis and Therapy will assist specialists from a variety of disciplines, including surgery, radiation therapy, gastroenterology, and medical oncology, in delivering optimal, up-to-date care to the benefit of patients.

Surgery for Gastrointestinal Cancer

Surgery for Gastrointestinal Cancer Book
Author : Harold J. Wanebo
Publisher : Lippincott Williams & Wilkins
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This text takes a multidisciplinary approach to the surgical management of gastronintestinal cancer. It begins with an introduction to cancer screening and detection of gastronintestinal cancer; recent advances in molecular biology and their potential applications in clinical management; hereditary factors; tumour markers; the role of nutrition in the outcome of cancer treatment; and an overview of endoscopic considerations, laparoscopic assessment and practical radiological issues. The work also presents approaches for the management of oesophageal, gastric, pancreatic, liver, bile duct and gallbladder, and lower gastrointestinal cancer.