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Molecular And Cellular Therapies For Motor Neuron Diseases

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Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases Book
Author : Nicholas M. Boulis,Deirdre O'Connor,Anthony Donsante
Publisher : Academic Press
Release : 2017-01-16
ISBN : 9780128022573
Language : En, Es, Fr & De

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Book Description :

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases Book
Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
Publisher : Academic Press
Release : 2017-01-18
ISBN : 0128025247
Language : En, Es, Fr & De

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Book Description :

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Motor Neuron Disease in Adults

Motor Neuron Disease in Adults Book
Author : Mark B. Bromberg
Publisher : Contemporary Neurology
Release : 2014-10-28
ISBN : 019978311X
Language : En, Es, Fr & De

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Book Description :

'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.

The Future of Pharmaceuticals

The Future of Pharmaceuticals Book
Author : Sarfaraz K. Niazi
Publisher : CRC Press
Release : 2022-03-01
ISBN : 1000458164
Language : En, Es, Fr & De

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Book Description :

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

Gene and Cell Therapy

Gene and Cell Therapy Book
Author : Nancy Smyth Templeton
Publisher : CRC Press
Release : 2003-12-17
ISBN : 0824758609
Language : En, Es, Fr & De

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Book Description :

This reference is completely revised and expanded to reflect the most critical studies, controversies, and technologies impacting the medical field, including probing research on lentivirus, gutless adenovirus, bacterial and baculovirus vectors, retargeted viral vectors, in vivo electroporation, in vitro and in vivo gene detection systems, and all inducible gene expression systems. Scrutinizing every tool, technology, and issue impacting the future of gene and cell research, it is specifically written and organized for laymen, scholars, and specialists from varying backgrounds and disciplines to understand the current status of gene and cell therapy and anticipate future developments in the field.

The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease Book
Author : Patrick A. Lewis,Jennifer E. Spillane
Publisher : Academic Press
Release : 2018-11-16
ISBN : 0128110708
Language : En, Es, Fr & De

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Book Description :

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

New Insights Into Adult Neurogenesis and Neurodegeneration Challenges for Brain Repair

New Insights Into Adult Neurogenesis and Neurodegeneration  Challenges for Brain Repair Book
Author : Jose Angel Morales-Garcia,Naoko Kaneko,Vicente Herranz-Pérez
Publisher : Frontiers Media SA
Release : 2022-04-04
ISBN : 2889749088
Language : En, Es, Fr & De

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Book Description :

Download New Insights Into Adult Neurogenesis and Neurodegeneration Challenges for Brain Repair book written by Jose Angel Morales-Garcia,Naoko Kaneko,Vicente Herranz-Pérez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

TDP 43 and Neurodegeneration

TDP 43 and Neurodegeneration Book
Author : Vijay Kumar,Manoj Kumar Jaiswal
Publisher : Academic Press
Release : 2021-10-23
ISBN : 0128204400
Language : En, Es, Fr & De

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Book Description :

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

Novel Aspects on Motor Neuron Disease

Novel Aspects on Motor Neuron Disease Book
Author : Humberto Foyaca Sibat,Lourdes de Fátima Ibañez-Valdés
Publisher : BoD – Books on Demand
Release : 2020-05-20
ISBN : 183880773X
Language : En, Es, Fr & De

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Book Description :

Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.

Motor Neuron Disease New Insights for the Healthcare Professional 2011 Edition

Motor Neuron Disease  New Insights for the Healthcare Professional  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464904421
Language : En, Es, Fr & De

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Book Description :

Motor Neuron Disease: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Motor Neuron Disease in a concise format. The editors have built Motor Neuron Disease: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Motor Neuron Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Motor Neuron Disease: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Inflammation the Common Link in Brain Pathologies

Inflammation  the Common Link in Brain Pathologies Book
Author : Nihar Jana,Anirban Basu,Prakash Narain Tandon
Publisher : Springer
Release : 2016-08-13
ISBN : 9811017115
Language : En, Es, Fr & De

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Book Description :

This unifying theme of this book-with sections on mechanisms of defense and neuropathogenesis, neurological diseases, infections of the nervous system, neuropharmacology, and novel therapies-is interactions of the immune and nervous systems. It also discusses the role of inflammation as a key mediator of different brain disorders. There have been significant scientific advances in the multidisciplinary field of neuroimmunology / neuroinflammation in the past decade, and this book, edited under the guidance of Professor P. N. Tandon, fosters communication between those who share an interest in this exciting area, including neuroscientists, immunologists, cell biologists, clinicians and neuropharmacologists.

Dementia and Motor Neuron Disease

Dementia and Motor Neuron Disease Book
Author : Michael Strong
Publisher : CRC Press
Release : 2006-07-27
ISBN : 9780415391665
Language : En, Es, Fr & De

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Book Description :

Dementia and Motor Neuron Disease is a single authoritative reference on the current understanding of frontotemporal dementia in amyotrophic lateral sclerosis (ALS). This comprehensive work is ideal for clinical and research groups focusing on dementia or ALS, as well as those working in the fields of neuroimaging and neuropsychology. Key topics covered include: • Frontotemporal dementia, including history, anatomy and impairment • Clinical phenomenology and treatment • Neuropathological, cognitive dysfunction and altered cognition spectrums • Neuroimaging • Molecular and cellular neuropathology • Genetics • Neurochemistry With contributions from international opinion leaders in dementia and motor neuron disease, this is a one-of-a-kind reference for established clinicians and researchers, as well as graduate students studying neurodegeneration.

Motor Neuron Disease Research Progress

Motor Neuron Disease Research Progress Book
Author : Raffaele L. Mancini
Publisher : Nova Publishers
Release : 2008
ISBN : 9781604561555
Language : En, Es, Fr & De

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Book Description :

The motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neurons control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region. Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech. This new book presents the latest research from around the globe.

Human Gene Therapy Current Opportunities and Future Trends

Human Gene Therapy  Current Opportunities and Future Trends Book
Author : G. M. Rubanyi,S. Ylä-Herttuala
Publisher : Springer Science & Business Media
Release : 2003-07-14
ISBN : 9783540004134
Language : En, Es, Fr & De

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Book Description :

Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases Book
Author : Michael S. Wolfe
Publisher : Academic Press
Release : 2018-03-29
ISBN : 0128113057
Language : En, Es, Fr & De

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Book Description :

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Translational Neuroscience

Translational Neuroscience Book
Author : Mark H. Tuszynski
Publisher : Springer
Release : 2018-04-08
ISBN : 9781493979424
Language : En, Es, Fr & De

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Book Description :

Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.

Regenerative Medicine and Cell Therapy

Regenerative Medicine and Cell Therapy Book
Author : Hossein Baharvand,Nasser Aghdami
Publisher : Springer Science & Business Media
Release : 2012-08-09
ISBN : 1627030980
Language : En, Es, Fr & De

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Book Description :

Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases. Regenerative Medicine and Cell Therapy discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors’ goal is that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Health Studies

Health Studies Book
Author : Jennie Naidoo,Jane Wills
Publisher : Springer Nature
Release : 2022-03-22
ISBN : 9811621497
Language : En, Es, Fr & De

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Book Description :

This new edition of Health Studies provides an authoritative and contemporary introduction to the study of health. With chapters including epidemiology, psychology, human and environmental geography, and anthropology, it is the only book to explore in one volume all of the core disciplines that contribute to understanding health. It illustrates how the complexity of health problems such as obesity should be viewed with an interdisciplinary perspective. Each chapter explains the disciplinary approach and then its theoretical and research approaches with examples. A highlight of this 4th edition is a new chapter on sports and exercise science providing another scientific chapter on physiology which is applied and will be of interest to all those thinking of employment in sports or leisure industry. The book is accessible and learner-centered and each chapter features: a connections feature that links the chapters together; learning tasks; questions for reflection and debate; examples to illustrate concepts, methodologies and to explore contemporary issues; a case study on obesity, food and diet. Comprehensive, accessible and written by leading experts in the different fields, this is the introductory text for all students of health studies.

Motor Neuron Disease New Insights for the Healthcare Professional 2013 Edition

Motor Neuron Disease  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481654217
Language : En, Es, Fr & De

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Book Description :

Motor Neuron Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Diagnosis and Screening in a concise format. The editors have built Motor Neuron Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Motor Neuron Disease: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research Book
Author : Anonim
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.