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Molecular Advancements In Tropical Diseases Drug Discovery

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Molecular Advancements in Tropical Diseases Drug Discovery

Molecular Advancements in Tropical Diseases Drug Discovery Book
Author : Gauri Misra,Vijay Kumar Srivastava
Publisher : Academic Press
Release : 2020-06
ISBN : 0128212020
Language : En, Es, Fr & De

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Book Description :

Molecular Advancements in Tropical Diseases Drug Discovery presents in-depth knowledge relating to the detection of infection, epidemiology, drugs against various tropical diseases, new target sites for drug discovery and multidrug resistance issues using bioinformatics tools and approaches. The book's chapters are written by experts in their respective fields so that each disease is covered in a rational manner and with a solid foundation on existing facts and prospective research ideas.

Molecular Advancements in Tropical Diseases Drug Discovery

Molecular Advancements in Tropical Diseases Drug Discovery Book
Author : Gauri Misra,Vijay Kumar Srivastava
Publisher : Academic Press
Release : 2020-05-12
ISBN : 0128213973
Language : En, Es, Fr & De

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Book Description :

Molecular Advancements in Tropical Diseases Drug Discovery presents in-depth knowledge relating to the detection of infection, epidemiology, drugs against various tropical diseases, new target sites for drug discovery and multidrug resistance issues using bioinformatics tools and approaches. The book's chapters are written by experts in their respective fields so that each disease is covered in a rational manner and with a solid foundation on existing facts and prospective research ideas. Updates knowledge about tropical diseases with recent advancements in the field Presents an overview of new research covering detection, infection, epidemiology and risk factors of the most common tropical diseases using bioinformatics tools Encompasses a detailed description of developments in drug discovery, new drugs and their molecular mechanisms of action

Medicinal Chemistry of Neglected and Tropical Diseases

Medicinal Chemistry of Neglected and Tropical Diseases Book
Author : Venkatesan Jayaprakash,Daniele Castagnolo,Yusuf Özkay
Publisher : CRC Press
Release : 2019-07-30
ISBN : 1351011634
Language : En, Es, Fr & De

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Book Description :

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.

Repurposing of Human Tyrosine Kinase Inhibitors for Neglected Diseases

Repurposing of Human Tyrosine Kinase Inhibitors for Neglected Diseases Book
Author : Uma Swaminathan
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

*Chapter 1: Neglected tropical disease, Chagas disease and target repurposing approach* The term "Neglected Tropical Diseases" (NTDs) most commonly refers to a group of parasitic and bacterial infectious disease affecting more than one billion people globally. There are 13 core diseases in the NTD group that are widespread across the countries from sub-Saharan Africa, Asia and to Latin America. These diseases primarily occur in rural areas, urban slums or conflict zones and affect 2.7 billion people who live on less than $2 per day, causing considerable morbidity and mortality. NTDs cause severe impact on physical and cognitive development, long-term illness, impaired childhood growth and development, adverse outcomes of pregnancy and trap the poor population in a cycle of poverty and disease. Many of these diseases are neglected at the global and local level by the government and private sector owing to the poor return of drug discovery research costs. Also, the emerging resistance to the current therapies can add more burdens to the poor nations The focus of this thesis is upon finding new leads for targeting protozoan parasite "Trypanosoma cruzi", responsible for Chagas disease (CD) by using Target repurposing approach. CD affects nearly 8 million people in Latin America and increasing number of cases reported across Europe and United States. Only two FDA approved drugs are currently available for treating CD. Target repurposing approach is a viable strategy to reduce the time and expense of discovering new therapeutic molecules. In this approach a molecular target in the parasites are matched with homologous human targets that has been previously pursued for drug discovery. We can utilize this knowledge of "druggable" targets in one organism to pursue new potential drug targets in the parasites. *Chapters 2 & 3: Scaffold replacements and head group truncation using in silico models* Our lab has applied target repurposing approach to identify several novel leads against protozoan parasites responsible for causing CD, human African sleeping sickness, leishmaniasis and malaria. Kinases are an extensively pursued class of drug targets to treat several diseases like cancer, immunological and neurological disorders, inflammation and infectious diseases. Lapatinib, an FDA approved dual tyrosine kinase inhibitor (EGFR/HER2) drug for treating breast cancer was repurposed for its anti-trypanosomal properties. Extensive SAR studies of lapatinib analogs led to sub-micromolar potent compound 1.25 (Figure 1.9) against the parasite "T. brucei". Hypothesizing that other parasites express similar kinase pathways, these libraries of compound were screened against other related parasites, which resulted in several lead compounds of micromolar potency. Encouraged by these results, we advanced our work to a scaffold replacement strategy. This resulted in the discovery of a potent lead 2.25b (Figure 2.6) with 0.09 μM activity against "T. cruzi". Despite having a good efficacy, the lead compound failed in the in vivo animal studies due to poor physicochemical properties. In an attempt to improve the physicochemical properties, we adopted a head group replacement strategy for the lead compound based on molecular modelling and virtual screening tools. The concept of ligand efficiency (LE) and lipophilic ligand efficiency (LLE/LiPE) were introduced with an aim to identify new leads. Finally, an attempt was made to establish a possible structure activity relationship (SAR) from the screening data of all the library series. *Chapter 4: Future directions* Final chapter summarizes the results of this thesis and provides the futuristic plan for the advancement of the current work to identify potent leads for Chagas disease.

Current Advances in Ecological Environmental Sciences

Current Advances in Ecological   Environmental Sciences Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Current Advances in Ecological Environmental Sciences book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

National Directory of Corporate Giving

National Directory of Corporate Giving Book
Author : Anonim
Publisher : Foundation Center
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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ASM News

ASM News Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Government Research Directory

Government Research Directory Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Awards Honors and Prizes

Awards  Honors and Prizes Book
Author : Gale Group
Publisher : Gale Cengage
Release : 2001-07-01
ISBN : 9780787652661
Language : En, Es, Fr & De

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Book Description :

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Annual report

Annual report Book
Author : Koninklijk Instituut voor de Tropen
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Government Reports Announcements Index

Government Reports Announcements   Index Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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International Research Centers Directory

International Research Centers Directory Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"A world guide to government, university, independent nonprofit, and commercial research and development centers, institutes, laboratories, bureaus, test facilities, experiment stations, and data collection and analysis centers, as well as foundations, councils and other organizations which support research," [1992/93-].

Research Centers Directory

Research Centers Directory Book
Author : Anonim
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Research institutes, foundations, centers, bureaus, laboratories, experiment stations, and other similar nonprofit facilities, organizations, and activities in the United States and Canada. Entry gives identifying and descriptive information of staff and work. Institutional, research centers, and subject indexes. 5th ed., 5491 entries; 6th ed., 6268 entries.

Directory of Research Grants

Directory of Research Grants Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Medical Sciences International Who s who

Medical Sciences International Who s who Book
Author : Informa Healthcare
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Medical Sciences International Who s who book written by Informa Healthcare, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

U S Government Research Development Reports

U S  Government Research   Development Reports Book
Author : Anonim
Publisher : Unknown
Release : 1965-04-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Current Advances in Protein Biochemistry

Current Advances in Protein Biochemistry Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Fulltext Sources Online

Fulltext Sources Online Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 9781573872799
Language : En, Es, Fr & De

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Current Advances in Applied Microbiology Biotechnology

Current Advances in Applied Microbiology   Biotechnology Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Maximizing the Investment

Maximizing the Investment Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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