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Modern Computational Approaches To Traditional Chinese Medicine

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Modern Computational Approaches to Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine Book
Author : Zhaohui Wu,Huajun Chen,Xiaohong Jiang
Publisher : Elsevier
Release : 2012-07-16
ISBN : 0123985102
Language : En, Es, Fr & De

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Book Description :

Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM's independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Modern Computational Approaches to Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine Book
Author : Zhaohui Wu,Huajun Chen,Xiaohong Jiang
Publisher : Elsevier
Release : 2012-10-22
ISBN : 0123985196
Language : En, Es, Fr & De

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Book Description :

Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM’s independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Frontiers in Computational Chemistry

Frontiers in Computational Chemistry Book
Author : Zaheer Ul-Haq
Publisher : Bentham Science Publishers
Release : 2022-09-08
ISBN : 9789815036862
Language : En, Es, Fr & De

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Book Description :

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The sixth volume of this series features these six different perspectives on the application of computational chemistry in rational drug design: 1.Computer-aided molecular design in computational chemistry 2.The role of ensemble conformational sampling using molecular docking & dynamics in drug discovery 3.Molecular dynamics applied to discover antiviral agents 4.Pharmacophore modeling approach in drug discovery against the tropical infectious disease malaria 5.Advances in computational network pharmacology for Traditional Chinese Medicine (TCM) research 6.Progress in electronic-structure based computational methods: from small molecules to large molecular systems of biological significance

Computational Toxicology

Computational Toxicology Book
Author : Sean Ekins
Publisher : John Wiley & Sons
Release : 2018-02-13
ISBN : 111928256X
Language : En, Es, Fr & De

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Book Description :

A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. Provides a perspective of what is currently achievable with computational toxicology and a view to future developments Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data

Network Pharmacology

Network Pharmacology Book
Author : Shao Li
Publisher : Springer Nature
Release : 2021-09-29
ISBN : 9811607532
Language : En, Es, Fr & De

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Book Description :

This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.

Know Your Remedies

Know Your Remedies Book
Author : He Bian
Publisher : Princeton University Press
Release : 2022-03-08
ISBN : 0691200130
Language : En, Es, Fr & De

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Book Description :

"Traditional Chinese medicine has been practiced in various forms for more than a thousand years. Practitioners may heal patients with herbal remedies, acupuncture, massage, exercise, and modified diets. Even today, herbal medicines are of particular importance; Chinese pharmacies containing a vast array of remedies can be found in cities and towns the world over. This book is an interdisciplinary and cultural history of the concept of "pharmacy," both the drugs themselves and the trade in medicine, during the Ming and Qing dynasties of early modern China. This was a time of change for traditional Chinese medicine and for Chinese science as a whole. Many historians have argued that sixteenth-century China was a high point of scientific inquiry, followed by a period of intellectual decline. Though political and intellectual shifts led to a crisis of authority over pharmaceutical knowledge in the sixteenth through eighteenth centuries, Bian argues that this period of supposed intellectual decline was in fact characterized by numerous efforts to further refine and spread the pharmacological knowledge amassed in the Ming dynasty. She draws on a wide range of primary sources, but particularly through the study of bencao (pronounced "pen ts'ao"), a genre of encyclopaedic works, often called matteria medica or pharmacopoeia in the West, that collect information on medicinal substances. As the early modern Chinese Empire expanded and print culture became more widespread, the pursuit of medical remedies became a significant commercial enterprise. The author connects theory and practice of pharmacy during the Ming and Qing dynasties to broader developments in intellectual history, book culture, commerce, and taxation"--

Traditional Chinese Medicine

Traditional Chinese Medicine Book
Author : James D Adams,Eric J Lien
Publisher : Royal Society of Chemistry
Release : 2015-10-20
ISBN : 1782624937
Language : En, Es, Fr & De

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Book Description :

Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex mixtures of plant extracts, rather than single purified drugs. The combination of different extracts is based on yin, yang and chi theories, which are often poorly understood in the West. Yin and yang are known to be the balance of agonists and antagonists, whereas chi derives from signalling processes in the body and regulates bodily functions. Traditional Chinese medical practitioners understand that yin, yang and chi constantly interact in the body to maintain health. Western medical practitioners understand how to use agonists and antagonists and how to modify signalling processes, but generally do not accept the use of complex plant extracts to perform these functions. Aimed at medical scientists, and including detailed explanations of the theories behind the science, this text may help researchers to understand, and communicate more effectively with, Chinese medical practitioners and will lead to greater acceptance of traditional medications in the West. Presenting a clear rationale for the use of traditional Chinese medications in Western medical facilities, it enables scientists to find new directions in experimental design and encourage examination of these useful, but often poorly understood, preparations in clinical trials.

 Book
Author : Anonim
Publisher : Unknown
Release : 2023-02-06
ISBN : 0190275332
Language : En, Es, Fr & De

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Book Description :

Download book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

On Their Own Terms

On Their Own Terms Book
Author : Benjamin A. ELMAN
Publisher : Harvard University Press
Release : 2009-06-30
ISBN : 0674036476
Language : En, Es, Fr & De

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Book Description :

Since the middle of the nineteenth century, imperial reformers, early Republicans, Guomindang party cadres, and Chinese Communists have all prioritized science and technology. In this book, Elman gives a nuanced account of the ways in which native Chinese science evolved over four centuries, under the influence of both Jesuit and Protestant missionaries. In the end, he argues, the Chinese produced modern science on their own terms.

Approaching Complex Diseases

Approaching Complex Diseases Book
Author : Mariano Bizzarri
Publisher : Springer Nature
Release : 2020-04-17
ISBN : 3030328570
Language : En, Es, Fr & De

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Book Description :

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Serum Pharmacochemistry of Traditional Chinese Medicine

Serum Pharmacochemistry of Traditional Chinese Medicine Book
Author : Xijun Wang,Aihua Zhang,Hui Sun
Publisher : Academic Press
Release : 2016-12-27
ISBN : 0128111488
Language : En, Es, Fr & De

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Book Description :

Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development. Provides a valuable guide for practitioners of serum pharmacochemistry of Traditional Chinese Medicine, along with insights to its current use and future applications Edited and written by leading scientists at the forefront of this research Presents well written chapters that include an introduction, description of the method, and identification of chemical constituents, with applications and references to the latest research and literature

Traditional Chinese Medicines Molecular Structures Natural Sources and Applications

Traditional Chinese Medicines  Molecular Structures  Natural Sources and Applications Book
Author : Xinjian Yan,Guirong Xie,Jiaju Zhou,G. W. A. Milne
Publisher : Routledge
Release : 2018-10-03
ISBN : 1351758098
Language : En, Es, Fr & De

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Book Description :

This title was first published in 2003. In laboratories around the world the active principles in traditional herbal medicines are being isolated and characterized. A systematic effort at the Chinese Academy of Sciences is underway to identify the structure-activity relationships that result from the link between chemistry and medicine that is permitted by this data. This book, which provides the only systematic English-language description of the chemical structures and pharmacological effects of compounds active in traditional Chinese medicines (TCMs), is now in its second edition. The new edition provides English-language monographs on over 9000 chemicals isolated from nearly 4000 natural sources used in Chinese medicine and features the addition of in-depth bioactivity data for many of the compounds. Effects and indications of the medicines are included. Extensive indexing permits cross-referencing among English, Chinese and Latin names for natural medicinal sources, effects and indications, and the chemical components of the medicines. The second edition of Traditional Chinese Medicines includes 2300 new compounds, 2400 additional plant sources, more CAS Registry Numbers, and more pharmacological data. The structure of the book has been extensively reorganised to make cross referencing the data much simpler. This new edition is therefore a substantial improvement on the first edition of this important reference on the structural chemistry of traditional Chinese medicines.

Chinmedomics

Chinmedomics Book
Author : Xijun Wang,Aihua Zhang,Hui Sun
Publisher : Academic Press
Release : 2015-07-15
ISBN : 0128031182
Language : En, Es, Fr & De

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Book Description :

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications Edited by the leading experts of research related to Chinmedomics

Chinese Drugs of Plant Origin

Chinese Drugs of Plant Origin Book
Author : Weici Tang,Gerhard Eisenbrand
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3642737390
Language : En, Es, Fr & De

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Book Description :

Traditional Chinese medicine has been used for thousands of years by a large population. It is currently still serving many of the health needs of the Chinese people; and still enjoying their confi dence it is practised in China in parallel with modern Western medical treatment. In addition to scientific organisations dedi cated to modern Western medicine, e. g. the Chinese Academy of Medical Sciences and various medical schools, a series of parallel institutions have been established in China to promote traditional Chinese medicine, such as the Academy of Traditional Chinese Medicine and training institutions. Almost all hospitals in China have a department of traditional medicine. Furthermore, a large number of scientific journals are dedicated to traditional Chinese medicine, covering both experimental and clinical investigations. Medicinal materials constitute a key topic in the treatment of disease according to traditional Chinese medicine. The Chinese Pharmacopoeia (1985 edition) is therefore divided into two sepa rate volumes, Volume I containing traditional Chinese medicinal materials and preparations and Volume II containing pharmaceu tics of Western medicine. The oldest Chinese review of medicinal materials, Shennong Bencao Jing (100-200 A. D. ), covered 365 herbal drugs. The clas sic compilation in this field, Bencao Gangmu (Compendium of Materia Medica), was published in 1578 by Li Shi-zhen and recorded as many as 1898 crude drugs of plant, animal and min eral origin.

Systems Biology for Traditional Chinese Medicine

Systems Biology for Traditional Chinese Medicine Book
Author : Guoan Luo,Yiming Wang,Qionglin Liang,Qingfei Liu
Publisher : John Wiley & Sons
Release : 2012-07-03
ISBN : 0470637978
Language : En, Es, Fr & De

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Book Description :

The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

Systems Biology and Its Application in TCM Formulas Research

Systems Biology and Its Application in TCM Formulas Research Book
Author : Wei-Dong Zhang
Publisher : Academic Press
Release : 2018-02-16
ISBN : 0128127457
Language : En, Es, Fr & De

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Book Description :

Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine. Explains, in detail, the Shexiang Baoxin Pill (SBP), a TCM formula efficiently applied in the treatment of cardiovascular diseases Presents TCM formulas from perspectives of systems biology, basic chemical material groups, modern pharmacology and network biology Offers an overview on biology, modern chemistry and information technology as applied in Systems Biology research

Pursuing The Elixir Of Life Chinese Medicine For Health

Pursuing The Elixir Of Life  Chinese Medicine For Health Book
Author : Hong Hai,Wee Karen Yan Ling
Publisher : World Scientific
Release : 2016-12-15
ISBN : 981320706X
Language : En, Es, Fr & De

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Book Description :

Since time immemorial Man has pursued the elusive elixir of life. The wisdom of ancient Chinese medicine declared immortality unattainable, but offered the elixir of longevity through lifestyle, diet, the judicious use of herbal tonics and the practice of subtle but powerful exercises of qigong and taijiquan. This concise volume explains in modern scientific language the principles of ancient Chinese methods of health and the practice of yangsheng 养生 or life cultivation. Natural holistic solutions to health issues and the intricacies of Chinese diagnosis and therapies are brilliantly exposed, complete with detailed descriptions of herbs, acupuncture and tuina. Discover appetizing recipes for soups, porridges and teas that give you that healthy glow and nourish your body and soul. Based on a series of popular lectures by the authors, this book opens a new chapter in your pursuit of a long and fulfilling life. It is also excellent preparation for more advanced studies in Chinese medicine.

Integrative Dermatology

Integrative Dermatology Book
Author : Robert A. Norman,Philip D. Shenefelt,Reena N. Rupani
Publisher : Oxford University Press
Release : 2014-04
ISBN : 0199907927
Language : En, Es, Fr & De

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Book Description :

This title combines conventional treatment options with time tested alternative treatment options for skin disorders. By integrating the best of Western and Eastern medicine, it aims to broaden the armamentarium of clinicians treating skin diseases.

Traditional and Complementary Medicine

Traditional and Complementary Medicine Book
Author : Cengiz Mordeniz
Publisher : BoD – Books on Demand
Release : 2019-12-11
ISBN : 1789841836
Language : En, Es, Fr & De

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Book Description :

Modern medicine has reached a point where the patient is not treated as a biopsychosocial-spiritual being but rather is seen as a virtual identity consisting of laboratory findings and images. More focus is placed on relieving the symptoms instead of curing the disease. Mostly, patients are turned into lifetime medication-dependent individuals. New medicines are needed to overcome the side effects, complications, resistance, and intolerance caused by pharmacological and interventional therapies. In hopes of drug-free and painless alternative treatments with fewer complications, there has been a trend to revisit traditional methods that have been dismissed by modern medicine. Traditional medicine has to be reevaluated with modern scientific methods to complement and integrate with evidence-based modern medicine.