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Modern Applications of Cycloaddition Chemistry

Modern Applications of Cycloaddition Chemistry Book
Author : Paolo Quadrelli
Publisher : Elsevier
Release : 2019-03-20
ISBN : 0128152745
Language : En, Es, Fr & De

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Book Description :

Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes Contains the most up-to-date review of the use of pericyclic reactions in drug delivery Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area

Current Topics in Chirality

Current Topics in Chirality Book
Author : Takashiro Akitsu
Publisher : BoD – Books on Demand
Release : 2021-09-01
ISBN : 1839689536
Language : En, Es, Fr & De

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Book Description :

Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Synthetic Applications of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products

Synthetic Applications of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products Book
Author : Albert Padwa,William H. Pearson
Publisher : John Wiley & Sons
Release : 2003-04-14
ISBN : 0471461369
Language : En, Es, Fr & De

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Book Description :

Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products updates the popular 1984 edition, featuring the advances made over the past twenty years and focusing on synthetic applications.

Modern Acetylene Chemistry

Modern Acetylene Chemistry Book
Author : Peter J. Stang,François Diederich
Publisher : John Wiley & Sons
Release : 2008-09-26
ISBN : 3527615261
Language : En, Es, Fr & De

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Book Description :

This comprehensive handbook presents the full potential of modern acetylene chemistry, from organic synthesis through materials science to bioorganic chemistry. K. Houk, H. Hopf, P. Stang, K. M. Nicholas, N. Schore, M. Regitz, K. C. Nicolaou, R. Gleiter, L. Scott, R. Grubbs, H. Iwamura, J. Moore, and F. Diederich - internationally renowned authors introduce the reader, in a didactically skilful manner, to the state-of-the-art in alkyne chemistry. Emphasis is placed on presenting carefully selected and instructive examples as well as essential references to the original literature. Special benefits: Each chapter is rounded off by useful experimental procedures.

Modern Aryne Chemistry

Modern Aryne Chemistry Book
Author : Akkattu T. Biju
Publisher : John Wiley & Sons
Release : 2021-07-26
ISBN : 3527346465
Language : En, Es, Fr & De

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Book Description :

A groundbreaking book to offer a a comprehensive account of important reactions involving arynes Modern Aryne Chemistry is the first book on the market to offer a conceptual framework to the reactions related to arynes. It also provides a systematic introduction to the cycloaddition reactions, insertion reactions and transition-metal-catalyzed transformations of arynes. The author, a noted expert on the topic, highlights a novel strategy for carbon-carbon and carbon-heteroatom bond construction using arynes. The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes. This important book: Presents a one-of-kind comprehensive guide to arynes reactions Offers a proven approach to the synthesis of natural product and polymers Reviews the most recent developments in the carbon-carbon and carbon-heteroatom bond-forming reactions involving arynes Written for organic, pharmaceutical, medicinal, natural products, and catalytic Chemists, Modern Aryne Chemistry offers a comprehensive review of the fundamentals of reactions related to arynes and the most recent developments in the field.

Modern Organonickel Chemistry

Modern Organonickel Chemistry Book
Author : Yoshinao Tamaru
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604235
Language : En, Es, Fr & De

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Book Description :

Organonickel chemistry plays an increasingly important role in organic chemistry, and interest in this topic is now just as keen as in organopalladium chemistry. While there are numerous, very successful books on the latter, a book specializing in organonickel chemistry is long overdue. Edited by one of the leading experts in the field, this volume covers the many discoveries made over the past 30 years, and previously scattered throughout the literature. Active researchers working at the forefront of organonickel chemistry provide a comprehensive review of the topic, including cross-coupling reactions, asymmetric synthesis and heterogeneous catalysis reaction types. A must-have for both organometallic chemists and synthetic organic chemists.

Modern Rhodium Catalyzed Organic Reactions

Modern Rhodium Catalyzed Organic Reactions Book
Author : P. Andrew Evans
Publisher : John Wiley & Sons
Release : 2005-03-04
ISBN : 9783527306831
Language : En, Es, Fr & De

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Book Description :

Rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations, with quite often-unique selectivity. Hydrogenation, C-H activation, allylic substitution, and numerous other reactions are catalyzed by this metal, which presumably accounts for the dramatic increase in the number of articles that have recently emerged on the topic. P. Andrew Evans, the editor of this much-needed book, has assembled an internationally renowned team to present the first comprehensive coverage of this important area. The book features contributions from leaders in the field of rhodium-catalyzed reactions, and thereby provides a detailed account of the most current developments, including: Rhodium-Catalyzed Asymmetric Hydrogenation (Zhang) Rhodium-Catalyzed Hydroborations and Related Reactions (Brown) Rhodium-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron Deficient Olefins (Hayashi) Recent Advances in Rhodium(I)-Catalyzed Asymmetric Olefin Isomerization and Hydroacylation Reactions (Fu) Stereoselective Rhodium(I)-Catalyzed Hydroformylation and Silylformylation Reactions and Their Application to Organic Synthesis (Leighton) Carbon-Carbon Bond-Forming Reactions Starting from Rh-H or Rh-Si Species (Matsuda) Rhodium(I)-Catalyzed Cycloisomerization and Cyclotrimerization Reactions (Ojima) The Rhodium(I)-Catalyzed Alder-ene Reaction (Brummond) Rhodium-Catalyzed Nucleophilic Ring Cleaving Reactions of Allylic Ethers and Amines (Fagnou) Rhodium(I)-Catalyzed Allylic Substitution Reactions and their Applications to Target Directed Synthesis (Evans) Rhodium(I)-Catalyzed [2+2+1] and [4+1] Carbocyclization Reactions (Jeong) Rhodium(I)-Catalyzed [4+2] and [4+2+2] Carbocyclizations (Robinson) Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis (Wender) Rhodium(II)-Stabilized Carbenoids Containing both Donor and Acceptor Substituents (Davies) Chiral Dirhodium(II)Carboxamidates for Asymmetric Cyclopropanation and Carbon-Hydrogen Insertion Reactions (Doyle) Cyclopentane Construction by Rhodium(II)-Mediated Intramolecular C-H Insertion (Taber) Rhodium(II)-Catalyzed Oxidative Amination (DuBois) Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)-Catalyzed Carbene-Transfer (West) Rhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions (Austin) "Modern Rhodium-Catalyzed Organic Reactions" is an essential reference text for researchers at all levels in the general area of organic chemistry. This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at pharmaceutical/agrochemical companies.

Methods and Applications of Cycloaddition Reactions in Organic Syntheses

Methods and Applications of Cycloaddition Reactions in Organic Syntheses Book
Author : Nagatoshi Nishiwaki
Publisher : John Wiley & Sons
Release : 2013-12-17
ISBN : 1118778200
Language : En, Es, Fr & De

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Book Description :

Advanced tools for developing new functional materials andapplications in chemical research, pharmaceuticals, and materialsscience Cycloadditions are among the most useful tools for organicchemists, enabling them to build carbocyclic and heterocyclicstructures. These structures can then be used to develop a broadrange of functional materials, including pharmaceuticals,agrochemicals, dyes, and optics. With contributions from aninternational team of leading experts and pioneers in cycloadditionchemistry, this book brings together and reviews recent advances,trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions inOrganic Syntheses focuses on two component cycloadditions, withchapters covering such topics as: N1 unit transfer reaction to C–C doublebonds [3+2] Cycloaddition of α, β-unsaturatedmetal-carbene complexes Formal [3+3] cycloaddition approach to natural productsynthesis Development of new methods for the construction of heterocyclesbased on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of largeπ-conjugated compounds Transition metal-catalyzed or mediated [5+1]cycloadditions Readers will learn methods for seamlessly executing importantreactions such as Diels-Alder and stereoselective dipolar reactionsin order to fabricate heterocyclic compounds, natural products, andfunctional molecules. The book not only features cutting-edgetopics, but also important background information, such as thecontributors’ process for developing new methodologies, tohelp novices become fully adept in the field. References at the endof each chapter lead to original research papers and reviews forfacilitating further investigation of individual topics. Covering the state of the science and technology, Methods andApplications of Cycloaddition Reactions in Organic Synthesesenables synthetic organic chemists to advance their research anddevelop new functional materials and applications in chemicalresearch, pharmaceuticals, and materials science.

Click Chemistry and Applications

Click Chemistry and Applications Book
Author : Adel S. El-Azab,Alaa A. -M. Abdel-Aziz
Publisher : LAP Lambert Academic Publishing
Release : 2014-06-13
ISBN : 9783659555466
Language : En, Es, Fr & De

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Book Description :

Click Chemistry 'CC' are Cu(I) catalyzed 1,3-dipolar [3]2] cycloaddition between azides and alkynes [CuAAC]. The versatility of CuAAC or 'click reaction' seem endless with the discovery and invention of new chemical transformations which meet 'click' status, the future looks bright for CC. Recently, Click chemistry has received considerable attention as powerful modular synthesis approach, which has found numerous applications in many areas of modern organic chemistry, drug discovery, radiopharmaceutical sciences and material science. The great success of CC encouraged researchers to develop alternative "spring-loaded" chemical reactions for use in different fields of chemistry. Initially, CuAAC was the only click reaction. In recent years, metal-free [3]2] cycloaddition reactions, Diels-Alder reactions, and thiol-alkene radical addition reactions have come to the fore as click reactions because of their simple synthetic procedures and high yields. Also, these metal-free reactions have wide applicability and are physiologically compatible. Alternative CC expand the opportunities for synthesizing small organic compounds well as tailor-made macromolecules and bioconjugates.

Modern Cyclophane Chemistry

Modern Cyclophane Chemistry Book
Author : Rolf Gleiter,Henning Hopf
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604634
Language : En, Es, Fr & De

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Book Description :

Here, the editors Rolf Gleiter and Henning Hopf present an excellent overview of all the important aspects and latest results in cyclophane chemistry. Clearly structured and covering the entire range, the book introduces readers to the most recent research in the field. Twenty chapters, written by well-known scientists, cover in particular: - synthesis of carbo- and heterocyclic cyclophanes and metallocenophanes, - structural and spectroscopic properties of cyclophanes, - current and future applications in synthesis and material science, - novel reactions of cyclophanes, - use of cyclophanes as building blocks in supramolecular chemistry for this fascinating class of compounds. Thus, this is not only an extremely valuable source of information for synthetic organic chemists, but also a ready reference for scientists working in related fields of arene chemistry, stereoselective synthesis, material science, and bioorganic chemistry.

Comprehensive Natural Products III

Comprehensive Natural Products III Book
Author : Anonim
Publisher : Elsevier
Release : 2020-07-22
ISBN : 0081026919
Language : En, Es, Fr & De

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Book Description :

Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Modern Fluoroorganic Chemistry

Modern Fluoroorganic Chemistry Book
Author : Peer Kirsch
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604197
Language : En, Es, Fr & De

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Book Description :

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides. This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

Modern Alkyne Chemistry

Modern Alkyne Chemistry Book
Author : Barry M. Trost,Chao-Jun Li
Publisher : John Wiley & Sons
Release : 2015-02-09
ISBN : 3527335056
Language : En, Es, Fr & De

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Book Description :

A comprehensive and up-to-date overview of alkyne chemistry, taking into account the progress made over the last two decades. The experienced editors are renowned world leaders in the field, while the list of contributors reads like a "Who's Who" of synthetic organic chemistry. The result is a valuable reference not only for organic chemists at universities and in the chemical industry, but also for biologists and material scientists involved in the modern synthesis of organic compounds and materials.

The Chemistry of Zirconacycles and 2 6 Diazasemibullvalenes

The Chemistry of Zirconacycles and 2 6 Diazasemibullvalenes Book
Author : Shaoguang Zhang
Publisher : Springer
Release : 2014-11-05
ISBN : 3662450216
Language : En, Es, Fr & De

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Book Description :

In this thesis, the author introduces two strategies used to construct various types of N-heterocycles, based on the chemistry of zirconacycles and 2,6-diazasemibullvalenes. In the first part, the author presents the development of multi-component cyclization of a zirconacyclobutene-silacyclobutene fused compound, nitriles and unsaturated compounds. These reactions provide synthetically useful methodology for various N-heterocycles such as 3-acyl pyrrole, pyrrolo[3,2-d]pyridazine and dihydropyrroloazepine, which are all difficult to synthesize by other means. The isolation and characterization of the key three-fused-ring Zr/Si-containing intermediates are also described in detail. These results show that the zirconacyclobutene-silacyclobutene fused compound behaves as a “chemical transformer” upon treatment with various substrates via the “coordination-induced skeleton rearrangement” mechanism. In the second part, the author demonstrates the synthesis and isolation of a series of 2,6-diazasemibullvalenes (NSBVs) from the reaction of 1,4-dilithio-1,3-dienes and nitriles, highlighting the significant progress made for the first time in this work: (1) determination of X-ray crystal structure of a substituted 2,6-diazasemibullvalene; (2) measurement of the activation barrier of its rapid intramolecular aza-Cope rearrangement in solution; (3) exploration of several reaction types of NSBV with diverse ring-expansion products and “bowl-shape” or “cage-shape” N-containing polycyclic skeletons; (4) demonstration of the localized structure as the predominant form and the homoaromatic delocalized structure as a minor component in the equilibrium using theoretical analysis. Based on well-founded results, this work sheds new light on this controversial topic.

CRC Handbook of Organic Photochemistry and Photobiology Third Edition Two Volume Set

CRC Handbook of Organic Photochemistry and Photobiology  Third Edition   Two Volume Set Book
Author : Axel Griesbeck,Michael Oelgemöller,Francesco Ghetti
Publisher : CRC Press
Release : 2019-04-05
ISBN : 1466561254
Language : En, Es, Fr & De

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Book Description :

The only combined organic photochemistry and photobiology handbookAs spectroscopic, synthetic and biological tools become more and more sophisticated, photochemistry and photobiology are merging-making interdisciplinary research essential. Following in the footsteps of its bestselling predecessors, the CRC Handbook of Organic Photochemistry and Pho

Diversity Oriented Synthesis

Diversity Oriented Synthesis Book
Author : Andrea Trabocchi
Publisher : John Wiley & Sons
Release : 2013-06-17
ISBN : 1118618149
Language : En, Es, Fr & De

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Book Description :

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology. Diversity-Oriented Synthesis begins with an introductorychapter that explores the basics, including a discussion of therelationship between diversity-oriented synthesis and classiccombinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of smallmolecules using diversity-oriented principles, includingpeptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis bydescribing chemical libraries Provides modern approaches to screening diversity-orientedsynthetic libraries, including high-throughput and high-contentscreening, small molecule microarrays, and smart screeningassays Presents the applications of diversity-oriented syntheticlibraries and small molecules in drug discovery and chemicalbiology, reporting the results of key studies and forecasting therole of diversity-oriented synthesis in future biomedicalresearch This book has been written and edited by leading internationalexperts in organic synthesis and its applications. Theircontributions are based on a thorough review of the currentliterature as well as their own firsthand experience developingsynthetic methods and applications. Clearly written and extensively referenced,Diversity-Oriented Synthesis introduces novices to thishighly promising field of research and serves as a springboard forexperts to advance their own research studies and develop newapplications.

Modern Aryne Chemistry

Modern Aryne Chemistry Book
Author : Akkattu T. Biju
Publisher : John Wiley & Sons
Release : 2021-05-19
ISBN : 3527823093
Language : En, Es, Fr & De

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Book Description :

A groundbreaking book to offer a a comprehensive account of important reactions involving arynes Modern Aryne Chemistry is the first book on the market to offer a conceptual framework to the reactions related to arynes. It also provides a systematic introduction to the cycloaddition reactions, insertion reactions and transition-metal-catalyzed transformations of arynes. The author, a noted expert on the topic, highlights a novel strategy for carbon-carbon and carbon-heteroatom bond construction using arynes. The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes. This important book: Presents a one-of-kind comprehensive guide to arynes reactions Offers a proven approach to the synthesis of natural product and polymers Reviews the most recent developments in the carbon-carbon and carbon-heteroatom bond-forming reactions involving arynes Written for organic, pharmaceutical, medicinal, natural products, and catalytic Chemists, Modern Aryne Chemistry offers a comprehensive review of the fundamentals of reactions related to arynes and the most recent developments in the field.

Organic Chemistry

Organic Chemistry Book
Author : Pierre Vogel,Kendall N. Houk
Publisher : John Wiley & Sons
Release : 2019-07-30
ISBN : 3527819258
Language : En, Es, Fr & De

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Book Description :

The know-how about reactivity, reaction mechanisms, thermodynamics and other basics in physical organic chemistry is the key for successful organic reactions. This textbook presents comprehensively this knowledge to the student and to the researcher, too. Includes Q&As.

Modern Physical Organic Chemistry

Modern Physical Organic Chemistry Book
Author : Eric V. Anslyn,Dennis A. Dougherty
Publisher : University Science Books
Release : 2006
ISBN : 9781891389313
Language : En, Es, Fr & De

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Book Description :

Making explicit the connections between physical organic chemistry and critical fields such as organometallic chemistry, materials chemistry, bioorganic chemistry and biochemistry, this book escorts the reader into an area that has been thoroughly updated in recent times.