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Models Of Seizures And Epilepsy

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Models of Seizures and Epilepsy

Models of Seizures and Epilepsy Book
Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
Publisher : Academic Press
Release : 2017-06-14
ISBN : 012804067X
Language : En, Es, Fr & De

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Book Description :

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Epilepsy

Epilepsy Book
Author : Jong Rho,Raman Sankar,Carl E. Stafstrom
Publisher : CRC Press
Release : 2010-06-18
ISBN : 1420085603
Language : En, Es, Fr & De

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Book Description :

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo

Epileptic Seizures and the EEG

Epileptic Seizures and the EEG Book
Author : Andrea Varsavsky,Iven Mareels,Mark Cook
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439812047
Language : En, Es, Fr & De

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Book Description :

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Seizures and Epilepsy

Seizures and Epilepsy Book
Author : Jerome Engel
Publisher : Oxford University Press
Release : 2013-01-31
ISBN : 019532854X
Language : En, Es, Fr & De

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Book Description :

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Epilepsy

Epilepsy Book
Author : Philip A. Schwartzkroin
Publisher : Cambridge University Press
Release : 1993-06-17
ISBN : 0521392985
Language : En, Es, Fr & De

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Book Description :

This book considers a number of major concepts and models in epilepsy research, to advance understanding of the basic mechanisms involved.

Jasper s Basic Mechanisms of the Epilepsies

Jasper s Basic Mechanisms of the Epilepsies Book
Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
Publisher : Oxford University Press
Release : 2012-06-01
ISBN : 0199842590
Language : En, Es, Fr & De

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Book Description :

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Introduction to Epilepsy

Introduction to Epilepsy Book
Author : Gonzalo Alarcón,Antonio Valentín
Publisher : Cambridge University Press
Release : 2012-04-26
ISBN : 0521691583
Language : En, Es, Fr & De

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Book Description :

Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Encyclopedia of Basic Epilepsy Research

Encyclopedia of Basic Epilepsy Research Book
Author : Anonim
Publisher : Academic Press
Release : 2009-05-27
ISBN : 0123739616
Language : En, Es, Fr & De

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Book Description :

As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Animal Models of Epilepsy

Animal Models of Epilepsy Book
Author : Scott C. Baraban
Publisher : Humana Press
Release : 2009-05-29
ISBN : 9781603272629
Language : En, Es, Fr & De

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Book Description :

In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

Computational Neuroscience in Epilepsy

Computational Neuroscience in Epilepsy Book
Author : Ivan Soltesz,Kevin Staley
Publisher : Academic Press
Release : 2011-09-02
ISBN : 9780080559537
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Astrocytes and Epilepsy

Astrocytes and Epilepsy Book
Author : Jacqueline A. Hubbard,Devin K. Binder
Publisher : Academic Press
Release : 2016-07-05
ISBN : 0128026243
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Atlas of Epilepsies

Atlas of Epilepsies Book
Author : S.R. Benbadis,R.G. Beran,A.T. Berg,J. Engel, Jr.,A.S. Galanopoulou,P.W. Kaplan,M. Koutroumanidis,S.L. Moshe,D.R. Nordli, Jr.,J.M. Serratosa,S.M. Sisodiya,W.O. Tatum,T. Valeta,A. Wilner
Publisher : Springer Science & Business Media
Release : 2010-09-20
ISBN : 1848821271
Language : En, Es, Fr & De

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Book Description :

Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.

Recent Advances in Predicting and Preventing Epileptic Seizures

Recent Advances in Predicting and Preventing Epileptic Seizures Book
Author : Ronald Tetzlaff,Christian E Elger,Klaus Lehnertz
Publisher : World Scientific
Release : 2013-08-28
ISBN : 9814525367
Language : En, Es, Fr & De

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Book Description :

This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational models of seizures and epilepsy. Furthermore the book covers recent developments of international databases and of parallel computing structures based on Cellular Nonlinear Networks that can play an important role in the realization of a portable seizure warning device. Contents:Epileptic Networks and Their Role for Seizure Prediction and Seizure Control:Transition Into and Out of a Focal Seizure (M de Curtis)Neuronal and Network Dynamics Preceding Experimental Seizures (P Jiruska, F Mormann and J G R Jefferys)Interictal EEG and Its Relevance for Seizure Prediction (A Schulze-Bonhage)Invasive Brain Stimulation in the Treatment of Epilepsy (M Sprengers, R Raedt, A Meurs, E Carrette, D van Roost, P Boon and K Vonck)Computational Models of Seizures and Epilepsy:Patient-Specific Neural Mass Modeling — Stochastic and Deterministic Methods (D R Freestone, L Kuhlmann, M S Chong, D Nesic and D B Grayden)Computational Modelling of Microseizures and Focal Seizure Onset (Y Wang, M Goodfellow, P N Taylor, D J Garry and G Baier)Predictability of Seizure-Like Events in a Complex Network Model of Integrate-and-Fire Neurons (A Rothkegel and K Lehnertz)Bursting and Synchrony in Networks of Model Neurons (C Geier, A Rothkegel and K Lehnertz)Advances in Analysis and Measurement Techniques:Signal Processing of the EEG: Approaches Tailored to Epilepsy (B Schelter, M Thiel, M Mader and W Mader)From Time Series to Complex Networks: An Overview (S Bialonski and K Lehnertz)Visualizing and Quantifying EEG Complexity on the Base of Ordinal Pattern Distributions (K Keller)Dynamics of Linear and Nonlinear Interrelation Networks in Peri-Ictal Intracranial EEG: Seizure Onset and Termination (C Rummel, M Müller, M Hauf, R Wiest and K Schindler)On the Centrality of the Focus in Human Epileptic Brain Networks (C Geier, M-T Kuhnert, C E Elger and K Lehnertz)Pre-Seizure States in Epileptic Brain Nnetworks: A Surrogate-Assisted, Weighted Network Analysis (G Ansmann, M-T Kuhnert, C E Elger and K Lehnertz)Network Analysis of Generalized Epileptic Discharges (P Ossenblok, P van Houdt, A Lüttjohann and G van Luijtelaar)Signal Processing Platform Based on Cellular Nonlinear Networks (J Müller, J Müller, R Becker and R Tetzlaff)Seizure Prediction by Cellular Nonlinear Networks? (V Senger and R Tetzlaff)Measuring Directed Interactions Using Cellular Neural Networks with Complex Connection Topologies (H Dickten, C E Elger and K Lehnertz)Seizure Prediction Using Optical Measurements of Blood Flow and Oxygenation (M Zhao, H Ma and T H Schwartz)Observing the Sleep-Wake Regulatory System to Improve Prediction of Seizures (M Sedigh-Sarvestani and B J Gluckman)The World's Largest Epilepsy Database: Content and Structure (M Ihle, B Schelter, J Timmer and A Schulze-Bonhage) Readership: Graduate students and professionals in the field of epileptology, neurosurgery and neuroscience. Keywords:Epileptic Networks;Seizure Prediction;Seizure Control;Computational Models;EpilepsyKey Features:Provides latest findings in the field of epilepsy research

Epilepsy

Epilepsy Book
Author : David W. McCandless
Publisher : Springer Science & Business Media
Release : 2011-11-02
ISBN : 9781461403616
Language : En, Es, Fr & De

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Book Description :

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

New Antiepileptic Drugs

New Antiepileptic Drugs Book
Author : Francesco Pisani
Publisher : Elsevier Science Limited
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.

Experimental Models of Epilepsy and Related Comorbidities

Experimental Models of Epilepsy and Related Comorbidities Book
Author : Mohd. Farooq Shaikh,Ayanabha Chakraborti,Annamaria Vezzani,Jafri Malin Abdullah
Publisher : Frontiers Media SA
Release : 2019-06-19
ISBN : 2889458431
Language : En, Es, Fr & De

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Book Description :

Epileptic patients live with epilepsy-associated complications such as cognitive dysfunction, psychological discomfort, and sexual function decline, and are more likely to experience emotional and mental health issues problems, including depression and anxiety. Many antiepileptic drugs are found to have a role in aggravating psychiatric symptoms. Animal models, which inform translational questions about epilepsy comorbidities, are used to study the relationship between epilepsy and related comorbidities. The aim of this Research Topic was to highlight basic, clinical and interdisciplinary research involved in studying the disease and its comorbid effects. Various experimental models are used to understand the mechansims of disease and to discover newer antiepileptic drugs. These experimental models combines the input from behavioral, biochemical and molecular level including genetic.

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury Book
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Release : 2015-12-01
ISBN : 1498766579
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Imaging Biomarkers in Epilepsy

Imaging Biomarkers in Epilepsy Book
Author : Andrea Bernasconi,Neda Bernasconi,Matthias Koepp
Publisher : Cambridge University Press
Release : 2019-01-10
ISBN : 1107108357
Language : En, Es, Fr & De

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Book Description :

Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.

The Epilepsies

The Epilepsies Book
Author : Chrysostomos P. Panayiotopoulos
Publisher : Bladon Medical Pub
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Epilepsies: Seizures, Syndromes and Management is the latest work from one of the world's leading experts and offers an exhaustive account of the classification and management of epileptic disorders. In thirteen chapters, Dr Panayiotopoulos gives clear and didactic guidance on the diagnosis, treatment and ongoing management of the full spectrum of epileptic syndromes with an insight and perception that only he can bring to the subject.This text is published in full colour throughout and is complemented by a pharmacopoeia and CD ROM with patient video-EEGs. An attractive, clear page layout and the accompanying supplementary material help the reader to easily identify the key components of each disorder, syndrome and seizure. Drawing on the author's outstanding collection of video-EEGs the accompanying CD ROM is cross-referenced within the text thus providing the reader with both a clinical and visual description of the various epileptic disorders and further aiding diagnosis.

Animal Models of Epilepsy

Animal Models of Epilepsy Book
Author : Scott C. Baraban
Publisher : Unknown
Release : 2009-01-01
ISBN : 9781603272636
Language : En, Es, Fr & De

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Book Description :

Animal models provide a means to investigate fundamental mechanisms of abnormal electrical discharge i.e., seizures. Taking advantage of transgenic and homologous recombination techniques, laboratories have recently moved beyond the standard convulsant or stimulation models in rat to develop novel mouse models of epilepsy. This book provides a review of the current and emerging animal models used to study epilepsy. Prior textbooks devoted to models of seizure and epilepsy almost exclusively categorized rat models with little attention paid to these more innovative approaches. In addition, this book goes beyond animal models, including also novel approaches to epilepsy research that are just now appearing in the literature, ranging from the modeling of seizure activity in silica to a discussion of advanced strategies for seizure detection and gene therapy. These latter innovations are important as some may lead to better therapeutic treatments for patients suffering with intractable forms of epilepsy.