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Models Of Seizures And Epilepsy

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Models of Seizures and Epilepsy

Models of Seizures and Epilepsy Book
Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
Publisher : Academic Press
Release : 2017-06-14
ISBN : 012804067X
Language : En, Es, Fr & De

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Book Description :

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Animal Models of Epilepsy

Animal Models of Epilepsy Book
Author : Scott C. Baraban
Publisher : Unknown
Release : 2009-01-01
ISBN : 9781603272636
Language : En, Es, Fr & De

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Book Description :

Animal models provide a means to investigate fundamental mechanisms of abnormal electrical discharge i.e., seizures. Taking advantage of transgenic and homologous recombination techniques, laboratories have recently moved beyond the standard convulsant or stimulation models in rat to develop novel mouse models of epilepsy. This book provides a review of the current and emerging animal models used to study epilepsy. Prior textbooks devoted to models of seizure and epilepsy almost exclusively categorized rat models with little attention paid to these more innovative approaches. In addition, this book goes beyond animal models, including also novel approaches to epilepsy research that are just now appearing in the literature, ranging from the modeling of seizure activity in silica to a discussion of advanced strategies for seizure detection and gene therapy. These latter innovations are important as some may lead to better therapeutic treatments for patients suffering with intractable forms of epilepsy.

Recent Advances in Predicting and Preventing Epileptic Seizures

Recent Advances in Predicting and Preventing Epileptic Seizures Book
Author : Ronald Tetzlaff,Christian E Elger,Klaus Lehnertz
Publisher : World Scientific
Release : 2013-08-28
ISBN : 9814525367
Language : En, Es, Fr & De

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Book Description :

This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational models of seizures and epilepsy. Furthermore the book covers recent developments of international databases and of parallel computing structures based on Cellular Nonlinear Networks that can play an important role in the realization of a portable seizure warning device. Contents:Epileptic Networks and Their Role for Seizure Prediction and Seizure Control:Transition Into and Out of a Focal Seizure (M de Curtis)Neuronal and Network Dynamics Preceding Experimental Seizures (P Jiruska, F Mormann and J G R Jefferys)Interictal EEG and Its Relevance for Seizure Prediction (A Schulze-Bonhage)Invasive Brain Stimulation in the Treatment of Epilepsy (M Sprengers, R Raedt, A Meurs, E Carrette, D van Roost, P Boon and K Vonck)Computational Models of Seizures and Epilepsy:Patient-Specific Neural Mass Modeling — Stochastic and Deterministic Methods (D R Freestone, L Kuhlmann, M S Chong, D Nesic and D B Grayden)Computational Modelling of Microseizures and Focal Seizure Onset (Y Wang, M Goodfellow, P N Taylor, D J Garry and G Baier)Predictability of Seizure-Like Events in a Complex Network Model of Integrate-and-Fire Neurons (A Rothkegel and K Lehnertz)Bursting and Synchrony in Networks of Model Neurons (C Geier, A Rothkegel and K Lehnertz)Advances in Analysis and Measurement Techniques:Signal Processing of the EEG: Approaches Tailored to Epilepsy (B Schelter, M Thiel, M Mader and W Mader)From Time Series to Complex Networks: An Overview (S Bialonski and K Lehnertz)Visualizing and Quantifying EEG Complexity on the Base of Ordinal Pattern Distributions (K Keller)Dynamics of Linear and Nonlinear Interrelation Networks in Peri-Ictal Intracranial EEG: Seizure Onset and Termination (C Rummel, M Müller, M Hauf, R Wiest and K Schindler)On the Centrality of the Focus in Human Epileptic Brain Networks (C Geier, M-T Kuhnert, C E Elger and K Lehnertz)Pre-Seizure States in Epileptic Brain Nnetworks: A Surrogate-Assisted, Weighted Network Analysis (G Ansmann, M-T Kuhnert, C E Elger and K Lehnertz)Network Analysis of Generalized Epileptic Discharges (P Ossenblok, P van Houdt, A Lüttjohann and G van Luijtelaar)Signal Processing Platform Based on Cellular Nonlinear Networks (J Müller, J Müller, R Becker and R Tetzlaff)Seizure Prediction by Cellular Nonlinear Networks? (V Senger and R Tetzlaff)Measuring Directed Interactions Using Cellular Neural Networks with Complex Connection Topologies (H Dickten, C E Elger and K Lehnertz)Seizure Prediction Using Optical Measurements of Blood Flow and Oxygenation (M Zhao, H Ma and T H Schwartz)Observing the Sleep-Wake Regulatory System to Improve Prediction of Seizures (M Sedigh-Sarvestani and B J Gluckman)The World's Largest Epilepsy Database: Content and Structure (M Ihle, B Schelter, J Timmer and A Schulze-Bonhage) Readership: Graduate students and professionals in the field of epileptology, neurosurgery and neuroscience. Keywords:Epileptic Networks;Seizure Prediction;Seizure Control;Computational Models;EpilepsyKey Features:Provides latest findings in the field of epilepsy research

Experimental Models of Epilepsy and Related Comorbidities

Experimental Models of Epilepsy and Related Comorbidities Book
Author : Mohd. Farooq Shaikh,Ayanabha Chakraborti,Annamaria Vezzani,Jafri Malin Abdullah
Publisher : Frontiers Media SA
Release : 2019-06-19
ISBN : 2889458431
Language : En, Es, Fr & De

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Book Description :

Epileptic patients live with epilepsy-associated complications such as cognitive dysfunction, psychological discomfort, and sexual function decline, and are more likely to experience emotional and mental health issues problems, including depression and anxiety. Many antiepileptic drugs are found to have a role in aggravating psychiatric symptoms. Animal models, which inform translational questions about epilepsy comorbidities, are used to study the relationship between epilepsy and related comorbidities. The aim of this Research Topic was to highlight basic, clinical and interdisciplinary research involved in studying the disease and its comorbid effects. Various experimental models are used to understand the mechansims of disease and to discover newer antiepileptic drugs. These experimental models combines the input from behavioral, biochemical and molecular level including genetic.

Epileptic Seizures and the EEG

Epileptic Seizures and the EEG Book
Author : Andrea Varsavsky,Iven Mareels,Mark Cook
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439812047
Language : En, Es, Fr & De

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Book Description :

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Astrocytes and Epilepsy

Astrocytes and Epilepsy Book
Author : Jacqueline A. Hubbard,Devin K. Binder
Publisher : Academic Press
Release : 2016-07-05
ISBN : 0128026243
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Recent Advances in Predicting and Preventing Epileptic Seizures

Recent Advances in Predicting and Preventing Epileptic Seizures Book
Author : Ronald Tetzlaff,Christian Erich Elger,Klaus Lehnertz
Publisher : World Scientific Publishing Company Incorporated
Release : 2013
ISBN : 9789814525343
Language : En, Es, Fr & De

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Book Description :

This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational models of seizures and epilepsy. Furthermore the book covers recent developments of international databases and of parallel computing structures based on Cellular Nonlinear Networks that can play an important role in the realization of a portable seizure warning device.

Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research Book
Author : Steven L. Peterson,Timothy E. Albertson
Publisher : CRC Press
Release : 2019-05-07
ISBN : 0429525354
Language : En, Es, Fr & De

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Book Description :

There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

Epileptic Seizures and the EEG

Epileptic Seizures and the EEG Book
Author : Andrea Varsavsky,Iven Mareels,Mark Cook
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1000218929
Language : En, Es, Fr & De

GET BOOK

Book Description :

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Seizures and Epilepsy

Seizures and Epilepsy Book
Author : Jerome Engel
Publisher : Oxford University Press
Release : 2013-01-31
ISBN : 019532854X
Language : En, Es, Fr & De

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Book Description :

This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology.

Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy

Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy Book
Author : Divya Vohora
Publisher : Humana
Release : 2021-06-23
ISBN : 9781071612538
Language : En, Es, Fr & De

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Book Description :

This volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field.

Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research Book
Author : Steven L. Peterson,Timothy E. Albertson
Publisher : CRC Press
Release : 2019-05-07
ISBN : 1420048880
Language : En, Es, Fr & De

GET BOOK

Book Description :

There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

Behavioral Aspects of Epilepsy

Behavioral Aspects of Epilepsy Book
Author : Gregory L. Holmes, MD,Steven C. Schachter,Dr. Dorothee GA Kasteleijn-Nolst Trenite, "MD,MPH"
Publisher : Demos Medical Publishing
Release : 2007-10-15
ISBN : 9781934559888
Language : En, Es, Fr & De

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Book Description :

The field of epilepsy and behavior has grown considerably in the past number of years, reflecting advances in the laboratory and clinic. Behavioral Aspects of Epilepsy: Principles and Practice is the definitive text on epilepsy behavioral issues, from basic science to clinical applications, for all neurologists, psychosocial specialists, and researchers in the fields of epilepsy, neuroscience, and psychology/psychiatry. Behavioral aspects of epilepsy include a patient's experiences during seizures, his or her reaction during and between seizures, the frequency of episodes and what can be determined from the number of seizures. With contributions by dozens of leading international experts, this is the only book to cover all aspects of this critical emerging science. Adult and pediatric patients, animal models, and epilepsy surgery and its effects are all covered in detail. Behavioral Aspects of Epilepsy is the only source for up-to-date information on a topic that has significant and growing interest in the medical community. This comprehensive, authoritative text has a bench to bedside, approach that covers: The mechanisms underlying epilepsy and behavior Neurophysiologic function Neuropsychiatric and behavioral disorders in patients with epilepsy The effects of treatments and surgery on behavior Pediatric and adolescent epilepsy Disorders associated with epilepsy that impact behavior And much more

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Book
Author : Ryuta Koyama
Publisher : Elsevier Inc. Chapters
Release : 2013-05-29
ISBN : 0128072261
Language : En, Es, Fr & De

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Book Description :

Epilepsy is a nervous system disorder characterized by recurrent seizures that commonly affects infants and children. It has been suggested that prolonged seizures in early life could affect the developing brain. Thus, adequate animal models for studying the causality and outcome of early-life seizures are necessary to facilitate the development of drugs and therapeutic strategies. Among early-life seizures, febrile seizures are the most common type of convulsive events in humans between 3 months and 5 years of age. Although febrile seizures are benign in most cases, it remains controversial whether complex febrile seizures are associated with the development of epilepsy later in life. To address this concern, animal models of febrile seizures have been developed and utilized to characterize the mechanisms and consequences underlying febrile seizure-induced alterations in the structure and function of neural circuits. In this chapter, the accumulated findings from experimental models of febrile seizures will be introduced and discussed.

Stochastic Process Models for Epileptic Seizures

Stochastic Process Models for Epileptic Seizures Book
Author : Maria Luz Marigomen
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Stochastic Process Models for Epileptic Seizures book written by Maria Luz Marigomen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Seizures and the Developing Brain

Seizures and the Developing Brain Book
Author : Aristea S. Galanopoulou
Publisher : Biota Publishing
Release : 2011-10-01
ISBN : 1615043551
Language : En, Es, Fr & De

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Book Description :

Seizures are more common early in life than in adulthood. Bidirectional interactions between seizures and normal developmental processes define their expression and outcomes. Several developmentally regulated factors control neuronal excitability. GABAA receptors hold a central role as they control neuronal activity in an age-specific manner. Early in development, GABAA receptors have depolarizing effects, which contribute to the increased susceptibility of immature neurons to seizures but they are also essential for normal brain development. During development, there is a gradual shift to the "adult-type" hyperpolarizing GABAA receptor signaling, creating more efficient inhibition. Seizures may disrupt GABAA receptor signaling by changing the expression of their subunits and by changing the direction of GABAA responses, which, in certain situations, may be detrimental for brain development. Furthermore, subcortical nuclei, such as the substantia nigra, control the expression and propagation of seizures in an age- and sex-dependent manner. These endogenous control centers and signaling pathways are further modified by independent genetic epigenetic, biologic, or other factors, which further increase the heterogeneity in presentation of seizures, their treatment, and their comorbidities. Elucidation of these complex interactions and identification of biomarkers guiding therapeutic interventions will be necessary to improve our ability to treat early-life epilepsies.

Epilepsy

Epilepsy Book
Author : Philip A. Schwartzkroin
Publisher : Cambridge University Press
Release : 2007-02
ISBN : 9780521033503
Language : En, Es, Fr & De

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Book Description :

This book considers a number of major concepts and models in epilepsy research, to advance understanding of the basic mechanisms involved.

Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders

Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders Book
Author : Hideo Yamanouchi,Solomon L. Moshé,Akihisa Okumura
Publisher : Elsevier Health Sciences
Release : 2017-10-21
ISBN : 0323530907
Language : En, Es, Fr & De

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Book Description :

Stay current with recent progress in the field of acute encephalopathy and encephalitis in infants with this practical resource by Drs. Hideo Yamanouchi, Solomon L. Moshé, and Akihisa Okumura. This practical resource covers key information relevant to physicians, surgeons, and nurses who often must take prompt action in the everyday clinical care of patients with these disorders. Features a wealth of information for all health care professionals who encounter these complex conditions. Covers diagnostic strategy, subtypes of acute encephalopathy, and management of acute encephalopathy and encephalitis. Consolidates today’s available information and guidance on acute encephalopathy and encephalitis in infancy, in addition to related disorders, into one convenient resource.

Bundle for Epilepsy Researchers

Bundle for Epilepsy Researchers Book
Author : Ruben Kuzniecky,Asla Pitknen,Ivan Soltesz
Publisher : Academic Press
Release : 2008-10-03
ISBN : 9780123748690
Language : En, Es, Fr & De

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Book Description :

Combining three essential Academic Press books, this bundle provides reference information for epilepsy researchers at a great price. Magnetic Resonance in Epilepsy is an in-depth look at the advances in imaging techology as applied to epilepsy research. Models of Seizures and Epilepsy speaks to the needs of both basic neuroscientists and clinical neurologists, in understanding the pathophysiology of seizures and the epilepsies and predicting the clinical effectiveness of antiepileptic treatments. Computational Neuroscience in Epilepsy is the first-ever book solely dedicated to the emerging discipline of computational epilepsy research.

A Novel Model of Optogenetic Kindling of Neocortex

A Novel Model of Optogenetic Kindling of Neocortex Book
Author : Elvis Cela
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Epilepsy is a major neurological disorder that is under intense scientific and medical investigation. The emergence of seizures is associated with other comorbidities and decreases the quality of life of patients. In addition, around 30% of patients do not respond to standard line of treatment using anti-epileptic drugs (AEDs). Furthermore, it is still unclear how seizures arise in the otherwise healthy brain. Therefore, it is critical to have well developed models where a causal understanding of epilepsy can emerge. While the development of seizures has been studied in many animal models, such as those using electrical induction, deciphering the results of such studies has been difficult due to the uncertainty of the cell population being targeted as well as potential confounds like brain damage from the procedure itself. The kindling model of epilepsy, an enduring electrical induction model has been used over time to dissect the steps of seizure development in animals that underlie epilepsy. We used the classical kindling model as a base to develop novel models from and addressed the disadvantages associated with current induction models.This thesis describes the development of a novel optogenetic kindling model of seizures along with a two-hit counterpart which can be used separately, as well circuit analysis methods these models can be combined with to study epileptogenesis. Using a combination of optogenetic stimulation and EEG recordings in awake freely moving animals, we tested the hypothesis that activity alone from repeated stimulation eventually causes seizures. The resulting seizures display several hallmarks features consistent with classical kindling such as a decrease in seizure threshold, worsening seizure symptoms and an elevated retention of seizure susceptibility in kindled animals. Using two-photon targeted paired whole-cell recordings and ex-vivo optogenetic manipulation of cellular activity we found that intrinsic excitability of cells from kindled brains did not differ from controls. To circumvent the labour and time constraints imposed by our optogenetic kindling protocol, we developed a two-hit model using rimonabant injections to test if CB1R blockade could accelerate optokindled seizures. Finally, we ran proof of principle experiments using optogenetic stimulation in acute slices that could serve as an alternative to paired recording for rapid circuit mapping following seizures. Taken together, our results demonstrate promoter-specific manipulation of excitatory cell populations can give rise to seizures, a variant model for accelerating seizure development and possible circuit mapping methodologies to dissect circuit changes following seizures. I anticipate my findings may serve as the inspiration for future studies using optogenetics and other modern techniques to probe potential mechanisms of seizure development and increase the probability of developing novel treatment options"--